Water Extraction of Bioactive Compounds

Water Extraction of Bioactive Compounds: From Plants to Drug Development draws together the expert knowledge of researchers from around the world to outline the essential knowledge and techniques required to successfully extract bioactive compounds for further study. The book is a practical tool for medicinal chemists, biochemists, pharmaceutical scientists and academics working in the discovery and development of drugs from natural sources.

The discovery and extraction of bioactive plant compounds from natural sources is of growing interest to drug developers, adding greater fuel to a simultaneous search for efficient, green technologies to support this. Particularly promising are aqueous based methods, as water is a cheap, safe and abundant solvent. Water Extraction of Bioactive Compounds: From Plants to Drug Development is a detailed guide to the fundamental concepts and considerations needed to successfully undertake such processes, supported by application examples and highlighting the most influential variables.

Beginning with an introduction to plants as sources of drugs, the book highlights the need for a move towards both more rational and greener techniques in the field, and presents multiple innovative water-based strategies for the discovery and extraction of bioactive constituents of botanicals. A broad range of available techniques are reviewed, including conventional and pressurized hot water extraction techniques, intensified processes such as microwave-assisted, ultrasound-assisted processes, and enzyme assisted extraction, and processes using combined techniques.

• Covers the theoretical background and range of techniques available to researchers, helping them to select the most appropriate extraction method for their needs
• Presents up-to-date and cutting edge applications by international experts
• Highlights current use and future potential for industrial scale applications
• Offers a thorough introduction to plants as sources of drugs, highlighting strategies for the discovery of novel bioactive constituents of botanicals

Medicinal chemists and drug development scientists, as well as research and development industrial specialists, production chemists and engineers, researchers, upper-level undergraduates and graduate students, and university professors working in the chemistry, processing and application of bioactive natural products

1. Introduction
2. Production of amino and organic acids from protein using sub-critical water technology
3. Hydrolysis of biopolymers in near critical and subcritical water
4. Subcritical water extraction and neoformation of antioxidants
5. Depolymerization and extraction of oligosaccharides from agroindustrial wastes
6. Microwave-assisted Water Extraction
7. Microwave superheated water of arabinoxylooligosaccharides
8. Microwave-assisted extraction of flavonoids
9. Microwave-assisted extraction of betalains
10. Microwave-assisted hydrothermal degradation of silk protein to amino acids
11. Fundamentals of Ultrasound assisted extraction
12. Ultrasound-assisted extraction of bioactive carbohydrates
13. Enzyme assisted aqueous extraction processes
14. Enzyme aided extraction of phenolic compopunds
15. Silymarin Extraction from Silybum marianum L. Gaertner
16. Potential of novel technologies for the aqueous extraction of plant bioactives
17. Combination of water based extraction technologies