Visceral and Ectopic Fat

Visceral and Ectopic Fat

Risk Factors for Type 2 Diabetes, Atherosclerosis, and Cardiovascular Disease

1st Edition - October 1, 2022

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  • Editor: Hildo Lamb
  • Paperback ISBN: 9780128221860

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While the health consequences and mechanisms by which visceral fat causes disease are well-studied, relatively less is known about ectopic fat, its patterns of deposition and its effects on the pathoetiology of type 2 diabetes, atherosclerosis, and cardiovascular disease. Visceral and Ectopic Fat: Risk Factors for Type 2 Diabetes, Atherosclerosis, and Cardiovascular Disease covers the wealth of literature that has been amassed over the past decade on this topic. This reference brings all the research and clinical data together in one volume and helps clinicians and academic researchers understand more thoroughly the underlying mechanisms and interrelation between fat depots and ectopic fat stores in relation to health and disease. It showcases some of the recent developments in adipose tissue biology, particularly on the impact of interventional strategies - bariatric surgery, liposuction, physical and dietary intervention - of which information is desired among health specialists and policy makers.

Key Features

  • Brings together up-to-date research on imaging, genetics, and risk factors for chronic diseases such as diabetes, heart disease, cancer, and fatty liver disease
  • Takes a deep dive into the current state of knowledge regarding fat stores, ectopic fat, regulation of fat stores, clinical implications, interventions, and imagining techniques
  • Provides up-to-date information specifically focused on visceral and ectopic fat. In addition, both pathophysiological and preventive and treatment aspects of the problem will be considered
  • Covers a broad range of organs - different fat stores such as skeletal muscle, bone marrow, liver and kidney
  • Discusses potential interventions to reduce abdominal fat


Endocrinologists; diabetologists; general practitioners; cardiologists; and internal medicine

Table of Contents

  • Part I: Fat Stores
    1. Obesity/VAT/SAT/Sex specific
    2. Obesity and fat distribution in children and adolescents
    3. Brown Adipose Tissue
    4. Pericardial and peri-coronary fat

    Part II: Ectopic fat stores
    5. Noninvasive profiling of ectopic lipids
    6. Flexibility of ectopic lipids
    7. Liver
    8. Myocardial Lipids - Techniques and Applications of Proton Magnetic Resonance Spectroscopy of the Human Heart
    9. Pancreas ectopic fat: imaging-based quantification
    10. Ectopic fat accumulation around and within the kidney
    11. Skeletal muscle
    12. Bone marrow adipose tissue

    Part III: Regulation of fat stores
    13. Endocrinological pathways
    14. The role of inflammation of fat tissue in relation to obesitas

    Part IV: Clinical Aspects
    15. Role of adipose tissue remodelling in diabetic heart disease
    16. Cardiovascular Disease 17. Obesity in Relation to Cardiorenal function
    18. Lung/Asthma
    19. Brain Atrophy

    Part V: Interventions
    20. The impact of Very Low-Calorie Diets on ectopic fat deposition
    21. Intermittent Fasting
    22. Exercise
    23. Combined Lifestyle Intervention
    24. Medical Therapy
    25. Gastric Volume Reduction
    26. Gastric Bypass
    27. Fecal Transplant

Product details

  • No. of pages: 350
  • Language: English
  • Copyright: © Elsevier 2022
  • Published: October 1, 2022
  • Imprint: Elsevier
  • Paperback ISBN: 9780128221860

About the Editor

Hildo Lamb

Prof. dr. Hildo J. Lamb MD, PhD is Professor of Radiology and Director of Cardiovascular Imaging at Leiden University Medical Center, The Netherlands. His clinical focus is on cardiovascular radiology, thoracic radiology, mammography, and pediatric radiology. His main research focus is currently on diseases related to obesity and diabetes mellitus. He is actively involved in scientific research in the field of non-invasive cardiovascular and body imaging, focusing on development of cardiovascular imaging techniques with fast conversion to clinical application, including 3D imaging, fast acquisition techniques and MR spectroscopy. He is a member of the Dutch scientific council for medical specialists (FMS), board member of the Dutch council for healthcare evaluation program, Dutch representative in the UEMS (European Union of Medical Specialists) section Radiology and member of the scientific board of the ESR. He is deputy editor of cardiovascular imaging for JMRI and a member of the cardiovascular scientific program committee for RSNA.

Affiliations and Expertise

Professor of Radiology and Director of Cardiovascular Imaging, Leiden University Medical Center, The Netherlands

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