Vitamins and Hormones, Volume 70

1st Edition

Editor-in-Chiefs: Gerald Litwack
Hardcover ISBN: 9780127098708
eBook ISBN: 9780080458045
Imprint: Academic Press
Published Date: 3rd March 2005
Page Count: 451
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Table of Contents

    <li>Former Editors<ul><li>Publisher Summary</li></ul></li> <li>Contributors<ul><li>Publisher Summary</li></ul></li> <li>Preface<ul><li>Publisher Summary</li></ul></li> <li>1: Extrapituitary Effects of the Growth Hormone-Releasing Hormone<ul><li>Abstract</li><li>I Introduction</li><li>II Endocrine Role of GHRH in Carcinogenesis</li><li>III Various Cancers and Normal Tissues That Produce and Respond to GHRH</li><li>IV Direct Effects of GHRH in Carcinogenesis</li><li>V Mechanism of Action for Locally Produced GHRH</li><li>VI Conclusions and Perspectives</li><li>Acknowledgements</li></ul></li> <li>2: IRS-1 and Vascular Complications in Diabetes Mellitus<ul><li>Abstract</li><li>I Introduction</li><li>II Insulin Receptor Superfamily</li><li>III Insulin Receptor Substrates</li><li>IV Signaling Pathways Regulated by IRS-1</li><li>V IRS-1 and Insulin Resistance</li><li>VI The Role of IRS-1 in Atherothrombotic Complications</li><li>VII Summary and Future Perspectives</li><li>Acknowledgements</li><li>Appendix List of Abbreviations</li></ul></li> <li>3: Structural and Functional Properties of CCN Proteins<ul><li>Abstract</li><li>I Discovery of the CCN Gene Family</li><li>II CCN Family Modular Structure</li><li>III CCN Family and Heparin Interactions</li><li>IV CCN Gene Family and Integrins</li><li>V CCN2 Binding to LRP</li><li>VI CCN Gene Family and Intracellular Signaling</li><li>VII The Link Between TGF-&#x3B2; and CCN2</li><li>VIII CCN Gene Family Action in Normal Biological Processes</li><li>IX CCN Protein Action in Pathological Disease Processes</li><li>X Summary</li><li>Acknowledgements</li></ul></li> <li>4: Stanniocalcin: No Longer Just a Fish Tale<ul><li>Abstract</li><li>I General Introduction</li><li>II Early Studies on the Discovery and Function of Stanniocalcin in Fish</li><li>III The Discovery of Mammalian Stanniocalcin</li><li>IV The Sequestering Hypothesis</li><li>V Future Directions</li><li>Acknowledgements</li></u


First published in 1943, VITAMINS AND HORMONES is the longest-running serial published by Academic Press. In the early days of the Serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, VITAMINS AND HORMONES continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

Key Features

  • First published in 1943, Vitamins and Hormones is AP's longest running serial
  • Each volume contains cutting edge reviews by leading contributors


Researchers, professors, and graduate students studying the molecular and cellular biology of vitamins, hormones, and related factors and co-factors


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About the Editor-in-Chiefs

Gerald Litwack Editor-in-Chief

Following a liberal arts education with a major in chemistry and biology at Hobart College, Gerald (Gerry) Litwack earned M.S. and PhD degrees in biochemistry from the University of Wisconsin, Madison where he served as a Lecturer in Enzymology before starting a postdoctoral fellowship from the National Foundation for Infantile Paralysis at the Biochemical Institute of the Sorbonne in Paris. His first academic position was assistant professor of biochemistry at Rutgers University where he started his work on hormone action for six years. During this period, he did a sabbatical at the University of California, Berkeley, where he concentrated on rapid enzyme kinetics. In 1960 he accepted an offer of an associate professorship at the University of Pennsylvania Graduate School of Medicine. In 1964, he was invited to be full professor of biochemistry at The Fels Institute for Cancer Research and Molecular Biology at Temple Medical School, simultaneously with a Career Development Award from the NIH, where he later was named Deputy Director of the Institute and the Laura H. Carnell Professor in biochemistry. Subsequently, he was given the Faculty Research Award. He co-discovered ligandin, later found to be in the family of glutathione S-transferases, enzymes that protect the body from carcinogens. In 1991, he moved to the Jefferson Medical College at Thomas Jefferson University as Professor of Biochemistry, Chair of the Department of Pharmacology and Deputy Director of the Kimmel Cancer Research Institute. Later, he became chair of the combined Department of Biochemistry and Molecular Pharmacology and concurrently held the position of Vice Dean for Research. In 2003, he moved to Los Angeles and from 2004-2006 was a Visiting Scholar at the University of California, Los Angeles, in the Department of Biological Chemistry of the Geffen School of Medicine and, in this period, wrote “Human Biochemistry and Disease” a volume of 1254 pages. In 2007, he moved to Scranton,

Affiliations and Expertise

Toluca Lake, North Hollywood, California, USA