Volume 1, Issue 4
This is the first time that Gastroenterology has had both an editor-in-chief (Rick Peek) and deputy editor-in-chief (Doug Corely). The AGA and editors are very excited about this collaboration and the enhancements it will bring to the Journal.
The ASGE’s new open access, online-only journal VideoGIE provides a space for a wide range of video-based case reports. In addition to publishing novel video articles, VideoGIE aims to create an educational endoscopic library that will guide endoscopists throughout the world in the study, diagnosis, and treatment of digestive diseases. This extensive library of videos will be a rich resource for all involved in the practice of endoscopy including endoscopists in training, general endoscopists, advanced endoscopists, endoscopy staff and industry, and patients. Read the latest issue and articles in press or submit your video article online.
In three articles, GIE: Gastrointestinal Endoscopy presents the best articles published across all GI journals in 2015 and 2016. Fouad Otaki and Prasad G. Iyer discuss “Best of foregut: esophagus, stomach, and duodenum,” Douglas G. Adler covers “Best of pancreaticobiliary endoscopy,” and Amit Rastogi and Sachin Wani present “Best of colonoscopy.” These articles are a comprehensive look at the top papers published in each area over the past two years. See all three in the January 2017 issue of GIE and online early in GIE’s Articles in Press:
Many patients with Crohn’s disease require a major abdominal resection at some point during their disease course; however, recurrence after surgery is common. Therefore, strategies to prevent or delay post-operative recurrence are clinically important. In the December issue of The Lancet Gastroenterology & Hepatology, Craig Mowat and colleagues present the results of the TOPPIC trial, the largest randomised trial to date of thiopurines for the prevention of post-operative recurrence of Crohn’s disease.
Measuring liver function tests is a routine part of the post-operative pathway for most patients undergoing hepatic resection, but what are we looking for? Traditional methods of identifying post-operative liver failure have been associated with the INR and bilirubin at 5 days. The significance of changes in transaminases have remained elusive with conflicting reports of its significance and etiology. In the November Issue of HPB, Olthof and colleagues produce a very detailed analysis of the significance of the rise in post-operative transaminases. The dataset consists of over 500 patients undergoing liver resection.
In vitro studies have shown that sofosbuvir has an effect on hepatitis E virus infections. Now for the first time a case is reported in the Journal of Hepatology where sofosbuvir is effective in a patient. Marc van der Valk and his colleagues first tried to suppress the virus with ribavirin. Due to hematologic toxicity, the ribavirin dose needed to be reduced and sofosbuvir was added. This proved very succesful. Though the effect didn’t last after the sofosbuvir regimes was stopped it does raise the question whether higher dosage, might have a more lasting effect.
Gut hormones are important in coordinated actions of intestine and they exert actions through G-protein–coupled receptors. We show that Gαq/11-mediated signaling plays a pivotal role in the maturation and positioning of Paneth cells and in the maintenance of intestinal homeostasis.
Chronic abdominal pain is a frequent symptom of chronic pancreatitis (CP). International guidelines have identified the lack of a standardized assessment of pain in CP. John Windsor and his group investigated the various method of pain assessment in this systematic review. Both CP specific and generic pain assessment tools were found. This study, published in Pancreatology, highlights clearly that a unified approach is lacking and helps in identifying the more successful tools in use today.
Treating patients with anti-tumour necrosis factor α (anti-TNFα) increases the risk of tuberculosis. Testing patients is therefore important. This study by Cândida Abreu and colleagues investigated the relative merit of the Tuberculin Skin test (TST) and Quantiferon-TB Gold in Tube (QFT-GIT). A cohort of 250 patients with IBD was followed. The authors report in Digestive and Liver Disease that TST has a signifcantly higher sensitivity and should therefore be considered the test of choice.
Though a minimal invasive technique, endoscopy is not without it’s risks. As endoscopy is now used for interventions beside the purely diagnostics techniques complications are on the rise. It is important to be aware of this and be prepared for such eventualities. Best Practice & Research: Clinical Gastroenterology presents a special issue dedicated to the topic. Every major complication is covered from the perspectives of epidemiology, risk factors and preventive measures. Combined these reviews present a must-read collection that will improve the success rates in clinical practice.