Xenobiotics and Inflammation - 1st Edition - ISBN: 9780126289305, 9780323140362

Xenobiotics and Inflammation

1st Edition

Roles of Cytokines and Growth Factors

Authors: Schook Lashkin
eBook ISBN: 9780323140362
Imprint: Academic Press
Published Date: 15th June 1994
Page Count: 361
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The affect of xenobiotics on host resistance in general and specific immune functions has become the focus of much current research. This book synthesises current information on how chemicals (xenobiotics) can affect the immune system to cuse dysfunction, focusing on the process of inflammation. It provides a much needed, single-source reference for researchers investigation the mechanisms responsible for altered host resistance following exposture to xenobiotics. Emphasis is placed on the roles of cytokines and growth factors in the inflammatory process and how such processes are altered and modulated by xenobiotics. This volume contains information pertinent to those exploring cell growth, angiogenesis, hematopoetic differentiation, and recruitment to and proliferation of cells in various tissue sites. This volume brings together experts in inflammation, cytokines, cell growth, immunology and toxicology to provide a highly yseful volume modulated by chemicals. Divided into three sections, the book offers an organ system approach to understanding inflammation and xenobiotics.

Table of Contents

Foreword. Immunotoxicity and Inflammation: An Overview. The Inflammatory Process. Inflammatory Cytokines. Induction of Inflammation: Cytokines and Acute Phase Proteins. Eole of Tumor Necrosis Factor-Alpha in Acute and Chronic Inflammatory Responses: Novel Therapeutic Approaches. Bone Marrow Phagocytes, Inflammatory Medicators and Benzene Toxicity. Nitrosamine-Induced Inflammation: Induction of Cytokines Affecting Macrophage Differentiation and Function. The Effects of Metals on Immune System Development and Function. Xenobiotic-Induced Skin Inflammation. The Pathogenesis of Atherosclerosis: A Cytokine Hypothesis. Ozone-Induced Inflammatory Response in Pulmonary Cells. Pulmonary Fibrosis Induced By Bleomycin and Fibers. Role of Inflammatory Mediators and Cytokines in Endotoxin-Induced Hepatotoxicity. CNS: Viral Infection and Immune-Mediated Inflammation. Subject Index.


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© Academic Press 1994
Academic Press
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