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Viral Polymerases - 1st Edition - ISBN: 9780128154229, 9780128154236

Viral Polymerases

1st Edition

Structures, Functions and Roles as Antiviral Drug Targets

Editor: Satya Gupta
Paperback ISBN: 9780128154229
eBook ISBN: 9780128154236
Imprint: Academic Press
Published Date: 29th October 2018
Page Count: 496
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Viral Polymerases: Structures, Functions and Roles as Antiviral Drug Targets presents in-depth study information on the structure and functions of polymerases and their roles in the lifecycle of viruses, and as drug targets. Viral polymerases constitute a vital component in the lifecycle of many viruses, such as human immunodeficiency virus (HIV), hepatitis viruses, influenza virus, and several others. They are essentially required for the replication of viruses. Thus, the polymerases that can be found in viruses (called viral polymerases) represent favorable targets for the design and development of antiviral drugs.

Key Features

  • Provides comprehensive, state-of-the-art coverage on virus infections, the virus lifecycle, and mechanisms of polymerase inhibition
  • Analyzes the structure-activity relationships of inhibitors of each viral polymerase
  • Presents a consistent and comprehensive coverage of all aspects of viral polymerases, including structure, function and their role as antiviral drug targets


Clinicians, researchers and academics in Virology, Microbiology/Immunology, medicinal chemistry, drug design, biochemistry, enzyme chemistry, molecular biology

Table of Contents

  1. RNA-Dependent RNA Polymerases and Their Emerging Roles in Antiviral Therapy
    2. Structure-Function Relationship of Negative-Stranded Viral RNA Polymerases: Prospectives for Antiviral Therapy
    3. RNA-Dependent RNA Polymerase of Alphaviruses: A Potential Target for the Design of Drugs Against Alphaviruses
    4. DNA-dependent DNA Polymerases as Drug Targets in Herpesviruses and Poxviruses
    5. Polio Virus Polymerase: An Effective Target for Design and Development of Anti-polio Drugs
    6. Studies on HIV-1 Polymerase and its Inhibitors
    7. Adenovirus DNA Polymerase: Structure, Function and Prospects in Diagnostics and Therapeutics
    8. Hepatitis C Virus NS5B RNA-Dependent RNA Polymerase: An Integral Part of HCV Antiviral Therapy
    9. HBV Polymerase as a Target for Development of Anti-HBV Drugs
    10. Polymerases of Coronaviruses: Structure, Function and Inhibitors
    11. Rhinovirus RNA Polymerase: Structure, Function, and Inhibitors
    12. Herpes Virus Polymerase Inhibitors
    13. Zika Virus Polymerase: Structure, Function and Inhibitors
    14. Dengue Virus Polymerase: A Crucial Target for Anti-Viral Drug Discovery
    15. Adenovirus DNA Polymerase: Structure, Function and Prospects in Diagnostics and Therapeutics


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© Academic Press 2018
29th October 2018
Academic Press
Paperback ISBN:
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About the Editor

Satya Gupta

Satya P. Gupta is presently a Professor Emeritus at Meerut Institute of Engineering and Technology (MIET), Meerut, India, after retiring as Professor in the Department of Applied Sciences at National Institute of Technical Teachers’ Training and Research (NITTTR), Bhopal. Earlier he served Tata Institute of Fundamental Research (TIFR), Mumbai, a world renowned Institution of India, Birla Institute of Technology and Science (BITS), Pilani, and then (MIET) as its Director-cum Professor of Eminence in the Department of Pharmacy. Professor Gupta has a very long standing of teaching Quantum Chemistry, Pharmaceutical Chemistry, Biophysics, and Drug Design. He had obtained his M. Sc and D. Phil degrees from University of Allahabad, Allahabad, in 1967 and 1971, respectively. He is a world renowned scientist. For his work in Drug Design, he has bagged several honors and awards. To his credit, Gupta has more than 200 research publications in highly reputed national and international journals and several reviews in such highly prestigious periodicals as Chemical Reviews (American Chemical Society), Progress in Drug Research (Birkhäuser Verlag Basel, Switzerland), and Current Medicinal Chemistry (Bentham Science, Netherlands), and has been on editorial board of several international journals. Dr. Gupta himself has been editor of several scientific journals and books of international repute published by Springer Verlag, Heidelberg Germany; CRC Press, Taylor and Francis Group; Nova Science Publishers, NY, USA; and Elsevier (Academic Press), USA. He has delivered several lectures on Drug Design across the world. His scientific activity has brought him on the forefront of scientific community of the world.

Affiliations and Expertise

Professor Emeritus, Department of Applied Sciences, National Institute of Technical Teachers’ Training and Research, India Fellow, National Academy of Sciences, India

Ratings and Reviews