Viruses, Evolution and Cancer Basic Considerations

Viruses, Evolution and Cancer Basic Considerations

1st Edition - January 1, 1974

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  • Editor: Edouard Kurstak
  • eBook ISBN: 9780323142298

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Viruses, Evolution and Cancer: Basic Considerations focuses on comparative biology and evolutionary aspects of DNA and RNA oncogenic viruses. Organized into seven parts, this book begins with a discussion on the host-cell-virus relationships. Some chapters follow that discuss the comparative aspects of DNA and RNA oncogenic viruses. This work also elucidates the effects of oncogenic viruses on cell surface metabolism. Other chapters explore the comparative viral oncology, comparative immunology of oncogenic viruses, and evolution of viruses. This book will be an invaluable material both to those concerned in the scientific and medical problems of cancer and will benefit all who are interested in virology and oncology.

Table of Contents

  • List of Contributors



    Part I Host-Cell-Virus Relationships

    Chapter 1. Host-Virus Relationship at the Embryonic Level

    I. Introduction

    II. Differentiation of Early Mammalian Embryos in Vitro

    III. Endogenous Viral Particles in Mouse Embryos

    IV. Interaction of Oncogenic Viruses with Mouse Embryos


    Chapter 2. DNA Transfer and Virus-Cell Relationships

    I. Introduction

    II. Rescue of SV40 from Transformed Cells

    III. Alteration of Hamster Cells by Exposure to Simian Cell DNA

    IV. Formation of "Heterologous" SV40 Pseudovirions

    V. Discussion and Forecast


    Chapter 3. Viruses with Separately Encapsidated Complementary DNA Strands

    I. Introduction and Nomenclature

    II. Adeno-associated Satellite Viruses (ASV, AAV) and Densonucleosis Virus (DNV)

    III. Adeno-associated Satellite Viruses and Densonucleosis Virus and Disease

    IV. Adeno-associated Satellite Viruses and Densonucleosis Virus and Cancer

    V. Conclusions


    Chapter 4. The Epstein-Barr Viral Genome and Its Interactions with Human Lymphoblastoid Cells and Chromosomes

    I. The Virus

    II. Viral DNA

    III. Techniques of Nucleic Acid Hybridization

    IV. Interactions of the Viral Genome in Various Tissues

    V. Problems and Conclusions


    Part II Comparative Aspects of DNA Oncogenic Viruses

    Chapter 5. Comparison of Genome Replication Mechanisms of Oncogenic DNA Viruses

    I. Introduction

    II. Papovaviruses

    III. Adenoviruses

    IV. Concluding Remarks


    Chapter 6. Early Proteins of Oncogenic Papovaviruses

    I. Introduction

    II. Early and Pre-early Functions

    III. Intranuclear and Plasma Membrane Events

    IV. Intranuclear Immunological Changes after Virus Infection

    V. Are Early Intranuclear Antigens Polypeptides of Viral Information?

    VI. Identification and Attempts to Purify Early Viral Proteins

    VII. Viral Enzymes: Possible Candidates


    Chapter 7. Adenovirus Genes and Cancer

    I. Introduction

    II . Conditionally Lethal Temperature-Sensitive (ts) Mutants of Type 5 Adenovirus

    III. Temperature-Sensitive Mutants of Type 12 Adenovirus

    IV. Intertypic Complementation with Type 5 and Type 12 ts Mutants

    V. Transformation of Rat Embryo Cells by Type 5 Adenoviruses

    VI. Perspectives


    Chapter 8. Herpesvirus Etiology of Abnormal Growth

    I. Introduction

    II. Oncogenicity of Animal Herpesviruses

    III. Association of Human Herpesviruses with Neoplasia

    IV. Transformation by Human Herpesviruses

    V. Role of the Herpesvirus Genome in Oncogenicity

    VI. Future Expectations


    Part III Comparative Aspects of RNA Oncogenic Viruses

    Chapter 9. Replication and Integration of the Genome of Oncornaviruses

    I. Introduction

    II. The Viral Genome

    III. The DNA "Provirus"

    IV. The Cryptic Viruses

    V. Discussion


    Chapter 10. Comparison and Evolution of RNA Tumor Virus Components

    I. Introduction

    II. Materials and Methods

    III. Results

    IV. Discussion


    Chapter 11. Genetics and Biology of Murine Leukemia Virus

    I. Introduction

    II. Isolation of ts Mutants of MuLV

    III. Complementation by ts Mutants of MuLV

    IV. Characterization of ts Mutants of MuLV

    V. Genetic Recombination in MuLV

    VI. Models of the Genome of MuLV

    VII. Evidence That the RNA of the Virion is Segmented

    VIII. Conclusions


    Chapter 12. Comparative Biology of Murine and Avian Tumor Viruses

    I. Introduction

    II. Delineation of the Oncornavirus Group

    III. Interactions between Host Genome and Oncornaviruses

    IV. Technological Aspects of the Study of Oncornaviruses

    V. Some Biological Aspects of Various Oncornaviruses

    VI. Comparative Biology of Avian and Murine Tumor Viruses

    VII. Genetics of Susceptibility to Oncornaviruses

    VIII. Endogenous Oncornaviruses

    IX. General Discussion

    X. Epilogue


    Part IV Viruses, Cell, Surface and Transformation

    Chapter 13. The Cell Surface, Virus Modification, and Virus Transformation

    I. Introduction

    II. Interactions of Viruses with the Cell Surface

    III. Oncogenic Viruses

    IV. Virus Transformation: Its Relationship to Cellular Metabolism of Surface Molecules

    V. Conclusions and Comments


    Part V Comparative Viral Oncology

    Chapter 14. Comparative Morphology, Immunology, and Biochemistry of Viruses Associated with Neoplasia of Animals and Man

    I. Introduction

    II. Morphological Studies

    III. Biological Studies

    IV. Immunological Studies

    V. Biochemical Studies

    VI. Conclusion


    Chapter 15. Comparative Properties of Plant Tumors

    I. Introduction

    II. Different Types of Tumors

    III. Plant Tumors: Differentiation, Dedifferentiation, and Cell Multiplication

    IV. Induction and the Nature of the Tumor-Inducing Principle

    V. Conclusion


    Chapter 16. A New Look at the Mode of Action of Polyoma and Related Tumor Viruses

    I. Introduction

    II. The Lysogeny Hypothesis

    III. The Lysogeny Hypothesis Critically Revisited

    IV. The Mitogenic Effect of SV 40 and Polyoma Virus in Tissue Culture Cells

    V. Polyoma-Induced Tumor Formation Revisited

    VI. The Shope Papilloma Virus (SPV)

    VII. A Comparison between Viral and Chemical Carcinogenesis

    VIII. Discussion and Conclusions


    Part VI Comparative Immunology of Oncogenic Viruses

    Chapter 17. Immunological Patterns of Virus-Transformed Neoplastic Cells

    I. Intranuclear Antigens

    II. Virus-Induced Membrane Antigen Changes


    Chapter 18. The Immune Response to Oncornavirus Infections

    I. Introduction

    II. Antigens of Avian, Feline, and Murine C Type Oncornaviruses

    III. Tumor Cell Membrane Antigens Associated with Oncornavirus Infections

    IV. Immune Response to Avian Oncornavirus Infections

    V. Immune Response to Feline Oncornavirus Infections

    VI. Immune Response to Murine Oncornavirus Infections

    VII. Summary and Conclusions


    Chapter 19. Prospects for Vaccines against Cancer

    I. Introduction

    II. Cancer

    III. Closing Remarks


    Part VII Viruses and Their Evolution

    Chapter 20. Visualization of the Evolution of Viral Genomes

    I. Introduction

    II. Reducing the Genome Size

    III. Increasing the Genome Size

    IV. Shortening the Intergene Distance

    V. Insertosomes

    VI. Acquiring a New Function

    VII. Hybrid Phages

    VIII. Plasmids

    IX. Conclusions

    X. Summary


    Chapter 21. Comparative Structure, Chemistry, and Evolution of Mycoplasmaviruses

    I. Historical Background

    II. Virus Particles

    III. Growth Cycle

    IV. Virus Replication

    V. Transfection

    VI. Evolutionary Considerations

    VII. Concluding Remarks

    VIII. Appendix: Calculation of Adsorption Rate Constant


    Chapter 22. The Evolution (Evovirology) of Herpesviruses

    I. Introduction

    II. The Problem of Classification

    III. Origin of Herpesviruses

    IV. The Matter of Survival

    V. Phytogeny of Herpesviruses

    VI. Envoi


    Chapter 23. Evolution of Orthomyxoviruses

    I. Introduction

    II. The Virus

    III. Antigenic Variation of Influenza Viruses

    IV. Possible Mechanisms for Evolution of Pandemic Influenza A Viruses

    V. Evidence for the Progenitors of the Hong Kong Strain of Human Influenza Virus

    VI. Conclusions


    Chapter 24. Reovirus: Early Events (in the Infected Cell) and Structure of the Double-Stranded RNA Genome

    I. Introduction

    II. Regulation of Transcription

    III. "Early" Proteins Synthesized in Infected Cells

    IV. Structure of the Viral Genome


    Chapter 25. Physiological Properties of Vesicular Stomatitis Virus and Some Related Rhabdoviruses

    I. Introduction

    II. Structural Features of the VSV Group

    III. Some Intracellular Events in the Replication of VSV

    IV. Replication of T Particles

    V. Intracellular Events during Interference

    VI. Nucleic Acid Homology to Indiana VSV

    VII. Conclusions and Speculations


    Chapter 26. Evolution of Rhabdovirus Tropisms

    I. Introduction

    II. Vesicular Stomatitis Virus Tropism in Experimental Animals

    III. Rabies and Rabies-Like Virus Tropism in Experimental Animals

    IV. Tropism of Other Rhabdoviruses of Animals

    V. Evolutionary Significance of Varying Tropisms


    Chapter 27. The Biological Activity of Heterogeneous Particle Types of Plant Viruses

    I. Terminology

    II. The Basis of Heterogeneity

    III. Techniques of Particle Separation

    IV. Variation in Proportion of Particle Types

    V. Role of Particle Types in Initiating Infection

    VI. Multiple-Hit Dilution Curves

    VII. Genetic Aspects of the Multiparticulate State

    VIII. Comments


    Chapter 28. Viroids as Prototypes or Degeneration Products of Viruses

    I. Introduction

    II. Recent Progress with the Potato Spindle Tuber Viroid (PSTV)

    III. Other Viroids and Suspected Viroids

    IV. Viroid Replication

    V. Possible Origin of Viroids



Product details

  • No. of pages: 836
  • Language: English
  • Copyright: © Academic Press 1974
  • Published: January 1, 1974
  • Imprint: Academic Press
  • eBook ISBN: 9780323142298

About the Editor

Edouard Kurstak

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