Special article collection to raise awareness for World AIDS Day 2017
Read an article on Elsevier Connect about the value of HIV research featuring Professor Eskild Petersen, Editor-in-Chief of the International Journal of Infectious Diseases.
Ending HIV transmission
Globally, an estimated 36.7 million people are living with HIV. Since the start of the pandemic in the early 1980s, more than 70 million people have been infected and 35 million people have died as a result.
On World AIDS Day, 1 December, people unite in the fight against HIV. The first ever global health day, it was founded in 1988 to “show support for people living with HIV, and to commemorate those who have died from an AIDS-related illness.” In 2017, the campaign is #LetsEndIt – end isolation, stigma and HIV transmission.
To mark World AIDS Day, you can read this special collection of articles published in Elsevier journals on different aspects of HIV – transmission, testing, treatment and beyond.
A viral epidemic
Human immunodeficiency virus (HIV) is transmitted sexually, through breast milk and through blood contact, for example by sharing needles. Over time, HIV infection can cause acquired immunodeficiency syndrome (AIDS) – a condition that weakens the immune system, leaving the person vulnerable to life-threatening infections and cancers.
HIV infects immune cells: CD4+ T cells, macrophages and dendritic cells. Infection with the virus either kills these cells or stops them from working, breaking down the body’s cell mediated immune response.
HIV is treated with antiretroviral medication, which can allow HIV positive people to live long and otherwise healthy lives, managing their infection and keeping their immune systems strong. However, medication is expensive and often inaccessible in the places where it’s most needed. In sub-Saharan Africa, nearly 1 in 25 adults lives with HIV.
Ending HIV transmission
Scientific advances have led to better treatments and faster diagnoses, but there is still a lot to learn about the virus. Researchers around the world are working to find out more about how HIV is transmitted, in order to identify weak spots that could be exploited. They are developing more sensitive, faster tests to diagnose infection, ultimately stopping transmission. And researchers are working on improving existing treatments and developing new ones.
Here you can read some of the latest studies published in Elsevier journals that are contributing to ending HIV transmission and stopping the pandemic. The collection is free to access until the 1st of February, 2018.
Clinical Microbiology and Infection
Ceftriaxone versus ceftriaxone plus a macrolide for community-acquired pneumonia in hospitalized patients with HIV/AIDS: a randomized controlled trial
C. Figueiredo-Mello, P. Naucler, M.D. Negra, A.S. Levin
Early detection of HIV infection and of asymptomatic sexually transmitted infections among men who have sex with men
Josep Coll, Sebastián Videla, Agathe Leon, Arelly Ornelas, Felipe García, Emma Fernández, José Luis Blanco, Antonio Carrillo, Isabel Bravo, Michael Meulbroek, Francesc García-Cuyas, Victoria González, Jordi Casabona, Lorna Leal, Bonaventura Clotet, Christian Brander, CHECK-EAR TEAM
Longitudinal trends of HIV drug resistance in a large Canadian cohort, 1996–2016
G. Rocheleau, C.J. Brumme, J. Shoveller, V.D. Lima, P.R. Harrigan
Successful control of a large outbreak of HIV infection associated with injection of cathinone derivatives in Tel Aviv, Israel
E. Katchman, R. Ben-Ami, M. Savyon, D. Chemtob, B. Avidor, A. Wasserman, I. Zeldis, S. Girshengorn, Z. Amitai, R. Sheffer, D. Turner
Journal of Infection
Incidence, presentation and outcome of toxoplasmosis in HIV infected in the combination antiretroviral therapy era
Martin-Iguacel, Raquel; Ahlstrom, Magnus Glindvad; Touma, Madeleine; et al.
Direct-acting antiviral treatment against hepatitis C virus infection in HIV-Infected patients – “En route for eradication”?
Pradat, Pierre; Pugliese, Pascal; Poizot-Martin, Isabelle; et al.
Multiple introductions and onward transmission of HIV-1 subtype B strains in Shanghai, China
Xiaoshan Li, Kexin Zhu, Yile Xue, Feiran Wei, Rong Gao, Ralf Duerr, Kun Fang, Wei Li, Yue Song, Guoping Du, Wenjuan Yan, Taha Hussein Musa, You Ge, Yu Ji, Ping Zhong, Pingmin Wei
Comparing viral load metrics and evaluating their use for HIV surveillance
Renee Bolijn, Eline L.M. Op de Coul, Ard van Sighem, Willem L. Blok, Mirjam E. Kretzschmar, Janneke C.M. Heijne, the ATHENA National Observational HIV Cohort
International Journal of Infectious Diseases
Tuberculosis and diabetes in Nigerian patients with and without HIV
L. Lawson, M. Muc, O. Oladimeji, C. Iweha, B. Opoola, S.T. Abdurhaman, J.S. Bimba, L.E. Cuevas
Efficacy and safety of a once-daily single-tablet regimen of tenofovir, lamivudine, and efavirenz assessed at 144 weeks among antiretroviral-naïve and experienced HIV-1-infected Thai adults
A. Avihingsanon, W. Maek-A-Nantawat, S. Gatechompol, V. Sapsirisavat, W. Thiansanguankul, J. Sophonphan, N. Thammajaruk, S. Ubolyam, D.M. Burger, K. Ruxrungtham
Tuberculosis associated mortality in a prospective cohort in Sub Saharan Africa: Association with HIV and antiretroviral therapy
T.J. Nagu, S. Aboud, R. Mwiru, M.I. Matee, M. Rao, W.W. Fawzi, A. Zumla, M.J. Maeurer, F. Mugusi
Journal of Clinical Virology
HIV misdiagnosis: A root cause analysis leading to improvements in HIV diagnosis and patient care
Raynell Lang, Carmen Charlton, Brenda Beckthold, Kiana Kadivar, Stephanie Lavoie, Doug Caswell, Paul Levett, Greg Horsman, John Kim, M. John Gill
Highlights from the 2016 HIV diagnostics conference: The new landscape of HIV testing in laboratories, public health programs and clinical practice
Laura G. Wesolowski, Monica M. Parker, Kevin P. Delaney, S. Michele Owen
A European multicientre study on the comparison of HIV-1 viral loads between VERIS HIV-1 Assay and Roche COBAS® TAQMAN® HIV-1 test, Abbott RealTime HIV-1 Assay, and Siemens VERSANT HIV-1 Assay
Patrick Braun, Rafael Delgado, Monica Drago, Diana Fanti, Hervé Fleury, Jörg Hofmann, Jacques Izopet, Sebastian Kühn, and others
Journal of Global Antimicrobial Resistance
Drug resistance in B and non-B subtypes amongst subjects recently diagnosed as primary/recent or chronic HIV-infected over the period 2013–2016: Impact on susceptibility to first-line strategies including integrase strand-transfer inhibitors
Samantha Andreis, Monica Basso, Renzo Scaggiante, Mario Cruciani, Roberto Ferretto, Vinicio Manfrin, Sandro Panese, Maria Cristina Rossi, and others
The HIV-1 reverse transcriptase polymorphism A98S improves the response to tenofovir disoproxil fumarate + emtricitabine-containing HAART both in vivo and in vitro
Claudia Alteri, Matteo Surdo, Velia Chiara Di Maio, Fabiola Di Santo, Giosuè Costa, Lucia Parrotta, Isabella Romeo, Caterina Gori, and others
Distribution scheme of anti-tuberculosis drug resistance among HIV patients in a referral center over 10 years
Parvaneh Baghaei, Payam Tabarsi, Afshin Moniri, Majid Marjani, Parissa Farnia, Sayena Jabbehdari, Ali Akbar Velayati
International Journal of Antimicrobial Agents
Impact of early versus deferred antiretroviral therapy on estimated glomerular filtration rate in HIV-positive individuals in the START trial
Amit C. Achhra, AmandaMocroft, Michael Ross, Lene Ryom-Nielson, Anchalee Avihingsanon, Elzbiet aBakowska, Waldo Belloso, Amanda Clarke, Hansjakob Furrer, Gregory M. Lucas, Matti Ristola, Mohammed Rassool, Jonatha Ross, Charurut Somboonwit, Shweta Sharma, Christina Wyatt
On the duration of the period between exposure to HIV and detectable infection
Bernhard P.Konrad, Darlene Taylor, Jessica M.Conway, Gina S.Ogilvie, DanielCoombs
Gender asymmetry in concurrent partnerships and HIV prevalence
Ka Yin Leung, Kimberly A.Powers, Mirjam Kretzschmar
Journal of Obstetrics and Gynaecology Canada
HIV Screening in Pregnancy
Lisa Keenan-Lindsay R N, M N, Mark H. Yudin M D, MSc, FRCSC
An Evaluation of Introduction of Rapid HIV Testing in a Perinatal Program
Sarah Saunders MD, Karen Tulloch Pharm D, Evelyn J. Maan RN, Juliannevan Schalkwyk MD, MSc Deborah M. MoneyMD
Fertility and Sterility
Effectiveness of semen washing to prevent human immunodeficiency virus (HIV) transmission and assist pregnancy in HIV-discordant couples: a systematic review and meta-analysis
Maryam Zafer M.S, Hacsi Horvath M.A, Okeoma Mmeje M.D, Sheryl van der Poel M.D, Augusto E. Semprini M.D, George Rutherford M.D, Joelle BrownPh.D
American Journal of Obstetrics and Gynecology
Trends in contraceptive use according to HIV status among privately insured women in the United States
Lisa B. HaddadMD, MS, MPHaMichaelMonsourPhDbNaomi K.TepperMD, MPHbMaura K.WhitemanPhDbAthena P.KourtisMD, PhD, MPHbDenise J.JamiesonMD, MPH
HIV-1 can infect northern pig-tailed macaques (Macaca leonina) and form viral reservoirs in vivo
Wei Pang, Gao-Hong Zhang, Jin Jiang, Hong-Yi Zheng, Lin-Tao Zhang, Xiao-Liang Zhang, Jia-Hao Song, Ming-Xu Zhang, Jia-Wu Zhu, Ai-Hua Lei, Ren-Rong Tian, Xiao-Ming Liu, Liguo Zhang, Guangxia Gao, Lishan Su, Yong-TangZheng
Journal of Infection and Chemotherapy
Addition of maraviroc to antiretroviral therapy decreased interferon-γ mRNA in the CD4+ T cells of patients with suboptimal CD4+ T-cell recovery
Rumi Minami, Soichiro Takahama, Yu Kaku, Masahiro Yamamoto