Volume Transmission Revisited describes the mounting evidence that cells of the central nervous system are able to communicate via a host of chemical signals that flow through the extracellular space. Volume transmission (VT) constitutes a novel and complementary communication system to classical synaptic transmission. The new modality, which does not require specific connections between cells, leads to a reconsideration of the spatial relationships of neurons and glia, brings a new dimension to network modelling and is relevant to both short term interactions and long term tonic states of the brain.

The reader will find 29 chapters describing many of the major discoveries in VT during the last decade.
The most striking feature of this publication is the collecting together of many compelling examples of the ubiquitous nature of VT. These point to its increasing relevance from basic neuroscience research to clinical practice. Those working in other areas will find numerous invaluable examples of how leading investigators have gone about assembling evidence for VT.

Table of Contents

List of contributors. Opening Address. Acknowledgements. Section I. Conceptual basis of VT. 1. Volume transmission as a key feature of information handling in the central nervous system. Possible new interpretative value of the Turing's B-type machine (L.F. Agnati, K. Fuxe). 2. Integration of wiring transmission and volume transmission (F.E. Bloom). 3. Ultrastructural evidence for diffuse transmission by monoamine and acetylcholine neurons of the central nervous system (L. Descarries, N. Mechawar). 4. Comparative aspects of volume transmission, with sidelight on other forms of intercellular communication (R. Nieuwenhuys). Section II. Diffusion and extracellular space. 5. Diffusion of molecules in brain extracellular space: theory and experiment (C. Nicholson, K.C. Chen, S. Hrabetová, L. Tao). 6. Extracellular space diffusion and pathological states (E. Syková, T. Mazel, L. Vargová, I. Voríek, S. Prokopová). 7. Diffusion of radiolabeled dopamine, its metabolites and mannitol in the rat striatum studied by dual-probe microdialysis (J. Kehr, M. Höistad, K. Fuxe). Section III. Glia-neuronal signaling. 8. Relationship between glia and the perineuronal nets of extracellular matrix in the rat cerebral cortex: importance for volume transmission in the brain (D. Viggiano, M.R. Celio) 9. Glial influence on neuronal signaling (A. Chvátal, E. Syková) 10. Glial modulation of neural excitability mediated by extracellular pH: a hypothesis revisited (B.R. Ransom). 11. The astr


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© 2000
Elsevier Science
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