Viral Replication Enzymes and their Inhibitors Part B

1st Edition, Volume 50 - November 25, 2021
Editors: Craig E. Cameron, Jamie J. Arnold
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 9 0 0 1 6 - 4
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 0 0 1 7 - 1

Viral Replication Enzymes and their Inhibitors, Part B, Volume 50 in The Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapte… Read more

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Viral Replication Enzymes and their Inhibitors, Part B, Volume 50 in The Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics surrounding enzymes.

Cover image
Title page
Table of Contents
Copyright
Contributors
Preface
Chapter One: Structure and function of the poxvirus transcription machinery
Abstract
1: Introduction
2: Structure of the poxviral core polymerase and its relation to nuclear polymerases
3: The elongation complex
4: The complete vaccinia RNA polymerase
5: Perspectives of poxvirus structural biology
Chapter Two: Structure and function of negative-strand RNA virus polymerase complexes
Abstract
1: Introduction
2: Architecture of the negative-strand RNA virus replication machinery
3: Polymerase domains and functions
4: Models of RNA synthesis
5: Conclusions and perspectives
Chapter Three: DNA polymerases of herpesviruses and their inhibitors
Abstract
1: Introduction
2: Herpesvirus DNA polymerases
3: Antiviral agents targeting herpesvirus DNA polymerases
4: Resistance of herpesviruses to DNA polymerase inhibitors
5: Conclusions and perspectives
Acknowledgments
Chapter Four: Herpesvirus DNA polymerase: Structures, functions, and mechanisms
Abstract
1: Introduction
2: Overview of mechanisms of genome replication during productive infection
3: HSV DNA polymerase—The first quarter century
4: Structures of herpesvirus polymerase subunits and the holoenzyme
5: Activities of Pol
6: Activities of UL42
7: Replication fidelity (or lack thereof)
8: Approaches to new antiviral DNA polymerase inhibitors
9: Conclusions and perspectives including unanswered questions
Acknowledgments
Chapter Five: Retroviral reverse transcriptase: Structure, function and inhibition
Abstract
1: Discovery of reverse transcriptase
2: HIV reverse transcription
3: Structure of HIV RT
4: Mechanism of RT DNA polymerization
5: Mechanism of HIV RT RNase H
6: Nucleoside RT inhibitors (NRTIs)
7: Nonnucleoside RT inhibitors (NNRTIs)
8: Conclusions
Acknowledgments
Chapter Six: The hepatitis B virus polymerase
Abstract
1: HBV—The virus and disease
2: Viral replication cycle
3: Reverse transcription
4: Polymerase gene structure, genetics, and expression
5: pgRNA binding, encapsidation, and enzymatic activation
6: DNA priming
7: Role of P in strand transfer reactions
8: Reverse transcriptase and DNA polymerase activities
9: Ribonuclease H activity
10: Roles of P in addition to genomic replication
11: P as a drug target
12: Comparison to retroviral reverse transcriptases
13: Perspectives
Acknowledgments
Chapter Seven: Retroviral RNase H: Structure, mechanism, and inhibition
Abstract
1: Introduction
2: RNH function in retrovirus
3: RNH inhibition
4: Summary
Chapter Eight: Retroviral integrase: Structure, mechanism, and inhibition
Abstract
1: Introduction
2: Enzymatic functions of retroviral IN
3: Structures of individual IN domains
4: IN multimerization
5: Structures of multi-domain IN constructs
6: Structures of nucleoprotein intasome assemblies
7: Molecular mechanism of retroviral integration
8: Chromatin engagement by a retroviral intasome
9: The role of host factors in the enzymatic activity of IN
10: Non-catalytic functions of retroviral IN
11: Catalytic inhibition of integration
12: Clinically approved INSTIs for use in antiretroviral therapy
13: Developmental INSTIs containing the naphthyridine core scaffold
14: Viral resistance against clinically used INSTIs
15: Future directions with INSTI development
16: Allosteric integrase inhibitors
17: Concluding remarks
Acknowledgments
Chapter Nine: Viral proteases: Structure, mechanism and inhibition
Abstract
1: Introduction
2: Viral proteases targeted with antiviral drugs
3: Viral proteases as emerging therapeutic targets
4: Conclusion
Acknowledgments
Chapter Ten: RNA helicases required for viral propagation in humans
Abstract
1: Introduction
2: Hepatitis C virus NS3 helicase
3: Coronaviruses, SARS CoV-1 and SARS CoV-2 NSP13 helicases
4: DEAD-Box RNA helicases in viral multiplication not encoded in the viral genome
Chapter Eleven: Viral genome packaging machines: Structure and enzymology
Abstract
1: Introduction
2: The terminase enzymes
3: The lambda system
4: Initiation of genome packaging
5: The genome packaging complex
6: The translocating motor
7: Termination of packaging
8: Conclusion

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Craig E. Cameron

Jamie J. Arnold