Information for Authors - Submitting a Manuscript

All manuscripts to be considered for publication in CMGH must be submitted using our online submission system at

Submission Guidelines

All manuscripts should be double-spaced and should contain the following sections in the order given below. New manuscripts can be uploaded as a single PDF with figures and tables at the appropriate point within the text and/or as separate files. Separate files will be required for all revised manuscripts in order to facilitate publication.

Cover Letter
CMGH strongly encourages authors to suggest 2 to 5 referees (include their email addresses, and phone and fax numbers) and the associate editor they believe is best qualified to review their paper. Authors may also list a non-preferred associate editor and non-preferred referees, but the ultimate selection of an associate editor and referees is at the sole discretion of the editor and associate editor.

Title Page
Title—Limit: 120 characters with spaces. Use no abbreviations.
Short Title—Limit: 45 characters.
Authors—Include first names of all authors and name and full location of department and institution where work was performed.
Grant Support—List grant support and other assistance.
Abbreviations—List abbreviations alphabetically (Note: In general, the use of abbreviations is discouraged.)
Correspondence—Provide name, complete address, e-mail address, telephone number, and fax number of corresponding author.
Disclosures—All authors must disclose any potential conflicts (financial, professional, or personal) that are relevant to the manuscript. If the author(s) has nothing to disclose, this must be stated.
Preprint server—If your manuscript is posted to a preprint server, you must indicate as such on the title page and include the DOI of the preprint.
Transcript Profiling—Provide accession number of repository for expression microarray data.
Word count—Include word count of main document text, not including methods, tables/figures, or references.
Writing Assistance—List the names and funding source for individuals who provided writing assistance.
Author Contributions—This information no longer needs to be included on the Title Page. Instead, the Corresponding Author will select from a list of roles for each co-author from CRediT Taxonomy. Detailed instructions can be found at when submitting a manuscript.

Corresponding Author Duties:

When submitting a manuscript, the Corresponding Author needs to contribute the following:

  • Have an active account on with a current email address.
  • Submit the manuscript with all of the steps.
  • List a current email address for all co-authors, so they can confirm their roles and co-authorship for the paper.
  • Respond promptly to all editorial correspondence.

All submissions should be accompanied by a 2 to 3 sentence synopsis that explains the primary accomplishments of the work. This should not exceed 40 words and should not include nonstandard abbreviations.

Abbreviations must be spelled out at least once. Do not use footnotes or references.
Limit: 260 words. Organize according to the following headings: Background & Aims, Methods, Results, Conclusions, and Keywords.
Background & Aims: Describe the importance of the study and the precise research objective(s) or study question(s).
Methods: Describe techniques, cell/animal models used, and critical reagents, chemicals, and equipment.
Results: Provide the main outcomes of the study including confidence intervals or P values. Report the absolute values and risk differences so that readers can determine the absolute, as well as the relative, impact of the results.
Conclusions: State only conclusions that are directly supported by the evidence and the implications of the findings.
Keywords: Include 3–4 keywords associated with your manuscript, separated by semicolons (eg, transcriptional regulation; steatosis; vesicular traffic; tight junction). The keywords should be different than the words in the title of your manuscript. Should your manuscript be accepted, the keywords will appear with the published manuscript, making it easier to find in search engines such as PubMed.

Drug, chemical, gene, and protein names
Identify drugs and chemicals used by generic name (if trademarks are mentioned, manufacturer name and city are given).
All gene and protein names must be written according to NCBI or HUGO nomenclature.

For manuscript flow and readability, the methods section should appear at the end of the manuscript, between the discussion and references.

Describe ethical guidelines followed; cite approval of animal welfare (IACUC) and human subjects protection (IRB) committees; describe in detail hazardous procedures or chemicals involved, including precautions observed and relevant oversight, e.g. IBC approval.

Statistical methods used must be described. When reporting the results of hypothesis testing, report P values and/or confidence intervals; avoid using phrases such as "not significant."

A statement that all authors had access to the study data and had reviewed and approved the final manuscript must be included within the methods section.

All commercially-obtained siRNA, viruses, plasmids, antibodies, mouse lines, cell lines, and other specialized materials should be fully-described, including vendor, catalog number, and for items with significant variation between lots, e.g. polyclonal antisera, lot number(s). For specialized materials obtained from non-commercial sources, sufficient detail should be provided to allow incontrovertible identification of the reagent used.

Studies involving animal experiments must conform to the Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines (, developed by the National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) to improve standards and reporting of animal research. Please review the ARRIVE checklist and disclose all relevant animal research information as directed.

Data Presentation and AnalysisCMGH is committed to publishing the highest quality, rigorous data. Data presentation and analysis should be in accordance with the following guidelines:

CMGH is committed to publishing the highest quality, rigorous data. Data presentation and analysis should be in accordance with the following guidelines:

  • All data should be shown. Do not refer to "data not shown" or to unpublished results not provided.
  • The number of biological and technical replicates, with a clear explanation of what these represent, should be provided for all data in every panel of every figure. Every experiment should be carried out independently at least 3 times. Statistical analyses should be carried out on the entire dataset, including points from all independent experiments.
  • It is acceptable to show representative images in figures, but when at all possible quantification for the entire dataset should be provided, and the image shown should be representative of the mean value.
  • Similarly, representative western blots may be shown, but quantification of bands from at least 3 independent blots should be provided.
  • The last paragraph in the Methods section should describe the statistical tests used to analyze data, including the post-tests used to derive P values for multiple comparison tests.

Authors who are uncertain about the appropriate statistical tests for their data are strongly encouraged to consult a biostatistician. This may be required for revisions where significant statistical concerns were identified in the original submission.

List references using arabic numerals by order of appearance in the text.
Cite personal communications and unpublished data directly in text without being numbered.
All abbreviations should follow the Index Medicus abbreviations.
This journal encourages you to cite underlying or relevant datasets in your manuscript by citing them in your text and including a data reference in your Reference List. Data references should include the following elements: author name(s), dataset title, data repository, version (where available), year, and global persistent identifier. Add [dataset] immediately before the reference so we can properly identify it as a data reference. The [dataset] identifier will not appear in your published article.
Follow CMGH requirements for style:

Article (list all authors):
1. Nam KT, Lee HJ, Mok H, Romero-Gallo J, Crowe JE, Jr., Peek RM, Jr., Goldenring JR. Amphiregulin-deficient mice develop spasmolytic polypeptide expressing metaplasia and intestinal metaplasia. Gastroenterology 2009;136:1288–96.

2. Sitaraman S and Friedman LS. Essentials of Gastroenterogy. West Sussex, UK: Wiley-Blackwell, 2012.

Chapter in Book:
3. Turner JR. The gastrointestinal tract. In: Kumar V, Abbas AK, Fausto N, Aster JC, eds. Robbins and Cotran Pathologic Basis of Disease. 8th ed: Elsevier, 2009:763–831.

[dataset] 5. Oguro, M, Imahiro, S, Saito, S, Nakashizuka, T. Mortality data for Japanese oak wilt disease and surrounding forest compositions, Mendeley Data, v1; 2015.

Tables may either be uploaded separately from the manuscript or embedded in the file that contains your manuscript. Tables should be prepared using the word processing software table tool, rather than tabs.


General Figure Concerns: Please use the following guidelines when preparing figures for CMGH.

  • All figures should be of high quality (300 dpi or greater when set to the size you would want the figure to print legibly).
  • The physical size of a figure cannot exceed 7 inches wide by 9 inches tall. All figures should be prepared in portrait orientation.
  • Text presented in figures should be 8-10 point sans-serif (preferably Arial or Helvetica), but may not go below 6 point or above 13 point, except for panel labels.
  • Panel labels must be 16 point Arial bold. Please avoid placing panel labels over images.
  • Figures should not be created in programs such as Word or PowerPoint. Images become compressed when embedded in these programs and will not be as clear and high-resolution as the originals. Software such as Adobe Illustrator should be used for figure creation.
  • Please review the Figure Submission FAQ document above for more detailed information on AGA journal style. Details regarding specific types of figures can be found below.

Images: Images should be of high quality as described above, clear, and in good focus. All photomicrographs and photographs must have unlabeled scale bars whose length is defined in the legend. Photographs must be scaled to the same extent in all dimensions, e.g. it is not permissible to stretch a photograph in the horizontal dimension without applying the same changes to the vertical dimension. If patients are studied, names and all other identifiers must be removed from figures.

Gel electrophoresis: The position of standard sizing markers must be included on all electrophoretic gels. The position and identity of relevant bands should also be indicated. The editors reserve the right to request full, uncropped gels during the editorial and image review processes.

Line Art and Graphs: Please follow the guidelines addressed in our Figure Submission FAQs. You may be contacted by our graphics staff with requests to modify your figures for consistency with the overall style of the AGA Institute journals. Please be sure that any graphs or line art you submit are at a resolution of at least 300 ppi so that they are readable to reviewers. Please do not submit 3-D style graphs or charts. When preparing graphs, color, and symbol shape should be used appropriately to clearly distinguish between different conditions. Where possible, it is preferable to show mean and standard deviation with individual data points rather than simply bar graphs with error bars.

Figure Legends: Where applicable, figure legends must specify the imaging equipment used, e.g. camera, microscope, etc., including lenses or objectives, as well as acquisition software and post-acquisition processing and analysis software. Additionally, figure legends must specify the number of replicates (n), e.g. samples, animals, etc., in each of the experimental and control groups for the individual experiment shown as well as the total number of times each experiment was performed independently. It is preferable, but not required, to also specify the number of replicates in the separate independent experiments.

Preferred Figure File Formats: The preferred formats for figure files are tiff (.tif) and jpeg (.jpg). For questions regarding the conversion of other file formats to .jpg or .tif, please view our Figure Submission FAQs.

Accepted Figure File Formats: Other acceptable file formats include: .bmp, .gif, .pbm, .pcx, .png, .pct, .msp, .tif, .eps, .xbm, .psd, .ai, .indd, .pdf, and .tga files. When sending image files, please do not embed them in Word. You may submit mixed file formats (image1.jpg, image2.tif, image3.eps, etc.).

Image File Formats not Supported at this Time: Microsoft Word, Microsoft PowerPoint, Microsoft Excel Spreadsheets, ChemDraw, CorelDraw, Canvas, FreeHand, SigmaPlot, QuarkXpress, and Equation Editor. You may export image files from these programs as PDF, JPEG, or other acceptable file formats. For questions regarding the conversion of these file formats to our preferred formats, please view our Figure Submission FAQs.

Color Files: Figures should be submitted in the RGB color space. This will allow optimal presentation of computer-generated imaging data. Authors are also encouraged to present color figures in a manner that will allow the data to be interpreted by colorblind readers. CMGH suggests that authors present dual-labeled images in green and magenta rather than in green and red.

Supplemental Material
For full-length original contributions, we encourage you to include all figures and text in the main manuscript. Supplementary material is limited to large data sets that are not amenable to typical page formats, including movies, or data that are tangential to the work, e.g. validation of an assay.

The portions of your manuscript that you would like to include as supplementary material (including figures and tables) must be uploaded separately from the manuscript file as "supporting documents." The supplementary material will appear at the end of the PDF and also be downloadable via a hyperlink.

Graphical Abstract
Graphical abstracts are strongly encouraged with all manuscript submitted to CMGH. Click here for more information.

Access to Data
In the methods section, a statement must be made that all authors had access to the all data and have reviewed and approved the final manuscript.

General Information
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Graphical Abstracts

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