Viral Replication Enzymes and their Inhibitors Part B

Viral Replication Enzymes and their Inhibitors Part B

1st Edition - November 25, 2021

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  • Editors: Craig Cameron, Jamie Arnold
  • Hardcover ISBN: 9780323900164
  • eBook ISBN: 9780323900171

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Description

Viral Replication Enzymes and their Inhibitors, Part B, Volume 50 in The Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics surrounding enzymes.

Key Features

  • Provides the authority and expertise of leading contributors from an international board of authors
  • Presents the latest release in The Enzymes series

Readership

Specialists in the field of Enzymes

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Contributors
  • Preface
  • Chapter One: Structure and function of the poxvirus transcription machinery
  • Abstract
  • 1: Introduction
  • 2: Structure of the poxviral core polymerase and its relation to nuclear polymerases
  • 3: The elongation complex
  • 4: The complete vaccinia RNA polymerase
  • 5: Perspectives of poxvirus structural biology
  • Chapter Two: Structure and function of negative-strand RNA virus polymerase complexes
  • Abstract
  • 1: Introduction
  • 2: Architecture of the negative-strand RNA virus replication machinery
  • 3: Polymerase domains and functions
  • 4: Models of RNA synthesis
  • 5: Conclusions and perspectives
  • Chapter Three: DNA polymerases of herpesviruses and their inhibitors
  • Abstract
  • 1: Introduction
  • 2: Herpesvirus DNA polymerases
  • 3: Antiviral agents targeting herpesvirus DNA polymerases
  • 4: Resistance of herpesviruses to DNA polymerase inhibitors
  • 5: Conclusions and perspectives
  • Acknowledgments
  • Chapter Four: Herpesvirus DNA polymerase: Structures, functions, and mechanisms
  • Abstract
  • 1: Introduction
  • 2: Overview of mechanisms of genome replication during productive infection
  • 3: HSV DNA polymerase—The first quarter century
  • 4: Structures of herpesvirus polymerase subunits and the holoenzyme
  • 5: Activities of Pol
  • 6: Activities of UL42
  • 7: Replication fidelity (or lack thereof)
  • 8: Approaches to new antiviral DNA polymerase inhibitors
  • 9: Conclusions and perspectives including unanswered questions
  • Acknowledgments
  • Chapter Five: Retroviral reverse transcriptase: Structure, function and inhibition
  • Abstract
  • 1: Discovery of reverse transcriptase
  • 2: HIV reverse transcription
  • 3: Structure of HIV RT
  • 4: Mechanism of RT DNA polymerization
  • 5: Mechanism of HIV RT RNase H
  • 6: Nucleoside RT inhibitors (NRTIs)
  • 7: Nonnucleoside RT inhibitors (NNRTIs)
  • 8: Conclusions
  • Acknowledgments
  • Chapter Six: The hepatitis B virus polymerase
  • Abstract
  • 1: HBV—The virus and disease
  • 2: Viral replication cycle
  • 3: Reverse transcription
  • 4: Polymerase gene structure, genetics, and expression
  • 5: pgRNA binding, encapsidation, and enzymatic activation
  • 6: DNA priming
  • 7: Role of P in strand transfer reactions
  • 8: Reverse transcriptase and DNA polymerase activities
  • 9: Ribonuclease H activity
  • 10: Roles of P in addition to genomic replication
  • 11: P as a drug target
  • 12: Comparison to retroviral reverse transcriptases
  • 13: Perspectives
  • Acknowledgments
  • Chapter Seven: Retroviral RNase H: Structure, mechanism, and inhibition
  • Abstract
  • 1: Introduction
  • 2: RNH function in retrovirus
  • 3: RNH inhibition
  • 4: Summary
  • Chapter Eight: Retroviral integrase: Structure, mechanism, and inhibition
  • Abstract
  • 1: Introduction
  • 2: Enzymatic functions of retroviral IN
  • 3: Structures of individual IN domains
  • 4: IN multimerization
  • 5: Structures of multi-domain IN constructs
  • 6: Structures of nucleoprotein intasome assemblies
  • 7: Molecular mechanism of retroviral integration
  • 8: Chromatin engagement by a retroviral intasome
  • 9: The role of host factors in the enzymatic activity of IN
  • 10: Non-catalytic functions of retroviral IN
  • 11: Catalytic inhibition of integration
  • 12: Clinically approved INSTIs for use in antiretroviral therapy
  • 13: Developmental INSTIs containing the naphthyridine core scaffold
  • 14: Viral resistance against clinically used INSTIs
  • 15: Future directions with INSTI development
  • 16: Allosteric integrase inhibitors
  • 17: Concluding remarks
  • Acknowledgments
  • Chapter Nine: Viral proteases: Structure, mechanism and inhibition
  • Abstract
  • 1: Introduction
  • 2: Viral proteases targeted with antiviral drugs
  • 3: Viral proteases as emerging therapeutic targets
  • 4: Conclusion
  • Acknowledgments
  • Chapter Ten: RNA helicases required for viral propagation in humans
  • Abstract
  • 1: Introduction
  • 2: Hepatitis C virus NS3 helicase
  • 3: Coronaviruses, SARS CoV-1 and SARS CoV-2 NSP13 helicases
  • 4: DEAD-Box RNA helicases in viral multiplication not encoded in the viral genome
  • Chapter Eleven: Viral genome packaging machines: Structure and enzymology
  • Abstract
  • 1: Introduction
  • 2: The terminase enzymes
  • 3: The lambda system
  • 4: Initiation of genome packaging
  • 5: The genome packaging complex
  • 6: The translocating motor
  • 7: Termination of packaging
  • 8: Conclusion

Product details

  • No. of pages: 430
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: November 25, 2021
  • Imprint: Academic Press
  • Hardcover ISBN: 9780323900164
  • eBook ISBN: 9780323900171

About the Serial Volume Editors

Craig Cameron

Craig E. Cameron is at UNC School of Medicine, NC, USA

Affiliations and Expertise

UNC School of Medicine, NC, USA

Jamie Arnold

Jamie J. Arnold is at UNC School of Medicine, Chapel Hill, NC, USA

Affiliations and Expertise

UNC School of Medicine, Chapel Hill, NC, USA

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