Venous Ulcers

Venous Ulcers

2nd Edition - September 1, 2022

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  • Editors: Cynthia K. Shortell, Jovan N. Markovic
  • Paperback ISBN: 9780323906104

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Venous Ulcers, Second Edition provides evidence-based data pertinent to genetics and molecular and biochemical mechanisms that lead to the development and progression of venous ulcers. The book summarizes new findings and advances in the field in a clinically applicable way and serves as an updated and comprehensive source for both researchers and medical professionals who need more information on chronic venous insufficiency. During the last two decades, management of venous ulcers has significantly improved. Most notably, our understanding of genetics, pathophysiology and hemodynamic has evolved along with novel diagnostic and treatment modalities in the management of chronic venous insufficiency patients.

Key Features

  • Provides detailed understanding of molecular mechanisms that lead to venous ulcerations that can provide fertile environment for scientists for further discoveries
  • Summarizes new findings on etiology, hemodynamics, pathophysiology, diagnosis and treatment of patients with venous ulcers
  • Discusses all currently utilized diagnostic and treatment modalities, as well as provides clear guidelines pertinent to special diagnostic considerations and emerging novel surgical and treatment techniques


Specialist in leg ulcers, vascular surgeons, vascular medicine cardiologists, dermatologists, angiologists, phlebologists and scientists

Table of Contents

  • Section I: Chronic Venous Insufficiency - Basic Considerations
    1. Pathophysiology of chronic venous disease: Genetic, molecular and biochemical mechanisms
    2. Venous hemodynamics and microcirculation in chronic venous insufficiency
    3. Venous ulcers of the lower extremity: Etiology, risks and predictive factors
    4. Venous ulcers of the lower extremity: Epidemiology and socio-economic burden

    Section II: Clinical Evaluation and Diagnostic Modalities
    5. Initial clinical evaluation in patients with chronic venous insufficiency
    6. Ultrasound evaluation of lower extremity chronic venous disease
    7. The diagnosis of major venous outflow obstruction in chronic venous insufficiency
    8. Hypercoagulable states associated with chronic venous insufficiency
    9. The chronically swollen leg with ulcers - finding the cause: theory and practice
    10. Lower extremity wounds associated with mixed venous and arterial insufficiency and relevant differential diagnosis in patients with non-healing wounds of the lower extremity
    11. Assessment tools and wound documentation for patients with chronic venous insufficiency

    Section III: Non-operative Management of Chronic Venous Insufficiency and Wound Care
    12. Compression therapy in venous leg ulcers
    13. Wound healing: Adjuvant therapy and treatment adherence
    14. Negative pressure dressings in venous ulcers
    15. Medical therapies for chronic venous insufficiency
    16. Treatment modalities for non-healing wounds in patients with chronic venous insufficiency
    17. Deep vein thrombosis and prevention of post-thrombotic syndrome
    18. Improving treatment outcomes - Management of coexisting co-morbidities in patients with venous ulcers
    19. Emerging modalities in local treatment of venous ulcers: advanced dressings, bioengineering and biologics

    Section IV: Operative and Endovascular Procedures for Chronic Venous Insufficiency
    20. Results comparing compression alone versus compression and surgery (or endovenous ablation) in treating venous ulceration
    21. Superficial surgery and perforator interruption in the treatment of venous leg ulcers
    22. Endovascular techniques for superficial vein ablation in treatment of venous ulcers
    23. Treatment of chronic venous insufficiency with foam sclerotherapy
    24. Ultrasound guidance for endovenous treatment
    25. Iliac vein stenting in venous leg ulcers
    26. Repair of venous valves in severe chronic venous insufficiency
    27. Emerging endovenous modalities in the treatment of chronic venous insufficiency

    Section V: Special Considerations
    28. Treatment of recalcitrant venous ulcers with free tissue transfer for limb salvage
    29. Management of venous ulcers in patients with congenital vascular malformations
    30. Lymphatic disorders in pathogenesis of chronic venous insufficiency

Product details

  • No. of pages: 500
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: September 1, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780323906104

About the Editors

Cynthia K. Shortell

Dr. Cynthia Shortell is professor of surgery and Chief of Vascular and Endovascular Surgery at Duke University Medical Center. For decades Dr. Shortell has worked relentlessly to advance management of patients with venous ulcers as well as in education and research. Dr. Shortell served as Director of Duke University Vein Center and Leader of Duke University Congenital Vascular Anomalies Team. Nationally, Dr. Shortell holds distinguished recognition as Associate Editor of the Journal of Vascular Surgery, the leading journal in the field. She is an elected member of many national and international societies and organizations including the Society for Vascular Surgery (SVS), the major national and international academic society for vascular surgeons, the American Venous Forum, the American College of Phlebology, and the International Society of Surgery. Dr. Shortell is Medical Director of Duke University Vascular Non-Invasive Laboratory, Chair for Appointments, Tenure and Promotions Committee at Duke Medical Center, Executive Vice Chair of the Department of Surgery, Chief of Staff in the Department of Surgery, Interim Division Chief of the Division of Trauma and Critical Care Surgery in the Department of Surgery, Director of the Vascular Surgery Fellowship Program at Duke University.

Affiliations and Expertise

Professor, Duke University Medical Center, USA

Jovan N. Markovic

Dr. Jovan Markovic is a staff M.D. at Duke University Medical Center where for more than a decade he has been extensively involved in advancing care of patients affected by Chronic Venous Insufficiency. Notably, Dr. Markovic was the first doctor (together with Dr. Shortell) to discover genes responsible for pathogenesis and progression of chronic venous insufficiency by evaluating the entire human genome of patients affected by this highly prevalent and often significantly debilitating vascular disorder. Dr. Markovic is currently a reviewer for the Journal of Vascular Surgery (including Venous and Lymphatic Disorders editon) and has authored numerous national and international guidelines pertinent to patients affected by vascular disorders. Dr. Markoivc has been member of American College of Phlebology when it was established in 2008. He is one of the authors of Report of the Society for Vascular Surgery and the American Venous Forum on the Medicare Evidence Development and Coverage Advisory Committee panel on lower extremity chronic venous disease, and most recently he published a book as an assistant editor on congenital vascular malformations, a complex group of vascular disorders that can lead to venous ulcerations.

Affiliations and Expertise

Medical Doctor, Duke University Medical Center, USA

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