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Zika Virus Biology, Transmission, and Pathways - 1st Edition - ISBN: 9780128202685, 9780323903080

Zika Virus Biology, Transmission, and Pathways

1st Edition

Volume 1: The Neuroscience of Zika Virus

Editors: Colin Martin Caroline Hollins-Martin Victor Preedy Rajkumar Rajendram
Hardcover ISBN: 9780128202685
eBook ISBN: 9780323903080
Imprint: Academic Press
Published Date: 25th June 2021
Page Count: 576
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Zika Virus Biology, Transmission, and Pathways: The Neuroscience of Zika, Volume One provides a detailed introduction to the molecular biology of the Zika virus and its features, transmission, and impact on neurological systems. Designed to better readers’ understanding of the Zika virus, this volume features chapters on the immune response, molecular mechanisms, and other areas to better understand underlying pathways. This book has applicability for neuroscientists, neurologists, virologists and anyone working to better understand the evolution and pathogenesis of Zika virus-related conditions.

Key Features

  • Presents the most comprehensive coverage of a broad range of topics related to the neuroscience of Zika, including transmission and virus biology
  • Contains an abstract, key facts, a mini dictionary of terms, and summary points to aid in understanding in each chapter
  • Features chapters on Zika vectors and fetal imaging
  • Includes coverage of microcephaly and developmental delays and examines Zika outbreaks in Brazil, Puerto Rico and India
  • Discusses unique topics in Zika biology, associated neuro-inflammation, and impacts on neurological systems


Neuroscientists, neurologists, virologists, health scientists, public health workers, doctors, pharmacologists and research scientists. Academic libraries that covers the domains of neurology and health sciences. Undergraduates, postgraduate, lecturers and academic professors

Table of Contents

Section A – Zika Virus: Introductory chapters
1. Flaviviruses and where the Zika virus fits in: An overview
Adrián Diaz
2. The innate immune response during Zika virus infection
Manuela Sales Lima Nascimento, Wilo Victor dos Santos, Amanda Costa Ayres Salmeron, Josélio Maria Galvão de Araújo, José Veríssimo Fernandes, and Paulo Marcos Matta Guedes
3. The public health perspective of Zika virus infection
Saurabh RamBihariLal Shrivastava and Prateek Saurabh Shrivastava
4. Inequality in Zika virus and congenital Zika syndrome
Finn Diderichsen and Lia Giraldo da Silva Augusto
5. Lifestyle factors and congenital Zika syndrome: Drugs, alcohol, and beyond
Daniela Pires Ferreira Vivacqua and Cristina Barroso Hofer
6. Economic impact of Zika virus infection and associated conditions
Henry Maia Peixoto, Luciana Guerra Gallo, Gilmara Lima Nascimento, and Maria Regina Fernandes de Oliveira
7. Health promotion, health education, and risk communication for Zika virus disease
Ernesto R. Gregorio Jr and Jun Kobayashi
8. Molecular mechanisms of Zika virus-induced neurological pathology
Trisha R. Barnard, Quinn H. Abram, and Selena M. Sagan
9. Validation of Zika virus infections: Nonmolecular aspects, immunoassays, and beyond
Anne J. Jääskeläinen
10. Validation of Zika virus infections: A focus on molecular methods
Anne J. Jääskeläinen
11. Coinfection of Zika with Dengue and Chikungunya virus
Marlen Yelitza Carrillo-Hernández, Julian Ruiz-Saenz, and Marlen Martínez-Gutiérrez
12. Zika virus, pathology, and control: Zika vaccine strategies in development
Gilles Gadea, Wildriss Viranaicken, and Philippe Desprès

Section B – Effects on neurological and body systems
13. The adult brain and neurologic manifestations of the Zika virus
Fernanda J.P. Marques and Osvaldo J.M. Nascimento
14. Postmortem studies: Contribution to understand the pathogenesis of congenital Zika syndrome
Leila Chimelli
15. Developmental trajectories in infants and toddlers born with congenital Zika syndrome
Fernanda J.P. Marques, Osvaldo J.M. Nascimento, and Marcio Leyser
16. Host genetic susceptibility to ZIKV congenital syndrome: A tale of twins
Luiz Carlos de Caires Junior, Ernesto Goulart, and Mayana Zatz
17. Zika virus infection disrupts development of both neurons and glial cells
Dan Xu and Zhiheng Xu
18. Neurological manifestations similar to multiple sclerosis in adults after Zika virus infection
Soniza Vieira Alves-Leon, Fabrı´cia Lima Fontes-Dantas, and Fernanda Cristina Rueda-Lopes
19. Zika virus and the blood-brain barrier
Rishya Manikam, Soe Hui Jen, Amni Adilah Ismail, Chandramathi Samudi Raju, and Shamala Devi Sekaran
20. Systems immunology of flavivirus infection
Viviane Schuch, Felipe Martins, Felipe Ten Caten, Mariana Araujo-Pereira, Marielton Dos Passos Cunha, Nadia El Khawanky, Otavio Cabral-Marques, and Helder I. Nakaya
21. Genetic susceptibility to congenital Zika syndrome: Current research and future perspectives
Átila Duque Rossi and Cynthia Chester Cardoso
22. Hearing and Zika virus infection
Maria Helena de M. Barbosa, Maria Clara de Magalhães-Barbosa, and Arnaldo Prata-Barbosa
23. Neuromyelitis optica spectrum disorder: What it is and how it relates to Zika virus
Maíra Cardoso Aspahan and Paulo Pereira Christo
24. Zika virus infection and cytokines
Simone G. Fonseca, Irmtraut Araci H. Pfrimer, Carla Judice, Fabio T.M. Costa, and Helder I. Nakaya
25. Urological sequels in the scope of the Congenital Zika Syndrome
Lucia Maria Costa Monteiro
26. Zika virus and impact on male fertility
Jocelyne Piret and Guy Boivin
27. Testicular cell types and infection by Zika virus
Luwanika Mlera and Marshall E. Bloom
28. Proteome alterations promoted by Zika virus infection
Juliana Miranda Tatara, Lucélia Santi, and Walter Orlando Beys-da-Silva
29. SOMAscan proteomics of Zika-infected cells
Kevin M. Coombs
30. Zika virus as an oncolytic therapy against brain tumors
Carolini Kaid, Matt Sherwood, Thiago Mitsugi, and Mayana Zatz

Section C – International aspects
31. Zika virus in Brazil
Andrezza Nascimento, Alberto José da Silva Duarte, and Sabri Saeed Sanabani
32. Zika virus and the Middle East
Eyal Meltzer
33. Genetic diversity of Zika virus in Thailand: How does this compare with other countries
Atchara Phumee and Padet Siriyasatien
34. Zika virus in Vietnam: Biology, transmission, pathology, associated conditions, and controls
Nguyen Thai Son, Ho Huu Tho, and Dinh-Toi Chu
35. Zika virus in Vietnam: Epidemic, distribution, strain origin, and potential risks for community health
Dinh-Toi Chu, Tiep Tien Nguyen, and Nguyen Thai Son
36. Zika virus infection in Mexico: Epidemiological and clinical data
Alfonso Vallejos Parás, Concepción Grajales Muñiz, Teresita Rojas Mendoza, Lumumba Arriaga Nieto, and David Alejandro Cabrera Gaytán

Section D – Features of the virus and transmission
37. Cytopathicity and pathogenesis of Zika virus strains
Sergio P. Alpuche-Lazcano and Anne Gatignol
38. Molecular evolution and codon usage bias of Zika virus
Marianoel Pereira-Gómez and Juan Cristina
39. Endosomal compartmentation and the transport route of Zika virus
Katarzyna Owczarek and Krzysztof Pyrć
40. Location of virus antigens in murine tissues infected with Zika virus
António Pedro Alves de Matos, Libia Zé-Zé, Fátima Amaro, and Maria João Alves
41. The role of seminal Zika viral shedding: Tropism, duration, and magnitude
Erin M. McDonald and Aaron C. Brault
42. Nonhuman occurrence of Zika virus infection: compare with other countries
Cécile Beck, Rodolphe Hamel, Marine Dumarest, Gaelle Gonzalez, and Sylvie Lecollinet
43. Zika virus intrusion into the blood supply: Concerns about transfusion safety
Bruno Deltreggia Benites and Marcelo Addas-Carvalho

Section E – Resources
44. Research and recommended resources on Zika virus, pathology, and control
Rajkumar Rajendram, Victor R. Preedy, and Vinood B. Patel


No. of pages:
© Academic Press 2021
25th June 2021
Academic Press
Hardcover ISBN:
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About the Editors

Colin Martin

Dr. Martin is a Professor of Mental Health at Buckinghamshire New University. He is a Registered Nurse, Chartered Health Psychologist, and a Chartered Scientist. He has published or has in press well over 250 research papers and book chapters. He is a keen book author and editor having written and/or edited several books all of which reflect his diverse academic and clinical interests that examine in-depth, the interface between mental health and physical health. These outputs include the Handbook of Behavior; Food and Nutrition (2011), Perinatal Mental Health: A Clinical Guide (2012); Nanomedicine and the Nervous System (2012), and the major reference works Comprehensive Guide to Autism (2014), Diet and Nutrition in Dementia and Cognitive Decline (2015), Comprehensive Guide to Post-Traumatic Stress Disorder (2016) and Metabolism and Pathophysiology of Bariatric Surgery: Nutrition, Procedures, Outcomes, and Adverse Effects (2017).

Affiliations and Expertise

Professor of Mental Health, Bickinghamshire New University, High Wycombe, Buckinghamshire, UK

Caroline Hollins-Martin

Dr. Hollins-Martin is a Professor of Maternal Health and has a background that has encompassed a career in women’s reproductive health that spans 30 years; the first 11 of these were spent as a clinical midwife in Ayrshire (Scotland) and 19 teaching and researching women’s reproductive health within universities. Caroline is an NMC Registered Midwife and Lecturer/Practice Educator. She is also a graduate and post graduate in psychology and a Member of the British Psychological Society (MBPsS).

Affiliations and Expertise

Edinburgh Napier University, School of Nursing, Midwifery and Social Work, Edinburgh, UK

Victor Preedy

Dr. Preedy is a senior member of King's College London and Director of the Genomics Centre and a member of the Faculty of Life Sciences and Medicine. Professor Preedy has longstanding academic interests in substance misuse especially in relation to health and well-being. In his career Professor Preedy was Reader at the Addictive Behaviour Centre at The University of Roehampton, and also Reader at the School of Pharmacy (now part of University College London; UCL). Professor Preedy is an extremely experienced book editor, having edited influential works including but not limited to The Handbook of Alcohol Related Pathology, The Neuropathology of Drug Addictions and Substance Misuse, The Handbook of Cannabis and Related Pathologies, The Neuroscience of Cocaine, and upcoming titles The Neuroscience of Alcohol, The Neuroscience of Nicotine, and more (all Elsevier).

Affiliations and Expertise

Professor of Nutritional Biochemistry, Department of Nutrition and Dietetics, Professor of Clinical Biochemistry, Department of Clinical Biochemistry; Director of the Genomics Centre, King’s College, London, UK

Rajkumar Rajendram

Dr. Rajendram is a clinician scientist whose focus is on perioperative medicine, anesthesia, and intensive care. He graduated in 2001 with a distinction from Guy’s, King’s, and St. Thomas Medical School in London, and began his postgraduate medical training in general medicine and intensive care in Oxford. Dr. Rajendram returned to Oxford as a consultant in general medicine at the John Radcliffe Hospital, Oxford, before moving to the Royal Free London Hospitals as a consultant in intensive care, anesthesia, and perioperative medicine. He is currently a consultant in internal and perioperative medicine at King Abdulaziz Medical City, Riyadh, Saudi Arabia. As a visiting lecturer in the Division of Diabetes and Nutritional Sciences, King’s College London, he has published over 100 textbook chapters, review articles, peer-reviewed papers, and abstracts.

Affiliations and Expertise

Visiting Lecturer in the Division of Diabetes and Nutritional Sciences, King’s College London, UK

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