Vitamin D - 3rd Edition - ISBN: 9780123870353

Vitamin D

3rd Edition

Volume One

Editors: David Feldman J. Wesley Pike John Adams
Hardcover ISBN: 9780123870353
Imprint: Academic Press
Published Date: 1st June 2011
Page Count: 1118
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Institutional Access


The Third Edition of this classic compendium, Vitamin D, is the most comprehensive, authoritative reference available in the field. In two volumes and over 100 chapters, the editors and authors have marshaled all currently available data on the basic mechanisms, normal physiology and effects on disease of Vitamin D; they have laid out for the reader up-to-date and expert information on the role of vitamin D in health and many disorders. With new chapters on multiple cancers, this complete reference work is essential for anyone working in endocrinology, osteology, bone biology, or cancer research.

Volume One chapters cover the chemistry and metabolism of vitamin D, role in mineralization, other target organs, and general physiological effects. Volume Two is more clinically oriented addressing deficiency problems (including diagnosis, interactions in the endocrine system, and involvement in malignancies). Volumes One and Two are now sold separately in print. Volume One ISBN: 9780123870353; Volume Two ISBN: 9780123870346.

Key Features

  • Most comprehensive, authoritative reference on Vitamin D
  • Volumes One and Two now sold separately
  • Volume One chapters cover the chemistry and metabolism of vitamin D, role in mineralization, other target organs, and general physiological effects
  • Volume Two is more clinically oriented addressing deficiency problems (including diagnosis, interactions in the endocrine system, and involvement in malignancies)
  • Offers 32 new chapters on squamous cell cancer, brain cancer, thyroid cancer and many more; new sections include emerging uses for treatments of auto-immune diseases and diabetes
  • Over 600 illustrations and figures available on Companion website


Bone specialists, endocrinologists, basic scientists and researchers interested in vitamin D and osteoporosis prevention

Table of Contents



1 Historical Overview of Vitamin D

Hector F. Deluca

2 Photobiology of Vitamin D

Michael F. Holick

3 The Activating Enzymes of Vitamin D Metabolism (25- and 1a-Hydroxylases)

Glenville Jones and David E. Prosser

4 CYP24A1: Structure, Function, and Physiological Role

Rene St. Arnaud

5 The Vitamin D Binding Protein: DBP

Roger Bouillon

6 Industrial Aspects of Vitamin D

Arnold L. Hirsch




J. Wesley Pike

8 Nuclear Vitamin D Receptor: Natural Ligands, Molecular Structure-Function, and Transcriptional Control of Vital Genes

Mark R. Haussler, Carol A. Haussler, Jui-Cheng Hsieh, Peter W. Jurutka, and G. Kerr Whitfield

9 Structural Basis for Ligand Activity in VDR

Dino Moras and Natacha Rochel

10 Coregulators of VDR-mediated Gene Expression

Paul McDonald and Diane R. Dowd

11 Target Genes of Vitamin D: Spatio-temporal Interaction of Chromatin, VDR and Response Elements

Carsten Carlberg

12 Epigenetic Modifications in Vitamin D Receptor Mediated Transrepression

Shigeaki Kato, Alexander Kouzmenko, Fumiaki Ohtake, and Ryoji Fujiki

13 Vitamin D and Wnt/ß-Catenin Signaling

Albert Munoz, José Manuel González-Sancho, and María Jesús Larriba

14 Vitamin D Response Element Binding Protein

John S. Adams, Thomas S. Lisse, Hong Chen, Mark S. Nanes, and Martin Hewison

15 Vitamin D Sterol/VDR Conformational Dynamics and Nongenomic Actions

Anthony W. Norman and Mathew T. Mizwicki



16 Development of the Skeleton

Jane B. Lian, Gary S. Stein, Martin Montecino, Janet L. Stein, Andre J. van Wijnen

17 Vitamin D Regulation of Os


No. of pages:
© Academic Press 2011
Academic Press
Hardcover ISBN:

About the Editor

David Feldman

David Feldman, MD, is Emeritus Professor of Medicine (Active) at Stanford University School of Medicine where he has been on the faculty since 1974. He has been a full professor since 1984 and was chief of the Endocrinology Division for 10 years. His laboratory studies the role of steroid hormone receptors, particularly the vitamin D receptor, and its mechanism of action. His current major research focus is hormone-dependent cancer including breast cancer and prostate cancer and the pathways by which vitamin D inhibits cancer growth. Professor Feldman is actively involved in both basic science approaches to the anti-cancer actions of vitamin D as well as to clinical trials studying the use of vitamin D in breast and prostate cancer. Professor Feldman was recently honored with an award for a Career of Outstanding Contributions to Vitamin D Research. He has authored over 290 medical research articles, reviews, editorials, and book chapters. In addition to being a co-editor of all four editions of OSTEOPOROSIS, he is the editor-in-chief of Vitamin D, just published in its third edition.

Affiliations and Expertise

Emeritus Professor of Medicine, Stanford University School of Medicine, Stanford, California, USA

J. Wesley Pike

Affiliations and Expertise

Professor, Department of Biochemistry, University of Wisconsin, Madison, USA

John Adams

Affiliations and Expertise

Vice Chair for Research, UCLA-Orthopaedic Hospital Department of Orthopaedic Surgery Director, Orthopaedic Hospital Research Center, University of California, Los Angeles


"In this brief review, it is impossible to cover all the nuances of vitamin D addressed in this book. Interested readers may want to peruse the book chapters to assess relevance to their personal interests. I regard this impressive text as a ‘‘must have’’ in the medical libraries of most hospitals. Clinicians and researchers with an interest in vitamin D may want their own personal copy for ready reference. I highly recommend it and congratulate the authors and editors in providing a much needed reference text on arguably one of the more important nutrients to our species."
--American Journal of Human Biology

"In this remarkable compendium, the editors provide a fresh and comprehensive review of a multifaceted and sometimes controversial vitamin D. This third edition is not just an update, but a greatly expanded work organized to authoritatively cover the evidence for new roles of vitamin D in cardiovascular health, immunity, psychiatric disorders, and much more. In more than 100 chapters, experts span the history of vitamin D, update its molecular mechanism and chemistry, provide specifics of clinical use in disorders of the skeleton, and review progress in an array of diseases including diabetes, inflammatory bowel disease, multiple sclerosis, and psoriasis. In this edition one finds new information for a broad audience including internal medicine, nutrition, orthopedics, basic scientists, and teachers. How does one define optimal vitamin D status? How does vitamin D affect innate immunity? What are the epigenetic modifications of the vitamin D receptor that contribute to its function? Are there other natural ligands for the vitamin D receptor? These are a part of the new increased scope of Vitamin D, Third Edition. If you are interested in vitamin D, you should have this book." --Mark S. Nanes, MD, PhD, Professor of Medicine, Emory University, Atlanta, GA, USA

"The Third Edition of the classic text