Vitamin D

Vitamin D

Volume 2: Health, Disease and Therapeutics

4th Edition - December 14, 2017

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  • Editors: Martin Hewison, Roger Bouillon, Edward Giovannucci, David Goltzman
  • eBook ISBN: 9780128099643

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Vitamin D: Volume 2: Health, Disease and Therapeutics, Fourth Edition, authoritatively covers the evidence for new roles for vitamin D, ranging from cardiovascular disease, to cancer, diabetes, inflammatory bowel disease, multiple sclerosis and renal disease. This collection represents a who’s who of vitamin D research and the coverage is appropriately broad, drawing in internal medicine, orthopedics, oncology and immunology. Clinical researchers will gain a strong understanding of the molecular basis for a particular area of focus.

Key Features

  • Offers a comprehensive reference, ranging from basic bone biology, to biochemistry, to the clinical diagnostic and management implications of vitamin D
  • Saves researchers and clinicians time in quickly accessing the very latest details on the diverse scientific and clinical aspects of Vitamin D, as opposed to searching through thousands of journal articles
  • Chapter authors include the most prominent and well-published names in the field
  • Targets chemistry, metabolism and circulation, mechanisms of action, mineral and bone homeostasis and vitamin D deficiency
  • Presents a clinical focus on disorders, analogs, cancer, immunity, inflammation, disease and therapeutic applications


Academic, medical, and pharmaceutical researchers in bone biology, physiology, biochemistry; clinician researchers in endocrinology, nephrology, oncology, immunology, orthopedic surgery, and radiology

Table of Contents

  • Preface
    David Feldman, J. Wesley Pike, Roger Bouillon, Edward Giovannucci, David Goltzman and Martin Hewison

    In Memoriam: Robert P. Heaney, MD (1928-2016)
    Robert R. Recker and Joan M. Lappe
    In Memoriam: Milan Uskokovic, PhD (1924-2015)
    Sylvia Christakos, Hubert Maehr, and Nanjoo Suh

    Volume II: Health, Disease and Therapeutics

    Section VII. Population Studies: Vitamin D Deficiency, Nutrition, Sunlight, Genes & Trials
    58. Methods of evaluating population studies of vitamin D: strengths & weaknesses
    Edward Giovannucci
    59. Worldwide vitamin D status
    Natasja van Schoor and Paul Lips
    60. Vitamin D in Foods: An Evolution of Knowledge
    Janet M. Roseland, Katherine M. Phillips, Kristine Y. Patterson, Pamela R. Pehrsson, and Christine L. Taylor
    61. Determinants of Vitamin D Deficiency from Sun Exposure: A Global Perspective
    William B. Grant, Harjit Pal Bhattoa, and Pawel Pludowski
    62. Vitamin D Fortification and Supplementation Policies to Correct Vitamin D Insufficiency/Deficiency Globally
    Susan J. Whiting and Mona S. Calvo
    63. Vitamin D and Food Fortification
    Kevin D. Cashman and Mairead Kiely
    64. Bariatric Surgery, Vitamin D, and Bone Loss
    Tiffany Kim, Anne Schafer
    65. Genetics of the Vitamin D Endocrine System
    André G. Uitterlinden
    66. Randomized Clinical Trials of Vitamin D for the Primary Prevention of Cancer and Cardiovascular Disease, with a Focus on the VITamin D and OmegA-3 TriaL (VITAL)
    Shari S. Bassuk, JoAnn E. Manson

    Section VIII. Disorders
    67. Vitamin D deficiency and nutritional rickets in children
    John M. Pettifor, Kebashni Thandrayen, and Thomas D. Thacher
    68. Vitamin D and Osteoporosis
    Peter R. Ebeling and John A. Eisman
    69. Adult Vitamin D deficiency: fracture & fall prevention
    Bess Dawson-Hughes and Heike A. Bischoff-Ferrari
    70. Clinical Disorders of Phosphate Homeostasis
    Eva S. Liu and Harald Jüppner
    71. Vitamin D hydroxylation-deficient rickets, type 1A: CYP27B1 mutations
    Francis H. Glorieux, René St-Arnaud
    72. Hereditary 1,25-Dihydroxyvitamin D Resistant Rickets
    Peter J. Malloy, Dov Tiosano and David Feldman
    73. The Role of Genetic Variation in CYP2R1, the Principal Vitamin D 25-hydroxylase, in Vitamin D Homeostasis
    Jeffrey David Roizen and Michael A. Levine
    74. Infantile Hypercalcemia and CYP24A1 Mutations
    Karl P. Schlingmann and Martin Konrad
    75. Drug and Hormone Effects on Vitamin D Metabolism
    Gregory R. Emkey and Sol Epstein
    76. Vitamin D and Organ Transplantation
    Jessica M. Furst, Emily M. Stein, and Elizabeth Shane
    77. The role of vitamin D in type 2 diabetes and hypertension
    Edith Angellotti and Anastassios G. Pittas
    78. Vitamin D, obesity and the metabolic syndrome
    Elina Hypponen and Barbara Boucher
    79. Vitamin D and Renal Disease
    Adriana S. Dusso and Jorge B. Cannata-Andia
    80. Calcitriol and Analogs in the Treatment of Chronic Kidney Disease
    Ishir Bhan and Ravi Thadhani
    81. Idiopathic Hypercalciuria and Nephrolithiasis
    Murray J. Favus, Meltem Zeytinoglu, Fredric L. Coe,
    82. Hypercalcemia Due to Vitamin D Toxicity
    Natalie E. Cusano, Susan Thys-Jacobs, John P. Bilezikian
    83. The Hypocalcemic Disorders
    Rachel I. Gafni, Karl L. Insogna, Thomas O. Carpenter
    84. Vitamin D: Cardiovascular Effects and Vascular Calcification
    Christoph Zechner and Dwight A. Towler
    85. Vitamin D and Paget’s Disease
    Noriyoshi Kurihara and David Roodman

    Section IX. Vitamin D Analogs
    86. Analogs of Calcitriol
    Lieve Verlinden, Annemieke Verstuyf
    87. Non-Secosteroidal Ligands and Modulators of VDR
    Ryan E. Stites, James G. MacKrell and Keith R. Stayrook
    88. Bile acid-derived vitamin D receptor ligands
    Makoto Makishima and Sachiko Yamada
    89. Bifunctional Vitamin D Hybrid Molecules
    James L. Gleason and John H. White
    90. Modulating Vitamin D Receptor–Coregulator Binding with Small Molecules
    Olivia B. Yu and Leggy A. Arnold
    91. Extended-release Calcifediol in Renal Disease
    Martin Petkovich and Charles W. Bishop
    92. Vitamin D Receptor Antagonists
    Hiroshi Saitoh
    93. Eldecalcitol and Osteoporosis
    Toshio Matsumoto and Fumiaki Takahashi

    Section X. Vitamin D and Cancer
    94. Overview of vitamin D actions in cancer
    Marjolein van Driel, Johannes P.T.M. van Leeuwen, Alberto Munoz, and David Feldman
    95. Vitamin D Status and Cancer Incidence, Mortality and Prognosis
    Irene Shui and Edward Giovannucci
    96. Effects of Vitamin D Derivatives on Differentiation, Cell Cycle and Apoptosis in Hematological Malignancies
    George P. Studzinski, Elzbieta Gocek, Frederick Coffman, and Michael Danilenko
    97. Vitamin D actions in mammary gland and breast cancer: genomics, metabolism and stem cells
    Sarah Beaudin and JoEllen Welsh
    98. Vitamin D Urologic Cancers
    Donald Trump
    99. Vitamin D and Colon Cancer
    Antonio Barbáchano, María Jesús Larriba, Gemma Ferrer-Mayorga, José Manuel González-Sancho, Alberto Muñoz
    100. Vitamin D and Skin Cancer
    Katherine J. Ransohoff, Ervin H. Epstein Jr., and Jean Y. Tang
    101. Vitamin D and Lung Cancer
    Tatiana Shaurova, Mukund Seshadri, and Pamela A. Hershberger
    102. Vitamin D inflammation and cancer
    Enikö Kallay and Laura Buburuzan

    Section XI. Immunity, Inflammation and Disease
    103. Vitamin D and Tuberculosis
    Adrian R. Martineau, David A. Jolliffe, and Julie Demaret
    104. Vitamin D and Adaptive Immunology in Health and Disease
    Elizabeth H Mann, Paul E. Pfeffer, and Catherine M Hawrylowicz
    105. Vitamin D and Innate Immunity
    Kathryn Zavala, Aria Vazirnia, and Philip T. Liu
    106. Vitamin D and Diabetes
    An-Sofie Vanherwegen, Conny Gysemans, and Chantal Mathieu
    107. Vitamin D and Multiple Sclerosis
    Colleen E. Hayes and Faye E. Nashold
    108. Vitamin D and Inflammatory Bowel Disease
    Margherita T. Cantorna, Danny Bruce
    109. Psoriasis and other Skin Diseases
    Jörg Reichrath and Michael F. Holick

    Section XII. Therapeutic Applications and New Advances
    110. Sunlight protection by vitamin D compounds
    Rebecca S. Mason, Mark S. Rybchyn, Katie M. Dixon
    111. Vitamin D, Cardiovascular Disease and Hypertension
    Stefan Pilz
    112. Vitamin D, Acute Respiratory Infection, and Asthma/COPD
    Carlos A. Camargo
    113. Vitamin D and Muscle Performance in Athletes
    Lisa Ceglia and Roberto Toni
    114. Vitamin D: Presence and Function in the Eye
    Jawaher A. Alsalem, Saaeha Rauz, and Graham R. Wallace
    115. Adult vitamin D deficiency and adverse brain outcomes
    Natalie J. Groves, John J. McGrath, and Thomas H. J. Burne
    116. Vitamin D in Pregnancy and Lactation: Moving into the Future
    Bruce W. Hollis and Carol L. Wagner
    117. Vitamin D and Critically Ill ICU Patients
    Kenneth B. Christopher

Product details

  • No. of pages: 1266
  • Language: English
  • Copyright: © Academic Press 2017
  • Published: December 14, 2017
  • Imprint: Academic Press
  • eBook ISBN: 9780128099643

About the Editors

Martin Hewison

Prof. Hewison’s work focuses on different facets of vitamin D physiology, including classical skeletal effects and non-classical extra-skeletal effects. He has a particular interest in the interaction between vitamin D and the immune system, where antigen-presenting cells such as dendritic cells and macrophages synthesize active vitamin D (calcitriol) and also express the nuclear receptor for calcitriol (VDR). Vitamin D can therefore act as an endogenous regulator of both innate and adaptive immunity by enhancing antibacterial activity, and modulating antigen presentation and T lymphocyte function. Crucially these responses are highly dependent on the bioavailability of vitamin D, and Prof. Hewison has hypothesized that immune function is influenced by vitamin D status in humans. His group is using a variety of models to test this hypothesis including basic molecular and cell analyses, and vitamin D supplementation trials in human cohorts. A key objective of his work is to increase awareness of vitamin D-deficiency in the UK population.

Affiliations and Expertise

Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK

Roger Bouillon

Roger Bouillon, MD, PhD, FRCP, biography Roger Bouillon is professor (emeritus since 2010) in endocrinology (internal medicine) at the University and University Hospital of the Catholic University of Leuven (K.U.Leuven) in Belgium. He is a member of the Royal Academy of Medicine (Belgium) and a Fellow of the Royal College of Physicians (London). He was a founding member and later President of the European Board of Endocrinology (UEMS 1988-2002). He was a member of several European Science Foundation Committees (Board member of the European Medical Research Council) and of the European Space Agency Life Science working group till 2012. He is past-president of the International Bone and Mineral Society (2011-13 ) and is co-organizer of the vitamin D workshop. He was vice president for research of the University of Leuven from 1995-2005. He is coauthor of more than 500 peer reviewed articles that generated about 26,000 ISI citations and a H index of 82. The topics of his research deal with (1) several aspects of diabetes an endocrinology in general but his main research focus deals with (2) hormonal aspects of bone and calcium homeostasis and this spans the spectrum of basic, translational and clinical research. (3) Vitamin D is a major research focus throughout his scientific career. Papers:

Affiliations and Expertise

Professor in Endocrinology, University and University Hospital, Catholic University of Leuven (K.U.Leuven), Belgium

Edward Giovannucci

Edward Giovannucci's research focuses on how nutritional, genetic, environmental and lifestyle factors relate to various malignancies, especially those of the prostate and large bowel. Much of his work is centered on large ongoing cohort studies, including the Nurses Health Study, the Health Professionals Follow-Up Study and the Physicians Health Study. A specific area of interest is the etiologic mechanisms underlying the relation between modifiable factors and cancer risk. His work has included the study of how nutrition and other lifestyle factors impact on cancer risk and progression by influencing levels of insulin, insulin-like growth factors, vitamin D metabolites, and steroid hormones. Another area of interest is how nutrients may interact with genetic susceptibilities in determining an individual's risk.

Affiliations and Expertise

Harvard TH Chan School of Public Health, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA

David Goltzman

David Goltzman is Professor in the Departments of Medicine and Physiology of McGill University, Director of the McGill Centre for Bone and Periodontal Research, and Senior Physician in the Endocrine Division of the Department of Medicine of the McGill University Health Centre. His research has focused on the hormonal regulation of mineral and skeletal homeostasis, and he has made many important contributions to our knowledge of parathyroid hormone (PTH), PTH related peptide and vitamin D, which have had major impact on our understanding of a variety of metabolic bone diseases. He is also principal investigator of the Canadian Multicentre Osteoporosis Study (CaMos) which examines the demographics, development, risk factors and outcomes of osteoporosis. Dr. Goltzman has received various honours and awards, including the Aurbach Award of the US Endocrine Society, the Raisz Award of the American Society for Bone and Mineral Research (ASBMR), fellowship in the Royal Society of Canada and in the Canadian Academy of Health Sciences, the Order of Canada, an honorary professorship from Nanjing University and the degree of Doctor Honoris Causa from the University of Athens. He is a past President of the ASBMR, the Canadian Society of Clinical Investigation and the Canadian Society of Endocrinology and Metabolism.

Affiliations and Expertise

Professor, Departments of Medicine and Physiology of McGill University, Director of the McGill Centre for Bone and Periodontal Research, and Senior Physician, Endocrine Division, Department of Medicine of the McGill University Health Centre, Canada

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