Vitamin D, a steroid hormone, has mainly been known for its effects on bone and osteoporosis. The current therapeutic practices expand into such markets as cancer research, pediatrics, nephrology, dermatology, immunology, and genetics. This 3e includes over 100 chapters covering everything from chemistry and metabolism to mechanisms of action, diagnosis and management, new analogs, and emerging therapies. This complete reference works is a must-have resource for anyone working in endocrinology, osteology, bone biology, or cancer research.


Bone specialists, endocrinologists, basic scientists and researchers interested in vitamin D and osteoporosis prevention.

Table of Contents

Preface to the 3rd Edition

Preface to the 2nd Edition

Preface to the 1st Edition




Relevant Lab Values in Adults and Children

Criteria for Vitamin D Deficiency: 25(OH)D Serum Levels

Approximate normal ranges for serum values in adults

Approximate normal ranges for serum values in children

Useful equivalencies of different units

Volume I

Section I: Chemistry, Metabolism, Circulation

Chapter 1. Historical Overview of Vitamin D

Discovery of the Vitamins

Discovery that Vitamin D is not a Vitamin

Isolation and Identification of Nutritional Forms of Vitamin D

Discovery of the Physiological Functions of Vitamin D

Discovery of the Hormonal Form of Vitamin D



Chapter 2. Photobiology of Vitamin D


Historical Perspective

Photobiology of Vitamin D

Role of Sunlight and Dietary Vitamin D in Bone Health, Overall Health, and Well-Being

Sunlight, Vitamin D, and Skin Cancer




Chapter 3. The Activating Enzymes of Vitamin D Metabolism (25- and 1α-Hydroxylases)


General Information Regarding Vitamin D Hydroxylases

Vitamin D3-25-Hydroxylases

25-Hydroxyvitamin D-1α-Hydroxylase

Additional Topics


Chapter 4. CYP24A1: Structure, Function, and Physiological Role


CYP24A1-Catalyzed Pathways

Structure–Function Relationships

Putative CYP24A1 Involvement in Nonclassical Systems



Chapter 5. The Vitamin D Binding Protein DBP


Vitamin D Binding Protein: Protein and Gene Structure

Functions of DBP

Conclusions and Perspectives



No. of pages:
© 2011
Academic Press
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About the author

John Adams

Affiliations and Expertise

Vice Chair for Research, UCLA-Orthopaedic Hospital Department of Orthopaedic Surgery Director, Orthopaedic Hospital Research Center, University of California, Los Angeles


"In this brief review, it is impossible to cover all the nuances of vitamin D addressed in this book. Interested readers may want to peruse the book chapters to assess relevance to their personal interests. I regard this impressive text as a ‘‘must have’’ in the medical libraries of most hospitals. Clinicians and researchers with an interest in vitamin D may want their own personal copy for ready reference. I highly recommend it and congratulate the authors and editors in providing a much needed reference text on arguably one of the more important nutrients to our species."--American Journal of Human Biology

"In this remarkable compendium, the editors provide a fresh and comprehensive review of a multifaceted and sometimes controversial vitamin D. This third edition is not just an update, but a greatly expanded work organized to authoritatively cover the evidence for new roles of vitamin D in cardiovascular health, immunity, psychiatric disorders, and much more. In more than 100 chapters, experts span the history of vitamin D, update its molecular mechanism and chemistry, provide specifics of clinical use in disorders of the skeleton, and review progress in an array of diseases including diabetes, inflammatory bowel disease, multiple sclerosis, and psoriasis. In this edition one finds new information for a broad audience including internal medicine, nutrition, orthopedics, basic scientists, and teachers. How does one define optimal vitamin D status? How does vitamin D affect innate immunity? What are the epigenetic modifications of the vitamin D receptor that contribute to its function? Are there other natural ligands for the vitamin D receptor? These are a part of the new increased scope of Vitamin D, Third Edition. If you are interested in vitamin D, you should have this book."

—Mark S. Nanes, MD, PhD, Professor of Medicine, Emory University, Atlanta, GA, USA

"The Third Edi