Volume 4 Issue 1
You all know Researcher Academy by now but if you want a mine of information and dedicated links to all you need as a journal author, how to find the journal in which to publish your article, publication policies and ethics, open access publishing and more, here is the place to go: Elsevier for Authors. Moreover, if you want to quickly be informed about news in the field, or suggest topics you want us to address, stay connected through Authors’ Update.
Elsevier and the The Pistoia Alliance recently worked together and have announced the results of a joint datathon for Drug Repurposing for Rare Diseases. The datathon, conducted in partnership with non-profit groups, Cures Within Reach and Mission: Cure, involved participants from a range of organizations including life sciences, technology and academia, and has succeeded in identifying new drug candidates for repurposing to treat chronic pancreatitis.
Participants used the AI environment created by Elsevier’s Entellect platform in collaborative effort to discover potential treatments. Entellect is a new cloud-based data platform designed to help life sciences companies overcome the challenges of modern R&D by enriching and harmonizing proprietary and external data and delivering it in an AI-ready environment.
Acceptance and Commitment Therapy Reduces Psychological Stress in Patients With Inflammatory Bowel Diseases
Acceptance and Commitment Therapy comprises acceptance and mindfulness procedures, along with commitment and behavior change strategies, to increase psychological flexibility and reduce stress. But does it work? We performed a randomized controlled trial to investigate the effect of ACT on stress in patients with inflammatory bowel diseases (IBD).
In most developed countries, the demography is changing with increasingly ageing populations and in keeping with this a higher proportion of people who are fitter and healthier. It should be no surprise, therefore, that there is a greater demand for specialist healthcare including liver transplantation. In the January edition of HPB, Gavara and colleagues, representing 3 centres in Europe, present a systematic review and meta-analysis of outcomes of liver transplantation in the elderly.
Each year, viral hepatitis kills 1.34 million people, which is comparable with deaths due to HIV/AIDS, malaria, and tuberculosis. With the advent of highly effective prevention measures and treatments, global elimination of viral hepatitis is a realistic goal; all WHO member states have committed to a global reduction in hepatitis-related deaths by 65% and new infections by 90% by 2030. This Lancet Gastroenterology & Hepatology Commission sets out to appraise the current global situation and to identify priorities—for countries, regions, and globally—to accelerate efforts towards these ambitious targets.
Immunotherapy has shown promise against solid tumors. However, the clinical significance of programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) in pancreatic ductal adenocarcinoma (PDAC) remains unclear. Through database searches of PubMed, Cochrane Library and Web of Science, articles describing the relationship between PD-L1 status and PDAC patient prognosis were identified to investigate the relationship between PD-1 and overall survival (OS). Authors found that the PD-L1 positive rate was associated with PDAC T stages; the PD-L1 positive rate in the T3–4 group was higher than that in the T1-2 group. High PD-L1 expression levels predicted a poor prognosis in PDAC patients. Thus, PD-L1 status helps determine treatment in PDAC patients.
Hepatitis E virus (HEV) typically causes an acute, self-limiting hepatitis and is among the commonest cause of such presentations. Hepatitis E viral infection is also increasingly recognized as a cause of chronic hepatitis amongst the immunocompromised, particularly amongst solid organ transplant recipients. Chronic HEV infection remains an underdiagnosed disease and chronic infection can lead to rapidly progressive liver fibrosis and cirrhosis. This review examines current understanding of the HEV. Typical clinical presentations, management strategies based upon guidelines from both the British Transplant Society (BTS) and European Association for the Study of the Liver (EASL) and outcomes of HEV infection in different cohorts of patients are illustrated by highlighting select transplant and non-transplant patient cases, from one of the largest tertiary hepatology centers in Europe.
Human gastrointestinal tract contains a large variety of microbes, in particular bacteria. Studies in recent years have strongly suggested a role for these microbes, collectively referred to as gut microbiota, in the maintenance of homeostasis during health. In addition, alterations in gut microbiota have been reported in several diseases, including those related to the gastrointestinal tract and several systemic conditions, and are believed to play a pathogenetic role in at least some of these. Given the close association between the human gut and liver, the association with gut microbiota appears to be particularly strong for a wide variety of liver diseases. This piece, aimed primarily at physicians, reviews in brief the methods used to study gut microbiota, with particular emphasis on those that use sequences of bacterial 16S rRNA gene or its components.
Comparison of Monopolar Hemostatic Forceps with Soft Coagulation Versus Hemoclip for Peptic Ulcer Bleeding: a Randomized Trial (with video)
A standard recommended approach for the treatment of peptic ulcer bleeding does not exist; the choice depends on multiple factors such as location of the ulcer, clinical experience of the endoscopist, and local facilities of the clinic. Bilal Toka et al aimed to compare the efficacy of monopolar hemostatic forceps soft coagulation and hemoclips in the treatment of peptic ulcer-related upper GI bleeding. Photo: Bilal Toka et al compare hemostatic forceps coagulation with hemoclips for peptic ulcer-related bleeding.
The Food Additive Maltodextrin Promotes Endoplasmic Reticulum Stress – Driven Mucus Depletion and Exacerbates Intestinal Inflammation
This study reports that the polysaccharide maltodextrin, which is a common additive used in Western diet for food processing, triggers endoplasmic reticulum stress in goblet cells. Our data support the hypothesis that a Western diet rich in maltodextrin can contribute to gut disease susceptibility and can help design preventive programs for subjects at high risk to develop inflammatory bowel diseases.
Read the latest Clinical Practice Guidelines on Hepatic Encrephalopathy from the Italian Association for the Study of the Liver (AISF) published in a recent issue of Digestive and Liver Disease. Hepatic encephalopathy (HE) is a common and sometimes difficult to manage complication of end-stage liver disease. HE is often recurrent, requiring multiple hospital admissions. It can have serious implications in terms of a patient’s ability to perform complex tasks (for example driving), their earning capacity, their social and family roles. This guideline reviews current knowledge on HE definition, pathophysiology, diagnosis and treatment, both by general principles and by way of a summary of available drugs and treatment strategies.
Recent advances in the management of viral hepatitis B and C with highly effective therapies are decreasing the proportion of patients with viral-related end-stage liver disease in many countries and attention is now turning towards other liver-related health burdens. This commissioned issue intends to provide an updated review of the current efforts by the scientific liver community to prevent the development of ALD and all articles are freely available.
Prognosis is poor for patients diagnosed with oesophageal cancer due to the aggressive nature of the disease, with an estimated overall 5-year survival of 10–15%. With this issue of Best Practice and Research: Clinical Gastroenterology; keep up to date with the latest reviews on the risk factors, molecular biology, diagnosis and treatment of this form of cancer.
JHEP Reports is the new open access basic, translational, and clinical research publication from the European Association for the Study of the Liver (EASL). JHEP Reports will publish original papers, reviews, and letters to the Editor concerning global issues in hepatology. We invite you to submit your research and benefit from:
- Open Science, Data Sharing – Innovative, transparent, and interactive publishing of all research data.
- Quality Review Process – Rigid peer reviewed by a renowned editorial team.
- Worldwide Access and Discoverability – Your research will be immediately and freely available to the scientific and medical communities as well as patients and policy makers via ScienceDirect, and tracked for citations via Scopus.
Submit your research
We invite you to submit your next article to one of these Elsevier journals.