Viral Proteases and Their Inhibitors - 1st Edition - ISBN: 9780128097120, 9780128096826

Viral Proteases and Their Inhibitors

1st Edition

Editors: Satya Gupta
eBook ISBN: 9780128096826
Paperback ISBN: 9780128097120
Imprint: Academic Press
Published Date: 6th July 2017
Page Count: 516
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Description

Viral Proteases and Their Inhibitors provides a thorough examination of viral proteases from their molecular components, to therapeutic applications. As information on three dimensional structures and biological functions of these viral proteases become known, unexpected protein folds and unique mechanisms of proteolysis are realized. This book investigates how this facilitates the design and development of potent antiviral agents used against life-threatening viruses. Users will find descriptions of each virus that detail the structure and function of viral proteases, discuss the design and development of inhibitors, and analyze the structure-activity relationships of inhibitors. This book is ideal biochemists, virologists and those working on antiviral agents.

Key Features

  • Provides comprehensive, state-of-the-art coverage of virus infections, the virus lifecycle, and mechanisms of protease inhibition
  • Analyzes structure-activity relationships of inhibitors of each viral protease
  • Presents an in-depth view of the structure and function of viral proteases

Readership

Clinicians, researchers and academics in Virology, Microbiology/Immunology, and Molecular Biology, and medicinal chemistry

Table of Contents

1. Fundamentals of Viruses and Their Proteases
Anjana Sharma and Satya P. Gupta

2. Design and Development of Some Viral Protease Inhibitors by QSAR and Molecular Modeling Studies
Noha Saleh Hanan Elhaes and Medhat Ibrahim

3. Advances in Studies on Adenovirus Proteases and Their Inhibitors
Satya P. Gupta Basheerulla Shaik and Y. S. Prabhakar

4. Alpha-virus Nonstructural Proteases and Their Inhibitors
Akalabya Bissoyi, Subrat Kumar Pattanayak Arindam Bit Ashish Patel, Abhishek

5. Structure and Function of Alphavirus Protease
Shailly Tomar and Megha Aggarwal

6. Flavivirus Protease: An Antiviral Target
Shailly Tomar, Rajat Mudgal and Benazir Fatma

7. Flavivirus NSB/NS3 Protease: Structure, Function, and Inhibition
Zhong Li Jing Zhang Hongmin Li

8. Design and Development of HCV NS5B Polymerase Inhibitors
Debasis Das

9. Studies on HIV-1 Protease and its Inhibitors
Sonal Dubey

10. Studies on Picornaviral Proteases and Their Inhibitors
Vaishali M. Patil and Satya P. Gupta

11. Structural Insight into the Viral 3C-like Protease inhibitors: Comparative SAR/QSAR Approaches
Nilanjan Adhikari Sandip Kumar Baidya Achintya Saha, Tarun Jha

12. Herpesvirus Proteases: Structure, Function, and Inhibition
Kriti Kashyap and Rita Kakkar

13. Design and Development of Inhibitors of Herpes Viral Proteases and Their SAR and QSAR
Dimitra Hadjipavlou-Litina and Satya P Gupta

14. Delicate Dance in Treating Hepatitis C Infections and Overcoming Resistance
Dolly A. Parasrampuria

Details

No. of pages:
516
Language:
English
Copyright:
© Academic Press 2017
Published:
Imprint:
Academic Press
eBook ISBN:
9780128096826
Paperback ISBN:
9780128097120

About the Editor

Satya Gupta

Dr. Gupta is one of the pioneers working in theoretical aspects of drug design. He has many excellent publications in highly reputed journals. He has published several reviews in Chemical Reviews and other review periodicals such as Progress in Drug Research, Current Medicinal Chemistry, etc., and contributed many chapters as well as edited several books for International publishers.

Affiliations and Expertise

Professor Emeritus, Department of Applied Sciences, National Institute of Technical Teachers’ Training and Research, India Fellow, National Academy of Sciences, India