To submit a manuscript please go to http://www.ees.elsevier.com/ophtha and log in as an author. This site is also available through http://www.ophsource.org/periodicals/ophtha or the American Academy of Ophthalmology at http://www.aao.org/.
- Manuscripts – A a “typical” submission; a manuscript that does not fall into any of the following categories:
- AAO Meeting Paper – A manuscript based on material that has or will be presented at an American Academy of Ophthalmology Annual Meeting. Ophthalmology always has right of first refusal on these manuscripts.
- Correspondence – Comments by readers about articles that have been published in Ophthalmology within 6 months of its online posting. Please see specific criteria for submission elsewhere in this Guide.
- Editorials – Typically by invitation from the Editor-in-Chief. Please see specific criteria for submission elsewhere in this Guide.
- Focused Reviews –Typically by invitation from the Editorial Board. Please see specific criteria for submission elsewhere in this Guide.
- Manuscript to Report (Invited) – Typically by invitation from the Editorial Board. Please see specific criteria for submission elsewhere in this Guide.
- Systematic Review or Meta-analysis – Please see specific criteria for submission elsewhere in this Guide.
- Translational Science Reviews – Typically by invitation from the Editorial Board. Please see specific criteria for submission elsewhere in this Guide.
- Pictures & Perspectives – Photographs, photomicrographs, radiologic or other imaging studies, or procedural illustrations that depict striking or unusual features of clinically important entities.
If you have questions about the submission process, please contact the Editorial Office by email at firstname.lastname@example.org or by phone at 415-447-0261. If you are having trouble logging in, please visit http://help.elsevier.com/app/answers/detail/a_id/204/p/7923/related/1 for more information or contact email@example.com.
User Name and Password
The Elsevier Electronic System (EES) is used for processing all submissions and relies on correct e-mail addresses for all authors and reviewers. Your user name and password are the same regardless of your role as author or reviewer.
IF YOU KNOW YOUR USER NAME AND PASSWORD:
- Log into the home page http://www.ees.elsevier.com/ophtha using your user name and password and hit enter or choose “Author Login.” If you have consolidated your EES profile, your primary email address is your username.
- Click on “Change details” (top of screen) and review your contact information. It is generally easier to use the full page view for this listing.
If you wish you can list two current e-mail addresses, but both addresses will receive all emails generated in the system.
Here you can update all of your current contact information as well as your “Personal Classifications” (your areas of expertise). If you scroll down this page and click on the personal classifications link, you can mark your correct areas of expertise so we can more accurately direct manuscripts to you for review. Please remember to click “Submit” to save changes before closing the window.
- Change data as needed – Be sure to click “Submit” on the bottom of the page. We greatly appreciate you taking the time to update your information.
- Log into the home page (http://www.ees.elsevier.com/ophtha)
- Click on “register” (at top of screen) and fill in your first name, last name, and e-mail address. If you are already in the system, it will offer to send your user name and password to your e-mail address. When you receive it, follow directions #2 and #3 above.
- If you have changed your email address relatively recently and the EES is not recognizing you, we suggest you also try putting in your previous e-mail address so that you do not generate duplicate registrations within the system. If your old e-mail is in the system (and it is still accessible to you) click on “register” and follow the step in #5 above. If you have never registered as an author or reviewer:
- If you have never been in the system in any role (author or reviewer) go to the home page at http://ees.elsevier.com/ophtha/ click on register and follow the steps provided on the website.
If you do not know your user name and password but believe you are in the system, please do the following:
If for any reason you cannot access your information or are not sure if you are in the system, please send an e-mail to firstname.lastname@example.org with your first name, last name, city and state or city and country as appropriate and your new e-mail address. The Editorial office can verify if you have an existing account.Author Checklist
Please ensure that the following items have been done prior to logging into the Elsevier Editorial System:
- ___ Designate one author as the corresponding author with contact details.
- ___ If the paper was previously rejected by another journal, please prepare and submit copies of the reviews and your responses to them.
- ___ Provide at least 3-5 classifications on the submission form.
- ___ Copy/paste the complete manuscript title page (not title only) into the abstract field on the submission form.
When uploading files, please make certain that:
- ___ Précis is 35 words or less and in a separate file.
- ___ Manuscript file contains a title page.
- ___ Manuscript file contains an abstract.
- ___ Manuscript file contains continuous line numbering.
- ___ Figures and tables are not embedded in the manuscript file; submit figures and tables as separate files.
- ___ Abstract conforms to the journal’s structured format.
- ___ Figures are in tiff or eps format.
- ___ Tables include titles, brief description, and footnotes.
- ___ Online-only figures/tables are in PDF and properly labeled. Appropriate callouts are added to the manuscript file.
Acceptable File types are used (http://cdn.elsevier.com/promis_misc/OPHTHA_Listofacceptablefiletypes.docx). Further considerations:
- ___Use the active voice when writing the manuscript.
- ___Spell out acronyms.
- ___ Spell-check and grammar-check your manuscript prior to submission.
- ___ Ensure that references are in the correct AMA style format.
- ___ Make certain that all references are cited in the text.
- ___ Obtain permission for use of copyrighted material from other sources.
ReviewersCME Credit Request for Manuscript Review
OtherConsort Agreement for a Randomized Controlled Trial Pictures & Perspectives Copyright
Submission of an article implies that the work described has not been published previously (except in the form of an abstract or as part of a published lecture or academic thesis or as an electronic preprint, see 'Multiple, redundant or concurrent publication' section of our ethics policy for more information), that it is not under consideration for publication elsewhere, that its publication is approved by all authors and tacitly or explicitly by the responsible authorities where the work was carried out, and that, if accepted, it will not be published elsewhere including electronically in the same form, in English or in any other language, without the written consent of the copyright-holder.
Once files are uploaded, the system will automatically put them in the correct order. The system will prompt you to go to “Submission Waiting for Author’s Approval” on your author main menu. If necessary, you may exit the system and return to approve the submission at your convenience. You will find it in your author queue either under “Pending approval” or “Incomplete items” depending on how long it has been in EES. Please review your submission and approve it, or, if necessary, make corrections and repeat the process until you are satisfied. Incorrect file formats or missing components will prevent the PDF of your submission from building. If any changes are required to the uploaded files, you will need to remove the original file and upload a new file with your corrections. Changes cannot be made to files once they have been uploaded into the system. At the last step, when you are ready to approve the submission and “Submit to Journal Office,” you must also agree to the Ethics in Publishing statement. A link is provided to the statement and you agree to it by checking the box on the far right of the submission approval page.
Once your submission is assigned to the Editorial Board, you will receive an email with the manuscript number. Please use this number in all communications regarding your submission.Copyright
Upon acceptance of an article, authors will be asked to complete a 'Journal Publishing Agreement' (for more information on this and copyright, see http://www.elsevier.com/copyright). An e-mail will be sent to the corresponding author confirming receipt of the manuscript together with a 'Journal Publishing Agreement' form or a link to the online version of this agreement.
Subscribers may reproduce tables of contents or prepare lists of articles including abstracts for internal circulation within their institutions. Permission of the Publisher is required for resale or distribution outside the institution and for all other derivative works, including compilations and translations (please consult http://www.elsevier.com/permissions). If excerpts from other copyrighted works are included, the author(s) must obtain written permission from the copyright owners and credit the source(s) in the article. Elsevier has preprinted forms for use by authors in these cases: please consult http://www.elsevier.com/permissions.Author rights
As an author you (or your employer or institution) have certain rights to reuse your work. For more information see http://www.elsevier.com/copyright.
Funding body agreements and policies
Elsevier has established a number of agreements with funding bodies which allow authors to comply with their funder's open access policies. Some authors may also be reimbursed for associated publication fees. To learn more about these agreements please visit http://www.elsevier.com/fundingbodies
• Articles are freely available to both subscribers and the wider public with permitted reuse
• An open access publication fee is payable by authors or on their behalf (e.g., by their research funder or institution)
• Articles are made available to subscribers as well as developing countries and patient groups through our universal access programs (http://www.elsevier.com/access).
• No open access publication fee payable by authors.
Regardless of how you choose to publish your article, the journal will apply the same peer-review criteria and acceptance standards.For open access articles, permitted third party (re)use is defined by the following Creative Commons user licenses:
Creative Commons Attribution-NonCommercial-NoDerivs (CC BY-NC-ND)This license allows others to distribute and copy the article for non-commercial purposes or include in a collective work (such as an anthology) as long as authors are properly credited and the article is not altered or modified.
Elsevier supports responsible sharing
Find out how you can share your research published in Elsevier journals.
The open access publication fee for this journal is USD 3000, excluding taxes. Learn more about Elsevier's pricing policy: http://www.elsevier.com/openaccesspricing.
This journal has an embargo period of 12 months.
Please be sure all abbreviations/acronyms are spelled out at first use in the abstract and again at first use in the text. An abbreviation/acronym should appear first in parentheses immediately after the term or phrase to which it refers. Every abbreviation used in any table or figure should be defined in each corresponding legend.When writing the manuscript, use the active voice whenever possible.
- Objective or Purpose: Concisely state the study goal.
- Design: Identify the study design using a phrase such as cross-sectional study, clinical trial, cohort study, etc. Study design types are summarized in the Study Design section of this guide. The CONSORT Worksheet is required for randomized controlled trials.
- Subjects, Participants, and/or Controls: Describe the persons or eyes studied and the controls if a separate control group is included.
- Methods, Intervention, or Testing: Describe the principal treatment(s), procedure(s), test(s), or observation(s) performed.
- Main Outcome Measures: Define the main parameter(s) being measured (e.g., intraocular pressure, visual acuity, degree of inflammation, etc.)
- Results: Summarize the principal measurements (data) obtained.
- Conclusions: State the conclusion(s) derived from the data analysis.
Abstracts for Systematic Reviews or Meta-Analyses should not exceed 350 words and must include 5 sections following the PRISMA guidelines:
- Topic: Provide an explicit statement of the specific clinical question being addressed with reference to a brief description of the participants, interventions (or exposures), comparators, and outcomes examined.
- Clinical relevance: Characterize the magnitude and importance of the condition; when relevant, define the current standard of care.
- Methods: Describe the key eligibility criteria for including studies in the systematic review, key databases searched and search dates, and methods of assessing the risk of bias in the individual included studies.
- Results: Summarize the number and type of included studies and participants, and relevant characteristics of studies; describe the results of main outcomes (benefits and harms), preferably indicating the number of studies and participants for each. If a meta-analysis was done, include summary measures and confidence intervals; report the direction of the effect or association (i.e., which group is favored) and size of the effect using language meaningful to clinicians and patients.
- Conclusion: Summarize the strengths and limitations of the evidence, your general interpretation of the results, and important implications.
AAO Meeting Papers and Posters
Ophthalmology has the right of first refusal to any manuscript derived from a presentation at the American Academy of Ophthalmology Annual Meeting. Presentations at the Academy’s subspecialty day programs are exempt from this requirement (although submissions from such presentations are welcome). Authors may submit their manuscript to the journal before, during, or after the Annual Meeting. Please note on the cover page of the manuscript that it is derived from an Annual Meeting paper or poster. Please be sure to select “AAO Meeting Paper” for the document type; please do not use “Manuscript” in these instances. A manuscript based on presentation at the AAO Annual Meeting can be submitted to other journals if Ophthalmology declines to accept it after review (as documented by a rejection letter from the journal office) or if a waiver is granted in writing by the Editor-in-Chief.
The journal requires acknowledgment of anyone who makes substantial contributions to a manuscript but does not qualify as an author. Please refer to the Authorship section of this guide, specifically regarding Ghost/Guest Authors. The journal does not allow ghost authors.
The journal will also acknowledge those who reviewed, discussed, edited scientific content, referred patients, translated references, provided extensive statistical assistance, or provided essential tissue, equipment, or other materials without which the study could not have been completed. (See: Lichter PR. The author wishes to thank. Ophthalmology 1988;95:293-4). In such cases, written permission from the person being acknowledged is required.The journal does not print acknowledgments for those who participated in studies (e.g., patients), those who edited for grammar or formatting, or those who provided “helpful” or “moral” support or similar collegial aid to the authors. The journal does not publish acknowledgments of individuals whose service as employees contributed to a study, e.g., secretaries, clinic coordinators, technicians, ophthalmic photographers, or technologists.
For clarity and uniformity, manuscripts about astigmatism should adhere to terminology and graphical representations originally described by Alpins.1-3 An editorial by Reinstein et al outlines the argument for standardization.4
- Alpins N. Astigmatism analysis by the Alpins method. J Cataract Refract Surg 2001;27:31-49.
- Alpins NA. Vector analysis of astigmatism changes by flattening, steepening, and torque. J Cataract Refract Surg 1997;23:1503-14.
- Alpins NA. A new method of analyzing vectors for changes in astigmatism. J Cataract Refract Surg 1993;19:524-33.
- Reinstein DZ, Archer TJ, Randleman JB. JRS standard for reporting astigmatism outcomes of refractive surgery. J Refract Surg 2014;30:654-9.
The journal adheres to the Uniform Requirements set by the International Committee of Medical Journal Editors (http://www.icmje.org/) for authorship. Each author must meet criteria for Authorship. The ICMJE recommends that authorship be based on the following 4 criteria:
- Substantial contributions to conception and design of the work; or the acquisition, analysis, or interpretation of data for the work; AND
- Drafting the work or revising it critically for important intellectual content; AND
- Final approval of the version to be published; AND
- Agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
It is the responsibility of the corresponding author to confirm that each coauthor meets the requirements for authorship. These forms should be uploaded during the revision stage. Please note that the list of contributions will publish with the manuscript should it be accepted.Ghost/Guest Authors
Please note that the journal does not allow ghost authorship, based on the definition of ghost authorship as the failure to designate an individual who has made a substantial contribution to the research or writing of a manuscript (JAMA 2008;299(15):1800-12). If it comes to light that a substantial contribution has not been disclosed, the journal shall advise the corresponding author and withdraw the submission.
Based on the definition of guest authorship as the designation and acknowledgment of an individual who has contributed significantly but does not meet authorship criteria, any guest authors must (a) provide written permission to the corresponding author which is to be uploaded with the submission and (b) be listed by the corresponding author in the acknowledgments section (after text and before references in manuscript file) for their contribution (e.g., James Smith for statistical analysis). If the guest author is being acknowledged for writing assistance, it should specifically address if the guest author prepared a manuscript draft for the named authors to edit or if the named authors prepared the manuscript and received writing and formatting assistance from the guest author. If not self-employed, the guest author should disclose the name of his/her employer and any funding sources.Corresponding Author
The corresponding author is the person responsible for a submission and all communication with the journal regarding a submission. The corresponding author must notify the editors and editorial office, via the submission form, of the following:
- Acknowledment of any guest author, defined as an individual who does not meet authorship criteria but has made a substantial contribution to the research or writing of a manuscript.
- Confirmation that there are no “ghost authors,” defined as an individual who has made a substantial contribution but does not qualify as an author and has not been disclosed to the editor.
- Submission of ICMJE conflict of interest and copyright forms from all authors; conflict of interest forms are to be sent and requisite disclosures should be reported on the manuscript’s cover page.
- Submission of the Contributorship Form (see downloadable forms).
- Acknowledgment of funding by the US National Institutes of Health (NIH). Articles accepted for publication in Ophthalmology from authors who have indicated that the underlying research reported in their articles was supported by an NIH grant will be sent by Elsevier to PubMed Central for public access 12 months after publication. The version of the article provided by Elsevier is the final accepted version after peer-review but before copyediting.
- Confirmation that Institutional Review Board issues have been addressed in the Methods section of the main manuscript.
- Confirmation that the authors are aware the journal occasionally, only after acceptance of a submission and on a confidential basis and with no rights prior to embargo date, shares some information with the American Academy of Ophthalmology public relations staff and/or EyeNet staff.
Study Group/Writing Committee Authorship
If study group/writing committee authorship is used and the corresponding author is the study chair, please state this on the cover page. However, if he/she is not the study chair, please enclose with the submission a statement from the study chair that the group authorship as stated on the cover page and/or members of the responsible writing committee are both correct. The journal promotes transparency of authorship to editors, reviewers, and readers.
With transparency and space limitations in mind, the following are the journal’s policies regarding study group/writing committee authorship:
- If an individual is authoring for a group (e.g., a Study Chair) it should be listed as Henry A. Fiddle, MD for the Laser ROP Study Group
- Small study groups (≤ 10 members) can author as the group or they can list writing committee members names “and the XYZ Study Group” as long as all the members qualify as authors. Otherwise, only those who qualify should be listed and the remainder can be acknowledged.Debra L Hanson, MS; Susan Y. Chu, PhD; Karen M. Farizo, MD; John W. Ward, MD; and the Adult and Adolescent Spectrum of HIV Disease Project Group
- Large study groups (>10 members) should not author a paper as an entity. In large groups it is not likely that every single member of the group or network contributed as required by the authorship criteria mentioned above. Large study groups should either list the writing committee members as authors and then “for the XYZ Study Group” or list “Writing committee for the XYZ Study Group*” as the author and the names of the writing committee members will be listed at the end of the article with the asterisk. Regardless, members of the writing committee must qualify as authors and complete the appropriate ICMJE authorship forms.Debra L Hanson, MS; Susan Y. Chu, PhD; Karen M. Farizo, MD; John W. Ward, MD for the Adult and Adolescent Spectrum of HIV Disease Project Group OR The Writing Group for the DISC Collaborative Research Group* OR The DISC Collaborative Research Group Writing Committee*
Any digression from these authorship guidelines must be addressed, prior to submission, via email to email@example.com. The Editorial Director and/or Editor-in-Chief will discuss with the corresponding author on a case-by-case basis.Entering Authors into the Submission System
Enter the name, degree(s), and affiliated institution for all authors. Number of authors on the submission form must match the list on the title page. Please provide no more than 2 degrees for each author. Be sure to indicate which author is the corresponding author by checking the appropriate box. All correspondence regarding a submission must come from and will be sent to the corresponding author only. Author order can be changed by double clicking on the arrow that points in the direction you want that name moved. It will only move one space each time you click it. Please do not have staff members list themselves as authors for the purpose of uploading files.
NOTE: Once a manuscript has been submitted, the order of authorship (including adding or removing authors) cannot be changed without a written request to the Editorial Office from the corresponding author. The request must include a statement that all authors are in agreement with the change and signed by all authors. Specifically, if an author is removed, a letter from that author agreeing to his/her removal is required. If the authors are not able to agree among themselves on authorship changes, please withdraw the paper. The editors and Editorial Office do not arbitrate such debates. Authorship changes cannot be submitted with proof changes. The publisher is not authorized to make such changes.Cancer Classifications
We encourage authors to use the American Joint Commission on Cancer TNM Classification scheme when describing patients with ophthalmic malignancies. AJCC Cancer Staging Manual. (7th ed. New York, NY: Springer; 2009). The classification scheme can also be found at https://cancerstaging.org/references-tools/Pages/What-is-Cancer-Staging.aspx.
Clinical Trial Registration
Clinical trial registration is required for all trial-related manuscripts. Please state in the Methods section that this has been done and where the registration information is publicly available.
Levin LA, Gottlieb JL, Beck RW, Albert DM, Liesegang TL, Hoyt CS, Dick A, Bhisitkul R, Schachat AP. Registration of clinical trials. Arch Ophthalmol 2005;123:1263-4.The International Committee of Medical Journal Editors (ICJME) has information at http://clinicaltrials.gov/ct2/manage-recs/resources#InternationalCommittee.
Our policies are similar to those of The Journal of the American Medical Association (JAMA) and The New England Journal of Medicine (NEJM). The JAMA policy can be viewed at http://jama.ama-assn.org/misc/authors.dtl. The NEJM summarizes their policy in 2 editorials: Clinical Trial Registration: A Statement from the International Committee of Medical Journal Editors. N Engl J Med 2004;351:1250-1 and Is this Clinical Trial Fully Registered? N Engl J Med 2005;352:2436-8.Ophthalmology supports the National Institutes of Health Principles and Guidelines for Reporting Preclinical Research. Please refer to the following site for additional information: http://www.nih.gov/about/reporting-preclinical-research.htm
Conflict of Interest (financial disclosure)
Every author must complete a copy of the ICMJE Conflict of Interest Form and submit it to the corresponding author. Although the ICMJE form requires “potential” and “relevant” conflicts, to promote transparency we request authors to report all financial relationships. Mutual funds need not be listed. Such disclosure will not affect the review of the manuscript.
Liesegang TJ, Bartley GB. Toward transparency of financial disclosure. Ophthalmology 2014;121:2077-9.Liesegang TJ, Bartley GB. Footnotes, acknowledgments, and authorship: toward greater responsibility, accountability, and transparency. Ophthalmology 2014;121:2297-8.
All submissions must have the ICMJE Conflict of Interest Form completed and uploaded for each author preferably as part of the initial submission process, but no later than first revision. The form posted on the ICMJE website (http://www.icmje.org/coi_disclosure.pdf) and enclosed in our guide as a downloadable form includes instructions to help authors provide the correct information. For non-native English speakers, there is a glossary of terms that are used in the form.Every published manuscript will have a blanket statement, inserted by the publisher; either "None of the authors has any conflicts of interest to disclose." OR "Authors with financial interests or relationships to disclose are listed after the references." Corresponding authors are asked to confirm or update conflict of interest statements as part of the final steps of manuscript acceptance with the journal office, prior to transmittal to the publisher.
Upon acceptance of an article, authors will be asked to complete a 'Journal Publishing Agreement' (for more information on this and copyright, see http://www.elsevier.com/copyright). An e-mail will be sent to the corresponding author confirming receipt of the manuscript together with a 'Journal Publishing Agreement' form or a link to the online version of this agreement.
NOTE: Once a manuscript has been accepted, the order of authorship (including adding or removing authors) cannot be changed without a written request to the Editorial Office from the corresponding author. This request must include a statement signed by all authors that they agree with the change along with a new copyright form, both signed by all authors. Specifically, if an author is removed, a letter from that author agreeing to his/her removal is required. The new copyright form must show the title and authors’ names in the order they should appear in print on the top of the form and include original signatures from each author; signature order does not matter. If the original authors are not able to agree among themselves on authorship changes, please withdraw the paper. Authorship changes cannot be submitted with proof changes. The publisher cannot approve such changes and it will delay publication of the manuscript.Correspondence and Replies
Correspondence (previously Letters to the Editor) allows concise commentary about an article published in the journal within 6 months of its online posting. The text should raise a question for clarification, offer an alternative perspective, or explain a flaw in methodology or a perceived misinterpretation of data. The correspondence should address no more than two or three points. Correspondence should not be used as an avenue to introduce new material without subjecting it to typical peer review.
Format: Correspondence is limited to 700 words, double-spaced, with no more than 5 references. Figures, tables, or graphs are typically not included. The title follows the following format: Re: [insert last name of first author of published article] et al.: [insert title of the published article to which the Correspondence refers.] The correspondence should start with “To the Editor” and the article being commented on should be referenced in the first paragraph and be the first listed reference. Comments such as “… I commend the author for their fine study” or overly critical remarks are neither necessary nor appropriate. Letters should end with the name, degree, and location (city, state or city, country) for each author.Submission: Signed ICMJE conflict of interest forms should be submitted along with your correspondence.
Process: Correspondence is reviewed by the Editor-in-Chief, members of the Editorial Board, and, in some instances, by outside reviewers. If the correspondence is accepted for publication, it is forwarded to the corresponding author of the original article for the opportunity to respond. If the invitation is accepted, both the correspondence and reply are edited and published together. If the invitation to reply is declined, the original correspondence will be processed and published by itself.When the journal office accepts correspondence addressing an article, the corresponding author of the article being discussed will receive an email entitled “Invitation to Reply to CORRESPONDENCE.” Authors of the original manuscript are given 10 days to submit a reply. All correspondence and replies are published online, although the material is listed in the print Table of Contents.
When requested to revise a Correspondence, please submit a point-by-point file to demonstrate how the editor’s questions or recommendations were addressed. The point-by-point template can be accessed at: http://cdn.elsevier.com/promis_misc/oph-template-form.docx.Drug and Equipment Names
Do not use drug trade names in titles. Please use the generic name in the abstract, as appropriate, but include the trade name once, in parentheses, after the first use of the generic name. Similarly, in the text, use the generic name, but include the trade name once, in parentheses, after the first use of the generic name.Device/Equipment Names
A device name is permitted in the title, abstract, and text. However after the device has been identified at first use in the abstract and text, thereafter refer to it generically. In the case of equipment, include the manufacturer’s name, city, state, and/or country parenthetically at the first use in the text.Editorials
Editorials are usually solicited by the Editor-in-Chief, although unsolicited submissions will also be considered. Editorials may address clinical or non-clinical topics in summary form and generally do not exceed 1700 words, including references. Often, editorials are linked with a particular manuscript awaiting publication; therefore, adherence to deadlines is critical. If a figure is desirable, please decrease the word count by approximately 200. The ICMJE conflict of interest form should be uploaded with initial submission and if accepted, copyright form will be collected during the production stage. Editorials, whether invited or unsolicited, undergo peer review.
English Editing Assistance
The journal office may return a submission and recommend professional editing prior to formal review. Authors who require editing to eliminate grammatical or spelling errors and to conform to correct scientific English may wish to use the English Language Editing service available from Elsevier’s WebShop http://webshop.elsevier.com/languageediting/ or visit the customer support site http://support.elsevier.com for more information. However, Ophthalmology neither endorses nor recommends any specific individual or service and professional editing does not ensure acceptance of a manuscript.
Figures (photographs, illustrations, or graphs) will be included in the final PDF but figure file names will not be visible to reviewers. Non-composite figures should be loaded to individual files and clearly identified. For all figures, the figure number must be entered in the file description field before uploading each figure. To upload figures, go to the “Attach Files” page of the submission form by choosing “Figure” in the pull-down menu. Find the “Description” box and enter the figure number before opening and attaching each figure file. Please do not enter legends here. Figures at revision should be uploaded as high resolution .tif or .eps files, one figure per file. Online-only Supplemental Figures must be PDF files with the legend included in the PDF, one figure per PDF file.
Photographs (including those generated electronically from MRI, fluorescein angiography, perimetry, OCT, etc.) must be masked to prevent patient identification. Clinical photographs that permit identification of an individual (those exposing anything more than just the eyes) must be accompanied by a signed statement by the patient or guardian granting permission for publication of the images for educational purposes. All graphics, including composites (such as clinical photographs, fluorescein angiography, CT, MRI, OCT, photomicrographs, etc.) should be submitted at the actual size that they would be presented in the journal, i.e., 100% of their print dimensions to avoid scaling. The width should be no more than 7 inches.The publisher will not re-draw or rework photographs or other figures. Submit all figures in the order they appear in the legends. If there are 6 or more color pictures, a composite maybe preferred. However, only use composites that do not compromise figure integrity or quality. The completed composite must meet the guidelines for artwork submission. Composites must also be labeled using typed text in the corner of each image. Composites are encouraged for multi-panel figures (e.g., Fig 1A, 1B, 1C, 1D, 1E). Please see this chart for additional details: http://cdn.elsevier.com/promis_misc/OPHTHAFigurechartupdated.pdf and Elsevier's Artwork and Media Instructions http://www.elsevier.com/authors/author-schemas/artwork-and-media-instructions.
- Physical dimensions of artwork must fit dimensions of the pages within the journal (i.e., width no more than 7 inches).
- Be consistent in font type and size used in the artwork (8-point Helvetica).
- Artwork must use recommended naming conventions. Some examples include fig1.tif (figure 1 in TIFF format). Ensure the file extension is present to allow format identification.
Use the Browse button to find the zipped file and click on the “Attach” button to upload it. As it loads, it will unzip automatically within the system. Using the drop down menus and description fields to the left of the file names, select the appropriate items and type in the correct descriptions, e.g. Figure, Figures 1A through E.Financial Support
Please disclose all funding sources, public and private. On the title page please state “Financial Support: None” or provide the agency name and city, company name and city, fellowship name, and grant number. If there is financial support, please provide also one of the two following statements, “The sponsor or funding organization had no role in the design or conduct of this research.” OR “The sponsor or funding organization participated in (list those that are appropriate, e.g., the design of the study, conducting the study, data collection, data management, data analysis, interpretation of the data, preparation, review or approval) of the manuscript.”
A graphical abstract is optional and should summarize the contents of the article in a concise, pictorial form designed to capture the attention of a wide readership online. Authors must provide images that clearly represent the work described in the article. Graphical abstracts should be submitted as a separate file in the online submission system. Image size: Please provide an image with a minimum of 531 × 1328 pixels (h × w) or proportionally more. The image should be readable at a size of 5 × 13 cm using a regular screen resolution of 96 dpi. Preferred file types: TIFF, EPS, PDF or MS Office files. See http://www.elsevier.com/graphicalabstracts for examples.
Institutional Review Board
If the study involved human subjects, human-derived materials, or human medical records, please include one of the two following statements in the Methods section: “Institutional Review Board (IRB)/Ethics Committee approval was obtained” OR “IRB/Ethics Committee ruled that approval was not required for this study.”
Legends for photographs, illustration, graphs, etc. should be written to be understandable on their own, without reference to the article’s text. Figures must be numbered consecutively as they appear in the text. Histological figures, stains, and magnifications should be noted in the legends. Any figure that has been published elsewhere should have an acknowledgment to the original source; a copy of the release to publish the figure, signed by the copyright holder, must also be submitted. Legends must identify all symbols, abbreviations, acronyms, or letters that appear on the prints. Table legends should be within the table. All abbreviations in each table must be defined even when repetitive to other tables.
Manuscript Text Format
Double-space the entire manuscript after the title page and add continuous line numbering to the manuscript file. The average published manuscript in Ophthalmology, including references, is 6 printed pages or less. This corresponds, depending on font size and printing, to 16-20 pages of double-spaced draft.
The title page should include the following information.
- a) Title: The title should be meaningful and brief (no longer than 135 characters); abbreviations should not be used. Please ensure the manuscript title on the cover page matches the title entered into the submission system.
- b) Authors: Provide first name, middle initial, last name, and no more than two advanced degrees. The journal does not print society affiliations. Also indicate each author's affiliation during the course of the study in footnotes on the title page using superscript numbers, not symbols (e.g., John Smith1). Specifically identify the corresponding author. Please carefully review the Authorship section of this guide, which addresses authorship criteria, group/writing committee authorship, ghost authors, guest authors, corresponding authors, and related responsibilities. Verify numbers of authors when entering author names into the system.
- c) Meeting Presentation: If the material is under consideration for presentation or has been previously presented, supply the name, place, and date of the meeting. (e.g., the American Academy of Ophthalmology Annual Meeting, 20XX). This is especially important for AAO Meeting papers as the journal has the right of first refusal for these manuscripts.
- d) Financial Support: Identify all sources, public, and private. On the title page please state “Financial Support: None” or provide the agency name and city, company name and city, fellowship name, and grant number. If there is financial support, please provide also one of the two following statements, “The sponsor or funding organization had no role in the design or conduct of this research.” OR “The sponsor or funding organization participated in (list those that are appropriate, e.g., the design of the study, conducting the study, data collection, data management, data analysis, interpretation of the data, preparation, review or approval of) the manuscript.”
- e) Conflict of Interest: A blanket statement that “no conflicting relationship exists for any author” is requested on the title page, if appropriate. Otherwise, the corresponding author should summarize the disclosures sent by each author and upload the ICMJE COI form of each author.
- f) Running head: The running head, also known as the short title, which appears on the top of each right hand published page of the manuscript, should be a maximum of 60 characters.
- g) Address for reprints
- a. Introduction: Without a heading, the two- to three-paragraph introduction should explain why the study was done and in particular what hypothesis is being tested. The introduction should refer only to the most pertinent past publications and should not be an extensive review of the literature.
- b. Methods, Intervention, or Testing: This section should be written with sufficient detail to permit others to duplicate the work. Also required are the following, as appropriate within the methods section:
FOR HUMAN SUBJECTS:
- Informed Consent - Manuscripts reporting the results of experimental investigation on human subjects must include a statement that informed consent was obtained.
- HIPAA - For studies conducted in the United States, a statement is required that the work is HIPAA-compliant (see Ophthalmology 2003;110:1074-5).
- IRB/Ethics Committee - Human subjects/materials/medical records - If the study involved human subjects, human-derived materials or human medical records, please include one of the following statements in the Methods section: "Institutional Review Board (IRB)/Ethics Committee approval was obtained" OR "IRB/Ethics Committee ruled that approval was not required for this study."
- Declaration of Helsinki - A statement is required that the described research adhered to the tenets of the Declaration of Helsinki.
- Clinical Trial Registration - A statement in the Methods confirming where the clinical trial is registered and publicly available. (See Clinical Trial Registration for more detailed information.)
- Authors are encouraged to use the American Joint Commission on Cancer TNM Classification scheme when describing patients with ophthalmic malignancies (AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer; 2009). The classification scheme can also be found at https://www.cancerstaging.org/references-tools/Pages/What-is-Cancer-Staging.aspx
- If animals were used in a study, the notice of approval by the appropriate Institutional Animal Care and Use Committee should be included in the Methods section of the manuscript.
- c. Results: Results should be concise. Information presented in tables should not be repeated in the text.
- d. Discussion: The discussion should be restricted to interpretation and application of the study’s notable findings. Discussion is the final section of a manuscript. Please do not insert a conclusion section; only the abstract has a conclusion section.
Online Supplemental Materials
Because space in Ophthalmology is highly competitive, some supplemental materials are published online only. Such supplements generally include tables, charts, figures, etc. that would further enhance a published article but for which there is insufficient room in the print edition.
When opting for an online supplement, add a reference to it in parentheses after the mention of the information to appear online: For example, “…as shown in Table N (available at http://www.aaojournal.org).” Online tables or figures should be numbered consecutively as they appear in the text, in the same sequence as printed figures or tables. Also, add a statement to the title page that should read similar to “This article contains additional online-only material. The following should appear online-only: Figures X, Y, Z and Table N.” All online-only supplemental files must be submitted as PDF files. One table, figure, or appendix per PDF file. Please note that these files will not be copyedited or composed and will be posted online as they appear submitted.
All supplemental materials must follow the same criteria as if they were to appear in print. For example, tables must be able to stand alone with all abbreviations, references, etc. identified. Table legends would include definitions for the abbreviations, if any. Supplemental Figures must include the legend with the image in the PDF file.Permission to Use Copyrighted Materials
Permission requests should be submitted to: Elsevier Health Sciences Rights Department, Global Rights Department, Oxford, United Kingdom; phone: 44-(0)1865-843830; fax: 44-(0)1865-853333. Requests may also be completed online; Email: firstname.lastname@example.org. However, it is preferable to submit any requests via the online form at http://www.elsevier.com/authors/obtain-permission as it ensures that Global Permissions receives the most complete information regarding your request.
You may contact the Permissions Helpdesk (email@example.com) with any questions prior to submitting your request. Authorization to photocopy items for internal or personal use or the internal or personal use of specific clients is granted by the American Academy of Ophthalmology, Inc. [Applies to libraries and others registered with the Copyright Clearance Center (CCC) transactional reporting service provided that the base fee of $20 is paid directly to CCC, 222 Rosewood Drive, Danvers, MA. 01923.] All other copyright inquiries should be addressed as shown above.Permission to use materials to which others hold copyright in a submission to Ophthalmology.
The copyright form states that the author either owns the copyright or has written permission to use all the material in a submission. Examples include a clinical image/chart that was published in another journal or book, or a photograph of an ophthalmic device obtained from a pharmaceutical company. In most cases, permission can be obtained by e-mailing the publisher or company and explaining specifically what the author wishes to use, where (print and online versions of Ophthalmology), and why (in an article entitled XXXXX). Most copyright holders will reply with a “permission granted” letter which should be uploaded with the submission. Please allow ample time (typically 3-6 weeks) to receive permissions.Pictures & Perspectives
The journal welcomes submission of photographs, photomicrographs, radiologic or other imaging studies, or procedural illustrations that depict striking or unusual features of clinically important entities. Single images or a related pair of images may be submitted and the accompanying legend should be 100 words or less. There is a limit of three authors. Preference is given to submissions that include histopathologic documentation. If accepted, the submission will be published when space permits.
To submit an image for consideration, please log in to http://ees.elsevier.com/ophtha as an Author and select “Pictures & Perspectives” as the Article Type for a New Submission. Upload a single or composite high resolution .tif or .eps image file and a Word document for the title, author byline, and legend. Ophthalmology will need a completed copyright transfer form at acceptance (see Downloadable Forms). Once the form is accepted and transmitted, the Editorial Office will assign the image for a future issue. Images submitted by photographers and clinicians in this manner are used for the “Pictures & Perspectives” section occasionally, so it may be several months before it appears in print.Précis
All manuscripts must include a précis of 35 words or less summarizing the main finding/outcome of the study. The précis should not duplicate the abstract conclusion. If the paper is published, the précis will appear under the title in the Table of Contents. The précis is submitted as a separate file and should not be included in the manuscript file. Please refrain from using abbreviations/acronyms in the précis.
Prior and Repetitive Publication; Plagiarism
The journal will not consider manuscripts that have appeared, in part or in total, in other publications, except in special circumstances approved by the Editor-in-Chief. Likewise, updates of previously published studies that add minimal new information to an existing publication will not be considered. Overlap between patient groups described in serial manuscripts must be acknowledged, and references to previous publications that include the same patients must be provided. Authors uncertain as to whether specific data might be considered prior or repetitive publication should alert the Editor-in-Chief in the author comments section of the submission process and provide copies of the publications in question.
Most manuscripts in Ophthalmology are neither intended to be review articles nor require encyclopedic referencing. Twenty or 30 references suffice for the majority of manuscripts and nearly all can be presented with less than 40. This limitation does not apply to Systematic Reviews or Meta-analyses.
If using automated reference numbering software or bibliography software, disable it before submitting the manuscript.
- Journal abbreviations should conform to those used by the National Library of Medicine (http://www.nlm.nih.gov/tsd/serials/lji.html). If in doubt as to the correct abbreviation, cite the complete journal name.
- References section should follow text and begin on a separate page.
- Unpublished data, submitted articles, abstracts, oral or poster presentations should be noted in parentheses within the text.
- References should be double-spaced and numbered consecutively in order of appearance in the text.
- In text, designate references by superscript numbers following all punctuation (except semicolons).
- If there are 4 or fewer authors, all authors should be listed. If there are more than 4 authors, list the first 3 and then “et al”.
- Include subtitles (Title: subtitle.).
- Use volume numbers. Do not use issue numbers or months unless pagination is not consecutive throughout a year. Add (suppl) if supplement.
- Delete digits when in the same range: 231-7 (not 231-237).
- Do not add a discussion to a reference. If the author provides a page range that includes discussion, break it out as 23-5, discussion 26-8.
- Suffixes such as Jr, Sr, and III follow authors initials: Brown AB Jr, or Smith JC III.
- No periods between journal title and year published.
- No period in use with initials anywhere.
- No spaces after colons and semicolons in date;vol:pages.
- Use italics for gene, genotype, and locus symbols and animal genetic terms.
- Each reference should end with a period.
- Software references depend on the context in which they are mentioned, please refer to the Reference Format Examples below for more detailed information.
Cite only published studies as references. Any references (including books or articles) that have been accepted for publication, but not yet published, should have the term “in press” in the reference in place of volume and page numbers. These should be updated prior to publication, if possible.References used in tables and figures should be numbered sequentially, in order of their first mention, and listed in the main reference list at the end of the manuscript. In other words, number the references in a table or figure at first mention of the table/figure just as if they were the next reference in the text and list them in the main reference list. If a reference to be used in a table or figure was used previously in the text, use the previously assigned number in the table/figure. This includes online-only tables and figures. Since these tables and figures are accessible at the end of the manuscript to which it relates, the manuscript’s main reference list is immediately available.
A signed permission letter must accompany reference to a “personal communication.” The comment should be cited within parentheses in the text. (Smith J, personal communication, 1 July 2013).
Reference Format Examples:
Published abstracts and unpublished data must be cited within parenthesis in the text.
- Abstract: (Invest Ophthalmol Vis Sci 28 [Suppl]:54,1989)
- Data: (Jones, unpublished data).
- Davis JT, Allen HD, Powers JD, et al. Population requirements for capitation planning in pediatric cardiac surgery. Arch Pediatr Adolesc Med 1996;150:257-9.
- Taulbee P. Maryland Quality Project puts new focus on processes of care. Rep Med Guideline Outcomes Res. June 1994;10-1.
- Davis JT, Allen HD, Powers JD, et al. Population requirements for capitation planning in pediatric cardiac surgery. Arch Pediatr Adolesc Med 1996;150(suppl):257-9.
- Davis JT, Allen HD, Powers JD, et al. Population requirements for capitation planning in pediatric cardiac surgery. Arch Pediatr Adolesc Med. In press.
- Allo MD. In discussion of: McKindley DS, Antibiotic pharmacokinectics following fluid resuscitation from traumatic shock. Arch Surg 1994;272:1825-31.
Please provide English titles whenever possible. When a translation is not printed from the published article but supplied by MS author:
- Kolmos HJ. Antibiotika i almen praksis [Antibiotics in general practice]. Ugeskr Laeger. 1996;158:258-60.
- Kolmos HJ. Antibiotics in general practice [in German]. Ugeskr Laeger. 1996;158:258-60.
Journal available only online:
- Hussain N, Clive J, Bhandari V. Current incidence of retinopathy of prematurity, 1989-1997. Pediatrics [serial online] 1999;104:e26. Available at http://www.pediatrics.org/cgi/content/full/104/3/e26. Accessed July 12, 2002.
- Davis JT, Allen HD, Powers JD, et al. Population requirements for capitation planning in pediatric cardiac surgery [letter]. Arch Pediatr Adolesc Med 1996;150:257-9.
Please cite authorship as designated on the published article, not as listed on PubMed. Cite study group as author if no individuals are named, or after individual named authors, following et al if necessary.
When authors listed:
- Crist WM, Garnsey L, Beltangady MS, the Intergroup Rhabdomyosarcoma Committee. Prognosis in children with rhabdomyosarcoma: a report of the intergroup rhabdomyosarcoma studies I and II. J Clin Oncol 1990;8:443-52.
- Fluorouracil Filtering Surgery Study Group. Fluorouracil filtering surgery study: one-year follow-up. Am J Ophthalmol 1990;109:613-6.
- Miller NR. Walsh and Hoyt’s Clinical Neuro-Ophthalmology. Baltimore, MD: Williams & Wilkins; 1991:xx-xx. (include specific inclusive pagination for material being referenced)
- Hollis S, Rozakis GW. Complications, special cases and management. In: Rozakis GW, ed. Refractive Lamellar Keratoplasty. Thorofare, NJ: SLACK Inc.; 1994:111-22.
- Letheridge S, Cannon CR, eds. Bilingual Education: Teaching English as a Second Language. Vol. 1. 3rd ed. New York: Praeger; 1980:xx-xx.
- Sluzki CE, Beavin J. Symmetry and complementarity. In: Watzlawick P, Weakland JH, eds. The Interactional View. New York: Norton; 1977:711-30. Reprint from: Acta Psiquiatr Psicol Am Lat 1965;11:321-30.
Proceedings published as a book:
- Chaddock TE. Gastric emptying of a nutritionally balanced liquid diet. In: Daniel EE, ed. Proceedings of the Fourth International Symposium on Gastrointestinal Motility. Ames, IA: Mitchell Press; 1974:83-92.
- College Bound Seniors. Princeton, NJ: College Board Publications; 1979:xx-xx.
Several volumes in a multi-volume edited work:
- Wilson JG, Fraser FC, eds. Handbook of Teratology. Vol. 1-4. New York: Plenum Press; 1977-88.
- Luria AR. The Mind of a Mnemonist [Solotarof L, trans]. New York: Avon Books; 1969:xx-xx. [original work published 1965].
URL (Electronic Citation)
Whenever possible, if resources are available online (that are identical to the referenced printed version) the URL is provided in the reference. Please provide a date of online access informing readers that as of that given date the link was accessible. This date can be either the date you accessed it for your research or the date you verified it was an accessible link.
- Health Care Financing Administration. 1996 statistics at a glance. Available at: http://www.hcfa.gov/stats/stathili.htm. Accessed December 2, 1996.
- Klein R, Klein BE. Beaver Dam Eye Study. Manual of Operations (Revised). Report for 16 Jun 87 - 31 May 92. Springfield, VA: US Dept of Commerce; 1991:xx-xx. NTIS Publication PB91-149823.
Reporting Refractive Surgery Outcomes and Astigmatism
Astigmatism_Reporting_links_to_Reporting_Refractive_Surgery_Outcomes_and_AstigmatismWhen reporting refractive surgery outcomes, please include 6 graphs to illustrate the following (references 1-3):
- Uncorrected distance visual acuity
- Change in corrected distance visual acuity
- Spherical equivalent (attempted versus achieved)
- Spherical equivalent refractive accuracy
- Spherical equivalent refraction stability
- Refractive astigmatism
- Waring GO III, Reinstein DZ, Dupps WJ, Kohnen T, Mamalis N, Rosen ES, Koch DD, Obstbaum SA, Stulting RD. Standardized graphs and terms for refractive surgery results. J Refract Surg 2011;27:7-Erratum in J Refract Surg 2011;27:88.
- Reinstein DZ, Waring GO III. Graphic reporting of outcomes of refractive surgery. J Refract Surg 2009;5:975-8.
- Waring GO III. Standard graphs for reporting refractive surgery. J Refract Surg 2000;16:459-66. Erratum in J Refract Surg 2001;17:following table of contents.
- Alpins N. Astigmatism analysis by the Alpins method. J Cataract Refract Surg 2001;27:31-49.
- Alpins NA. Vector analysis of astigmatism changes by flattening, steepening, and torque. J Cataract Refract Surg 1997;23:1503-14.
- Alpins NA. A new method of analyzing vectors for changes in astigmatism. J Cataract Refract Surg 1993;19:524-33.
- Reinstein DZ, Archer TJ, Randleman JB. JRS standard for reporting astigmatism outcomes of refractive surgery. J Refract Surg 2014;30:654-9. Erratum in: J Refract Surg 2015;3:129.
Reports are typically submitted after invitation from the Editorial Board. Specifically, some full-length manuscripts contain noteworthy information that can be presented in a more concise communique. The Editorial Board may invite the authors to abridge their work, taking into consideration suggestions for revision in the initial reviews, and resubmit the paper as a Report. Reports do not exceed 1000 words or include more than 5 references, and may feature one figure, graph, chart, or concise table on the print version. Two additional items can be included as online supplemental material. Please insert “(available at www.aaojournal.org)” at relevant point(s) in your manuscript. Please note that online supplemental material must conform to the same requirements regarding legends, abbreviations, etc. as for the print publication. An abstract is not required and the text should be in narrative rather than a structured format. When uploading Reports, please select the “Manuscript to Report (Invited)” submission type and include the manuscript number of the original submission in the “author comments” section of the submission form. Please include a point-by-point response to the original reviewer(s)’ questions and suggestions. Please note that an acknowledgment section is reserved for grants and funding only. Focused Review
Focused Review provides an in-depth summaries of the literature, current thinking, and future directions on topics of interest to practicing ophthalmologists. The submission should not exceed 4000 words and should include a precis of 35 words or less and narrative (unstructured) abstract of 350 words or less. Figures and/or tables are welcome. Figures must be high-resolution in either a tif or eps format. Tables must be submitted in Word. Authors should submit ICMJE forms with their submission. Focused Reviews undergo peer-review similar to original research submissions and are usually solicited by the editor for this section, Lynn K. Gordon, M.D., Ph.D. However, suggestions for topics are welcome and can be directed to Dr. Gordon (LGordon@mednet.ucla.edu).
Systematic Reviews and Meta-analysis
Systematic reviews seek to collect and critically assess all evidence that fits pre-specified criteria to answer a clinical question pertaining to the cause, diagnosis, prognosis, prevention, or therapy for a condition. A systematic review may contain a meta-analysis, which uses statistical methods to combine results from similar but independent studies.
It is possible to conduct a systematic review and meta-analysis of the evidence supporting any type of research question, whether the question is about intervention effectiveness or harm, etiology, prognosis, diagnostic accuracy, toxicity, incidence, or prevalence. Where intervention effectiveness questions are typically addressed by randomized controlled trials, most other questions are addressed using observational studies. Systematic reviews may be conducted for human or animal studies, in vivo or in vitro.For standards and classic references in conducting systematic reviews and meta-analyses, please refer to:
- Institute of Medicine.Finding what works in health care: standards for systematic reviews. 2011.
- Chandler J, Churchill R, Higgins J, Tovey D. Methodological standards for the conduct of new Cochrane Intervention Reviews. Version 2.2. 17 December 2012.
- Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011.
- Handbook for Diagnostic Accuracy Reviews [Draft]
- Little J, Higgins JPT (editors). The HuGENE™ HuGE Review Handbook, version 1.0. Guidelines for systematic review and meta-analysis of gene disease association studies (see also Systematic Reviews of Genetic Association Studies, PLoS Medicine 2009;6(3):e1000028)
- Systematic Reviews. CRD's guidance for undertaking reviews in health care. Centre for Reviews and Dissemination, University of York, 2009
For reporting systematic reviews and meta-analyses, if you are submitting a report of
- A systematic review and/or meta-analysis of randomized controlled trials, please follow the PRISMA guidelines for reporting;
- A systematic review and/or meta-analysis of observational studies, please follow the MOOSE guidelines for reporting.
Title Page:The title should clearly describe the research question and identify the report as a systematic review, meta-analysis, or both in the subtitle. (Example: Anti-vascular endothelial growth factor for neovascular age-related macular degeneration – A systematic review and meta-analysis.)
Précis:The précis should indicate a new insight the article offers or a principal controversy that is addressed.
Structured Abstracts:Abstracts for systematic reviews and meta-analysis must be limited to 350 words and include five sections following the PRISMA guidelines:
- Topic: provide an explicit statement of the specific clinical question being addressed with reference to a brief description of the participants, interventions (or exposures), comparators, and outcomes examined.
- Clinical relevance: characterize the magnitude and importance of the condition; when relevant, define the current standard of care.
- Methods: describe the key eligibility criteria for including studies in the systematic review, key databases searched and search dates, methods of assessing the risk of bias in the individual studies.
- Results: summarize the number and type of included studies and participants, and relevant characteristics of studies; describe the results of main outcomes (benefits and harms), preferably indicating the number of studies and participants for each. If a meta-analysis was done, include summary measures and confidence intervals; report the direction of the effect or association (i.e., which group is favored) and size of the effect using language meaningful to clinicians and patients.
- Conclusion: summarize the strengths and limitations of the evidence, your general interpretation of the results, and important implications.
Manuscript textThe text should utilize standard journal formatting and be divided into four distinct sections. The brief descriptions below are gathered from the PRISMA, the MOOSE guidelines, and the Standards for the Reporting of Cochrane Intervention Reviews. The text should report institutional review board approval or exemption, financial disclosures and potential conflicts of interest of the authors, and funding sources of the review.
1. Introduction (unlabeled) should provide a concise description of the condition or clinical problem addressed by the review question, provide perspectives on the importance of its management to patient well-being and quality of life, and why it is important to do the review. Always end the introduction with a clear and concise statement of the study’s main objectives or hypotheses.2. Methods: The methods section should include the following subheadings:
- Eligibility criteria for considering studies for this review: state eligibility criteria for participants, interventions (or exposures) and comparators, and eligible study design(s) if applicable. Define primary and secondary outcomes of the review and state whether an article had to report measurement of at least one of the outcomes to be eligible. If so, provide rationale.
- Search methods for identifying studies: list all information sources searched, including databases, trial registries, websites, difficult-to-access literature (e.g., grey literature, conference proceedings), reference lists of included studies, and whether individuals or organizations were contacted. For all searches, provide the date of the last search and whether there was any time period or language restriction. Present the exact full search strategy (or strategies) used for at least one database in an Appendix with sufficient detail to permit replication. Report which software was used to manage the records identified and eligibility status.
- Study selection: describe the process for selecting studies, how many people were involved at each step of the review, whether any steps were done by more than one person, and if so whether they worked independently and how different opinions were resolved.
- Data collection and risk of bias assessment: List and define data items extracted from the reports of included studies. Describe methods used for assessing risk of bias of included studies (risk of bias is a formal assessment of what is often considered study “quality”), and how this information was used in any data synthesis. Describe the process for data extraction and risk of bias assessment, how many people were involved at each step, whether any steps were done by more than one person, and if so whether they worked independently and how different opinions were resolved. Report the software used for data collection and management.
- Data synthesis and analysis: state the methods for combining results across studies, which include qualitative synthesis (see Chapter 4, section on “Qualitative Synthesis of the Body of Evidence; Finding what works in health care: standards for systematic reviews) and quantitative synthesis (i.e., meta-analysis). State the summary measures used to quantify the treatment effect or association such as risk ratio, odds ratio, and difference in means. Describe methods for assessing clinical, methodological, and statistical heterogeneity (e.g., I2 statistic, tau-squared, statistical test). Describe methods for additional analyses such as meta-regression, subgroup analysis, and sensitivity analysis, if done, indicate which were pre-specified. State the statistical software used for analysis. Indicate whether a systematic review protocol exists, if so, where and how it can be accessed; and if available, provide systematic review registration information including registration number.
3. Results: Provide numbers of studies retrieved, screened, assessed in full for eligibility, included in the review, and included in the meta-analysis, with reasons for exclusion at each stage, ideally with a flow diagram. Present characteristics of included studies including information on the study design, participants, interventions (or exposures) and comparators, outcomes, and source of funding, ideally in a table. Present domain-based risk of bias assessment of each study, ideally in a table or a figure. Composite quality scores and scales are discouraged. For all outcomes considered, irrespective of the direction or strength of the results, present, (1) simple summary data for each group, and (2) estimates of treatment effect (or association) between groups with a measure of statistical uncertainty (e.g., confidence intervals). If meta-analysis was done, report meta-analytical results ideally with a forest plot, number of studies and participants for each meta-analysis, as well as measures of statistical heterogeneity. Present results of any additional analyses (such as meta-regression, subgroup analysis, and sensitivity analysis) if done. Provide a thoughtful qualitative synthesis by analyzing the nature, strengths, and weaknesses of the evidence, and developing a deeper understanding of how an intervention might work (or not), or whether a true association exists, for whom and under what circumstances.4.Discussion: Summarizes the main findings including the strength of evidence for each main outcome. Provide a general interpretation of the evidence considering their relevance to key stakeholders, including patients, healthcare providers, researchers, payers, and policy makers. A Summary of Findings or GRADE table is optional. Discuss limitations at study and outcome level (such as risk of bias), and at review level (such as incomplete retrieval of identified studies, reporting biases). Provide a general interpretation of the results in the context of other evidence, and implications for practice and future research.
In the cover letter to the Editor, please state explicitly (1) whether reporting guidelines have been followed, if so, which reporting guidelines; (2) whether the exact full search strategy (or strategies) used for at least one database was presented in an Appendix with sufficient detail to permit replication. Failure to follow the reporting guidelines or upload the search strategy may result in delay in review or rejection of the manuscript. Please submit a PRISMA worksheet and diagram as separate files.Checklist: http://www.prisma-statement.org/2.1.2%20-%20PRISMA%202009%20Checklist.pdf Translational Science Reviews
Translational Science Reviews aim to provide authoritative and cutting-edge summaries of topical state-of-the-art basic research that is expected to have broad clinical impact within a few years. For example, in the years prior to the FDA approval of anti-VEGF drugs to treat neovascular age related macular degeneration, an article in this section might have summarized the relevant basic research that supported Phase 1 human studies for anti-VEGF drugs that are now widely used. Manuscripts should be broadly accessible as the intended audience includes ophthalmologists whose primary focus is usually clinical practice. Please avoid jargon and do not assume that laboratory techniques will be understood by all readers. Translational Science Reviews are usually solicited by the editor for this section, Jayakrishna Ambati, M.D. However, suggestions for topics are welcome and can be directed to Dr. Ambati (firstname.lastname@example.org).
Statistical methods must be identified in table footnotes, illustration legends, or text explanations. Software programs used for complex statistical analyses must be identified to enable reviewers to verify calculations. For manuscripts in which the study conclusions infer equivalency in treatment effect, a sample size calculation and power analysis should be included. Levels for alpha and beta errors should be clearly stated in the Methods section of the Abstract and text. Authors should state the clinically significant difference that was used to determine the power calculation. The journal strongly advises statistical consultation about data collection and analysis.
Authors are asked to describe the design of their study as part of the structured abstract. Doing so serves several purposes. It encourages authors to give careful thought to what they have actually done, it provides a useful shortcut for editors and reviewers to categorize the submission, and it gives the reader a useful descriptor of the type of study that was performed.
Tables require substantial space; please give careful consideration to the number of tables submitted and design tables to fit on one formatted page. The information should not be extensively iterated in the text. Place the information in the text or in a table but not both.
Tables for print publication must be uploaded as individual Word documents, one table per file. If a table is longer than one page in Microsoft Word, it may be too large to print and would work better as an online-only Supplemental Table. Online-only Supplemental Tables must be uploaded as PDF files, one table per PDF file.Video Clips
If submitting video as an online supplement, add a reference to it in parentheses at an appropriate place within the text of the manuscript. Also, add a statement to the title page that should read similar to “This article contains a video as additional online-only material. The following should appear online-only: Clip 1, Clip 2 and Clip 3.” The materials will be archived with the online version on the publisher’s website http://www.ophsource.com/periodicals/ophtha and accessible through Medline and other online databases.
We do not have video editing software, but a website with useful tips on reducing file size can be found at http://www.deskshare.com/Resources/articles/dmc_ReduceFileSize.aspx
- Maximum: 8 minutes total. We recommend several smaller clips that do not exceed 8 minutes.
- Size: recommended size 10-50 MB, and the maximum size is 100 MB.
- File extension types: .MPG (MPEG-1 or 2), .AVI, .MOV
- Upload a still image of each video clip.
- Audio commentary to describe the video is highly recommended. Please do not use background music.
- Within the submission, there must be a brief legend describing contents of the video and indicates the viewing order.
- Video files should be loaded with the submission into the electronic submission system. File names should correspond to video legends.
- On the title page include “This manuscript contains [insert number of video clips].
- Upload with submission using the “multimedia” file type.
It is the corresponding author’s responsibility to check periodically the status of his/her manuscript. An email with a decision will be sent with instructions to the corresponding author to go to the online submission site if a revision is warranted.
Each manuscript submission will be acknowledged in the order received in the Editorial Office. The acknowledgment letter will note the number assigned to the manuscript. All subsequent inquiries about the manuscript must indicate the manuscript number. Usually two and sometimes several reviewers and Editorial Board members will participate in the review of a manuscript. The journal does not reveal the identity of its reviewers but does provide pertinent comments to the corresponding author. Re-review may be required after revision if, in the judgment of the Editor-in-Chief, sufficient modification of the manuscript or data justifies another review cycle or if one (or more) of the reviewers requested to see the revision. A point-by-point response is required to the reviewers’ comments. Authors should upload two versions of the revised manuscript – one showing “track changes” to show where revisions have been made and a “clean” copy.Revision Submission
If invited to revise a manuscript, the corresponding author will receive an email that contains the revise decision as well as the reviewers’ and/or editors’ comments. Log on as an author to http://ees.elsevier.com/ophtha/ with your user name and password. The manuscript will be in the author menu under “Submissions needing revision.” Separate files can be accessed by clicking on the “Download files” button. It is recommended to work from the “Download files” instead of the “View submission” screen.
To submit a revised manuscript, make changes to text, figures, etc. in the files downloaded from the website. These will have the content of what was sent to the journal office as the original submission. “View files” is the best way to access individual files versus “View submission,” which only generates a PDF view.In the “revise” notification email there may be mention of our having added to the submission a PDF file with an editor’s “track changes” or comments. This can be found by logging in as an author, locating the specific submission, and under action items you will see “Manage Review Attachments.” The link provides access to the pertinent file(s). These files may include a full text document or pages that contain editorial comments.
Review the PDF and, as appropriate, make changes to files based on these comments as well as editors’, reviewers’, or journal office comments. Save two versions of the manuscript file – one showing “track changes” and the other a clean copy with all changes accepted. When all files are revised, go to http://ees.elsevier.com/ophtha/ and log in as an author. Under "Revisions" select "Submissions needing revision" and click on "Submit revision."Instructions are provided on how to upload revised files to replace old ones. In the “Attach files” section, there is a listing with check boxes on the right side for files for a resubmission. Unclick any of those which will be replaced with the revised version. Leave the boxes checked for files that did not need revision. For example, a précis often does not change during a revision, so that would remain checked and the computer will use the file from the original submission and automatically put the file into the revised version.
Click "Next" to move forward unchanged files and arrive at the screen (“Attach files”) that will allow the revised files to be uploaded. The files that remained checked will be forwarded from the original submission and added to the revised PDF.A final opportunity is provided to review the completed revised version before clicking the final button “Submit to journal office.” Please read and acknowledge the Ethics in Publishing statement before final submission.
- Point-by-point response: Please include a point-by-point response to each of the comments from the reviewer(s), editor(s), and/or editorial office. One technique that has proved useful both for authors and the Editorial Office is to create a 3-columned table, in a Word file, to summarize your revisions. (See templatehttp://cdn.elsevier.com/promis_misc/oph-template-form.docx and samplehttp://cdn.elsevier.com/promis_misc/oph-sample-form.docx.) In the first column, list the reviewer's suggestion, question, or comment. In the second column, outline your response. If you disagree with the reviewer, please explain your reasoning. In the third column, specify where in the manuscript you have made any changes. Adding line numbers to the manuscript file and referring to specific line numbers will be useful in determining which parts of the manuscript changed. Please ensure that revisions in the text are also changed in any relevant tables or figures.
- References: At first revision, please review the reference format style guide and ensure that references are in the correct format.
- To expedite processing of a revised manuscript, please provide a photocopy of the title page (including journal name, volume number, year, page numbers) of any work cited that was published prior to 1970 in the United States. This information can be submitted as “related file.”
- Figures: Please note any changes to figures in the point-by-point response.
- If applicable, the revision decision letter will provide instructions on how to prepare figures to meet specific artwork guidelines for the publisher. If you cannot meet these guidelines, contact the Editorial Office before submitting your revisions.
- Please insert into the text at first mention of the supplemental figures “(available at www.aaojournal.org)” as well as specify on the cover page which figures are to be online-only supplemental materials.
- Authors: Please ensure the manuscript title on the cover page matches the title entered into the submission system. Any changes to authors require written explanation, as detailed above under “Authorship.”
- File submission: Please upload two versions of your revised manuscript -- one showing “track changes” and one that is “clean.” Do not submit more than one version of any other file type unless specifically requested by the editorial office. Each file, revised or not, should be the current version of the submission. If not done with the initial submission, ICMJE conflict of interest forms from all authors and the Contributorship Form must be included at revision.
By Other Journals
Rejection by another journal does not compromise consideration by Ophthalmology. Authors are required to inform the Editor-in-Chief of rejection by another journal in the author comments section of the submission process and include copies of the previous review commentary and the authors’ responses. Please use the point-by-point response template: http://cdn.elsevier.com/promis_misc/oph-template-form.docx.Appeals Regarding Manuscripts Rejected by Ophthalmology
Ophthalmology is able to accept a relatively small percentage of submissions received. Therefore, many good manuscripts have to be declined, oftentimes despite favorable peer reviews. If your paper is rejected but the reviews are accurate, please do not appeal the decision and request additional reviews. Doing so distracts the journal's editorial staff from processing other manuscripts and is unfair to the authors of those papers. If, however, the reviewer or editor assessments are in error, the Editor-in-Chief will entertain an appeal and reopen the manuscript's file.
Occasionally, a manuscript is rejected but the Editorial Board offers the option to resubmit a revised, abridged version as a Report. Please see the relevant section above for details.Reference management software
Most Elsevier journals have their reference template available in many of the most popular reference management software products. These include all products that support Citation Style Language styles, such as Mendeley and Zotero, as well as EndNote. Using the word processor plug-ins from these products, authors only need to select the appropriate journal template when preparing their article, after which citations and bibliographies will be automatically formatted in the journal's style. If no template is yet available for this journal, please follow the format of the sample references and citations as shown in this Guide.
Users of Mendeley Desktop can easily install the reference style for this journal by clicking the following link:
When preparing your manuscript, you will then be able to select this style using the Mendeley plug-ins for Microsoft Word or LibreOffice. Proofs
If the submission is accepted, the corresponding author will receive typeset page proofs online. Each corresponding author is expected to proofread all pages carefully and answer all queries posed by the copy editor. Page proofs should be reviewed by more than one person to enhance accuracy. All page proofs must be returned to the publisher within 72 hours of receipt to avoid delay in publication. The publisher does not send reminders; responding to the publisher with responses to author queries and requested changes is the corresponding author’s responsibility. The journal reserves final editorial approval for style, format, and grammar.
A reprint order form will either be e-mailed or accompany your copyedited manuscript and page proofs. You must return this form to the publisher with your corrected page proofs, whether or not you order reprints. The cost of reprints increases significantly if they are ordered after the initial print run. Reprints, except special orders of 100 or more, are available only for authors.
Ophthalmology publishes photographs and images on the cover of the printed journal. The images are selected by Editorial Board member James D. Brandt, M.D.
Cover figures are usually generated from figures in articles appearing in a given issue. Images should be visually striking, technically excellent, and of appropriate size for the cover format. If there are no appropriate images among the articles slated to appear in a given issue, we consider photographs submitted by ophthalmic photographers and clinicians for consideration. Square format images work best. Composites of several photographs (e.g., a sequence over time or a comparison of color photography with angiography, pathology, etc.) also work well and provide flexibility in layout.To submit an image for consideration as a cover, please send the files to the Editorial Office at email@example.com. Please use the subject header “Cover Image for Ophthalmology” so that the e-mail is appropriately flagged. Send the Editorial Office a JPG version of the image along with a photograph title, photographer and institutional affiliation, and equipment used to capture the image. If the photograph is appropriate, the Editorial Office will work with the submitter to generate appropriate file(s) for publication (see technical considerations below).
If an image is selected for use as a potential cover image, Ophthalmology will need a completed copyright transfer form (see downloadable forms.) Once the form is received, the Editorial Office will assign the image for a future issue. Cover images submitted by photographers and clinicians in this manner are used for covers only occasionally, so it may be several months before it appears in print.Technical Considerations
The four-color printing process used in producing the journal cover requires high resolution files to achieve the best quality. Should an image be chosen for the cover, the file(s) should be available as minimally compressed JPG or ideally uncompressed (e.g., TIF or PSD) high resolution files of at least 8"x8" at 300 dpi. Screen grabs from video (even high definition video) do not upscale adequately for print and can appear blurred; similarly, output from most diagnostic instruments do not upscale well and can look pixelated.Please do not perform any post-processing of the digital image other than light dusting and spot removal. sRGB colorspace is fine; do not convert to CMYK as this will be done by the publisher during pre-press processing. The high resolution files for final publication are usually too big to send by e-mail. A web-based large file transfer service (e.g., http://www.yousendit.com) can be used; please contact the Editorial Office (firstname.lastname@example.org) if you need assistance with transmitting large files.
Copyright ConsiderationsCopyright for the image(s) must be transferred to the American Academy of Ophthalmology. The copyright transfer form must be signed by all the listed authors. Please note that if the image has already appeared as part of an article in another journal or in a textbook, the author or photographer probably does not have the right to transfer the copyright to the AAO. Similarly, if the image has appeared as part of a photography contest (and especially if it won a prize), the conditions of contest participation should be clarified. The copyright transfer form should be submitted to the Editorial Office at email@example.com.
In Press/Online Release
Manuscripts are available online as "in press" articles after completing the publisher’s proofing process. The online release is not a draft version since it is produced after all editorial and author corrections are made; however, there is a disclaimer in case a critical error is found. No routine editing will occur once an article appears online. The "in press" designation is removed as soon as the monthly issue is available online.
To promote transparency and opportunities for further research, authors of work published in Ophthalmology are encouraged to provide access to relevant datasets in compliance with contemporary reporting standards. Authors may use domain-specific public archives (for example, ClinicalTrials.gov, GenBank, Protein Data Bank), or generic databases (for example, Dataverse, Dryad, Mendeley, or the Open Science Framework, or an institutional repository).
Taichman DB, Backus J, Baethge C, et al. Sharing Clinical Trial Data: A Proposal From the International Committee of Medical Journal Editors. JAMA 2016;315(5):467-468.
If you have questions about the submission process or are unable to access the system, please contact the editorial office by e-mail at firstname.lastname@example.org or by phone at 415-447-0261.