Viruses: Molecular Biology, Host Interactions, and Applications to Biotechnology provides an up-to-date introduction to human, animal and plant viruses within the context of recent advances in high-throughput sequencing that have demonstrated that viruses are vastly greater and more diverse than previously recognized. It covers discoveries such as the Mimivirus and its virophage which have stimulated new discussions on the definition of viruses, their place in the current view, and their inherent and derived ‘interactomics’ as defined by the molecules and the processes by which virus gene products interact with themselves and their host’s cellular gene products.
Further, the book includes perspectives on basic aspects of virology, including the structure of viruses, the organization of their genomes, and basic strategies in replication and expression, emphasizing the diversity and versatility of viruses, how they cause disease and how their hosts react to such disease, and exploring developments in the field of host-microbe interactions in recent years. The book is likely to appeal, and be useful, to a wide audience that includes students, academics and researchers studying the molecular biology and applications of viruses
- Provides key insights into recent technological advances, including high-throughput sequencing
- Presents viruses not only as formidable foes, but also as entities that can be beneficial to their hosts and humankind that are helping to shape the tree of life
- Features exposition on the diversity and versatility of viruses, how they cause disease, and an exploration of virus-host interactions
Researchers, students and academics in Virology, Molecular Biology, Biotechnology, and Microbiology
Section 1. Virus biology, taxonomy, replication and host interactions
1. Introduction. A short history along with the reasons why viruses are studied and used.
2. Structure and Taxonomy. Types (nucleic acids) and organization of virus genomes and how these two factors define Virus Taxonomy.
3. Replication and expression strategies. Strategies of expression exploited by viruses, many of which are not utilized by cellular organisms.
4. Origin and evolution of viruses. Recently discovered viruses, hypotheses of virus origin and evolution.
5. Virus- host interactions, virus transmission and emerging diseases. The three areas will be presented separately, with emphasis on how the first two define the latter.
6. Host resistance and pathogen virulence. Explanations of the molecular mechanics of viral diseases.
7. Diagnosis and management of virus diseases. Ways by which viruses are detected, characterized and controlled/managed-if not avoided
Section 2 Viruses as pathogens, symbionts and tools for biotechnology
8. Viruses as Pathogens
Each section will address the causative virus, taxonomy (structure, genetics, (strains+ phylogenetics), host range, transmission, disease and symptoms induced in the hosts, distribution, economic impact, diagnostic methods and management strategies. The pathogenic viruses (at least two examples from each group of the Baltimore system) to be covered include:
African cassava mosaic disease begomovirus complex
Banana bunchy top nanovirus
Barley yellow dwarf disease luteovirus complex
Cucumber mosaic cucumovirus
Maize streak mastrevirus
Sweet potato feathery mottle potyvirus
Human immunodeficiency virus, Hepatitis C virus and cancer viruses
Foot and mouth disease virus
Saccharomyces cerevisiae virus L-A, Leishmania virus
Prymnesium kappa virus RF01
Bacteriophages of the digestive tract
Chapter 9. Viruses as Symbionts
It is becoming increasingly evident that the view of viruses as mere pathogens is outdated. These entities are being seen as symbiotic agents directly contributing, and in some cases essential, to the health and fitness of their hosts. This chapter will explore the nature of these interactions across a range of hosts.
• Virus- bacteria interactions: enhanced growth and fecundity, and expanded host range
• Virus- insect interactions: enhanced fitness parameters including virus resistance
• Virus –mammal interactions: regulated immunophenotypes
• Virus-plant interactions: improved drought and cold tolerance, enhanced resistance to secondary pathogens and manipulated pathogen transmission
Chapter 10. Viruses as Tools for Biotechnology: Therapeutic agents, carriers of therapeutic agents and genes
Virus-based treatments constitute a fast-growing niche. This chapter will cover developments in the areas of:
• Anti-cancer oncolytic viruses
• Virus vectors for gene therapy
• Virus immunotherapy: active vs. passive immunity; cellular vs. humoral responses
• Virus-based vaccine technologies: active, attenuated viruses; inactivated viruses; protein subunits; vaccines based in active recombinant viruses, including viruses expressing neutralizing antibodies and synthetic peptides; mass production of virus-based vaccines: embryonated eggs and plant virus vectors
• Viruses as biotemplates for nanomaterials
• Antiviral resistance in transgenic plants
- No. of pages:
- © Academic Press 2018
- 1st March 2018
- Academic Press
- Paperback ISBN:
Dr. Tennant received her PhD from Cornell University were she also completed her postdoc prior to returning to Jamaica as a Professor within the Life Sciences at The University of the West Indies. She has been a Visiting Scientist at Cornell University, US Pacific Basin Agricultural Research Center, and Texas A&M and a visiting lecturer at the Universidad de Los Andes, Venezuela. She has edited or co-edited 6 books and contributed chapters to an additional 7 volumes. She has received numerous awards, including Principal’s Award for the Best Publication, Principal’s Award for the Most Outstanding Researcher, HKA Career Hall of Fame Award, and Faculty’s Award for Outstanding Achievement.
University of West Indies, Kingston, Jamaica
Dr. Fermin completed his PhD at Cornell University and took positions at Cornell University and University of Hawaii and Pacific Basin Agricultural Research Center before returning to Venezuela as a faculty member at Universidad de Los Andes. His research is within molecular biology and plant pathology with a focus on viral impacts. He has received the Regional Award in Exact and Natural Sciences and multiple Researcher’s Recognition awards for his work. He has authored or edited 12 monographs.
Universidad de Los Andes, Merida, Venezuela
Dr. Jerome Foster completed his PhD in Biochemistry at the University of the West indies, St. Augustine (2004). He pubished 14 articles on virology focusing on viruses in Trinidad and S. America.
University of West-Indies, St. Augustine, Trinidad