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First fruits of the Gene Wiki project in the journal Gene

Gene Wiki review series marries Wikipedia’s crowdsourcing with traditional peer review

The ongoing transition from printed works to internet accessible free media is a revolution we are living through. Both sides of the publishing enterprise – the publishers on the one hand, and the consumers of scientific information on the other – are doing their best to find reliable sources as we are flooded with information.

The peer-review process that has served the scientific publishing system is not keeping up with the pace of growth of publicly accessible information on the Internet. Meanwhile, while many people doubt and complain about the quality and reliability of Wikipedia-type sources, their use grows day by day as Wikipedia emerges as the first option in internet search results.

Since 2007, the Gene Wiki Initiative has been working to improve the availability and quality of scientific information in Wikipedia by creating Wikipedia articles for every human gene of interest.

Dr. Andrew Su, the principal investigator behind the Gene Wiki initiative in Wikipedia, explained:

Like many other bioinformatics labs and companies, we were integrating data from a large number of biomedical databases as part of our data analysis pipelines for genomics. We realized this integrated view of gene annotation could be interesting to the Wikipedia community, so we had a master’s student simply reformat our database and create several thousand gene-specific articles as part of his thesis project. Initially this was a one-and-done project, but the enthusiastic community participation made us realize that the Gene Wiki was a valuable and unique resource for scientists, students, and the general public.

The Gene Wiki meets Gene

Three years ago, Dr. Benjamin Good, the project lead for the Gene Wiki Initiative, suggested partnering with journals to entice scientists to give a hand in improving the Gene Wiki articles. “We knew something similar had worked for RNA Biology back in 2008, but it was hard to find a journal that was willing to partner with us,” he said. “We approached a number of journals, finally finding in Gene a willing and capable partner.”

After extensive discussions, Dr. Su became a co-executive editor for Gene, allowing him to help with the implementation. He and Dr. Good invited leading experts on popular genes to write review articles – on the condition that they would also write and update the respective Wikipedia page on the same gene. In 2013, they published an editorial highlighting the first articles to come out of this effort.

All articles from the Gene Wiki Review series are published in various issues of Gene and collated in a Virtual Special Issue. As with other NIH funded projects, the Gene Wiki Initiative also requires that Gene Wiki Review articles be deposited into PubMed Central — the National Institutes of Health’s free, full-text archive.

Experts on notable genes are invited to contribute to the Gene Wiki Review series under a dual publication model, in which authors commit to both writing an article for the journal <em>Gene</em> and significantly improving the corresponding Wikipedia article. This design creates two versions that have distinct functions — one article of record that can be cited and treated as an authoritative snapshot of the field, and one "living article" on the web that will continue to evolve as new biological insights are revealed. (Illustration by Anne Ruimy and Ginger Tsueng)

Dr. Ginger Tsueng joined the efforts in 2014, working with Gene’s staff to streamline the process. “Andrew was the primary editor for the series, and was becoming overwhelmed,” Dr Tsueng recalled. ”For the project to grow, we needed more help. Fortunately, after inviting and working with so many authors, we were able to find some who would make a positive difference. Both Erica and Israel were extremely enthusiastic about contributing to this series and had a lot of great suggestions.”

Dr. Israel Hanukoglu, professor of biochemistry and molecular biology at Ariel University in Israel and editor for this series, said:

When we were invited to write a review for Gene, we gladly accepted the condition for writing a separate page for Wikipedia, as this would force us to update resource pages for the use of the general Internet community. During the review process, I saw that the team of Dr. Tsueng and Dr. Su are friendly and dedicated to the cause of improving Wikipedia pages with the meticulousness of scientists and the volunteering spirit of Wikipedians and happily joined them.

Dr. Erica Golemis, professor at the Fox Chase Cancer Center in Philadelphia and the first author to join as an editor for this series, said there is strong justification for this project:

People have varying — often strong — opinions about whether it is a good or bad thing that students often turn first to Wikipedia when investigating new topics. However, speaking pragmatically, it is a primary information source for a large community. Hence, making Wikipedia entries accurately reflect the history of discovery and the best currently available science for genes of interest will provide an essential gateway to the peer-reviewed literature. With the genomics era in full flower, a growing number of genes are being identified as likely cancer drivers, or risk factors for diseases with hereditary components. For many of these genes, relatively little has been published, or publications have never been systematically collected in one place. Wikipedia and these accompanying Gene articles could provide a vital service in covering these genes..

The first fruits

Now, in a new editorial in Gene, the editorial team of the Gene Wiki project summarizes the progress of this pioneering project. After more than 40 reviews in Gene and 50 peer-reviewed Wikipedia pages, the project is declared a success.

But these are just the first fruits, and there are thousands of genes waiting their turn.

One of the goals of the Gene Wiki Review series is to enhance the participation of scientists in editing and updating Wikipedia, even after publication of their Gene review. To examine the impact of the Gene Wiki Review series, the editors of the Review series surveyed the authors about their attitudes towards future involvement in Wikipedia editing. They found an increase in positive attitude and involvement of authors in acting as Wikipedia editors, as they are finding the process less difficult than expected. Articles updated as part of the Gene Wiki review series were edited eight times more, on average, resulting in longer, more comprehensive entries in Wikipedia for the concerned genes.

“Many of our authors are editing Wikipedia articles for the first time and aren’t familiar with the formatting and citation standards used in Wikipedia,” Dr. Tsueng acknowledged. “Thanks to the contributions of Wikipedians like Boghog and others, our authors can focus first on getting their expert knowledge onto Wikipedia. Like many of the scientific articles in Wikipedia, Gene Wiki articles just would not be the same without the Wikipedians who have helped to improve the articles our authors contributed.”

The <a href="https://en.wikipedia.org/wiki/Portal:Gene_Wiki">Gene Wiki portal</a> contains detailed instructions for editing a Gene Wiki article in Wikipedia.

D. Hanukoglu said he hopes this leads to more connections between traditional publishing and expert-generated content on Wikipedia: “I hope that the Gene Wiki process will be adopted by other journals and editors to improve the scientific content of Wikipedia, which has become one of the major resources for not just the lay public but for students in academia as well. The link between a high-quality review article in a journal and the Wikipedia page provides two-tiers of interconnected information that satisfies the needs of scientists, students and lay public. Moreover, Ginger's results on author survey indicate that the initial article in Wikipedia enhances the rate of update of the article as well.”

Gene Wiki Review Editors

The Gene Wiki Review series in Gene is edited By Andre J. van Wijnen, Andrew I. Su, Erica Golemis, Ginger Tsueng and Israel Hanukoglu. They also contributed to this report.

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