Vascular Pharmacology, Volume 78

Chapter One: Nanojunctions of the Sarcoplasmic Reticulum Deliver Site- and Function-Specific Calcium Signaling in Vascular Smooth Muscles

• Abstract
• 1 Introduction
• 2 What Defines a Nanojunction?
• 3 Conclusion
• Conflict of Interest
• Acknowledgments

Chapter Two: Calcium Channels in Vascular Smooth Muscle

• Abstract
• 1 Introduction
• 2 Plasmalemmal Ca2 +-Permeable Channels
• 3 SR Ca2 + Channels
• 4 Mitochondrial Ca2 + Channels
• 5 Conclusion
• Conflict of Interest
• Acknowledgments

Chapter Three: Potassium Channels in Regulation of Vascular Smooth Muscle Contraction and Growth

• Abstract
• 1 Introduction
• 2 Potassium Channels and Regulation of VSM Contraction
• 3 K+ Channels and VSM Proliferation
• 4 Conclusion
• Conflict of Interest
• Acknowledgments

Chapter Four: Sodium–Calcium Exchanger in Pig Coronary Artery

• Abstract
• 1 Introduction
• 2 NCX in Coronary Artery Smooth Muscle
• 3 NCX in SMC
• 4 Functional Coupling of NCX and SER in SMC
• 5 Colocalization of NCX1 and SERCA2 in SMC
• 6 Effect of Thapsigargin on Colocalization of NCX1 and SERCA2 in SMC
• 7 Comparison of NCX in Coronary Artery SMC and EC
• 8 Conclusion
• Conflict of Interest
• Acknowledgments

Chapter Five: Ca2 +/Calmodulin-Dependent Protein Kinase II in Vascular Smooth Muscle

• Abstract
• 1 Introduction
• 2 CaMKII Structure and Expression in VSM
• 3 CaMKII Activation in VSM
• 4 CaMKII Function in VSM
• 5 Conclusion
• Conflict of Interest

Chapter Six: Protein Kinase C as Regulator of Vascular Smooth Muscle Function and Potential Target in Vascular Disorders

• Abstract
• 1 Introduction
• 2 PKC Structure and Isoforms
• 3 PKC Distribution and Translocation
• 4 PKC Phosphorylation
• 5 PKC Activators
• 6 PKC Substrates
• 7 PKC Inhibitors
• 8 Vascular Effects of PKC
• 9 Physiological Changes in PKC
• 10 PKC in Vascular Injury and Disease
• 11 Conclusion
• Conflict of Interest
• Acknowledgments

Chapter Seven: Rho-Mancing to Sensitize Calcium Signaling for Contraction in the Vasculature: Role of Rho Kinase

• Abstract
• 1 Introduction
• 2 RhoA/Rho Kinase Structure and Expression
• 3 Rho Kinase Function
• 4 Regulation of RhoA/Rho Kinase Activity via Posttranslational Modifications
• 5 RhoA/Rho Kinase-Mediated Ca2 + Sensitization in Vascular Disease and Rho Kinase Inhibitors: Focus on Hypertension
• 6 Conclusion
• Conflict of Interest

Chapter Eight: Vascular Cells in Blood Vessel Wall Development and Disease

• Abstract
• 1 Introduction
• 2 Blood Vessel Development
• 3 Cardiovascular Diseases
• 4 Conclusion
• Conflict of Interest

Chapter Nine: Notch Signaling in Vascular Smooth Muscle Cells

• Abstract
• 1 Introduction
• 2 The Notch Signaling Pathway
• 3 Notch Signaling in VSMC Development
• 4 Notch Signaling and VSMC Phenotype
• 5 Notch Signaling in Vascular Disease
• 6 Conclusion
• Conflict of Interests
• Acknowledgments

Chapter Ten: Smooth Muscle Phenotypic Diversity: Effect on Vascular Function and Drug Responses

• Abstract
• 1 Introduction
• 2 Brief Review of the Players in VSM Contractile Function
• 3 Diversity Within the Vascular System
• 4 Agonist-Mediated Vasoconstriction and Its Antagonism
• 5 Signaling-Mediated Vasodilation and Its Agonism
• 6 Calcium Flux and Its Inhibition
• 7 Diversity Within Human Populations
• 8 Conclusion
• Conflict of Interest
• Acknowledgment

Vascular Pharmacology: Smooth Muscle provides up-to-date information on the structure, function, signaling, and development of vascular smooth muscle. Contributors include prominent scientists and highly-recognized experts with major accomplishments in the field of vascular smooth muscle research.

• Presents a must read reference on vascular smooth muscle physiology and pharmacology
• Contains up-to-date information on the structure, function, signaling, and development of vascular smooth muscle
• Includes contributors from prominent scientists and highly-recognized experts with major accomplishments in the field of vascular smooth muscle research

Undergraduate and graduate students and postgraduate trainees as well as established scientists, physicians and medical professionals with interest in the vascular field