From Understanding to Investigation

2nd Edition - September 23, 2022

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  • Author: Susan Payne
  • Paperback ISBN: 9780323903851
  • eBook ISBN: 9780323984768

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Viruses: From Understanding to Investigation, Second Edition presents the definitions and unique characteristics of viruses. The book includes major topics such as virus lifecycle, structure, taxonomy, evolution, history, host-virus interactions, and methods to study. In addition, the book assesses the connections between the aforementioned topics and provides an integrated approach and in-depth understanding of how viruses work. The new edition also provides an expanded methods chapter containing new information on deep sequencing for in virus identification, mathematical formulas to calculate titers and a description of quantitiative PCR for enumerating viruses. The vaccine chapter has been updated to include vaccine efficacy, mRNA vaccines and SARS-CoV-2 vaccine development. The viral pathogenesis chapter has been expanded to include mechanisms of virally induced cancers. Viral taxonomy sections have been updated and chapters revised to accommodate new virus family designations. New chapters include nucleocytoplasmic viruses (very large DNA viruses), replication of viroids and COVID-19/SARS-CoV-2.

Key Features

  • Employs a comparative strategy to emphasize unique structural and molecular characteristics that inform transmission, disease processes, vaccine strategies, and host responses
  • Presents a review of host cell, molecular biology, and the immune system
  • Features topical areas of research, including genomics in virus discovery, the virome, and beneficial interactions between viruses and their hosts
  • Includes text boxes throughout with experimental approaches used by virologists
  • Covers learning objectives in each chapter


Advanced undergraduate, graduate students, and professors in virology, molecular biology and microbiology

Table of Contents

  • 1. Introduction to animal viruses
    2. Virus structure
    3. Virus interactions with the cell
    4. Methods to study viruses
    5. Virus transmission and epidemiology
    6. Immunity and resistance to viruses
    7. Viral vaccines
    8. Antiviral agents
    9. Virus evolution and genetics
    10. Viral pathogenesis
    11. Introduction to RNA viruses
    12. Family Picornaviridae
    13. Family Caliciviridae
    14. Family Hepeviridae
    15. Family Astroviridae
    16. Family Flaviviridae
    Families Togaviridae and Matonaviridae
    18. Family Coronaviridae
    19. SARS-CoV-2/COVID-19
    20. Family Arteriviridae
    21. Family Rhabdoviridae
    22. Family Paramyxoviridae
    23. Family Pneumoviridae
    24. Family Filoviridae
    25. Family Bornaviridae
    26. Family Orthomyxoviridae
    27. Family Hantaviridae
    28. Order Bunyavirales: Families Peribunyaviridae, Phenuiviridae, and Nairoviridae
    29. Family Arenaviridae
    30. Family Reoviridae
    31. Family Birnaviridae
    32. Hepatitis delta virus
    33. Introduction to DNA viruses
    34. Family Parvoviridae
    35. Other small DNA viruses
    36. Family Polyomaviridae
    37. Family Papillomaviridae
    38. Family Adenoviridae
    39. Family Herpesviridae
    40. Family Poxviridae
    41. Other large DNA viruses
    42. Family Retroviridae
    43. Replication and pathogenesis of human immunodeficiency virus
    44. Family Hepadnaviridae


Product details

  • No. of pages: 438
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: September 23, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780323903851
  • eBook ISBN: 9780323984768

About the Author

Susan Payne

Susan Payne is an associate professor emeritus at Texas A&M University. Her primary research interests were molecular aspects of viral replication, pathogenesis and evolution. For many years her research focused on equine infectious anemia virus (EIAV), an equine retrovirus. She published extensively on genetic and antigenic variation and the molecular basis of EIAV pathogenesis. She also studied avian bornaviruses, negative strand RNA viruses that are the etiological agents of proventricular dilatation disease of parrots. Her long teaching career included courses for undergraduate and graduate students as well as participation in courses for medical and veterinary students. She was a member of the Bornavirus Study Group of the International Committee for Taxonomy of Viruses from 2014-2019.

Affiliations and Expertise

Associate Professor, Department of Veterinary Medicine and Biomedical Sciences, Texas A&M University, USA

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