World Antibiotic Awareness Week 2017, 13-19 November 2017

Handle Antibiotics with care

Special article collection for Antibiotic Awareness Week

Antibiotic resistance is a serious global threat: every year, at least 700,000 people around the world die from infections with superbugs that are resistant to antibiotics – and this is predicted to rise to 10 million by 2050.

This year’s World Antibiotic Awareness Week (13-19 November 2017), run by the World Health Organization (WHO), has the theme Seek advice from a qualified healthcare professional before taking antibiotics – and it’s easy to see why. The overuse of antibiotics has resulted in the medicines finding their way into our water system, making wastewater a perfect breeding ground for superbugs.

To coincide with World Antibiotic Awareness Week, we have collated a special collection of the latest research published in Elsevier journals – free to access until the 1st of February 2018.

An estimated 50 percent of antibiotics worldwide can be bought without a prescription, particularly in some parts of South America and Asia where they can be bought easily on the black market. But in many places, antibiotics are also easy to buy over the counter – a 2014 report by the WHO revealed 19 countries across Europe where antibiotics were easy to obtain. This contributes to the overuse of antibiotics and the growing threat of superbugs.

World Antibiotic Awareness Week coincides with World Toilet Day, which has the theme Wastewater – one of the major conduits of antibiotic resistance. Globally, 80 percent of wastewater generated by society goes back into the ecosystem without being treated. When people ingest antibiotics, their bodies do not fully metabolize them so their residues end up in our sewage systems, or people flush their old antibiotics down the toilet. If feces are not contained and treated, they can cause thousands of diseases to spread because antibiotics kill all the susceptible bacteria, leaving only the strong, resistant ones to flourish with no competition.

This poses huge problems for human health – especially for urban wastewater treatment plants (WWTPs) where the complete treatment of domestic wastewater from homes, workspaces and hospitals becomes almost impossible. Drug-resistant bacteria can also pass on resistance to other bacteria by a process called horizontal gene transfer – thought to be the major cause of resistance spreading among bacteria.

For this reason, the UN’s Sustainability Development Goals aim to halve the proportion of untreated wastewater by 2030. By treating human and animal waste safely, it can turn into “brown gold” and be used for energy generation or fertilizer in food production.

Research is a major part of our fight against antibiotic resistance, looking at why resistance develops, how it can be prevented and also identifying new classes of antibiotics.

This special article collection features some of the latest research published in Elsevier journals. You can find out how to detect multidrug resistant bacteria in wastewater, why researchers are looking at old antibiotics to treat superbug infections and what antibiotic stewardship is, by reading the collection – free until 1st of February 2018.

International Journal of Antimicrobial Agents

Old antibiotics for multidrug-resistant pathogens: from in vitro activity to clinical outcomes
Keith S. Kaye, Ana C. Gales, Grégory Dubourg

Clinical Microbiology and Infection

New agents for the treatment of infections with Gram-negative bacteria: restoring the miracle or false dawn?
H. Wright, R.A. Bonomo, D.L. Paterson

What is antimicrobial stewardship?
Oliver J. Dyar, Benedikt Huttner, Jeroen Schouten, Céline Pulcini, ESGAP (ESCMID Study Group for Antimicrobial stewardshiP)

Ensuring universal access to old antibiotics: a critical but neglected priority
C. Pulcini, B. Beovic, G. Béraud, J. Carlet, O. Cars, P. Howard, G. Levy-Hara, G. Li, D. Nathwani, F. Roblot, M. Sharland

Preserving the 'commons': addressing the sustaibable use of anitbiotics through an economic lens
C.M. Morel, S.E. Edwards, S. Harbarth

Journal of Infection

Double-carbapenem regimen, alone or in combination with colistin, in the treatment of infections caused by carbapenem-resistant Klebsiella pneumoniae
Alessandra Oliva, L. Scorzolini, D. Castaldi, F. Gizzi, M. De Angelis, M. Storto, A. D'Abramo, F. Aloj, M.T. Mascellino, C.M. Mastroianni, V. Vullo

Clinical translation of polymyxin-based combination therapy: Facts, challenges and future opportunities
Xueli Zhang, Fengmei Guo, Hua Shao, Xiao Zheng

Empirical mono- versus combination antibiotic therapy in adult intensive care patients with severe sepsis - A systematic review with meta-analysis and trial sequential analysis
Fredrik Sjövall, Anders Perner, Morten Hylander Møller

Successful treatment of Pseudomonas aeruginosa osteomyelitis with antibiotic monotherapy of limited duration
Nadir Laghmouche, Fabrice Compain, Anne-Sophie Jannot, Pierre Guigui, Jean-Luc Mainardi, Guillaume Lonjon, Benjamin Bouyer, Marie-Paule Fernandez-Gerlinger

International Journal of Infectious Diseases

Candida auris: An emerging multidrug-resistant pathogen
Sears D, Schwartz BS

Beta-lactam combination therapy for the treatment of Staphylococcus aureus and Enterococcus species bacteremia: A summary and appraisal of the evidence
Bartash R, Nori P.

A situational analysis of current antimicrobial governance, regulation and utilisation in South Africa
Schellack N, Benjamin D, Brink A, Duse A, Faure K, Goff D, Mendelson M, Meyer J, Miot J, Perovic O, Pople T, Suleman F, van Vuuren M, Essack S

Journal of Hospital Infection

Impact of an antimicrobial stewardship program to optimize antimicrobial use for outpatients at emergency department
A. Dinh, C. Duran, B. Davido,F. Bouchand, L. Deconinck, M. Matt, O. Sénard, C. Guyot, A. So Levasseur, J. Attal, D. Razazi, T. Tritz, A. Beauchet, J. Salomon, S. Beaune, J. Grenet

Effectiveness of postprescription antibiotic stewardship to reduce carbapenem consumption: a quantitative study
H. Kallel, P. Abboud, S.Nkouka, A. Mahamat, B.Moreau, F. Nkont Cho, G. Saint-Lorant, F.Djossou

Journal of Clinical Virology

Multiplex PCR reveals that viruses are more frequent than bacteria in children with cystic fibrosis
Sílvia Miró-Cañís, Sílvia Capilla-Rubio, Laura Marzo-Checa, Dionisia Fontanals-Aymerich, Isabel Sanfeliu-Sala, Mateu Espasa-Soley, Oscar Asensio-de-la-Cruz

A 3-month course of ciprofloxacin does not prevent BK virus replication in heavily immunosuppressed kidney-transplant patients
Marine Lebreton, Laure Esposito, Catherine Mengelle, Arnaud Del Bello, Antoine Delarche, Gaëlle Dörr, David Milongo, Olivier Marion, Jacques Izopet, Nassim Kamar

Bacterial and viral co-infections complicating severe influenza: Incidence and impact among 507 U.S. patients, 2013–14
Nirav S. Shah et al.

Infection, Genetics and Evolution

Quadruple-first line drug resistance in Mycobacterium tuberculosis in Vietnam: What can we learn from genes?
Huy Quang Nguyen, Nhung Viet Nguyen, Lucie Contamin, Thanh Hoa Thi Tran, Thuong Thi Vu, Hung Van Nguyen, Ngoc Lan Thi Nguyen, Son Thai Nguyen, Anh Duc Dang

Seasonal cycle of inbreeding and recombination of the parasitic mite Varroa destructor in honeybee colonies and its implications for the selection of acaricide resistance
Alexis L. Beaurepaire, Klemens J. Krieger, Robin F.A. Moritz

Genomic sequencing of a strain of Acinetobacter baumannii and potential mechanisms to antibiotics resistance
Lei Zhao, Hongru Lid, Ziwen Zhu, Mark R. Wakefield, Yujiang Fang, Ying Ye

Differences in the integrase and reverse transcriptase transmitted resistance patterns in Northern Poland
Milosz Parczewski, Magdalena Leszczyszyn-Pynka, Anna Urbanska

Journal of Obstetrics and Gynaecology Canada

Antibiotic Therapy in Preterm Premature Rupture of the Membranes
Mark H.Yudin, Julie van Schalkwyk, Nancy Van Eyk

Antibiotic Prophylaxis in Obstetric Procedures
Julievan Schalkwyk, Nancy Van Eyk

American Journal of Obstetrics and Gynecology

Drug interactions between non-rifamycin antibiotics and hormonal contraception: a systematic review
Katharine B. Simmons, Lisa B.Haddad, Kavita Nanda, Kathryn M. Curtis

Fertility and Sterility

Old habits die hard: retrospective analysis of outcomes with use of corticosteroids and antibiotics before embryo transfer
Leah Kaye, Chantal Bartels, Alison Bartolucci, Lawrence Engmann, John Nulsen, Claudio Benadiva

Science Bulletin

Effect of feeding Lactobacillus plantarum P-8 on the faecal microbiota of broiler chickens exposed to lincomycin
Pengfei Gao, Qiangchuan Hou, Lai-Yu Kwok, Dongxue Huo, Shuzhen Feng, Heping Zhang

Near infrared light triggered nitric oxide releasing platform based on upconversion nanoparticles for synergistic therapy of cancer stem-like cells
XiaoZhang, Zhao Guo, Jing Liu, Gan Tian, Kui Chen, Shicang Yu, Zhanjun Gu

Journal of Infection and Chemotherapy

Bactericidal activity and post-antibiotic effect of ozenoxacin against Propionibacterium acnes
Shoji Kanayama, Kazuaki Okamoto, Fumiaki Ikeda, RitsukoIshii, Tatsumi Matsumoto, Naoki Hayashi, Naomas Gotoh

A randomized controlled trial of sitafloxacin vs. ertapenem as a switch therapy after treatment for acute pyelonephritis caused by extended-spectrum β-lactamase-producing Escherichia coli: A pilot study
Chitprasong Malaisri,  Angsana Phuphuakrat, Arrug Wibulpolprasert, Pitak Santanirand, Sasisopin Kiertiburanakul

Infection, Disease & Health

The burden of healthcare-associated infection in Australian hospitals: A systematic review of the literatureBrett G.Mitchell, Ramon Z. Shaban, Deborough MacBeth, Claudia-Jayne Wooda, Philip L. Russo

Heart, Lung and Circulation

Prosthetic Valve Infective Endocarditis With Mycobacterium Fortuitum: Antibiotics Alone Can Be Curative
Sonali R. Gnanenthiran, Eunice Y.T.Liu, Michael Wilson, Tommy Chung, Thomas Gottlie

Clinical Lymphoma Myeloma and Leukemia

Identifying Transcription Factors that Dictate Drug-Resistance in Acute Lymphoblastic Leukemia
Ninad Walavalkar, Nancy Lee, Michael Guertin

Oral Oncology

Considerations for antibiotic prophylaxis in head and neck cancer surgery
Michael P. Veve, Susan L. Davis, Amy M. Williams, John E. McKinnon Tamer, A. Ghanem