Water Extraction of Bioactive Compounds - 1st Edition - ISBN: 9780128093801, 9780128096154

Water Extraction of Bioactive Compounds

1st Edition

From Plants to Drug Development

Editors: Herminia Dominguez Maria Gonzalez Munoz
eBook ISBN: 9780128096154
Paperback ISBN: 9780128093801
Imprint: Elsevier
Published Date: 22nd September 2017
Page Count: 530
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Water Extraction of Bioactive Compounds: From Plants to Drug Development draws together the expert knowledge of researchers from around the world to outline the essential knowledge and techniques required to successfully extract bioactive compounds for further study. The book is a practical tool for medicinal chemists, biochemists, pharmaceutical scientists and academics working in the discovery and development of drugs from natural sources.

The discovery and extraction of bioactive plant compounds from natural sources is of growing interest to drug developers, adding greater fuel to a simultaneous search for efficient, green technologies to support this. Particularly promising are aqueous based methods, as water is a cheap, safe and abundant solvent. The book is a detailed guide to the fundamental concepts and necessary equipment needed to successfully undertake such processes, supported by application examples and highlighting the most influential variables.

Part 1 begins with a thorough introduction to plants as sources of drugs, highlighting strategies for the discovery of novel bioactive constituents of botanicals, the need for standardization and a move toward more rational and greener techniques in the field, the development of plant-based extraction processes and pretreatments for the efficient extraction. Part 2 then reviews a broad range of available techniques, including sections on conventional hot water extraction and pressurized hot water extraction in a range of settings. Intensified processes are then discussed in detail, including sections on microwave-assisted processes, ultrasound-assisted processes and enzyme assisted extraction.

Key Features

  • Covers the theoretical background and range of techniques available to researchers, helping them to select the most appropriate extraction method for their needs
  • Presents up-to-date and cutting edge applications by international experts
  • Highlights current use and future potential for industrial scale applications
  • Offers a thorough introduction to plants as sources of drugs, highlighting strategies for the discovery of novel bioactive constituents of botanicals


Medicinal chemists and drug development scientists, as well as research and development industrial specialists, production chemists and engineers, researchers, upper-level undergraduates and graduate students, and university professors working in the chemistry, processing and application of bioactive natural products

Table of Contents

1. Plant as source of drugs. Constituents and biological actions
2. Strategies in drug discovery of novel bioactive constituents of botanicals
3. The need of standardization of botanicals and herbal preparations
4. Towards more rational techniques for the isolation of valuable compounds from plants
5. Searching for green solvents: water
6. Process Development of Plant-Based Extraction Processes
7. Pretreatments for the efficient extraction of bioactive compounds from plants

Conventional hot water extraction
8. Aqueous extracts with medicinal properties

Pressurized hot water extraction
9. Solubility of plant active compounds in superheated water
10. Hydrolysis of biopolymers in near critical and subcritical water
11. Neoformation of antioxidants in glycation model systems treated under subcritical water extraction conditions
12. Reactor configurations for subcritical water extraction
13. Production of amino and organic acids from protein using sub-critical water technology
14. Extraction of functional substances from agricultural products or by products by subcritical water treatment
15. Pressurized hot water extraction of botanicals and medicinal plants
16. Conversion of alpha-zein to an angiotensin I-converting enzyme inhibitor under supercritical water conditions
17. Silymarin Extraction from Silybum marianum L. Gaertner

Intensified processes

Microwave-assisted processes
18. Fundamentals of microwave assisted extraction processes
19. Microwave-assisted extraction of medicinal plants
20. Influence of microwave heating on the stability of plant compounds
21. Effect of dielectric microwave heating on the color and antiradical capacity of betanin
22. Microwave-assisted extraction of flavonoids
23. Solvent free extraction processes using ultrasound and microwave techniques to obtain essential oil, polyphenols and pectin
24. Microwave superheated water of arabinoxylooligosaccharides
25. Microwave-assisted extraction of bioactive compounds from cabbage leaves

US-Assisted Extraction
26. Fundamentals of Ultrasound assisted extraction
27. Molecular properties and antioxidant activities of polysaccharide-protein complexes from selected mushrooms by ultrasound-assisted extraction
28. Degradation during application of ultrasound in food processing: A review
29. Modeling approaches to optimize the ultrasound-assisted extraction of antioxidant compounds from plants
30. Ultrasound-assisted extraction of amino acids from grapes
31. US assisted extraction of polysaccharides

Enzyme assisted extraction
32. Enzyme hydrolytic activities for assisting in cell breakage
33. Commercial enzymes
34. Aqueous enzyme assisted oil extraction and emulsion de-emulsifying methods
35. Enzyme-Assisted Aqueous Extraction of Soybeans
36. Downstream processing of stevioside and its potential applications
37. Enzyme-assisted extraction of flavorings and colorants


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© Elsevier 2018
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About the Editor

Herminia Dominguez

Herminia received her PhD Degree in Chemistry from the University of Santiago de Compostela. She is professor of Chemical Engineering at University of Vigo (Spain), where she has been working on the extraction of bioactive compounds from underutilized and residual sources using green technologies, particularly pressurized solvents and membrane technology.

Professor Dominguez has over 144 publications to her name. With a strong focus on research that enhances industrial processes whilst taking a greener approach, she understands the needs of both academic and commercial chemists well, presenting work that intends to support both.

Affiliations and Expertise

University of Vigo, Spain

Maria Gonzalez Munoz

University of Vigo, Spain

Affiliations and Expertise

University of Vigo, Spain