Viruses are increasingly recognised as the cause of acute gastroenteritis in man, particularly in children. This book provides overviews and updates on current issues relating to basic research, clinical diagnosis, immunology, epidemiology, treatment and prevention of infections with gastroenteritis viruses.

Data are presented and interpreted by leading research groups in 33 chapters spread over 6 sections. The book will be of interest to virologists, gut physiologists, immunologists, epidemiologists, vaccinologists, paediatricians and physicians (infectious diseases), and public health physicians. It will also capture the interests of medical and natural science students and postdoctoral scientists at various levels of their careers.


Virologists, physiologists, immunologists, epidemiologists, vaccinologists, paediatricians and physicians (infectious diseases), and public health physicians.

Table of Contents

Preface. Section I. Viral gastroenteritis: Causes, pathophysiology, immunology, treatment and epidemiology. Introduction. 1. Viral causes of gastroenteritis (U.D. Parashar, R.I. Glass). 2. Physiology and pathophysiology of the gut in relation to viral diarrhea (F. Michelangeli, M.C. Ruiz). 3. The enteric nervous system and infectious diarrhea (O. Lundgren, L. Svensson). 4. Immunology of the gut (P. Brandtzaeg, F.-E. Johansen). 5. Treatment of viral gastroenteritis (D. Bass). Section II. Rotaviruses. Introduction. 1. Structural organization of the genome in rotavirus (J.B. Pesavento, M.K. Estes, B.V.V. Prasad). 2. The three-dimensional structure of rotavirus VP6 (F.A. Rey, J. Lepault, J. Cohen). 3. Attachment and post-attachment receptors for rotavirus (S. López, C.F. Arias). 4. Rotavirus genome replication: role of the RNA-binding proteins (J.T. Patton, K. Kearney, Z. Taraporewala). 5. Translation of rotavirus mRNAs in the infected cell (D. Poncet). 6. The rotavirus NSP4 enterotoxin: current status and challenges (M.K. Estes). 7. Interaction of the rotavirus nonstructural glycoprotein NSP4 with viral and cellular components (J.A. Taylor, A.R. Bellamy). 8. Effects of rotavirus infection on the structure and functions of intestinal cells (A.L. Servin). 9. Microarrays and host-virus interactions: A transcriptional analysis of Caco-2 cells following rotavirus infection (D.A. Feigelstock, M.A. Cuadras, H.B. Greenberg). 10. The rat model of rotavirus infection (M. Ciarlet, M.E. Conner, M.K. Estes). 11. Human adaptive immunity to rotaviruses: A model of intestinal mucosal adaptive immunity (A.M. Gonzalez, M.C. Jaimes et al.). 12. Molecular epidemiology of rotaviruses: Genetic mechanisms associated with diversity (M. Iturriza-Gómara, U. Desselberger, J. Gray). 13. Current state of development of human rotavirus vaccines (P.A. Offit, H.F. Clark, R.L. Ward). 14. Rotavirus-like particle vaccines


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© 2003
Elsevier Science
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About the editors

U. Desselberger

Affiliations and Expertise

Virologie Moléculaire et Structurale, UMR 2472, CNRS, Gif-sur-Yvette, France

J. Gray

Affiliations and Expertise

Enteric Virus Unit, Enteric, Respiratory and Neurological Virus Laboratory, Central Public Health Laboratory, London, UK