Volume 1, Issue 3
The Virtual Microscope is a browser-based viewer that provides easy access to high-resolution images captured by slide scanners, optical microscopes and other devices. As a reader you can zoom into the details of the slide to really see the evidence up close. As an author it’s a great way to enrich and extend your article. Pancreatology is the first among gastroenterology journals to adopt this tool. Two example articles are available to show you how it works. The journal invites all authors to consider submitting relevant high resolution slides with their submission.
Histopathologic examination is critical for diagnosing autoimmune pancreatitis, but specimens obtained with EUS-guided FNA are not recommended because of inadequate sample size volume. Atsushi Kanno and colleagues evaluated 78 patients at 12 institutions, testing EUS-FNA efficacy when using a 22G needle. Samples were evaluated for tissue sampling conditions, CD38- and IgG4-positive plasma cell counts, storiform fibrosis, and obliterative phlebitis. See what these investigators learned by reading
The development of Spasmolytic Polypeptide/TFF2-Expressing Metaplasia (SPEM) during gastric repair is absent in the aged stomach
This study demonstrates the emergence of spasmolytic polypeptide/TFF2-expressing metaplasia during regeneration of the gastric epithelium. The development of spasmolytic polypeptide/TFF2-expressing metaplasia in response to injury is absent in the aged stomach. In addition, transplantation of gastric organoids promoted gastric regeneration.
The liver surgery community has been searching for an investigative technique that relates liver volume to liver function in a surgically meaningful way for years. Hepatobiliary scintigraphy (HBS) using technetium labeled mebrofenin has emerged as one of the best techniques and has been shown to demonstrate both regional and global liver function in a reproducible way. The Amsterdam group, led by Thomas van Gulik, has pioneered this technology and in this issue of HPB, Cieslak and colleagues show how HBS has impacted on their liver surgery practice.
Pancreatic cancer is a leading cause of cancer mortality worldwide, with more than 330,000 new cases and approximately the same number of deaths annually. Mortality from pancreatic cancer has not decreased as it has for other cancers in recent years. A notable exception is a decrease in mortality in men 25–49 years old, which could indicate a reversal in the current increasing global trends.
"Global Trends in Pancreatic Cancer Mortality From 1980 Through 2013 and Predictions for
2017" by Aimee L. Lucas et al.
Elderly patients form a heterogeneous population with specific characteristics. Standards of care cannot be simply transposed from young to elderly patients. Screening regimes tend to be different and efficacy of some treatments is not always established. Factors like multimorbidity, increased risk of malnutrition, and decreased life expectancy complicate the management of the disease. Digestive and Liver Disease brings together two review articles that look at these issues in the context of GI cancer care in the elderly.
“Cancer and inflammatory bowel disease in the elderly” by Sasha Taleban et al.
“Colorectal cancer care in elderly patients: Unsolved issues” by Thomas Aparicio et al.
The development of direct acting antivirals to cure hepatitis C is a tremendous success story. Especially when you keep in mind that the virus was only first identified in 1989. With the availability of a cure the question arises whether further research on the topic will be needed; some groups have shifted their research focus. Xavier Forns and Thomas Berg, guest editors for this Journal of Hepatology supplement, make a convincing case that many important questions do remain. Together with a group of authoritative voices they provide the reader with profound insights into the most important fields of HCV research today.
The combination of chemotherapy with radiotherapy is of great importance in gastrointestinal oncology. Nearly all cancers are treated in this way. This was a reason for Best Practice & Research: Clinical Gastroenterology to ask Thomas Brunner and Thomas Seufferlein to guest edit a special issue on the topic. The resulting issue looks at the various chemotherapeutic agents and their characteristics. The different sections of the digestive tract all have a dedicated chapter in the issue. The single exception is the increased use of stereotactic body radiation therapy to treat liver cancers. This growing success warranted a chapter of its own in this essential resource.
Finding a place to publish your case reports is becoming more difficult, but we have the solution. The ASGE has a new open-access online-only journal, VideoGIE! We will publish original, peer-reviewed video case reports and case series of endoscopic procedures used in the study, diagnosis, and treatment of digestive diseases. Submit your video-based case report or case series to GIE’s new sister journal, VideoGIE.See the first issue online now. Add a video to your case report and submit your article today.