International Journal of Phytotherapy and Phytopharmacology Scope
The journal covers the following sections:
- Trends in Phytopharmacology: innovative technologies and emerging concepts - Reviews
- Clinical pharmacology and toxicology
- Pre-clinical pharmacology and toxicology
- Mechanisms of action of herbal medicines and their active constituents
- Endocrine pharmacology
- Infectious diseases
- Cardiovascular diseases
- Ageing associated disorders
- Quality of Herbal preparations/botanicals: adulteration, standardization, analysis
- Legislation of Herbal preparations/botanicals
- Current issues in Phytomedicine research (various topics which are not covered in all other volumes).
Your article must meet the scope of Phytomedicine (please see above). Articles that are not in the scope, will be rejected immediately!
- Articles on the isolation and structure elucidation of novel bioactive compounds or the development of new analytical methods do not fall into the scope of Phytomedicine. However, pharmacological and clinical studies of novel natural products, where new compounds or methods of analysis of active of pharmaceutical ingredients in herbal preparations and biological fluids and tissues are reported (e.g. in pharmacokinetic studies), are welcome.
- Dietary Supplements, "Botanicals" or "Functional Food" are not within the scope of Phytomedicine unless they are specified/standardized and pharmacologically investigated analogues to herbal drugs and if the evidence presented is comparable to therapeutic outcomes with a positive control.
- Studies on pure compounds are not accepted if their origin is not clearly related to the plant kingdom.
- Pharmacological studies of isolated compounds in various forms (salts, ethers, etc.), which do not exist in nature are out of scope of Phytomedicine.
- Screening results of a large number of plant extracts or plant constituents for pharmacological activities will not be considered unless they are focused on those plants or constituents which show superior activities in comparison with generally accepted positive (reference) compounds.
- Plant name and herbal substance
Latin binomial name and the author, local name and English name and plant part(s) used must by specified for all plants used in the study. It should be stated that the plant name has been checked with http://www.theplantlist.org. The authentication of fresh plants or dried herbal drugs, including those of formulas, must be carried out by means of macroscopic and/or microscopic, molecular biological, chemical, chromatographic and/or other suitable pharmacognostic methods. Voucher specimens of plant materials used for all studies must be deposited and identified with a voucher number, the date and location of collection. The plant material may derive from natural origin, from cultivated plants, or from an herbal drug market. In case of commercially procured material the source, batch number, and quality control data should be specified. All scientific names of the plants must be written in italics through the whole manuscript!
- Herbal medicinal products and herbal extracts
Herbal medicinal products or herbal preparations must be declared in accordance to EMA guidelines. In particular, herbal extracts must be clearly and comprehensively described with respect to the plant part used, the drug extract ratio, type and concentration of extraction solvent, extraction conditions etc. They must be sufficiently characterized (e.g. by HPLC fingerprints) and specified for the content of marker compounds to ensure a consistent quality and reproducible pharmacological activity. The choice of marker must be justified. The analytical methods have to be validated for selectivity, accuracy and precision and briefly described, providing the most important information necessary to obtain reproducible results. Traditional and commercial names of herbal preparations should be mentioned in the Introduction of the manuscript, but not in the title. Phytomedicine accepts only international standard terminology – binomial Latin names of the plants and their combinations.
- Herbal combinations
Studies with herbal drug combinations (e.g. 2-5 plants) will be accepted only if each herbal drug undergo the same authentication and standardization process as described above, each single herbal extracts is HPLC fingerprinted and relevant marker constituents are quantified before and after the extracts are mixed. A 3-D-HPLC-profile of the multiherbal drug combination must be provided. Authors must clearly demonstrate which analytical marker specifically indicates on the presence each of herbal ingredients in the combination.Additionally, we encourage the use other relevant and validated physiological, biological, or biochemical methods, which ensure reproducible pharmacological activity of multi-herbal drug combinations.
- Chemicals, phytochemicals and other purified compounds For purified compounds, please provide chemical names using relevant information from the NCBI PubChem which can be found on the website http://www.ncbi.nlm.nih.gov/pccompound. In studies with purified compounds the evidences of their purity (13C NMR or HPLC peak purity test) are required.
- Gene nomenclature Authors should use approved nomenclature for gene symbols. Please consult the appropriate nomenclature data bases for correct gene names and symbols. "Entrez Gene" is a useful resource. Approved human gene symbols are provided by HUGO Gene Nomenclature committee (HGNC): http://www.gene.ucl.ac.uk/nomenclature Approved Mouse symbols are provided by The Jackson Laboratory: http://www.informatics.jaxorg/mgihome/nomen
Approved C. elegans symbols are provided by Caenorhabditis Genetics Center: http://www.cbs.unmn.edu/CGC/Nomenclature/no menguid.htm For approved S. cerevisiae and S. pombe symbols see http://yeastgenome.org/help/yeastGeneNomenclature.shtml and http://www.sanger.ac.uk/Projects/S_pombe/SP_Name_FAQ.shtml, respectively
- Statistical analysis
Statistical hypothesis and methods should be described in detail. Actual P values should be used unless less than 0.001. Reporting of 95% confidence intervals is encouraged. The choice of appropriate parametric or nonparametric tools has to be justified. Refer to B.S. Evererett. Statistical Methods for Medica Investigations, Oxford University Press, New York, 1989.
Scientific novelty of your study must be clearly demonstrated. The articles limited with a repetition of well-known data or identification of only well-known ubiquitous compounds with little or no relation to activity are not acceptable.
- In vitro studies with concentrations of active compounds, which could not be implemented in-vivo and that are not appropriate for further pharmaceutical development.
- In vitro studies without results on organs, tissues, fluids or cells.
- In vitro studies without positive control.
- In vivo single dose studies or studies with one set of experiments and few animals.
- Studies on antimicrobial activity with only single dose, very high concentration, measuring only inhibition zones without MIC values, without information on type of activity (or growth inhibition) or microorganisms investigation.
- Pharmacological studies of pure compounds, which are not supported by evidences on pharmacological activity of plant extract where it was identified.
- Clinical studies must meet the current standards for clinical trials (GCP = Good Clinical Practice), which are equivalent to those required for synthetic drugs. http://www.fda.gov/downloads/Drugs/Guidances/ucm073122.pdf, http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2009/09/WC500002832.pdf
- Articles should be in line with Extensions of the Consolidated Standards of Reporting Trials Statement for Herbal Medicinal Interventions (CONSORT), particularly when it comes to description of study medication, which is a strict requirement of acceptance for Phytomedicine. For guidelines and necessary information, please use the following internet addresses: http://www.consort-statement.org, http://www.consort-statement.org/extensions?ContentWidgetId=557, http://www.consort-statement.org/Media/Default/Downloads/Extensions/CONSORT Extension for Herbal Interventions.pdf, http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2009/09/WC500003370.pdf. Use of a CONSORT checklist and flow diagram is recommended for illustration of grouping and flow of patients in all clinical studies, randomized clinical trials as well as other trials.
- Clinical studies must be approved by an Institutional Ethics Committee or its equivalent. The Methods section must state that the study followed the guidelines of the Declaration of Helsinki and Tokyo for humans!
Requirements for pharmacological studies (in vitro, ex vivo or in vivo):
- Investigations with animals must state in the Methods section that the research was conducted in accordance with internationally accepted principles for laboratory animal use and care (e.g. European community guidelines/ EEC Directive of 1986 or the US guidelines/ NIH publication).
- The route of drug administration, different of oral, must be justified.
- Appropriate and justified statistical methods must be used.Positive controls (reference standards must be included in study design).
- Many natural compounds are known for their polyvalent (pleiotropic) activities and are only of interest if one or two pharmacological activities are dominant and somehow superior in comparison with generally accepted reference standards/compounds. Their potential therapeutic application must be justified for specified indication.
- Antimicrobial evaluation of plants are of scientific value only if these plant extracts show superior biological activities in comparison with a synthetic or natural antimicrobial agent standard. It is preferred that in vitro activity (MIC) of an extract in not higher than 100 ìg/ml. For the correct determination of MIC values, standardized methodologies such as those of CLSI or EUCAST are preferred.
- All articles that are reporting gene expression profiling data (microarray experiments) should comply with the Minimum Information about Microarray Experiments (MIAME, http://www.mged.org/Workgroups/MIAME/miame.html).
- At least two microarrays should be provided for each experimental condition. Results of selected genes should be validated by a second method (e.g. RT-PCR) or protein data should be provided. In addition functional test (animal experiments/clinical data) undertaken simultaneously are desirable to allow an appraisement of the biological/clinical relevance of the data. Alternatively, results of in vivo experiments with comparable dosages can be discussed. The presentation of a sole data collection is not acceptable. Biologically relevant information should be presented.
- We recommend do not overuse specific names, notions and terms from various theories of traditional medical systems (e.g. TCM, Ayurveda, etc.). That makes articles difficult for perceptions and understanding. The essence of these theories should be translated into internationally accepted scientific theories, while traditional names and terms should be converted to English. Final interpretation of the results of the study must adhere to conventional scientific theories.
Please see our information pages on Ethics in publishing and Ethical guidelines for journal publication.
Declaration of interest
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Articles should not exceed 12-15 typewritten pages or up to 5,000 words, including references, tables and figures. Previously reported methods should be referenced only. The number of references should not exceed 30 (except for review articles or reports on microarray data). Review articles
Review articles will only be by invitation. Review articles can provide concise and critical updates on a subject of current interest. Herbal drug-monographs are only acceptable if they contain the newest pharmacological and toxicological issues and an outlook on future directions.
Prof. Hildebert Wagner Award
The "Prof. Hildebert Wagner Award" was created to honor the outstanding efforts of Prof. Wagner for the journal Phytomedicine. This award will be granted to a graduate student or young post-doctoral researcher who is the first author of a paper reviewed by the Editors of Phytomedicine to be the best one in the Journal during the previous calendar year. The prize will be sponsored by Elsevier with EUR 500 for the awardee and a certificate for every Co-Author. Additionally an official notice will be published on the journal homepage of Phytomedicine (http://www.elsevier.com/locate/phymed), on which the article will be available free of charge for one year. The reviewing editors for the first contribution to be awarded in Phytomedicine will be Prof. Hildebert Wagner himself, Prof. Alexander Panossian, and Prof. Susana Zacchino. To qualify, nominees must be younger than 35 years and an outstanding contribution to the field must be provided. Nominations can be made by first authors (resp. corresponding authors).
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Anti-stress effects of 20(S)-protopanaxadiol and 20(S)-protopanaxatriol in immobilized mice
Hyun A Oha, Dae-Eung Kimb, Hyuck Jai Choic, Nam Jae Kimc, and Dong-Hyun Kimac,*
a Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-ku, Seoul 130-701, Republic of Korea
b Sempio Foods Company, 183, Osongsaengmyung-4ro, Cheongwongun, Chungcheongbukdo 363-954, Republic of Korea
c East-West Medical Research Institute, Kyung Hee University Medical Center, 23, Kyungheedae-ro, Dongdaemun-ku, Seoul 130-872, Republic of Korea
* Corresponding author
Dong-Hyun Kim, Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-ku, Seoul 130-701, Republic of Korea
Tel.: +82 2 961 0374; fax: +82 2 957 5030.
E-mail address: firstname.lastname@example.org (D.H. Kim).
**The phone, fax and email address of the corresponding author should be placed on the title page.
A concise and factual abstract is required. Abstracts should summarize the contents of the article in 350 words or less. The abstract should be structured in the following format:
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Conclusion: State the answer to your original question or hypothesis.Summarize the most important conclusions that can be directly drawn from your study.
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A section of abbreviations should precede the manuscript. Define abbreviations that are not standard in this field in a footnote to be placed on the first page of the article. Abbreviations that are unavoidable in the abstract must be defined at their first mention there, as well as in the footnote. Ensure consistency of abbreviations throughout the article.
See "Uniform requirements for manuscripts submitted to biomedical journals" (1991) New England Journal of Medicine 324:424–428. Introduction
Provide an adequate background, avoiding a detailed literature survey or a summary of the results. State the objectives of the work. No results of the study should be described in this section.
- Plant names and parts used (requirements see above)
- Study medication, herbal extracts (requirements see above)
- Chemical compounds (requirements see above)
- Statistical analysis (requirements see above)
- Assays (requirements see above)
- Animal studies (requirements see above)
- Study design (requirements see above)
This should explore the significance of the results of the work, not repeat them. A combined Results and Discussion section is often appropriate. Avoid extensive citations and discussion of published literature. Acknowledgements
Collate acknowledgements in a separate section at the end of the article before the references and do not, therefore, include them on the title page, as a footnote to the title or otherwise. List here those individuals who provided help during the research (e.g., providing language help, writing assistance or proof reading the article, etc.).
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This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.Units
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Please ensure that every reference cited in the text is also present in the reference list (and vice versa). Any references cited in the abstract must be given in full. Unpublished results and personal communications are not recommended in the reference list, but may be mentioned in the text. If these references are included in the reference list they should follow the standard reference style of the journal and should include a substitution of the publication date with either 'Unpublished results' or 'Personal communication'. Citation of a reference as 'in press' implies that the item has been accepted for publication.
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This journal encourages you to cite underlying or relevant datasets in your manuscript by citing them in your text and including a data reference in your Reference List. Data references should include the following elements: author name(s), dataset title, data repository, version (where available), year, and global persistent identifier. Add [dataset] immediately before the reference so we can properly identify it as a data reference. This identifier will not appear in your published article.
[dataset] Oguro, M., Imahiro, S., Saito, S., Nakashizuka, T., 2015. Mortality data for Japanese oak wilt disease and surrounding forest compositions. Mendeley Data, v1. http://dx.doi.org/10.17632/xwj98nb39r.1.
References in a special issue
Please ensure that the words 'this issue' are added to any references in the list (and any citations in the text) to other articles in the same Special Issue.
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Text: All citations in the text should refer to:
1. Single author: the author's name (without initials, unless there is ambiguity) and the year of publication;
2. Two authors: both authors' names and the year of publication;
3. Three or more authors: first author's name followed by 'et al.' and the year of publication.
Citations may be made directly (or parenthetically). Groups of references should be listed first alphabetically, then chronologically.
Examples: 'as demonstrated (Allan, 2000a, 2000b, 1999; Allan and Jones, 1999). Kramer et al. (2010) have recently shown ....'
Reference to a journal publication:
Wagner., H., Ulrich-Merzenich, G., 2009. Synergy research: Approaching a new generation of phytopharmaceuticals. Phytomedicine 16, 97–110.
Argyropoulos D, Kudadam J, Müller J, 2009. Color degradation of lemon balm (Melissa officinalis L.) as affected by the drying process. In: 5th International Technical Symposium on Food Processing, Monitoring Technology in Bioprocesses and Food Quality Management, Potsdam, Germany, August 31– September 2, pp. 730–736.
Willcox, M.L., Graz, B., Falquet, J., Diakite, C., Giani, S., Diallo, D., 2011. A "reverse pharmacology" approach for developing an anti-malarial phytomedicine. Malaria J. 10 (Suppl. 1), S8.Reference to a book:
Cramer, J.A., Spilker, B., 1998. Quality of Life and Pharmacoeconomics. An Introduction. Lippincott-Raven, Philadelphia.
Reference to a chapter in an edited book:
Cragg, G.M., Boyd, M., 1996. Drug discovery and development at the National Cancer Institute: the role of natural products of plant origin. In: Balick, M.J., Elisabetsky, E., Laird, S.A. (Eds.), Medicinal Plan Resources of the Tropical Forest. Columbia University Press, New York, pp. 101–136.
Journal names should be abbreviated according to the List of Title Word Abbreviations.
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The journal encourages authors to create an AudioSlides presentation with their published article. AudioSlides are brief, webinar-style presentations that are shown next to the online article on ScienceDirect. This gives authors the opportunity to summarize their research in their own words and to help readers understand what the paper is about. More information and examples are available. Authors of this journal will automatically receive an invitation e-mail to create an AudioSlides presentation after acceptance of their paper.
Include interactive data visualizations in your publication and let your readers interact and engage more closely with your research. Follow the instructions here to find out about available data visualization options and how to include them with your article.
Supplementary material such as applications, images and sound clips, can be published with your article to enhance it. Submitted supplementary items are published exactly as they are received (Excel or PowerPoint files will appear as such online). Please submit your material together with the article and supply a concise, descriptive caption for each supplementary file. If you wish to make changes to supplementary material during any stage of the process, please make sure to provide an updated file. Do not annotate any corrections on a previous version. Please switch off the 'Track Changes' option in Microsoft Office files as these will appear in the published version.
This journal encourages and enables you to share data that supports your research publication where appropriate, and enables you to interlink the data with your published articles. Research data refers to the results of observations or experimentation that validate research findings. To facilitate reproducibility and data reuse, this journal also encourages you to share your software, code, models, algorithms, protocols, methods and other useful materials related to the project.
Below are a number of ways in which you can associate data with your article or make a statement about the availability of your data when submitting your manuscript. If you are sharing data in one of these ways, you are encouraged to cite the data in your manuscript and reference list. Please refer to the "References" section for more information about data citation. For more information on depositing, sharing and using research data and other relevant research materials, visit the research data page.Data linking
If you have made your research data available in a data repository, you can link your article directly to the dataset. Elsevier collaborates with a number of repositories to link articles on ScienceDirect with relevant repositories, giving readers access to underlying data that gives them a better understanding of the research described.
There are different ways to link your datasets to your article. When available, you can directly link your dataset to your article by providing the relevant information in the submission system. For more information, visit the database linking page.For supported data repositories a repository banner will automatically appear next to your published article on ScienceDirect.
In addition, you can link to relevant data or entities through identifiers within the text of your manuscript, using the following format: Database: xxxx (e.g., TAIR: AT1G01020; CCDC: 734053; PDB: 1XFN).Data in Brief
You have the option of converting any or all parts of your supplementary or additional raw data into one or multiple data articles, a new kind of article that houses and describes your data. Data articles ensure that your data is actively reviewed, curated, formatted, indexed, given a DOI and publicly available to all upon publication. You are encouraged to submit your article for Data in Brief as an additional item directly alongside the revised version of your manuscript. If your research article is accepted, your data article will automatically be transferred over to Data in Brief where it will be editorially reviewed and published in the open access data journal, Data in Brief. Please note an open access fee of 500 USD is payable for publication in Data in Brief. Full details can be found on the Data in Brief website. Please use this template to write your Data in Brief.
- Full postal address
- E-mail address
- Tel / fax number
- Author Agreement
- Cover letter
- Graphical Abstract (mandatory)
- Supplementary material (if needed)
3. Correct order within the manuscript:
- Title Page (Heading, Author names (the superscripts behind the names which indicates the Institutes/affiliation of the authors have to be a,b,c,.... and * for the corresponding author in addition), Institutes/affiliation, Corresponding Author with full address, Word count)
- Abstract: has to be structured into Background, Hypothesis/Purpose, Study Design, Methods, Results, Conclusion
- Keywords not more than 6
- Materials and methods
- Results and discussion
- Conflict of interest (mandatory)
- Table legends
- Figure legends
- Page and line numbers throughout the manuscript
- References are in the correct format for this journal
- References in alphabetical order
- All references mentioned in the Reference list are cited in the text, and vice versa
- Citation according to our journal style
5. Choose the correct section for your article6. Further considerations
- Manuscript has been 'spell-checked' and 'grammar-checked'
- Permission has been obtained for use of copyrighted material from other sources (including the Internet) Printed version of figures (if applicable) in color or black-and-white
- Indicate clearly whether or not color or black-and-white in print is required.
- For reproduction in black-and-white, please supply black-and-white versions of the figures for printing purposes. For any further information please visit our Support Center.
Corresponding authors will receive an e-mail with a link to our online proofing system, allowing annotation and correction of proofs online. The environment is similar to MS Word: in addition to editing text, you can also comment on figures/tables and answer questions from the Copy Editor. Web-based proofing provides a faster and less error-prone process by allowing you to directly type your corrections, eliminating the potential introduction of errors.
If preferred, you can still choose to annotate and upload your edits on the PDF version. All instructions for proofing will be given in the e-mail we send to authors, including alternative methods to the online version and PDF.
We will do everything possible to get your article published quickly and accurately. Please use this proof only for checking the typesetting, editing, completeness and correctness of the text, tables and figures. Significant changes to the article as accepted for publication will only be considered at this stage with permission from the Editor. It is important to ensure that all corrections are sent back to us in one communication. Please check carefully before replying, as inclusion of any subsequent corrections cannot be guaranteed. Proofreading is solely your responsibility.
The corresponding author will, at no cost, receive a customized Share Link providing 50 days free access to the final published version of the article on ScienceDirect. The Share Link can be used for sharing the article via any communication channel, including email and social media. For an extra charge, paper offprints can be ordered via the offprint order form which is sent once the article is accepted for publication. Both corresponding and co-authors may order offprints at any time via Elsevier's Webshop. Corresponding authors who have published their article gold open access do not receive a Share Link as their final published version of the article is available open access on ScienceDirect and can be shared through the article DOI link.
Visit the Elsevier Support Center to find the answers you need. Here you will find everything from Frequently Asked Questions to ways to get in touch.
You can also check the status of your submitted article or find out when your accepted article will be published.