Vitamin D

Volume 2: Health, Disease and Therapeutics

4th Edition - December 14, 2017
Editors: Martin Hewison, Roger Bouillon, Edward Giovannucci, David Goltzman
Language: English
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 0 9 9 6 4 - 3

Vitamin D: Volume 2: Health, Disease and Therapeutics, Fourth Edition, authoritatively covers the evidence for new roles for vitamin D, ranging from cardiovascular disease,… Read more

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Vitamin D: Volume 2: Health, Disease and Therapeutics, Fourth Edition, authoritatively covers the evidence for new roles for vitamin D, ranging from cardiovascular disease, to cancer, diabetes, inflammatory bowel disease, multiple sclerosis and renal disease.

This collection represents a who’s who of vitamin D research and the coverage is appropriately broad, drawing in internal medicine, orthopedics, oncology and immunology. Clinical researchers will gain a strong understanding of the molecular basis for a particular area of focus.

Preface
David Feldman, J. Wesley Pike, Roger Bouillon, Edward Giovannucci, David Goltzman and Martin Hewison

In Memoriam: Robert P. Heaney, MD (1928-2016)
Robert R. Recker and Joan M. Lappe
In Memoriam: Milan Uskokovic, PhD (1924-2015)
Sylvia Christakos, Hubert Maehr, and Nanjoo Suh

Volume II: Health, Disease and Therapeutics

Section VII. Population Studies: Vitamin D Deficiency, Nutrition, Sunlight, Genes & Trials

58. Methods of evaluating population studies of vitamin D: strengths & weaknesses
Edward Giovannucci

59. Worldwide vitamin D status
Natasja van Schoor and Paul Lips

60. Vitamin D in Foods: An Evolution of Knowledge
Janet M. Roseland, Katherine M. Phillips, Kristine Y. Patterson, Pamela R. Pehrsson, and Christine L. Taylor

61. Determinants of Vitamin D Deficiency from Sun Exposure: A Global Perspective
William B. Grant, Harjit Pal Bhattoa, and Pawel Pludowski

62. Vitamin D Fortification and Supplementation Policies to Correct Vitamin D Insufficiency/Deficiency Globally
Susan J. Whiting and Mona S. Calvo

63. Vitamin D and Food Fortification
Kevin D. Cashman and Mairead Kiely

64. Bariatric Surgery, Vitamin D, and Bone Loss
Tiffany Kim, Anne Schafer

65. Genetics of the Vitamin D Endocrine System
André G. Uitterlinden

66. Randomized Clinical Trials of Vitamin D for the Primary Prevention of Cancer and Cardiovascular Disease, with a Focus on the VITamin D and OmegA-3 TriaL (VITAL)
Shari S. Bassuk, JoAnn E. Manson

Section VIII. Disorders

67. Vitamin D deficiency and nutritional rickets in children
John M. Pettifor, Kebashni Thandrayen, and Thomas D. Thacher

68. Vitamin D and Osteoporosis
Peter R. Ebeling and John A. Eisman

69. Adult Vitamin D deficiency: fracture & fall prevention
Bess Dawson-Hughes and Heike A. Bischoff-Ferrari

70. Clinical Disorders of Phosphate Homeostasis
Eva S. Liu and Harald Jüppner

71. Vitamin D hydroxylation-deficient rickets, type 1A: CYP27B1 mutations
Francis H. Glorieux, René St-Arnaud

72. Hereditary 1,25-Dihydroxyvitamin D Resistant Rickets
Peter J. Malloy, Dov Tiosano and David Feldman

73. The Role of Genetic Variation in CYP2R1, the Principal Vitamin D 25-hydroxylase, in Vitamin D Homeostasis
Jeffrey David Roizen and Michael A. Levine

74. Infantile Hypercalcemia and CYP24A1 Mutations
Karl P. Schlingmann and Martin Konrad

75. Drug and Hormone Effects on Vitamin D Metabolism
Gregory R. Emkey and Sol Epstein

76. Vitamin D and Organ Transplantation
Jessica M. Furst, Emily M. Stein, and Elizabeth Shane

77. The role of vitamin D in type 2 diabetes and hypertension
Edith Angellotti and Anastassios G. Pittas

78. Vitamin D, obesity and the metabolic syndrome
Elina Hypponen and Barbara Boucher

79. Vitamin D and Renal Disease
Adriana S. Dusso and Jorge B. Cannata-Andia

80. Calcitriol and Analogs in the Treatment of Chronic Kidney Disease
Ishir Bhan and Ravi Thadhani

81. Idiopathic Hypercalciuria and Nephrolithiasis
Murray J. Favus, Meltem Zeytinoglu, Fredric L. Coe,

82. Hypercalcemia Due to Vitamin D Toxicity
Natalie E. Cusano, Susan Thys-Jacobs, John P. Bilezikian

83. The Hypocalcemic Disorders
Rachel I. Gafni, Karl L. Insogna, Thomas O. Carpenter

84. Vitamin D: Cardiovascular Effects and Vascular Calcification
Christoph Zechner and Dwight A. Towler

85. Vitamin D and Paget’s Disease
Noriyoshi Kurihara and David Roodman

Section IX. Vitamin D Analogs

86. Analogs of Calcitriol
Lieve Verlinden, Annemieke Verstuyf

87. Non-Secosteroidal Ligands and Modulators of VDR
Ryan E. Stites, James G. MacKrell and Keith R. Stayrook

88. Bile acid-derived vitamin D receptor ligands
Makoto Makishima and Sachiko Yamada

89. Bifunctional Vitamin D Hybrid Molecules
James L. Gleason and John H. White

90. Modulating Vitamin D Receptor–Coregulator Binding with Small Molecules
Olivia B. Yu and Leggy A. Arnold

91. Extended-release Calcifediol in Renal Disease
Martin Petkovich and Charles W. Bishop

92. Vitamin D Receptor Antagonists
Hiroshi Saitoh

93. Eldecalcitol and Osteoporosis
Toshio Matsumoto and Fumiaki Takahashi

Section X. Vitamin D and Cancer

94. Overview of vitamin D actions in cancer
Marjolein van Driel, Johannes P.T.M. van Leeuwen, Alberto Munoz, and David Feldman

95. Vitamin D Status and Cancer Incidence, Mortality and Prognosis
Irene Shui and Edward Giovannucci

96. Effects of Vitamin D Derivatives on Differentiation, Cell Cycle and Apoptosis in Hematological Malignancies
George P. Studzinski, Elzbieta Gocek, Frederick Coffman, and Michael Danilenko

97. Vitamin D actions in mammary gland and breast cancer: genomics, metabolism and stem cells
Sarah Beaudin and JoEllen Welsh

98. Vitamin D Urologic Cancers
Donald Trump

99. Vitamin D and Colon Cancer
Antonio Barbáchano, María Jesús Larriba, Gemma Ferrer-Mayorga, José Manuel González-Sancho, Alberto Muñoz

100. Vitamin D and Skin Cancer
Katherine J. Ransohoff, Ervin H. Epstein Jr., and Jean Y. Tang

101. Vitamin D and Lung Cancer
Tatiana Shaurova, Mukund Seshadri, and Pamela A. Hershberger

102. Vitamin D inflammation and cancer
Enikö Kallay and Laura Buburuzan

Section XI. Immunity, Inflammation and Disease

103. Vitamin D and Tuberculosis
Adrian R. Martineau, David A. Jolliffe, and Julie Demaret

104. Vitamin D and Adaptive Immunology in Health and Disease
Elizabeth H Mann, Paul E. Pfeffer, and Catherine M Hawrylowicz

105. Vitamin D and Innate Immunity
Kathryn Zavala, Aria Vazirnia, and Philip T. Liu

106. Vitamin D and Diabetes
An-Sofie Vanherwegen, Conny Gysemans, and Chantal Mathieu

107. Vitamin D and Multiple Sclerosis
Colleen E. Hayes and Faye E. Nashold

108. Vitamin D and Inflammatory Bowel Disease
Margherita T. Cantorna, Danny Bruce

109. Psoriasis and other Skin Diseases
Jörg Reichrath and Michael F. Holick

Section XII. Therapeutic Applications and New Advances

110. Sunlight protection by vitamin D compounds
Rebecca S. Mason, Mark S. Rybchyn, Katie M. Dixon

111. Vitamin D, Cardiovascular Disease and Hypertension
Stefan Pilz

112. Vitamin D, Acute Respiratory Infection, and Asthma/COPD
Carlos A. Camargo

113. Vitamin D and Muscle Performance in Athletes
Lisa Ceglia and Roberto Toni

114. Vitamin D: Presence and Function in the Eye
Jawaher A. Alsalem, Saaeha Rauz, and Graham R. Wallace

115. Adult vitamin D deficiency and adverse brain outcomes
Natalie J. Groves, John J. McGrath, and Thomas H. J. Burne

116. Vitamin D in Pregnancy and Lactation: Moving into the Future
Bruce W. Hollis and Carol L. Wagner

117. Vitamin D and Critically Ill ICU Patients
Kenneth B. Christopher

Martin Hewison

Prof. Hewison’s work focuses on different facets of vitamin D physiology, including classical skeletal effects and non-classical extra-skeletal effects. He has a particular interest in the interaction between vitamin D and the immune system, where antigen-presenting cells such as dendritic cells and macrophages synthesize active vitamin D (calcitriol) and also express the nuclear receptor for calcitriol (VDR). Vitamin D can therefore act as an endogenous regulator of both innate and adaptive immunity by enhancing antibacterial activity, and modulating antigen presentation and T lymphocyte function. Crucially these responses are highly dependent on the bioavailability of vitamin D, and Prof. Hewison has hypothesized that immune function is influenced by vitamin D status in humans. His group is using a variety of models to test this hypothesis including basic molecular and cell analyses, and vitamin D supplementation trials in human cohorts. A key objective of his work is to increase awareness of vitamin D-deficiency in the UK population.

Affiliations and expertise

Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK

Roger Bouillon

Roger Bouillon, MD, PhD, FRCP, biography Roger Bouillon is professor (emeritus since 2010) in endocrinology (internal medicine) at the University and University Hospital of the Catholic University of Leuven (K.U.Leuven) in Belgium. He is a member of the Royal Academy of Medicine (Belgium) and a Fellow of the Royal College of Physicians (London). He was a founding member and later President of the European Board of Endocrinology (UEMS 1988-2002). He was a member of several European Science Foundation Committees (Board member of the European Medical Research Council) and of the European Space Agency Life Science working group till 2012. He is past-president of the International Bone and Mineral Society (2011-13 ) and is co-organizer of the vitamin D workshop. He was vice president for research of the University of Leuven from 1995-2005. He is coauthor of more than 500 peer reviewed articles that generated about 26,000 ISI citations and a H index of 82. The topics of his research deal with (1) several aspects of diabetes an endocrinology in general but his main research focus deals with (2) hormonal aspects of bone and calcium homeostasis and this spans the spectrum of basic, translational and clinical research. (3) Vitamin D is a major research focus throughout his scientific career. Papers:

Affiliations and expertise

Professor in Endocrinology, University and University Hospital, Catholic University of Leuven (K.U.Leuven), Belgium

Edward Giovannucci

Edward Giovannucci's research focuses on how nutritional, genetic, environmental and lifestyle factors relate to various malignancies, especially those of the prostate and large bowel. Much of his work is centered on large ongoing cohort studies, including the Nurses Health Study, the Health Professionals Follow-Up Study and the Physicians Health Study. A specific area of interest is the etiologic mechanisms underlying the relation between modifiable factors and cancer risk. His work has included the study of how nutrition and other lifestyle factors impact on cancer risk and progression by influencing levels of insulin, insulin-like growth factors, vitamin D metabolites, and steroid hormones. Another area of interest is how nutrients may interact with genetic susceptibilities in determining an individual's risk.

Affiliations and expertise

Harvard TH Chan School of Public Health, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA

David Goltzman

David Goltzman is Professor in the Departments of Medicine and Physiology of McGill University, Director of the McGill Centre for Bone and Periodontal Research, and Senior Physician in the Endocrine Division of the Department of Medicine of the McGill University Health Centre. His research has focused on the hormonal regulation of mineral and skeletal homeostasis, and he has made many important contributions to our knowledge of parathyroid hormone (PTH), PTH related peptide and vitamin D, which have had major impact on our understanding of a variety of metabolic bone diseases. He is also principal investigator of the Canadian Multicentre Osteoporosis Study (CaMos) which examines the demographics, development, risk factors and outcomes of osteoporosis. Dr. Goltzman has received various honours and awards, including the Aurbach Award of the US Endocrine Society, the Raisz Award of the American Society for Bone and Mineral Research (ASBMR), fellowship in the Royal Society of Canada and in the Canadian Academy of Health Sciences, the Order of Canada, an honorary professorship from Nanjing University and the degree of Doctor Honoris Causa from the University of Athens. He is a past President of the ASBMR, the Canadian Society of Clinical Investigation and the Canadian Society of Endocrinology and Metabolism.

Affiliations and expertise

Professor, Departments of Medicine and Physiology of McGill University, Director of the McGill Centre for Bone and Periodontal Research, and Senior Physician, Endocrine Division, Department of Medicine of the McGill University Health Centre, Canada