- Print ISBN 9780444505804
- Electronic ISBN 9780080953649
In some countries, HCC is one of the most common tumors of adult men. In addition, there is evidence that the incidence of this cancer has doubled in the past 15 to 20 years in many countries, and the incidence has doubled every 20 years for the past half century in Japan. In some studies, the increase has been shown to be due primarily to cases associated with HCV infection.
Molecular studies of HCC show that mutations in oncogenes, in various cellular repair pathways, and in tumor suppressor genes together appear to contribute to the development of this cancer. In HCCs associated with hepatitis B virus, the virus itself can interact with tumor suppressor proteins and other cellular signals in ways that probably permit HCC to develop even when there are no mutations in the genes for these signals.
This work discusses the latest concepts in molecular biology and the study of HCC which have led to dramatic breakthroughs in our understanding of how it develops.
B. Molecular Biology of Hepatocellular Carcinoma.
1. Oncogenes and Growth Factors (Y. Morishita).
2. Tumor Suppressor Genes (R.B. Ray).
3. Viral Molecular Biology of Hepatitis C Virus in Hepatocellular Carcinoma (K. Kobayashi).
C. Clinical Aspects of Hepatocellular Carcinoma Associated with Virus Infections (D. Shouval).
D. Pathology of Hepatocellular Carcinoma (M. Kojiro).
E. Animal Viruses as Models for Human Hepatocellular Carcinoma (P. Tiollais).
F. Prevention of Hepatocellular Carcinoma Associated with Virus Infections.
1. Immunization (D.-S. Chen).
2. Interferon (J. Bruix).
G. Treatment of Hepatocellular Carcinoma Associated with Virus Infections (A. DiBisceglie).