Zika Virus Impact, Diagnosis, Control, and Models

Zika Virus Impact, Diagnosis, Control, and Models

Volume 2: The Neuroscience of Zika Virus

1st Edition - June 25, 2021

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  • Editors: Colin Martin, Caroline Hollins-Martin, Victor Preedy, Rajkumar Rajendram
  • eBook ISBN: 9780323903097
  • Hardcover ISBN: 9780128202678

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Zika Virus Impact, Diagnosis, Control, and Models: Volume Two: The Neuroscience of Zika examines diagnosis, vaccines, and potential therapy methods for Zika virus syndrome. The book also details the neuroscience of Guillain-Barré syndrome, its effects and neuromuscular rehabilitation. It is designed to help readers better understand detection, therapies for Zika virus, preventative vaccines, diagnosis and associated microcephaly. Chapters on models enable further research and understanding. This book has applicability for neuroscientists, neurologists, virologists and anyone working to better understand the evolution and pathogenesis of Zika virus-related conditions.

Key Features

  • Provides a broad range of topics related to the neuroscience of Zika, including its diagnosis, vaccines and therapy
  • Contains chapter abstracts, key facts, a dictionary of terms and summary points to aid in understanding
  • Discusses novel and non-pharmacological therapies, Guillain-Barré Syndrome and vaccine development
  • Features chapters on rat, mouse, and guinea pig models of Zika and case reports of Zika co-infection with chikungunya, dengue-2 and Guillain-Barré
  • Includes coverage of microcephaly and developmental delays and examines Zika outbreaks in Brazil, Honduras, Uganda, Jamaica and Mozambique


Neuroscientists, neurologists, virologists, health scientists, public health workers, doctors, pharmacologists and research scientists. Academic libraries that covers the domains of neurology and health sciences. Undergraduates, postgraduate, lecturers and academic professors

Table of Contents

  • Section A: Zika virus: Setting the scene

    1. How Zika virus emerged and spread worldwide
    Joselio Maria Galvao de Araujo, Manuela Sales Lima Nascimento, Paulo Marcos da Matta Guedes, and Jose Verissimo Fernandes

    2. Clinical neurological spectrum of adult and congenital ZIKV infection: An overview of virology, pathogenesis, and management
    Walter Sze Tung Lam, Tay Wei Xuan, Paul Ananth Tambyah, and Derek Tuck Loong Soon

    3. Classification of Zika virus sequences with respect to their species and subspecies
    Joilson Xavier, Stephane Tosta, Talita Adelino, Vagner Fonseca, Marta Giovanetti, and Luiz Carlos Junior Alcantara

    4. Health knowledge about Zika virus: Brazil aspects
    Ana Luiza Vilela Borges and Raquel Zanatta Coutinho

    5. Zika virus infection and replication organelle biogenesis
    Masashi Arakawa and Eiji Morita

    Section B: Microcephaly and congenital syndromes

    6. Microcephaly: Zika and other congenital infections
    Lawrence Frenkel and Fernando Gomez

    7. Zika and impact on the nervous system in children
    Aline Almeida Bentes and Erna Geessien Kroon

    8. Use of induced pluripotent stem cells and cerebral organoids to profile Zika virus infection: Features and findings
    Fernanda Majolo, Daniel Rodrigo Marinowic, Pamella Nunes Azevedo, Guilherme Liberato da Silva, Denise Cantarelli Machado, and Jaderson Costa DaCosta

    9. Zika, miRNAs, and microcephaly genes
    Omar Bagasra and Ewen McLean

    10. Adherens junctions and cell polarity: What they are and how they relate to congenital Zika virus syndrome
    Felipe A. Bustamante-Barrientos, Roberto Henzi, and Luis Federico Batiz

    Section C: Guillain-Barre syndrome

    11. Severe Guillain-Barre syndrome
    Selman Kesici and Benan Bayrakci

    12. Oxidative stress in Guillain-Barre syndrome and linkage with neurology
    Serdar Baraklı, Sadiye Gumusyayla, Gonul Vural, and Orhan Deniz

    13. Neuromuscular effects and rehabilitation in Guillain-Barre syndrome
    Thomas Harbo and Henning Andersen

    14. Postinfectious demyelinating diseases: Guillain-Barre syndrome and beyond
    T. Foiadelli, C. Trabatti, G.L. Marseglia, and S. Savasta

    15. Linking in placental alterations, Zika virus, and Guillain-Barre syndrome
    Kissila Rabelo, Natalia Gedeao Salomao, and Marciano Viana Paes

    Section D: Case studies and short reports

    16. Case study: Neuroimaging of adults and Zika virus
    Diogo Goulart Correa and Luiz Celso Hygino da Cruz

    17. Case study: Magnetic resonance imaging and babies with Zika virus infection
    Diogo Goulart Correa, Heron Werner, and Luiz Celso Hygino da Cruz

    18. A case study of Guillain-Barre syndrome associated with Zika virus infection
    Jose Luis Soto-Hernandez, Karina Carrillo Loza, and Steven Vargas Canas

    19. Clinical manifestations and outcomes of Guillain-Barre syndrome complicating Zika virus infection
    Ayman Alboudi and Andrew Jameson

    20. Auditory brainstem in Zika virus: Insights about brain development in microcephaly
    Dimitri Marques Abramov, Tania Regina Saad Salles, Cecilia Hedin-Pereira, Maria Elizabeth Lopes Moreira, and Vladimir V. Lazarev

    Section E: Methods, biomarkers, and diagnosis

    21. Magnetic resonance imaging use in detecting neurological abnormalities in Zika virus infection
    Diogo Goulart Correa, Heron Werner, Osvaldo J.M. Nascimento, and Luiz Celso Hygino da Cruz Junior

    22. Magnetic modulation biosensing: How it works and how it can be used to detect the Zika virus
    Shira Roth and Amos Danielli

    23. RNA extraction techniques of different body fluids for Zika virus: Blood, genitourinary specimens, saliva, and other relevant fluids
    Shannon E. Ronca, Bonnie E. Gulas-Wroblewski, Rebecca B. Kairis, and Kristy O. Murray

    24. Saliva and urine analysis of Zika virus using loop-mediated isothermal amplification (LAMP)
    Talita Castro

    25. Graphene-based biosensors for the detection of Zika virus
    Ameya Chaudhari and Prajakta Dandekar

    26. The ZIKV Detect IgM Capture ELISA
    Alison Jane Basile and Holly R. Hughes

    27. Quantum dot-based fluoroassays for Zika
    Jessika F.F. Ribeiro, Maria I.A. Pereira, Paulo E. Cabral Filho, Giovannia A.L. Pereira, Beate S. Santos, Goreti Pereira, and Adriana Fontes

    28. Serological detection of specific IgA antibodies against Zika virus nonstructural protein 1 contributes to diagnosis of acute Zika virus infections
    Katja Steinhagen, Viola Borchardt-Loholter, Konstanze Stiba, Julia Maria Klemens, Erik Lattwein, Sandra Saschenbrecker, and Wolfgang Schlumberger

    29. Serological algorithms: How they can be used for differentiating ZIKV from DENV infection
    Day-Yu Chao and Gwong-Jen J. Chang

    Section F: Control, vaccines, and treatments

    30. Aedes aegypti and the use of natural molecules for its control: Implications in the decrease of Zika disease
    Stelia Mendez-Sanchez, Duverney Chaverra-Rodriguez, and Jonny Duque

    31. Strategies of Zika virus control with larvicides and their toxic potential: A focus on pyriproxyfen
    Patricia e Silva Alves, Maria das Dores Alves de Oliveira, Teresinha De Jesus Aguiar Dos Santos Andrade, Nerilson Marques Lima, and Joaquim Soares da Costa Junior

    32. Larvicides: Plant oils and Zika control
    Taruna Kaura, Naveed Pervaiz, and Abhishek Mewara

    33. Pyridobenzothiazolones as anti-flavivirus agents: Impact on Zika virus
    Maria Sole Burali and Giuseppe Manfroni

    34. The development of human monoclonal antibodies against Zika virus
    Cui Li and Zhiheng Xu

    35. The Zika virus NS1 protein as a vaccine target
    Mark J. Bailey and Gene S. Tan

    36. Zika vaccines must prevent sexual transmission
    Omar Bagasra and Ewen McLean

    37. Nucleoside analogue inhibitors for Zika virus infection
    Jean A. Bernatchez, Michael Coste, Byron W. Purse, and Jair L. Siqueira-Neto

    38. Medicinal plants as promising source of natural antiviral substances against Zika virus
    Juliano G. Haddad, Gilles Gadea, Philippe Despres, and Chaker El Kalamouni

    39. Protein kinase C as a target in the control of viruses and implication for Zika virus
    A.B. Blazquez and J.C. Saiz

    40. Nanotechnology applied in the control and diagnosis of Zika virus and its vectors
    Gabriel Augusto Pires de Souza, Livia Sacchetto, Betania Paiva Drumond, Jonatas Santos Abrahao, Tulio Cesar Rodrigues Leite, Breno de Mello Silva, Anna Carolina Toledo da Cunha Pereira, Gustavo Portela Ferreira, Luiz Cosme Cotta Malaquias, and Luiz Felipe Leomil Coelho

    Section G: Models and modeling

    41. Neonatal microcephaly and humanized mouse models for Zika viral pathogenesis and immunity
    Kimberly Schmitt, Tawfik Aboellail, and Ramesh Akkina

    42. Use of liver cells to discover novel peptides for anti-Zika strategies
    Ahmad Suhail Khazali and Rohana Yusof

    43. In vivo mouse models to investigate the microcephaly associated with Zika virus
    Raissa R. Christoff and Patricia P. Garcez

    44. Zika virus infection with primates: Fetal outcomes
    Sunam Gurung, Rachel Jordan, James Papin, and Dean Myers







Product details

  • No. of pages: 554
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: June 25, 2021
  • Imprint: Academic Press
  • eBook ISBN: 9780323903097
  • Hardcover ISBN: 9780128202678

About the Editors

Colin Martin

Dr. Martin is a Professor of Mental Health at Buckinghamshire New University. He is a Registered Nurse, Chartered Health Psychologist, and a Chartered Scientist. He has published or has in press well over 250 research papers and book chapters. He is a keen book author and editor having written and/or edited several books all of which reflect his diverse academic and clinical interests that examine in-depth, the interface between mental health and physical health. These outputs include the Handbook of Behavior; Food and Nutrition (2011), Perinatal Mental Health: A Clinical Guide (2012); Nanomedicine and the Nervous System (2012), and the major reference works Comprehensive Guide to Autism (2014), Diet and Nutrition in Dementia and Cognitive Decline (2015), Comprehensive Guide to Post-Traumatic Stress Disorder (2016) and Metabolism and Pathophysiology of Bariatric Surgery: Nutrition, Procedures, Outcomes, and Adverse Effects (2017).

Affiliations and Expertise

Professor of Mental Health, Bickinghamshire New University, High Wycombe, Buckinghamshire, UK

Caroline Hollins-Martin

Dr. Hollins-Martin is a Professor of Maternal Health and has a background that has encompassed a career in women’s reproductive health that spans 30 years; the first 11 of these were spent as a clinical midwife in Ayrshire (Scotland) and 19 teaching and researching women’s reproductive health within universities. Caroline is an NMC Registered Midwife and Lecturer/Practice Educator. She is also a graduate and post graduate in psychology and a Member of the British Psychological Society (MBPsS).

Affiliations and Expertise

Edinburgh Napier University, School of Nursing, Midwifery and Social Work, Edinburgh, UK

Victor Preedy

Dr. Preedy is a senior member of King's College London and Director of the Genomics Centre and a member of the Faculty of Life Sciences and Medicine. Professor Preedy has longstanding academic interests in substance misuse especially in relation to health and well-being. In his career Professor Preedy was Reader at the Addictive Behaviour Centre at The University of Roehampton, and also Reader at the School of Pharmacy (now part of University College London; UCL). Professor Preedy is an extremely experienced book editor, having edited influential works including but not limited to The Handbook of Alcohol Related Pathology, The Neuropathology of Drug Addictions and Substance Misuse, The Handbook of Cannabis and Related Pathologies, The Neuroscience of Cocaine, and upcoming titles The Neuroscience of Alcohol, The Neuroscience of Nicotine, and more (all Elsevier).

Affiliations and Expertise

Professor of Nutritional Biochemistry, Department of Nutrition and Dietetics, Professor of Clinical Biochemistry, Department of Clinical Biochemistry; Director of the Genomics Centre, King’s College, London, UK

Rajkumar Rajendram

Dr. Rajendram is a clinician scientist whose focus is on perioperative medicine, anesthesia, and intensive care. He graduated in 2001 with a distinction from Guy’s, King’s, and St. Thomas Medical School in London, and began his postgraduate medical training in general medicine and intensive care in Oxford. Dr. Rajendram returned to Oxford as a consultant in general medicine at the John Radcliffe Hospital, Oxford, before moving to the Royal Free London Hospitals as a consultant in intensive care, anesthesia, and perioperative medicine. He is currently a consultant in internal and perioperative medicine at King Abdulaziz Medical City, Riyadh, Saudi Arabia. As a visiting lecturer in the Division of Diabetes and Nutritional Sciences, King’s College London, he has published over 100 textbook chapters, review articles, peer-reviewed papers, and abstracts.

Affiliations and Expertise

Visiting Lecturer, Division of Diabetes and Nutritional Sciences, King’s College London, UK

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