Vitamin D

Vitamin D

Volume Two

3rd Edition - June 1, 2011

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  • Editors: David Feldman, J. Wesley Pike, John Adams
  • Hardcover ISBN: 9780123870346

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The Third Edition of this classic compendium, Vitamin D, is the most comprehensive, authoritative reference available in the field. In two volumes and over 100 chapters, the editors and authors have marshaled all currently available data on the basic mechanisms, normal physiology and effects on disease of Vitamin D; they have laid out for the reader up-to-date and expert information on the role of vitamin D in health and many disorders. With new chapters on multiple cancers, this complete reference work is essential for anyone working in endocrinology, osteology, bone biology, or cancer research. Volume One chapters cover the chemistry and metabolism of vitamin D, role in mineralization, other target organs, and general physiological effects. Volume Two is more clinically oriented addressing deficiency problems (including diagnosis, interactions in the endocrine system, and involvement in malignancies). Volumes One and Two are now sold separately in print. Volume One ISBN: 9780123870353; Volume Two ISBN: 9780123870346.

Key Features

  • Most comprehensive, authoritative reference on Vitamin D
  • Volumes One and Two now sold separately
  • Volume One chapters cover the chemistry and metabolism of vitamin D, role in mineralization, other target organs, and general physiological effects
  • Volume Two is more clinically oriented addressing deficiency problems (including diagnosis, interactions in the endocrine system, and involvement in malignancies)
  • Offers 32 new chapters on squamous cell cancer, brain cancer, thyroid cancer and many more; new sections include emerging uses for treatments of auto-immune diseases and diabetes
  • Over 600 illustrations and figures available on Companion website


Bone specialists, endocrinologists, basic scientists and researchers interested in vitamin D and osteoporosis prevention

Table of Contents



    1 Historical Overview of Vitamin D

    Hector F. Deluca

    2 Photobiology of Vitamin D

    Michael F. Holick

    3 The Activating Enzymes of Vitamin D Metabolism (25- and 1a-Hydroxylases)

    Glenville Jones and David E. Prosser

    4 CYP24A1: Structure, Function, and Physiological Role

    Rene St. Arnaud

    5 The Vitamin D Binding Protein: DBP

    Roger Bouillon

    6 Industrial Aspects of Vitamin D

    Arnold L. Hirsch



    7 VDR

    J. Wesley Pike

    8 Nuclear Vitamin D Receptor: Natural Ligands, Molecular Structure-Function, and Transcriptional Control of Vital Genes

    Mark R. Haussler, Carol A. Haussler, Jui-Cheng Hsieh, Peter W. Jurutka, and G. Kerr Whitfield

    9 Structural Basis for Ligand Activity in VDR

    Dino Moras and Natacha Rochel

    10 Coregulators of VDR-mediated Gene Expression

    Paul McDonald and Diane R. Dowd

    11 Target Genes of Vitamin D: Spatio-temporal Interaction of Chromatin, VDR and Response Elements

    Carsten Carlberg

    12 Epigenetic Modifications in Vitamin D Receptor Mediated Transrepression

    Shigeaki Kato, Alexander Kouzmenko, Fumiaki Ohtake, and Ryoji Fujiki

    13 Vitamin D and Wnt/ß-Catenin Signaling

    Albert Munoz, José Manuel González-Sancho, and María Jesús Larriba

    14 Vitamin D Response Element Binding Protein

    John S. Adams, Thomas S. Lisse, Hong Chen, Mark S. Nanes, and Martin Hewison

    15 Vitamin D Sterol/VDR Conformational Dynamics and Nongenomic Actions

    Anthony W. Norman and Mathew T. Mizwicki



    16 Development of the Skeleton

    Jane B. Lian, Gary S. Stein, Martin Montecino, Janet L. Stein, Andre J. van Wijnen

    17 Vitamin D Regulation of Osteoblast Function

    Renny Franchesci and Yan Li

    18 Osteoclasts

    F. Patrick Ross

    19 Molecular Mechanisms for Regulation of Intestinal Calcium and Phosphate Absorption by Vitamin D

    James Fleet and Ryan D. Schoch

    20 The Calbindins: Calbindin-D28K and Calbindin-D9K and the Epithelial Calcium Channels TRPV5 and TRPV6

    Sylvia Christakos, Leila Mady, and Puneet Dhawan

    21 Mineralization

    Adele Boskey and Eve Donnelly

    22 VITAMIN D Regulation of Type I Collagen Expression in Bone

    Barbara Kream and Alexander Lichtler

    23 Target Genes: Bone Proteins

    Howard Morris, Paul H. Anderson, Gerald J. Atkins, and David M. Findlay

    24 Vitamin D and the Calcium-Sensing Receptor

    Edward M. Brown

    25 Effects of 1,25-Dihydroxyvitamin D3 on Voltage-Sensitive Calcium Channels in Osteoblast Differentiation and Morphology

    Mary Farach-Carson and William R. Thompson



    26 Vitamin D and the Kidney

    Rajiv Kumar and Peter Tebben

    27 Vitamin D and the Parathyroids

    Justin Silver and Tally Neveh-Many

    28 Cartilage

    Barbara D. Boyan, Maryam Doroudi and Zvi Schwartz

    29 Vitamin D and Oral Heath

    Ariane Berdal, Muriel Molla, Vianney Descroix

    30 The Role of Vitamin D and its Receptor in Skin and Hair Follicle Biology

    Marie B. Demay

    31 Vitamin D and the Cardiovascular System

    David Gardner, Songcang Chen, Denis Glenn, and Wei Ni

    32 Vitamin D: A Neurosteroid Affecting Brain Development and Function; Implications for Neurological and Psychiatric Disorders

    John McGrath, Darryl Eyles, and Thomas Burne

    33 Contributions of Genetically Modified Mouse Models to Understanding the Physiology and Pathophysiology of the 25-hydroxyvitamin D-1-alpha Hydroxylase Enzyme [1a(OH)ase] and the Vitamin D Receptor (VDR)

    David Goltzman, Geoffrey N. Hendy, and Richard Kremer



    34 Vitamin D: Role in the Calcium and Phosphorus Economies

    Robert P. Heaney

    35 Fetus, Neonate and Infant

    Chris Kovacs

    36 Vitamin D Deficiency and Calcium Absorption During Childhood

    Steven A. Abrams

    37 Adolescence and Acquisition of Peak Bone Mass

    Connie Weaver, Rick Lewis, and Emma Liang

    38 Vitamin D Metabolism in Pregnancy and Lactation

    Bonny Specker, Natalie W. Thiex, and Heidi J. Kalkwarf

    39 Vitamin D: Relevance in Reproductive Biology and Pathophysiological Implications in Reproductive Dysfunction

    Hugh S. Taylor and Lubna Pal

    40 Vitamin D and the Renin-Angiotensin System

    Yan Chun Li

    41 Parathyroid Hormone, Parathyroid Hormone-Related Protein and Calcitonin

    John J. Wysolmerski and Elizabeth Holt

    42 FGF23/Klotho New Regulators of Vitamin D Metabolism

    L. Darryl Quarles and Valentin David

    43 The Role of the Vitamin D Receptor in Bile Acid Homeostasis

    David J. Mangelsdorf, Daniel R. Schmidt, Steven A. Kliewer

    44 Vitamin D and Fat

    Clifford J. Rosen and Francisco J. A. de Paula

    45 Extra-renal 1a-hydroxylase

    Martin Hewison and John S. Adams

    Section VI: Diagnosis and Management

    46 Approach to the Patient

    Michael P. Whyte

    47 Detection of Vitamin D and Its Major Metabolites

    Bruce W. Hollis

    48 Bone Histomorphometry

    Juliet E. Compston and Linda Skingle

    49 Radiology

    Judith E. Adams

    50 High-Resolution Imagine Techniques for Bone Quality Assessment

    Sharmila Majumdar, Andrew J. Burghardt, and Roland Krug

    51 The Role of Vitamin D in Orthopaedic Surgery

    Joseph M. Lane, Aasis Unnanuntana, and Brian J. Rebolledo



    52 Worldwide Vitamin D Status

    Paul Lips and Natasja van Schoor

    53 Sunlight, Vitamin D and Prostate Cancer Epidemiology

    Gary G. Schwartz

    54 Nutrition and lifestyle effects on vitamin D status

    Susan J. Whiting and Mona S. Calvo

    55 Bone Loss, Vitamin D and Bariatric Surgery: Nutrition, Obesity and Bariatric Surgery

    Lenore Arab and Ian Yip

    56 Genes and Risk of Disease

    André G. Uitterlinden

    57 The Pharmacology of Vitamin D

    Reinhold Vieth

    58 How to Define Optimal Vitamin D Status?

    Roger Bouillon




    59 The Hypocalcemic Disorders: Differential Diagnosis and Therapeutic Use of Vitamin D

    Thomas O. Carpenter and Karl L. Insogna

    60 Vitamin D Deficiency and Nutritional Rickets in Children

    John M. Pettifor

    61 Vitamin D and Osteoporosis

    Peter R. Ebeling and John A. Eisman

    62 Relevance of Vitamin D Deficiency in Adult Fracture and Fall Prevention

    Heike Bischoff-Ferrari and Bess Dawson-Hughes

    63 Clinical Disorders of Phosphate Homeostasis

    Marc K. Drezner and Karen E. Hansen

    64 Pseudo-vitamin D Deficiency

    Francis H. Glorieux, Thomas Edouard, and René St-Arnaud

    65 Hereditary 1,25-Dihydroxyvitamin D Resistant Rickets

    Peter J. Malloy, David Feldman, and Dov Tiosano

    66 Glucocorticoids and Vitamin D

    Philip Sambrook

    67 Drug and Hormone Effects on Vitamin D Metabolism

    Sol Epstein and Barrie M. Weinstein

    68 Vitamin D and Organ Transplantation

    Elizabeth Shane and Emily M. Stein

    69 Vitamin D and Bone Mineral Metabolism in Hepatogastrointestinal Diseases
    Daniel Bikle

    70 Vitamin D and Renal Disease

    Adriana S. Dusso and Eduardo Slatopolsky

    71 Idiopathic Hypercalciuria and Nephrolithiasis

    Murray J. Favus and Fredric L. Coe

    72 Hypercalcemia Due to Vitamin D Toxicity

    John P. Bilezikian, Natalie E. Cusano, and Susan Thys-Jacobs

    73 Vitamin D: Cardiovascular Effects and Vascular Calcification

    Dwight A. Towler



    74 New Analogs

    Hector DeLuca and Lori A. Plum

    75 Mechanisms for the Selective Actions of Vitamin D Analogs

    Alex J. Brown

    76 Analogs of Calcitriol

    Annemieke Verstuyf, Pierre De Clercq, Roger Bouillon, Lieve Verlinden, Guy Eelen, and Maurits Vandewalle

    77 Analogs and Fx Prevention

    Noboru Kubodera and Fumiaki Takahashi

    78 Non-Secosteroidal Ligands and Modulators

    Keith R. Stayrook, Yanfei L. Ma, Matthew W. Carson, and Jeffrey A. Dodge

    79 The bile acid derivatives lithocholic acid acetate and lithocholic acid propionate are functionally selective vitamin D receptor ligands

    Makoto Makishima and Sachiko Yamada

    80 CYP24A1 Regulation in Health and Disease

    Martin Petkovich, Tina Epps, and Christian Helvig

    81 Calcitriol and Analogs in the Treatment of Chronic Kidney Disease

    Ravi Thadhani and Ishir Bhan



    82 The Epidemiology of Vitamin D and Cancer Risk

    Edward Giovannucci

    83 Vitamin D: Cancer and Differentiation

    Johannes P. T. M. van Leeuwen, Alberto Munoz, Marjolein van Driel, and David Feldman

    84 Vitamin D Effects on Differentiation and Cell Cycle

    George P. Studzinski, Elzbieta Gocek, and Michael Danilenko

    85 Vitamin D Actions in Mammary Gland and Breast Cancer

    Joellen Welsh

    86 Vitamin D and Prostate Cancer

    David Feldman and Aruna V. Krishnan

    87 The VITAMIN D System and Colorectal Cancer Prevention

    Heide S. Cross

    88 Hematological Malignancy

    H. Phillip Koeffler and Ryoko Okamoto

    89 Vitamin D and Skin Cancer

    Jean Y. Tang and Ervin H. Epstein

    90 The Anti-Tumor Effects of Vitamin D in Other Cancers

    Donald Trump and Candace Johnson



    91 Vitamin D and Innate Immunity

    John H. White

    92 Control of Adaptive Immunity by Vitamin D Receptor Agonists

    Luciano Adorini

    93 The role of vitamin D in innate immunity: Antimicrobial Activity, Oxidative Stress and Barrier Function

    Philip T. Liu

    94 Vitamin D and Diabetes

    Chantal Mathieu, Conny Gysemans, and Hannelie Korf

    95 Vitamin D and Multiple Sclerosis

    Colleen E. Hayes, Faye E. Nashold, Justin A. Spanier, Corwin D. Nelson, and Christopher G. Mayne

    96 Vitamin D and Inflammatory Bowel Disease

    Margherita Cantorna and Danny Bruce

    97 Psoriasis and other Skin Diseases

    Jörg Reichrath and Michael F. Holick



    98 The Role of Vitamin D in Type 2 Diabetes and Hypertension

    Bess Dawson-Hughes and Anastassios G. Pittas

    99 Vitamin D Receptor Agonists in the Treatment of Benign Prostatic Hyperplasia

    Mario Maggi, Annamaria Morelli, and Luciano Adorini

    100 Sunlight protection by Vitamin D Compounds

    Rebecca S. Mason, Katie M. Dixon, Vanessa Sequiera, and Clare Gordon-Thomas

    101 The Role of Vitamin D in Osteoarthritis and Rheumatic Disease

    Timothy M. McAlindon and M. Kyla Shea

    102 Vitamin D and cardiovascular Disease

    Harald Dobnig and Harald Sourij

    103 Vitamin D, Childhood Wheezing, Asthma, and Chronic Obstructive Pulmonary Disease

    Carlos A. Camargo, Jonathan Mansbach, and Adit Ginde

    104 Vitamin D and Skeletal Muscle Function

    Robert U. Simpson and Lisa Ceglia

    105 VITAL

    JoAnn E. Manson

Product details

  • No. of pages: 1024
  • Language: English
  • Copyright: © Academic Press 2011
  • Published: June 1, 2011
  • Imprint: Academic Press
  • Hardcover ISBN: 9780123870346

About the Editors

David Feldman

David Feldman, MD, is Emeritus Professor of Medicine (Active) at Stanford University School of Medicine where he has been on the faculty since 1974. He has been a full professor since 1984 and was chief of the Endocrinology Division for 10 years. His laboratory studies the role of steroid hormone receptors, particularly the vitamin D receptor, and its mechanism of action. His current major research focus is hormone-dependent cancer including breast cancer and prostate cancer and the pathways by which vitamin D inhibits cancer growth. Professor Feldman is actively involved in both basic science approaches to the anti-cancer actions of vitamin D as well as to clinical trials studying the use of vitamin D in breast and prostate cancer. Professor Feldman was recently honored with an award for a Career of Outstanding Contributions to Vitamin D Research. He has authored over 290 medical research articles, reviews, editorials, and book chapters. In addition to being a co-editor of all four editions of OSTEOPOROSIS, he is the editor-in-chief of Vitamin D, just published in its third edition.

Affiliations and Expertise

Emeritus Professor of Medicine, Stanford University School of Medicine, Stanford, California, USA

J. Wesley Pike

Dr. Pike’s laboratory is focused on the molecular mechanisms whereby vitamin D, the sex steroids, and other systemic hormones regulate the production as well as cellular activity of bone-forming osteoblasts and bone-resorbing osteoclasts. A long-term area of interest has been in the actions of vitamin D. His laboratory has shown that these actions are mediated by a specific receptor that is localized to the nucleus of target cells and which functions as a transcription factor following activation by its hormonal vitamin D ligand. This research led to the molecular cloning of this factor and elucidation of its regulation and mechanism of action.

Affiliations and Expertise

Professor, Department of Biochemistry, University of Wisconsin, Madison, USA

John Adams

Affiliations and Expertise

Vice Chair for Research, UCLA-Orthopaedic Hospital Department of Orthopaedic Surgery Director, Orthopaedic Hospital Research Center, University of California, Los Angeles

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