Volume Transmission Revisited, Volume 125

1st Edition

Editors: L.F. Agnati K. Fuxe C. Nicholson E. Syková
Hardcover ISBN: 9780444503145
eBook ISBN: 9780080929293
Imprint: Elsevier Science
Published Date: 7th November 2000
Page Count: 470

Institutional Access

Table of Contents

List of contributors. Opening Address. Acknowledgements.

Section I. Conceptual basis of VT.
  1. Volume transmission as a key feature of information handling in the central nervous system. Possible new interpretative value of the Turing's B-type machine (L.F. Agnati, K. Fuxe).

  2. Integration of wiring transmission and volume transmission (F.E. Bloom).

  3. Ultrastructural evidence for diffuse transmission by monoamine and acetylcholine neurons of the central nervous system (L. Descarries, N. Mechawar).

  4. Comparative aspects of volume transmission, with sidelight on other forms of intercellular communication (R. Nieuwenhuys).

Section II. Diffusion and extracellular space.
  1. Diffusion of molecules in brain extracellular space: theory and experiment (C. Nicholson, K.C. Chen, S. Hrabetová, L. Tao).

  2. Extracellular space diffusion and pathological states (E. Syková, T. Mazel, L. Vargová, I. Voríek, S. Prokopová).

  1. Diffusion of radiolabeled dopamine, its metabolites and mannitol in the rat striatum studied by dual-probe microdialysis (J. Kehr, M. Höistad, K. Fuxe). Section III. Glia-neuronal signaling.

  2. Relationship between glia and the perineuronal nets of extracellular matrix in the rat cerebral cortex: importance for volume transmission in the brain (D. Viggiano, M.R. Celio)

  3. Glial influence on neuronal signaling (A. Chvátal, E. Syková)

  4. Glial modulation of neural excitability mediated by extracellular pH: a hypothesis revisited (B.R. Ransom).

  5. The astr


Volume Transmission Revisited describes the mounting evidence that cells of the central nervous system are able to communicate via a host of chemical signals that flow through the extracellular space. Volume transmission (VT) constitutes a novel and complementary communication system to classical synaptic transmission. The new modality, which does not require specific connections between cells, leads to a reconsideration of the spatial relationships of neurons and glia, brings a new dimension to network modelling and is relevant to both short term interactions and long term tonic states of the brain.

The reader will find 29 chapters describing many of the major discoveries in VT during the last decade.
The most striking feature of this publication is the collecting together of many compelling examples of the ubiquitous nature of VT. These point to its increasing relevance from basic neuroscience research to clinical practice. Those working in other areas will find numerous invaluable examples of how leading investigators have gone about assembling evidence for VT.


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About the Editors

L.F. Agnati Editor

Affiliations and Expertise

Department of Human Physiology, University of Modena, Via Campi 287, I-41100 Modena, Italy

K. Fuxe Editor

Affiliations and Expertise

Department of Neuroscience, Karolinska Institute, 171 77 Stockholm, Sweden

C. Nicholson Editor

Affiliations and Expertise

Department of Physiology and Neuroscience, New Youk University, School of Medicine, 550 First Avenue, New York, NY 10016, USA

E. Syková Editor

Affiliations and Expertise

Department of Neuroscience, 2nd Medical Faculty, Charles University and Institute of Experimental Medicine, Academy of Sciences of the Czech Republic Videnska 1083, 142 20 Prague 4, Czech Republic