The articles comprising this volume were first presented at the World Congress on Neurohypophysial Hormones held in Bordeaux, France on September 8-12, 2001. This conference brought together more than 170 scientists from 18 countries who belong to the different fields of interest representing research in the hypothalamo-neurohypophysial system.

Two neurohypophysial neurohormones, oxytocin and vasopressin, exert a variety of central and peripheral actions and thus involve different scientific domains, which too often, even today, do not always find the appropriate occasion to interact. This volume is composed of chapters dealing with topics varying from basic and clinical neurosciences and neuroendocrinology, to reproductive, renal, cardiovascular physiology and pathology. It encompasses all areas of current neurohypophysial research and should be of vital interest as an integrative reference volume to specialized investigators and as an excellent introductory text to students, scientists and clinicians not yet closely familiar with the field. To ensure novelty and to make sure that all topics of current importance were covered, plenary and symposium speakers as well as poster presentations concentrated on recent advances made in the last few years.

Table of Contents

List of contributors. Preface. 1. The magnocellular neuronal phenotype: cell-specific gene expression in the hypothalamo-neurohypophysial system (H. Gainer et al.). 2. Estrogen modulates oxytocin gene expression in regions of the rat supraoptic and paraventricular nuclei that contain estrogen receptor-&bgr; (P.J. Shughrue, T.L. Dellovade, I. Merchenthaler). 3. Short term modulation of GABAA-receptor in the adult female rat (A.B. Brussaard, J.J. Koksma). 4. Cholesterol and steroid hormones: modulators of oxytocin receptor function (G. Gimpl et al.). 5. Central vasopressin systems and steroid hormones (A. Kalsbeek, I.F. Palm, R.M. Buijs). 6. Regulation of renal salt and water transporters during vasopressin escape (C.A. Ecelbarger et al.). 7. Stretch-inactivated cation channels: cellular targets for modulation of osmosensitivity in supraoptic neurons (C.W. Bourque, D.L. Voisin, Y. Chakfe). 8. Glial cells in the hypothalamo-neurohypophysial system: key elements of the regulation of neuronal electrical and secretory activity (N. Hussy). 9. Functional synaptic plasticity in hypothalamic magnocellular neurons (J.G. Tasker, S. Di, C. Boudaba). 10. Post synaptic GABAB receptors in supraoptic oxytocin and vasopressin neurons (J.E. Stern, Y. Li, D.S. Richards). 11. Neurohypophyseal hormones in the integration of physiological responses to immune challenges (K.J. Kovács). 12. Involvement of the brain oxytocin system in stress coping: interactions with the hypothalamo-pituitary-adrenal axis (I.D. Neumann). 13. Expression of human vasopressin and oxytocin receptors in Escherichia coli (B. Mouillac et al.). 14. Molecular pharmacology and modeling of vasopressin receptors (M. Thibonnier et al.). 15. Nonpeptide vasopressin receptor antagonists: development of selective and orally-active V1A, V2 and V1B receptor ligands (C.


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© 2002
Elsevier Science
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About the editors

D. Theodosis

Affiliations and Expertise

INSERM U.378, Neurobiologie Morphofonctionnelle, Institut François Magendie, 1 rue Camille St.-Saëns, 33077 Bordeaux Cedex, France