Guide for Authors

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INTRODUCTION
• Types of article
• Word Counts
• Page charges
BEFORE YOU BEGIN
• Ethics in publishing
• Studies in humans and animals
• Informed consent and patient details
• Declaration of Potential Conflicts of Interest
• Submission declaration and verification
• Use of inclusive language
• Changes to authorship
• Reporting Clinical Trials
• Copyright
• Disclaimer
• Role of the funding source
• Open access
• Submit your article
PREPARATION
• Article Structure
• Appendices
• Essential title page information
• Structured abstract
• Keywords
• Decimal numerals
• Highlights
• Collaborators
• Artwork
• Tables
• References
• Supplementary material
AFTER ACCEPTANCE
• Proofs
• Offprints
AUTHOR INQUIRIES
• Requests about the status of your manuscript



Annals of Oncology publishes manuscripts that describe new findings of particular significance in any area related to clinical oncology and clinically-oriented basic cancer research. The criteria for acceptance are originality and high scientific quality. Manuscripts should be submitted with a letter specifying that the report is not under consideration for publication elsewhere and that all named authors have agreed to its submission. Papers reporting clinical studies should, where appropriate, contain a statement that they have been carried out with ethics committee approval. Papers disregarding the welfare of experimental animals will be rejected. Studies should be carried out in accordance with the relevant national and local guidelines.

If you plan to submit a manuscript to Annals of Oncology please read the editorials Annals of Oncology: an editorial perspective (Ann Oncol 2014; 25: 5-6) by J.-C. Soria and Annals of Oncology: a statement of editorial intent (Ann Oncol 2012; 23: 1931-1932) by J. B. Vermorken, which describes in some detail the kinds of manuscripts the journal will, and will not, now consider for publication.

The editorial office will rapidly review manuscripts in order that new findings may appear with minimum delay. The editorial office will return to authors within 3 weeks, whenever possible, all papers that are found to be of insufficient priority for further consideration. Papers of high interest will be sent out for external review. Authors will normally be notified of acceptance, rejection, or need for revision within 6 weeks of submission. Contributors will be provided with an electronic pdf proof, and corrections must be returned within three working days.

Types of article

Annals of Oncology publishes material in the form of editorials, original articles, letters, reviews, industry corner, and special articles.

Editorials. Editorials are solicited by the editor and are generally related to a paper published in the same issue. Length and format of the editorial will be agreed upon between editor and author.

Original articles. Full articles should generally be no longer than 4500 words, excluding manuscript heading, abstract, acknowledgements, and funding. Tables and figures are not limited in number but no more than 6 in total is recommended; each (including their legends, captions and footnotes) will count as 150 words towards the total word count of 4500; tables with excessive word counts will have the total words included in the final manuscript word count, however, extended material may be published as Supplementary Materials.

In the case of Supplementary Material, please indicate if it can be published online only. Online-only Supplementary Material should be uploaded in separate file(s), and described in the manuscript, in order to allow proper linking.

Figures, tables and references must be prepared according to specific instructions (see below). There is no limit on the number of figures or tables, but please consider that the journal is limited for space and that it may be possible to present some figures and tables as online only Supplementary Data. For further information see Supplementary material section below. Supplementary tables or figures should be named and numbered accordingly (S1, S2 etc.) in the manuscript and in the file.

Similarly, it may be possible to present an extended bibliography for online-only presentation.

Pre-submission queries are welcome, but for original articles direct online submission should get a rapid response.

Letters to the editor. Letters to the editor are for correspondence relating to previously published articles, and only then within an appropriate time frame, or with interesting practice points, e.g. emerging side-effects of new drugs or rare diseases where there is a real practice issue.

Letters are welcome and will be published if appropriate. They should be no longer than 500 words and a maximum of five references; one table or figure is acceptable if absolutely necessary. No abstract is required.

Reviews. Meeting reports can only be considered for publication as reviews under exceptional circumstances; in such cases, the report should not simply be a report of new data presented but an attempt to synthesise the state of the art in a particular field.

Consensus documents based on the views of ad hoc expert panels are no longer acceptable, unless the panel was convened under the auspices of a widely recognised body or meeting and be identified as such in the title.

The journal places no restriction on the style of review: narrative reviews, systematic reviews, and meta-analyses will all be considered.

Reviews are generally solicited by the editor. Unsolicited contributions will also be considered and should be submitted to the journal directly online for a rapid response.

Review manuscripts summarize the state-of-the-art in a particular field. Reviews should be no longer than 5000 words, on first submission, excluding manuscript heading, abstract, references (which are unrestricted in number), acknowledgements, funding, tables and figures. In the case of Supplementary Material, please indicate if it can be published online only; confidential materials for review only should be clearly indicated as such. If so, please upload it in separate file(s) (see appendices section). There is no limit on the number of figures or tables, but please consider that the journal is limited for space and that it may be possible to present some figures and tables as online only. Similarly, it may be possible to present an extended bibliography for online-only presentation.

Word Counts

Manuscripts that marginally exceed the stated word counts (not more than 10%) will not be automatically rejected on the grounds of length alone, although immediate rejection remains a possibility, if the editors deem it necessary on the grounds of insufficient interest. If an overlong manuscript is submitted to peer review, shortening of the manuscript may be required if the manuscript is returned for revision.

When providing word counts please indicate which word processing software and which version you are using.

Page charges

This journal has no page charges.

Ethics in publishing

Please see our information pages on Ethics in publishing and Ethical guidelines for journal publication.

Studies in humans and animals

If the work involves the use of human subjects, the author should ensure that the work described has been carried out in accordance with The Code of Ethics of the World Medical Association (Declaration of Helsinki) for experiments involving humans. The manuscript should be in line with the Recommendations for the Conduct, Reporting, Editing and Publication of Scholarly Work in Medical Journals and aim for the inclusion of representative human populations (sex, age and ethnicity) as per those recommendations. The terms sex and gender should be used correctly.

Authors should include a statement in the manuscript that informed consent was obtained for experimentation with human subjects. The privacy rights of human subjects must always be observed.

All animal experiments should comply with the ARRIVE guidelines and should be carried out in accordance with the U.K. Animals (Scientific Procedures) Act, 1986 and associated guidelines, EU Directive 2010/63/EU for animal experiments, or the National Institutes of Health guide for the care and use of Laboratory animals (NIH Publications No. 8023, revised 1978) and the authors should clearly indicate in the manuscript that such guidelines have been followed. The sex of animals must be indicated, and where appropriate, the influence (or association) of sex on the results of the study.

Informed consent and patient details

Studies on patients or volunteers require ethics committee approval and informed consent, which should be documented in the paper. Appropriate consents, permissions and releases must be obtained where an author wishes to include case details or other personal information or images of patients and any other individuals in an Elsevier publication. Written consents must be retained by the author but copies should not be provided to the journal. Only if specifically requested by the journal in exceptional circumstances (for example if a legal issue arises) the author must provide copies of the consents or evidence that such consents have been obtained. For more information, please review the Elsevier Policy on the Use of Images or Personal Information of Patients or other Individuals. Unless you have written permission from the patient (or, where applicable, the next of kin), the personal details of any patient included in any part of the article and in any supplementary materials (including all illustrations and videos) must be removed before submission.

Declaration of Potential Conflicts of Interest

Any financial interests or connections, direct or indirect, or other situations that might raise the question of bias in the work reported or the conclusions, implications or opinions stated - including pertinent commercial or other sources of funding for the individual author(s) or for the associated department(s) or organization(s), personal relationships, or direct academic competition - should be disclosed. Examples of potential conflicts of interest include employment, consultancies, stock ownership, honoraria, paid expert testimony, patent applications/registrations, and grants or other funding.

If there are none, the disclosure should say: 'The authors have declared no conflicts of interest.'

If one or a few authors have a conflict to disclose, further to that statement, there should be an additional statement for those remaining authors who do not have any, e.g. 'All remaining authors have declared no conflicts of interest.'

Submission declaration and verification

Submission of an article implies that the work described has not been published previously (except in the form of an abstract, a published lecture or academic thesis, see 'Multiple, redundant or concurrent publication' for more information), that it is not under consideration for publication elsewhere, that its publication is approved by all authors and tacitly or explicitly by the responsible authorities where the work was carried out, and that, if accepted, it will not be published elsewhere in the same form, in English or in any other language, including electronically without the written consent of the copyright-holder. To verify originality, your article may be checked by the originality detection service Crossref Similarity Check.

Preprints
Please note that preprints can be shared anywhere at any time, in line with Elsevier's sharing policy. Sharing your preprints e.g. on a preprint server will not count as prior publication (see 'Multiple, redundant or concurrent publication' for more information).

Use of inclusive language

Inclusive language acknowledges diversity, conveys respect to all people, is sensitive to differences, and promotes equal opportunities. Content should make no assumptions about the beliefs or commitments of any reader; contain nothing which might imply that one individual is superior to another on the grounds of age, gender, race, ethnicity, culture, sexual orientation, disability or health condition; and use inclusive language throughout. Authors should ensure that writing is free from bias, stereotypes, slang, reference to dominant culture and/or cultural assumptions. We advise to seek gender neutrality by using plural nouns ("clinicians, patients/clients") as default/wherever possible to avoid using "he, she," or "he/she." We recommend avoiding the use of descriptors that refer to personal attributes such as age, gender, race, ethnicity, culture, sexual orientation, disability or health condition unless they are relevant and valid. These guidelines are meant as a point of reference to help identify appropriate language but are by no means exhaustive or definitive.

Changes to authorship

Authors are expected to consider carefully the list and order of authors before submitting their manuscript and provide the definitive list of authors at the time of the original submission. Any addition, deletion or rearrangement of author names in the authorship list should be made only before the manuscript has been accepted and only if approved by the journal Editor. To request such a change, the Editor must receive the following from the corresponding author: (a) the reason for the change in author list and (b) written confirmation (e-mail, letter) from all authors that they agree with the addition, removal or rearrangement. In the case of addition or removal of authors, this includes confirmation from the author being added or removed.
Only in exceptional circumstances will the Editor consider the addition, deletion or rearrangement of authors after the manuscript has been accepted. While the Editor considers the request, publication of the manuscript will be suspended. If the manuscript has already been published in an online issue, any requests approved by the Editor will result in a corrigendum.

Reporting Clinical Trials

Authors reporting clinical trials may find the guidelines given in the report of Simon and Wittes useful. (Simon R, Wittes RE. Methodologic guidelines for reports of clinical trials. Cancer Treat Rep 1985; 69: 1-3.) Particularly critical is the correct application and presentation of survival analyses: useful guidelines can be found in the appendix of the report by D. G. Altman et al. (Altman DG, De Stavola BL, Love SB, Stepniewska KA. Review of survival analyses published in cancer journals. Br J Cancer 1995; 72: 511-518).

The quality of data reporting on randomized clinical trials will be evaluated following the rules and checklist of the CONSORT statement (CONSORT 2010 Statement: Updated Guidelines for Reporting Parallel Group Randomized Trials. Schulz KF, Altman DG, Moher D et al. Ann Intern Med 2010; 152: 1-7); if required, material concerning this statement will be forwarded to the authors (the CONSORT Flow Diagarm is available here: http://www.consort-statement.org/consort-statement/flow-diagram). Randomized clinical trials, which have begun after 1 January 1997, must be monitored and carried out in a manner permitting an absolute adherence to the rules of the CONSORT statement, as regards publication of their results. Potentially acceptable manuscripts will be submitted for statistical review. Any registered clinical trial number should be indicated after the abstract.

Phase I trials
Reports of phase I studies can only be considered where there are additional translational research components. In exceptional cases, specifically where a remarkable response rate was observed, translational research is not required. The reporting of response rates for rare tumors is in any case encouraged.

Phase II trials
Reports of phase II studies should be testing novel and innovative ideas and producing data that form the basis for important RCTs, or data that clearly suggest the lack of potential for such RCTs. There is no objection to negative phase II studies, provided they give clear guidance for future work. Single-arm phase II studies with combination schedules that include established drugs, but without additional translational research, cannot be considered. Phase II studies should use recognised statistical designs.

Phase III trials
Submission of reports of prospective, randomised phase III studies is encouraged. Fast-track facilities for editorial handling and, potentially, publication (to print) are available subject to agreement via a pre-submission query. Please contact the Editorial office.

Longer-term follow up reports of previously reported phase III trials are welcomed.

Studies of prognostic markers of no real future clinical utility and single biomarkers studies cannot be considered. These studies should be prospective and have a clear view of the practical clinical applications of the results. Retrospective analysis of biomarkers will be considered if done within the framework of data collected from a prospective trial, with appropriate statistics and with multivariate analysis that includes established predictive/prognostic markers.

Reports of tumor registry studies need to have clear clinical relevance; pre- submission queries are encouraged.

The journal is committed to translational research for the development of oncology, including basic, i.e. wholly preclinical, cancer research where clinical potential is clear.

Copyright

Upon acceptance of an article, authors will be asked to complete a 'Journal Publishing Agreement' (see more information on this). An e-mail will be sent to the corresponding author confirming receipt of the manuscript together with a 'Journal Publishing Agreement' form or a link to the online version of this agreement.

Subscribers may reproduce tables of contents or prepare lists of articles including abstracts for internal circulation within their institutions. Permission of the Publisher is required for resale or distribution outside the institution and for all other derivative works, including compilations and translations. If excerpts from other copyrighted works are included, the author(s) must obtain written permission from the copyright owners and credit the source(s) in the article. Elsevier has preprinted forms for use by authors in these cases.

Author rights
As an author you (or your employer or institution) have certain rights to reuse your work. More information.

Disclaimer

Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds or experiments described herein. Because of rapid advances in the medical sciences, in particular, independent verification of diagnoses and drug dosages should be made. To the fullest extent of the law, no responsibility is assumed by the publisher the European Society for Medical Oncology and Japanese Society for Medical Oncology for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions or ideas contained in the material herein.

Role of the funding source

Details of all funding sources for the work in question are mandatory; please include a funding statement before the disclosure, or add 'none declared'.

The following rules should be followed.

  • The sentence should begin: 'This work was supported by ?'
  • The full official funding agency name should be given, i.e. 'the National Cancer Institute at the National Institutes of Health' or simply 'National Institutes of Health' not 'NCI' (one of the 27 sub-institutions) or 'NCI at NIH' (full RIN-approved list of UK funding agencies). Grant numbers should be given in brackets as follows: '[grant number xxxx]'
  • Multiple grant numbers should be separated by a comma as follows: '[grant numbers xxxx, yyyy]'
  • Agencies should be separated by a semi-colon (plus 'and' before the last funding agency) or grant number 'to [author initials]'.
  • Where individuals need to be specified for certain sources of funding the following text should be added after the relevant agency or grant number 'to [author initials]'.
  • Please state if no grant number is applicable

An example is given here: 'This work was supported by the National Institutes of Health [AA123456 to C.S., BB765432 to M.H.]; and the Alcohol & Education Research Council [hfygr667789].'

The NIH public access policy requires authors to submit accepted manuscripts that arise from NIH funding to PubMed Central, immediately upon acceptance for publication, to be made publicly available after 12 months. Elsevier and NIH have an arrangement that supports NIH-funded authors and NIH employees who publish with Elsevier to comply with NIH's public access requirements.

Crossref Funding Data Registry: In order to meet your funding requirements authors are required to name their funding sources, or state if there are none, during the submission process. For further information on this process or to find out more about the CHORUS initiative please see: https://www.elsevier.com/en-gb/about/open-science/open-access/chorus

Open access

Please visit our Open Access page for more information.

Language (usage and editing services)
Please write your text in good English (American or British usage is accepted, but not a mixture of these). Authors who feel their English language manuscript may require editing to eliminate possible grammatical or spelling errors and to conform to correct scientific English may wish to use the English Language Editing service available from Elsevier's Author Services.

Submit your article

Please submit your article via the online submission web site.

Use of word processing software
It is important that the file be saved in the native format of the word processor used. The text should be in single-column format. Keep the layout of the text as simple as possible. Most formatting codes will be removed and replaced on processing the article. In particular, do not use the word processor's options to justify text or to hyphenate words. However, do use bold face, italics, subscripts, superscripts etc. When preparing tables, if you are using a table grid, use only one grid for each individual table and not a grid for each row. If no grid is used, use tabs, not spaces, to align columns. The electronic text should be prepared in a way very similar to that of conventional manuscripts (see also the Guide to Publishing with Elsevier). Note that source files of figures, tables and text graphics will be required whether or not you embed your figures in the text. See also the section on Electronic artwork.
To avoid unnecessary errors you are strongly advised to use the 'spell-check' and 'grammar-check' functions of your word processor.

Article Structure

Divide your article into clearly defined sections. Each subsection is given a brief heading. Each heading should appear on its own separate line. Subsections should be used as much as possible when cross-referencing text: refer to the subsection by heading as opposed to simply 'the text'.

Generally, an original article should be structured as follows: introduction; methods-patients and methods-materials and methods-etc; results; discussion (conclusion may be used as a subheading in the discussion); acknowledgements; funding; disclosure; references.

Appendices

If there is more than one appendix, they should be identified as A, B, etc. Formulae and equations in appendices should be given separate numbering: Eq. (A.1), Eq. (A.2), etc.; in a subsequent appendix, Eq. (B.1) and so on. Similarly for tables and figures: Table A.1; Fig. A.1, etc.

Essential title page information

Number the pages consecutively with the first page containing the following headings:

  • article type
  • title
  • author(s) list: first name(s) written with initials only, and followed by the last name - e.g. J. E. Smith
    There is no restriction on the number of authors; manuscripts can have as many authors as needed
  • affiliation(s) list: the affiliation list should be written as follows: Department/Division Name (in English), Affiliation/Institution, City, Country
  • full address for correspondence
  • Corresponding Author should be designated.
  • For Original Article and Review:
    this should be written as follows: title of corresponding author (Mr/Mrs/Ms/Dr/Prof ) without academic title (MD, PhD, etc.), author name (written with first name, middle initial, then last name) Department/Division/Unit Name (in English), Affiliation/Institution, street address, city, postal code, country, country code and telephone number, email address
  • For Editorial and Letter to the Editor:
    Corresponding Author e-mail address in brackets, e.g. (*E-mail:???.@?..) Author ORCID indemnifiers; for further information on ORCID see https://www.elsevier.com/connect/authors-update/ten-reasons-to-get-and-use-an-orcid-id!

Structured abstract

Please provide a short summary of 300 words or less. The summary should not contain any undefined abbreviations or unspecified references. Summaries should be organized and formatted according to the following headings: (1) Background, (2) Patients and methods, (3) Results and (4) Conclusion(s). Authors may substitute 'Design' or 'Materials and methods' for 'Patients and methods' in summaries of Review articles or of papers dealing with basic research.

Keywords

Immediately after the abstract, provide a maximum of 6 keywords, using American spelling and avoiding general and plural terms and multiple concepts (avoid, for example, 'and', 'of'). Be sparing with abbreviations: only abbreviations firmly established in the field may be eligible. These keywords will be used for indexing purposes.

Acknowledgements
Collate acknowledgements in a separate section at the end of the article before the references and do not, therefore, include them on the title page, as a footnote to the title or otherwise. List here those individuals who provided help during the research (e.g., providing language help, writing assistance or proof reading the article, etc.).

Decimal numerals

To enhance readability and clarity of the text as well as tables and figures, decimal numerals should - with the obvious exception of P-values - be rounded to the unit whenever possible (i.e. in all cases in which the rounding procedure does not change the meaning). Value "N" and "P" should always be written in italic.

Highlights

Highlights are a short collection of bullet points that convey the core findings and provide readers with a quick textual overview of the article. These three to five bullet points describe the essence of the research (e.g. results or conclusions) and highlight what is distinctive about it. Highlights will be displayed in online search result lists, the contents list and in the online article, but will not (yet) appear in the article PDF file or print.

Specifications:

  • Include 3 to 5 highlights.
  • There should be a maximum of 125 characters, including spaces, per highlight.
  • Only the core results of the paper should be covered.

Collaborators

Collaborators (sometimes called non-author contributors) will be listed on PubMed as collaborators rather than authors. In order to be indexed as collaborators, the names of the consortium or working group members should be listed in an Appendix in the main text document, not as supplementary material. The consortium or working group should also be included in the main author list. PubMed will list the names of individual group members who are authors or collaborators. There should be a note associated with the author list clearly stating that the individual names are elsewhere in the paper and whether those names are authors or collaborators. Collaborator names are searchable on PubMed in the same way as authors.

Artwork

Electronic artwork
General points
• Make sure you use uniform lettering and sizing of your original artwork.
• Embed the used fonts if the application provides that option.
• Aim to use the following fonts in your illustrations: Arial, Courier, Times New Roman, Symbol, or use fonts that look similar.
• Number the illustrations according to their sequence in the text.
• Use a logical naming convention for your artwork files.
• Provide captions to illustrations separately.
• Size the illustrations close to the desired dimensions of the published version.
• Submit each illustration as a separate file.
• Ensure that color images are accessible to all, including those with impaired color vision.

A detailed guide on electronic artwork is available.
You are urged to visit this site; some excerpts from the detailed information are given here.
Formats
If your electronic artwork is created in a Microsoft Office application (Word, PowerPoint, Excel) then please supply 'as is' in the native document format.
Regardless of the application used other than Microsoft Office, when your electronic artwork is finalized, please 'Save as' or convert the images to one of the following formats (note the resolution requirements for line drawings, halftones, and line/halftone combinations given below):
EPS (or PDF): Vector drawings, embed all used fonts.
TIFF (or JPEG): Color or grayscale photographs (halftones), keep to a minimum of 300 dpi.
TIFF (or JPEG): Bitmapped (pure black & white pixels) line drawings, keep to a minimum of 1000 dpi.
TIFF (or JPEG): Combinations bitmapped line/half-tone (color or grayscale), keep to a minimum of 500 dpi.
Please do not:
• Supply files that are optimized for screen use (e.g., GIF, BMP, PICT, WPG); these typically have a low number of pixels and limited set of colors;
• Supply files that are too low in resolution;
• Submit graphics that are disproportionately large for the content.

Color artwork
Please make sure that artwork files are in an acceptable format (TIFF (or JPEG), EPS (or PDF), or MS Office files) and with the correct resolution. If, together with your accepted article, you submit usable color figures then Elsevier will ensure, at no additional charge, that these figures will appear in color online (e.g., ScienceDirect and other sites) regardless of whether or not these illustrations are reproduced in color in the printed version. For colour reproduction in print any colour figures are published at the authors' expense. The charges are: US$700 for the first unit, followed by US$400 for any following units. The price in EUR and GBP will depend on the current exchange rate. Please indicate your preference for color: in print or online only. Further information on the preparation of electronic artwork.

Cover Images
Authors are particularly encouraged to submit colour images relating to their article, but not necessarily part of it, for consideration as a potential cover image for a journal issue. Files should be uploaded separately and labeled as potential cover art; the images should also be mentioned in the submission letter.

Permissions

As a general rule, permission should be sought from the rightsholder to reproduce any substantial part of a copyrighted work. This includes any text, illustrations, charts, tables, photographs, or other material from previously published sources.

To read our full Permissions Guidelines and determine if you require permission, please click here.

Figure captions
Ensure that each illustration has a caption. Supply captions separately, not attached to the figure. A caption should comprise a brief title (not on the figure itself) and a description of the illustration. Keep text in the illustrations themselves to a minimum but explain all symbols and abbreviations used.

Tables

Please submit tables as editable text and not as images. Tables can be placed either next to the relevant text in the article, or on separate page(s) at the end. Number tables consecutively in accordance with their appearance in the text and place any table notes below the table body. Be sparing in the use of tables and ensure that the data presented in them do not duplicate results described elsewhere in the article. Please avoid using vertical rules and shading in table cells. Value " N " and " P " should always be written in italic, throughout tables, figures and manuscript.

References

Please ensure that every reference cited in the text is also present in the reference list (and vice versa). Any references cited in the abstract must be given in full. Unpublished results and personal communications are not recommended in the reference list, but may be mentioned in the text. If these references are included in the reference list they should follow the standard reference style of the journal and should include a substitution of the publication date with either 'Unpublished results' or 'Personal communication'. Citation of a reference as 'in press' implies that the item has been accepted for publication and a copy of the title page of the relevant article must be submitted.

In the text, a reference identified by means of an author's name should be followed by the reference number in superscripts. When there are more than two authors, only the first author's name should be mentioned, followed by et al.

Examples.
Winograd1
Bullen and Bennett2
Wilson et al.3

References to books, journal articles, articles in collections and conference or workshop proceedings, and technical reports should be listed at the end of the article in numbered order following the Index Medicus style (see examples below). References to abstracts and Letters to the editor must be identified as such. List all authors if three or fewer; if four or more, list only the first three, followed by et al. Articles in preparation or articles submitted for publication, unpublished observations, personal communications, etc. should not be included in the reference list but should only be mentioned in the article text (e.g. T. Moore, personal communication).

References to books should include the author's name; year of publication; title; page numbers where appropriate; publisher; place of publication, in the order given in the example below.

  1. Pecorino L. Molecular Biology of Cancer Mechanisms, Targets, and Therapeutics, 3rd edition: Oxford University Press, Oxford, 2012.

References to articles in an edited collection should include the author's name; year of publication; article title; editor's name; title of collection; first and last page numbers; publisher; place of publication, in the order given in the example below.

  1. Brennan MF, Alektiar KM, Maki RG. Soft tissue sarcoma. In DeVita VT Jr, Hellman S, Rosenberg SA (eds): Cancer: Principles and Practice of Oncology, 6th edition. Philadelphia, PA: Lippincott Williams & Wilkins 2001; 1841-1980.

References to articles in periodicals should include the author's name; year of publication; article title; full abbreviated title of periodical; volume number (issue number where appropriate); first and last page numbers, in the order given in the example below.

  1. Selle F, Sevin E, Ray-Coquard I et al. A phase II study of lenalidomide in platinum-sensitive recurrent ovarian carcinoma. Ann Oncol 2014; 25: 2191-2196.

If an article has been published online but has not yet been given issue or page numbers please use the Digital Object Identifier (doi) number when referencing the article as in the example below.

  1. Islami F, Liu Y, Jemal A et al. Breastfeeding and breast cancer risk by receptor status - a systematic review and meta-analysis Ann Oncol 2015. October 26 [Epub ahead of print] doi:10.1093/annonc/mdv379

Supplementary material

Supplementary material such as applications, images and sound clips, can be published with your article to enhance it. Submitted supplementary items are published exactly as they are received (Excel or PowerPoint files will appear as such online). Please submit your material together with the article and supply a concise, descriptive caption for each supplementary file. If you wish to make changes to supplementary material during any stage of the process, please make sure to provide an updated file. Do not annotate any corrections on a previous version. Please switch off the 'Track Changes' option in Microsoft Office files as these will appear in the published version.

Availability of accepted article
This journal makes articles available online as soon as possible after acceptance. This concerns the Journal Pre-proofs (both in HTML and PDF format), which have undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but are not yet the definitive versions of record. A Digital Object Identifier (DOI) is allocated, thereby making it fully citable and searchable by title, author name(s) and the full text. The article's PDF also carries a disclaimer stating that it is an unedited article. Subsequent production stages will simply replace this version.

Proofs

One set of page proofs (as PDF files) will be sent by e-mail to the corresponding author (if we do not have an e-mail address then paper proofs will be sent by post) or a link will be provided in the e-mail so that authors can download the files themselves. To ensure a fast publication process of the article, we kindly ask authors to provide us with their proof corrections within two days. Elsevier now provides authors with PDF proofs which can be annotated; for this you will need to download the free Adobe Reader, version 9 (or higher). Instructions on how to annotate PDF files will accompany the proofs (also given online). The exact system requirements are given at the Adobe site.
If you do not wish to use the PDF annotations function, you may list the corrections (including replies to the Query Form) and return them to Elsevier in an e-mail. Please list your corrections quoting line number. If, for any reason, this is not possible, then mark the corrections and any other comments (including replies to the Query Form) on a printout of your proof and scan the pages and return via e-mail. Please use this proof only for checking the typesetting, editing, completeness and correctness of the text, tables and figures. Significant changes to the article as accepted for publication will only be considered at this stage with permission from the Editor. We will do everything possible to get your article published quickly and accurately. It is important to ensure that all corrections are sent back to us in one communication: please check carefully before replying, as inclusion of any subsequent corrections cannot be guaranteed. Proofreading is solely your responsibility.

Offprints

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Once a manuscript is submitted, you can follow manuscript developments from your online account, at the Annals of Oncology online submission website http://mc.manuscriptcentral.com/annonc. In particular questions about the status of your manuscript should be addressed to the Editorial Office at annals1@esmo.org or annals2@esmo.org. Please include your manuscript number (this number was sent to you upon receipt of your manuscript). However, considering the processes are confidential, the Editorial Office can rarely provide more details than those available in the author account; queries not from the author will not be answered.

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