CRYSTAL STRUCTURE OF HUMAN QUINONE REDUCTASE Gas6 GENE IN EARLY DIABETES VITAMIN K-DEPENDENT ?×-CARBOXYLATION VITAMIN K-DEPENDENT CARBOXYLATION DETERMINANTS OF VITAMIN K IN HUMANS VITAMIN K AND BONE CONDITION IN HUMAN ADULTS VITAMIN K DEPENDENT Gas6 ACTION CONGENITAL BLEEDING DISORDERS OF THE VITAMIN K DEPENDENT CLOTTING FACTORS DIAGNOSIS OF OSTEOPOROSIS QUINONE OXIDOREDUCTASES AND VITAMIN K METABOLISM DEEP VEIN THROMBOSIS AND VITAMIN K HEPATOCELLULAR CARCINOMA AND VITAMIN K VITAMIN K AND MITOCHONDRIAL TRANSMEMBRANE POTENTIAL NEW UNDERSTANDING OF THE VITAMIN K CYCLE AND ITS DOWNSTREAM PATHWAYS VKORC1 AND THE VITAMIN K CYCLE STRUCTURE AND FUNCTION OF VITAMIN K EPOXIDE REDUCTASE WARFARIN THERAPY AND VITAMIN K VKORC1 AND HUMAN CLOTTING FACTORS
Vitamin K, one of the group of fat-soluble vitamins (A, D, E and K), has come into prominence lately because its activity as a blood coagulation factor impinges on the widespread occurrence of deep vein thrombosis in the human population especially in the older age group. This volume focuses, not only on the problem of blood coagulation and hypercoagulability, but upon the individual status of vitamin K in the human.
First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists.
Focuses on the problem of blood coagulation and hypercoagulability as well as bone metabolism and vascular biology In the category of basic science, contributions cover: VKOR1, the quinone reductases including structure, function and mechanism, vitamin K-dependent carboxylation, the actions of Gas6, vitamin K2-mediated apoptosis and other topics *In the category of disease-related subjects, contributions cover warfarin therapy, diabetic nephropathy, bone health, including osteoporosis and tumor cell suppression, as well as other topics
Researchers, faculty, and graduate students interested in cutting-edge review concerning the molecular and cellular biology of vitamins, hormones, and related factors and co-factors.
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- © Academic Press 2008
- 3rd March 2008
- Academic Press
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Following a liberal arts education with a major in chemistry and biology at Hobart College, Gerald (Gerry) Litwack earned M.S. and PhD degrees in biochemistry from the University of Wisconsin, Madison where he served as a Lecturer in Enzymology before starting a postdoctoral fellowship from the National Foundation for Infantile Paralysis at the Biochemical Institute of the Sorbonne in Paris. His first academic position was assistant professor of biochemistry at Rutgers University where he started his work on hormone action for six years. During this period, he did a sabbatical at the University of California, Berkeley, where he concentrated on rapid enzyme kinetics. In 1960 he accepted an offer of an associate professorship at the University of Pennsylvania Graduate School of Medicine. In 1964, he was invited to be full professor of biochemistry at The Fels Institute for Cancer Research and Molecular Biology at Temple Medical School, simultaneously with a Career Development Award from the NIH, where he later was named Deputy Director of the Institute and the Laura H. Carnell Professor in biochemistry. Subsequently, he was given the Faculty Research Award. He co-discovered ligandin, later found to be in the family of glutathione S-transferases, enzymes that protect the body from carcinogens. In 1991, he moved to the Jefferson Medical College at Thomas Jefferson University as Professor of Biochemistry, Chair of the Department of Pharmacology and Deputy Director of the Kimmel Cancer Research Institute. Later, he became chair of the combined Department of Biochemistry and Molecular Pharmacology and concurrently held the position of Vice Dean for Research. In 2003, he moved to Los Angeles and from 2004-2006 was a Visiting Scholar at the University of California, Los Angeles, in the Department of Biological Chemistry of the Geffen School of Medicine and, in this period, wrote “Human Biochemistry and Disease” a volume of 1254 pages. In 2007, he moved to Scranton,
Toluca Lake, North Hollywood, California, USA