Wnt Signaling in Embryonic Development

Wnt Signaling in Embryonic Development

1st Edition - January 4, 2007

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  • Editor: Sergei Sokol
  • eBook ISBN: 9780080471341
  • Hardcover ISBN: 9780444528742

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A superb compilation of reviews from leading experts in the field of Wnt signaling (signaling molecules that regulate cell-to-cell interactions during embryogenesis), volume 17 in the Advances in Developmental Biology series offers 7 chapters, each devoted to a separate area of research on Wnt signaling. Written by specialists in the field, these chapters cover different levels of signaling, including: ligands, receptors, cytoplasmic and nuclear components of the pathway. This book discusses a number of model systems including mice, Drosophila, Xenopus, zebrafish, C. elegans, and mammalian cells. Together, these chapters review the available knowledge and will fill gaps in our understanding of this interesting network of cell signaling processes.

Key Features

* Includes two parts devoted to the canonical (beta-catenin dependent) and non-canonical branches of Wnt signalling to the cytoskeleton
* Offers insight to large genomic data that are now available for the analysis of Wnt gene targets
* Discusses regulators of the cytoskeleton such as small GTPAses of the Rho family, jun-N-terminal kinases and other MAP kinases, and proteins involved in the generation of cell polarity


Researchers and graduate students in the field of cell biology, developmental biology, biochemistry, and genetics

Table of Contents

  • 1. Wnt/-catenin-mediated transcriptional regulation
    David S. Parker, Timothy Blauwkamp and Ken M. Cadigan

    2. Wnt signalling and the establishment of cell polarity
    Gretchen L. Dollar and Sergei Y. Sokol

    3. Wnts in Angiogenesis
    T. Néstor H. Masckauchán and Jan Kitajewski

    4. Wnt signaling in C. elegans: new insights into the regulation of POP-1/TCF mediated activation and repression
    Hendrik C. Korswagen

    5. Cell migration under control of Wnt-signaling in the vertebrate embryo
    Almut Köhler, Alexandra Schambony and Doris Wedlich

    6. The Wnt signaling pathways in mammalian patterning and morphogenesis
    Jianbo Wang, Leah Etheridge and Anthony Wynshaw-Boris

    7. Wnt signaling in the neural crest
    Carole LaBonne

Product details

  • No. of pages: 264
  • Language: English
  • Copyright: © Elsevier Science 2007
  • Published: January 4, 2007
  • Imprint: Elsevier Science
  • eBook ISBN: 9780080471341
  • Hardcover ISBN: 9780444528742

About the Editor

Sergei Sokol

Sergei Sokol is at Department of Molecular, Cell and Developmental Biology, Mount Sinai School of Medicine, New York, USA.

Affiliations and Expertise

Department of Molecular, Cell and Developmental Biology, Mount Sinai School of Medicine, NY, USA

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