Vascular and Neurological Changes in Early Diabetes - 1st Edition - ISBN: 9780120273621, 9781483215556

Vascular and Neurological Changes in Early Diabetes

1st Edition

Advances in Metabolic Disorders, Vol. 2

Editors: Rafael A. Camerini-Dávalos Harold S. Cole
eBook ISBN: 9781483215556
Imprint: Academic Press
Published Date: 1st January 1973
Page Count: 620
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Advances in Metabolic Disorders, Supplement 2: Vascular and Neurological Changes in Early Diabetes covers knowledge of the vascular and neurological changes in early diabetes. The book discusses the prevalence of macroangiopathy in asymptomatic diabetes, the prevalence of asymptomatic diabetes in human atherosclerosis, and the observations made in seeking evidence for macroangiopathy, microangiopathy, and neurological changes in patients with latent diabetes. The text also describes angiopathy and neuropathy in mild juvenile diabetes; the role of insulin in the development of atherosclerosis; and the effect of insulin on lipid metabolism of human arteries.
Discussions about microangiopathy, including topics on serum glycoprotein disturbances and their rheological effects in diabetes mellitus; the biochemical properties of human glomerular basement membrane in normal and diabetic kidneys; and the plasma levels of growth hormone and glucagon in diabetic patients and relatives of diabetic patients are also considered. The book further tackles topics about neuropathy, including the role of sorbitol pathway in neuropathy, the polyol pathway in the neuropathy of early diabetes, as well as nervous abnormalities in early diabetes. The text concludes by looking into the effect of treatment on diabetes. Endocrinologist, biochemists, physiologists, and researchers working on related topics will find the book useful.

Table of Contents

List of Contributors



I. Macroangiopathy

Macroangiopathy—Its Prevalence in Asymptomatic Diabetes

The Prevalence of Asymptomatic Diabetes in Human Atherosclerosis

A Search for Macroangiopathy in Patients with Latent Diabetes

Angiopathy and Neuropathy in Mild Juvenile Diabetes


The Role of Insulin in the Development of Atherosclerosis

Effect of Insulin on Lipid Metabolism of Human Arteries

Glucose Lipogenesis in Rabbit Aorta in Relation to Age, Degree of Atherosclerosis, and the Presence of Insulin


Hypertriglyceridemia in Early Diabetes

Altered Carbohydrate and Lipid Metabolism and Coronary Heart Disease among Men in Tecumseh, Michigan

Insulin, Glucose and Lipid Levels in Mild Diabetics in Relation to Complications

Invited Discussants


Studies in the Functional Properties of Vascular Mucopolysaccharides

Proline Hydroxylase in Injury-Induced Arteriosclerosis

Polyol Pathway Activity in Aorta

Invited Discussant


Diabetic Macroangiopathy: Blood Flow and Radiological Studies


II. Microangiopathy

Genetic Transmission of Vasculopathy in KK Mice


The Metabolism of the Isolated Renal Glomerulus and Its Basement Membranes

Serum Glycoprotein Disturbances and their Rheological Effects in Diabetes Mellitus


Biochemical Properties of Human Glomerular Basement Membrane in Normal and Diabetic Kidneys

Biochemistry of the Glomerular Basement Membrane in Diabetes


Growth Hormone and Diabetic Angiopathy

Comparative Metabolic and Clinical Studies of Sexual Ateliotic Dwarfs and Diabetics

Plasma Levels of Growth Hormone and Glucagon in Diabetic Patients and Relatives of Diabetic Patients


Plasma Epinephrine and Plasma Norepinephrine Concentrations in Early Diabetes


Microangiopathy and Early Diabeticlike Sugar Tolerances in Animals with Induced Thyroid Immunity

Microangiopathy in the Experimentally Diabetic Animal

Vascular Changes Accompanying Dysmetabolism in Rabbits

Microvascular Alterations in Chronically Streptozotocin-Diabetic Rats


Ultrastructure of Glomerular Lesions in KK Mice

Related Factors in the Progression of Microangiopathy in KK Mice

Microangiopathy in Animals with Spontaneous Diabetes

Retinal and Renal Microangiopathy in Carp with Spontaneous Diabetes Mellitus

Invited Discussant


Diabetic Basement Membranelike Changes Demonstrable in Perippheral Blood Lymphocytes

Ophthalmoscopic Findings and Changes in Hormonal and Metabolic Parameters in “Protodiabetes”

Kidney Structural Abnormalities in Early Diabetes

Invited Discussants


The Capillaries of South African Diabetics in Perspective

Diabetic Microangiopathy: Electron Microscope Findings in Human Muscle

Capillary Basement Membrane Thickness in Early Diabetes

Early Capillary Basement Membrane Changes in Subjects with Diabetes Mellitus


Deterioration of Tolerance to Glucose and Progression of the Microangiopathy: Effect of Treatment (Preliminary Report)

Microvascular Changes in Early Diabetes Mellitus


Basement Membrane Thickening in Latent Diabetes

The Microvascular Complications of Early Diabetes in the Pima Indians


III. Neuropathy

Role of Sorbitol Pathway in Neuropathy

The Polyol Pathway in the Neuropathy of Early Diabetes


Nervous Abnormalities in Early Diabetes


Ultrastructural Pathology of Peripheral Nervous System in Early Diabetes

Neurological Findings in Chemical Diabetes

Neurological Changes in Early Diabetes

Clinical Features of Peripheral Neuropathy Associated with Hypoglycemia

Invited Discussants


IV. Effect of Treatment

Effect of Hypophysectory and Growth Hormone Treatment on the Composition of Canine Aorta


Cardiovascular Complications in Diabetics


Therapy of Early Diabetes: The University Group Diabetes Program

Invited Discussants


Borderline Diabetics and their Response to Tolbutamide

Long-Term Treatment of Patients with Abnormal Intravenous Glucose Tolerance after Myocardial Infarction

Vascular Disease in Diabetes and the Effect of Oral Antidiabetic Agents

Treatment of Chemical Diabetes with Chlorpropamide and the Associated Mortality

Progress Report on the Prophylactic Use of Oral Hypoglycemic Drugs in Asymptomatic Diabetes: Neurovascular Studies

Improvement in Motor Nerve Conduction Following Treatment in Newly Diagnosed Diabetics

The Effects of Metformin on Lipid-Induced Atherosclerosis

Invited Discussants


Subject Index


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© Academic Press 1973
Academic Press
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About the Editor

Rafael A. Camerini-Dávalos

Harold S. Cole

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