Visceral Leishmaniasis

1. Visceral leishmaniasis: An overview
2. Maintenance of Leishmania parasite
3. Host immunity and immunomodulation
4. VL and natural products
5. Antileishmanial drug screening
6. Vaccine and Vaccination
7. Different vaccination approaches for development of vaccine
8. Adjuvants
9. Vaccine delivery system
10. Routes of vaccination
11. Animal models for VL
12. Vaccination approaches for VL
13. Current status in Leishmania vaccine and problems to be solved
14. Amastigote based vaccine: Silver lining in Leishmaniasis

Visceral Leishmaniasis: Therapeutics and Vaccines describes current therapeutics, natural anti-leishmanial molecules, anti-leishmanial screening, and explores vaccine candidates and amastigote-based vaccination strategies for Leishmania. The book provides a precise view on VL, Leishmania parasite culture, host immunity and immunomodulation, natural compounds effective against VL, animal models for VL, and methodologies available for anti-leishmanial drug screening procedures against VL, as well as vaccine and vaccination-related information on Leishmaniasis. Readers will find concrete information on past and current hurdles facing vaccine development for Leishmania, along with scientific opportunities and the potential impact of vaccines, including problems encountered.

The book is designed to increase the understanding of vaccines, particularly in VL, for students and researchers. Although vaccines are now available for many diseases, there are still challenges ahead for a vaccine for VL. The ideal vaccine must be safe and able to induce an immune response that is strong and effective. In a nutshell, a combination of chemotherapy (drugs) and immunoprophylaxis (vaccine) would be ideal to win the battle against VL.

• Provides the first dedicated book on Visceral Leishmaniasis (VL) and anti-leishmanial screening
• Covers major aspects of the fatal disease Visceral Leishmaniasis
• Provides plenty of illustrations and figures
• Includes methods of anti-leishmanial drug screening
• Expands the perspective of readers on the complex problem of drug screening

Basic and applied researchers in immunology, microbiology, biochemistry, molecular biology, medicinal chemistry. Specialists in different sub-disciplines in medicine (parasitology, infection biology), and students in related areas