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Zika Virus Impact, Diagnosis, Control, and Models - 1st Edition - ISBN: 9780128202678

Zika Virus Impact, Diagnosis, Control, and Models

1st Edition

Volume 2: The Neuroscience of Zika

Editors: Colin Martin Caroline Hollins-Martin Victor Preedy Rajkumar Rajendram
Hardcover ISBN: 9780128202678
Imprint: Academic Press
Published Date: 11th June 2021
Page Count: 650
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Zika Virus Impact, Diagnosis, Control, and Models: Volume 2: The Neuroscience of Zika examines diagnosis, vaccines, and potential therapy methods for Zika virus syndrome. This book also details the neuroscience of Guillain-Barré syndrome, its effects, and neuromuscular rehabilitation. This volume is designed to better readers’ understanding of detection, therapies for Zika virus as well as preventative vaccines, diagnosis, and the associated microcephaly. Chapters on models enable further research and understanding. This book has applicability for neuroscientists, neurologists, virologists, and anyone working to better understand the evolution and pathogenesis of Zika virus-related conditions.

Key Features

  • Provides a broad range of topics related to the neuroscience of zika including diagnosis, vaccines, and therapy
  • Contains chapter abstracts, key facts, dictionary of terms, and summary points to aid in understanding
  • Discusses potential novel and non-pharmacological therapies, Guillain-Barré Syndrome, and vaccine development
  • Features chapters on rat, mouse, and guinea pig models of Zika and case reports of zika co-infection with chikungunya, dengue-2 and Guillain-Barré
  • Includes coverage of microcephaly and developmental delays and examines Zika outbreaks in Brazil, Honduras, Uganda, Jamaica, and Mozambique


Neuroscientists, neurologists, virologists, health scientists, public health workers, doctors, pharmacologists and research scientists. Academic libraries that covers the domains of neurology and health sciences. Undergraduates, postgraduate, lecturers and academic professors

Table of Contents

Section 1 – Methods, Biomarkers, and Diagnosis
1. Imaging Zika virus infection
Prof. S.M. Horner, Department of Molecular Genetics & Microbiology, Duke University Medical Center, Durham, NC, USA
2. Use of CRISPR: applications to flaviviruses
Prof. J.E. Carette, Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA
3. Methods of investigating neurotoxicity of larvicides: applications of systems biology
Prof. P. Grandjean, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA
4. Methods for the detection of Zika virus infectivity
Prof. A. Marcello, Molecular Virology Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy

Section 2 – Vector Control, Vaccines, Pharmacology
5. Vector control and Zika virus: a focus on mosquitoes
Prof. R. Barrera, Entomology and Ecology Team, Dengue Branch, Centers for Disease Control and Prevention, San Juan, Puerto Rico
6. Vector control: a focus on rural household containers: applications to Zika virus
Prof. H.J. Overgaard, Faculty of Science and Technology, Norwegian University of Life Sciences, As, Norway
7. Zika virus Vaccines: an overview
Prof. X. Xie, Department of Biochemistry & Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA
8. Novel treatment with 2,8-bis(trifluoromethyl)quinoline analogs in Zika infection in vitro
Prof. M.V.N. de Souza, Instituto de Tecnologia em Farmacos - Far-Manguinhos, Fiocruz - Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil
9. Zika virus use of human neutralizing antibody in microcephaly prevention: a modelling system
Prof. Z. Xu, Parkinson’s Disease Center, Beijing Institute for Brain Disorders, Beijing, China
10. Policies on Zika virus Control
Prof. A.P. Galvani, Center for Infectious Disease Modeling and Analysis, Yale School of Public Health, Yale University, New Haven, CT, USA

Section 3 – Novel and Non-Pharmacologic Therapies
11. Role of the pediatric neurologist in treating Zika virus syndrome
Prof. D.I. Zafeiriou, 1st Department of Pediatrics, Aristotle University, Thessaloniki, Greece
12. 25-Hydroxycholesterol usage in Zika Virus Infection
Prof. B.G. Novitch, Department of Neurobiology and Eli & Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, CA, USA
13. Screening and inhibition of the flavivirus NS2B-NS3 protease: application to zika virus
Prof. H. Li, Wadsworth Center, New York State Department of Health, 120 New Scotland Ave, Albany, NY, USA
14. Gene silencing and applications to zika virus
Prof. M.A. Hashem, Department of Biochemistry and Biotechnology, University of Science and Technology Chittagong (USTC), Bangladesh
15. Screening phytochemicals that react against Zika virus
Prof. W.N. Setzer, Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL, USA

Section 4 – Models and Modelling
16. Guinea pig model of Zika virus: features and applications
Prof. M. Kumar, Department of Tropical Medicine, Medical Microbiology and Pharmacology, Pacific Center for Emerging Infectious Diseases Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA
17. Rat model of Zika virus: features and applications
Prof. P. Despres, Processus Infectieux en Milieu Insulaire Tropical (PIMIT), Universite de La Reunion, Platform CYROI, Sainte-Clotilde, La Reunion, France
18. Mouse model of Zika virus: features and applications
Prof. M.S. Diamond, Department of Medicine, Washington University, School of Medicine, St. Louis, MO, USA
19. Modelling Zika virus in the USA
Prof. S. Merler, Fondazione Bruno Kessler, Trento, Italy
20. Modelling Zika virus infection in laboratory animals: impact on neurological systems
Prof. J.R. Clarke, School of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

Section 5 – Neuroscience of Guillain-Barré Syndrome
21. Severe Guillain-Barré Syndrome
Prof. S. Kesici, Pediatric Intensive Care Unit, Dr. Sami Ulus Education and Research Hospital, Ankara, Turkey
22. Plasmablasts, plasma and neurotoxic antibodies in Guillain-Barré syndrome
Prof. R. Huizinga, Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands
23. Oxidative stress in Guillain-Barré Syndrome and linkage with neurology
Prof. S. Gumusyayla, Faculty of Medicine, Departmant of Neurology, Ankara Yildirim Beyazit University, Ankara, Turkey
24. Neuromuscular effects and rehabilitation in Guillain-Barré syndrome
Prof. T. Harbo, Department of Neurology, Aarhus University Hospital, Aarhus, Denmark
25. Post-infectious demyelinating diseases: Guillain-Barré syndrome and beyond
Prof. T. Foiadelli, Fondazione IRCCS Policlinico "San Matteo", Clinica Pediatrica, V.le Camillo Golgi, Pavia, Italy

Section 6 – Neuroscience of Microcephaly
26. Microcephaly and developmental delays
Prof. S.H. Yoon, Department of Neurosurgery, Ajou University School of Medicine, Suwon, South Korea
27. Congenital microcephaly: features and risk factors
Prof. S.M. Kerr, Slone Epidemiology Center at Boston University, Boston, MA, USA
28. Microcephaly in fetal alcohol syndrome
Prof. G.G. Hicks, Regenerative Medicine Program and the Department of Biochemistry & Medical Genetics, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada
29. Microcephaly in genetic disorders: the case of MFSD2A and hypomyelination
Prof. T. Harel, Department of Genetic and Metabolic Diseases, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
30. Folate metabolism, 5,10-methenyltetrahydrofolate synthetase and microcephaly
Prof. L.H. Rodan, Boston Children’s Hospital, Boston, MA, USA

Section 7 – International Aspects
31. Zika Virus in Honduras
Prof. A. Rosales, World Vision, Department of Health, District of Columbia, WA, USA
32. Zika Virus in Uganda
Prof. B. Arif, Scientist Emeritus, Laboratory for Molecular Virology, Canada
33. Zika Virus in Jamaica
Prof. R. Melbourne-Chambers, Department of Child and Adolescent Health, Faculty of Medical Sciences, The University of theWest Indies, Jamaica
34. Zika virus in Mozambique
Prof. E.S. Gudo, Virus Isolation Laboratory, National Institute of Health, Ministry of Health, Maputo, Mozambique
35. Zika virus in Brazil
Prof. S.S. Sanabani, Department of Pathology, Hospital das Clinicas, School of Medicine University of Sao Paulo, Sao Paulo, Brazil

Section 8 – Case Reports
36. Case reports: Zika and Chikungunya virus infection
Prof. S. Kutsuna, Disease Control and Prevention Center, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan
37. Case reports: Zika virus neuroretinitis
Prof. A. Panday, Department of Medicine, Eric Williams Medical Sciences Complex, Mt. Hope, Trinidad, WI, Trinidad and Tobago
38. Case reports: Zika virus infection in Singapore
Prof. B.Y. Xu, Sengkang Health, SingHealth, Alexandra Hospital, Department of Family Medicine, Singapore, Singapore
39. Case reports: Coinfection with Zika virus and dengue-2 viruses
Prof. N.M. Iovine, Department of Medicine, Division of Infectious Diseases, College of Medicine, FL, USA
40. Case report: Guillain-Barré and Zika virus infection
Prof. P.F. Walker, HealthPartners Center for International Health, MN, USA


No. of pages:
© Academic Press 2021
11th June 2021
Academic Press
Hardcover ISBN:

About the Editors

Colin Martin

Dr. Martin is a Professor of Mental Health at Buckinghamshire New University. He is a Registered Nurse, Chartered Health Psychologist, and a Chartered Scientist. He has published or has in press well over 250 research papers and book chapters. He is a keen book author and editor having written and/or edited several books all of which reflect his diverse academic and clinical interests that examine in-depth, the interface between mental health and physical health. These outputs include the Handbook of Behavior; Food and Nutrition (2011), Perinatal Mental Health: A Clinical Guide (2012); Nanomedicine and the Nervous System (2012), and the major reference works Comprehensive Guide to Autism (2014), Diet and Nutrition in Dementia and Cognitive Decline (2015), Comprehensive Guide to Post-Traumatic Stress Disorder (2016) and Metabolism and Pathophysiology of Bariatric Surgery: Nutrition, Procedures, Outcomes, and Adverse Effects (2017).

Affiliations and Expertise

Professor of Mental Health, Bickinghamshire New University, High Wycombe, Buckinghamshire, UK

Caroline Hollins-Martin

Dr. Hollins-Martin is a Professor of Maternal Health and has a background that has encompassed a career in women’s reproductive health that spans 30 years; the first 11 of these were spent as a clinical midwife in Ayrshire (Scotland) and 19 teaching and researching women’s reproductive health within universities. Caroline is an NMC Registered Midwife and Lecturer/Practice Educator. She is also a graduate and post graduate in psychology and a Member of the British Psychological Society (MBPsS).

Affiliations and Expertise

Edinburgh Napier University, School of Nursing, Midwifery and Social Work, Edinburgh, UK

Victor Preedy

Dr. Preedy is a senior member of King's College London and Director of the Genomics Centre and a member of the Faculty of Life Sciences and Medicine. Professor Preedy has longstanding academic interests in substance misuse especially in relation to health and well-being. In his career Professor Preedy was Reader at the Addictive Behaviour Centre at The University of Roehampton, and also Reader at the School of Pharmacy (now part of University College London; UCL). Professor Preedy is an extremely experienced book editor, having edited influential works including but not limited to The Handbook of Alcohol Related Pathology, The Neuropathology of Drug Addictions and Substance Misuse, The Handbook of Cannabis and Related Pathologies, The Neuroscience of Cocaine, and upcoming titles The Neuroscience of Alcohol, The Neuroscience of Nicotine, and more (all Elsevier).

Affiliations and Expertise

Professor of Nutritional Biochemistry, Department of Nutrition and Dietetics, Professor of Clinical Biochemistry, Department of Clinical Biochemistry; Director of the Genomics Centre, King’s College, London, UK

Rajkumar Rajendram

Dr. Rajendram is a clinician scientist whose focus is on perioperative medicine, anesthesia, and intensive care. He graduated in 2001 with a distinction from Guy’s, King’s, and St. Thomas Medical School in London, and began his postgraduate medical training in general medicine and intensive care in Oxford. Dr. Rajendram returned to Oxford as a consultant in general medicine at the John Radcliffe Hospital, Oxford, before moving to the Royal Free London Hospitals as a consultant in intensive care, anesthesia, and perioperative medicine. He is currently a consultant in internal and perioperative medicine at King Abdulaziz Medical City, Riyadh, Saudi Arabia. As a visiting lecturer in the Division of Diabetes and Nutritional Sciences, King’s College London, he has published over 100 textbook chapters, review articles, peer-reviewed papers, and abstracts.

Affiliations and Expertise

King’s College London, UK

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