Vaccines - 6th Edition - ISBN: 9781455700905, 9781455737987


6th Edition

Expert Consult - Online and Print

Authors: Stanley Plotkin Walter Orenstein Paul Offit
Hardcover ISBN: 9781455700905
eBook ISBN: 9781455737987
Imprint: Saunders
Published Date: 22nd September 2012
Page Count: 1570

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2013 BMA Medical Book Awards Highly Commended in Public Health!

Apply the latest vaccination knowledge with a reference that Bill Gates calls "an indispensable guide to the enhancement of the well-being of our world." Inside Vaccines, you’ll find comprehensive and current coverage of every aspect of vaccination, from the development of each vaccine to its use in reducing disease. This medical reference book offers the expert information you need to apply the very latest techniques and information in your practice!

Key Features

  • Gain a complete understanding of each disease, including clinical characteristics, microbiology, pathogenesis, diagnosis, and treatment, as well as epidemiology and public health and regulatory issues.
  • Update your knowledge of both existing vaccines and vaccines currently in the research and development stage.
  • Get complete answers on each vaccine, including its stability, immunogenicity, efficacy, duration of immunity, adverse events, indications, contraindications, precautions, administration with other vaccines, and disease-control strategies.
  • Analyze the cost-benefit and cost-effectiveness of different vaccine options.
  • Clearly visualize concepts and objective data through an abundance of tables and figures.
  • Perform seamless searches of the complete text online, access all the references, and download all the images at

Table of Contents

SECTION 1: General aspects of vaccination

1 A short history of vaccination 1

2 Vaccine immunology 14

3 The vaccine industry 33

4 Vaccine manufacturing 44

5 Evolution of adjuvants across the centuries 58

6 Vaccine additives and manufacturing residuals in the United States:

licensed vaccines 71

7 Passive immunization 80

8 General immunization practices 88

SECTION 2: Licensed vaccines

9 Adenovirus vaccines 113

10 Anthrax vaccines 127

11 Cholera vaccines 141

12 Diphtheria toxoid 153

13 Haemophilus influenzae vaccines 167

14 Hepatitis A vaccines 183

15 Hepatitis B vaccines 205

16 Human papillomavirus vaccines 235

17 Inactivated influenza vaccines 257

18 Influenza vaccine—live 294

19 Japanese encephalitis vaccines 312

20 Measles vaccines 352

21 Meningococcal vaccines 388

22 Mumps vaccine 419

23 Pertussis vaccines . 447

24 Plague vaccines 493

25 Pneumococcal conjugate vaccine and pneumococcal common protein vaccines 504

26 Pneumococcal polysaccharide vaccines 542

27 Poliovirus vaccine—inactivated . 573

28 Poliovirus vaccine—live 598

29 Rabies vaccines .646

30 Rotavirus vaccines . 669

31 Rubella vaccine 688

32 Smallpox and vaccinia 718

33 Tetanus toxoid 746

34 Tick-borne encephalitis virus vaccines 773

35 Tuberculosis vaccines 789

36 Typhoid fever vaccines 812

37 Varicella vaccine 837

38 Yellow fever vaccine 870

39 Zoster vaccine 969

40 Combination vaccines 981

SECTION 3: Vaccines in development and new vaccine strategies

41 Biodefense and special pathogen vaccines 1008

42 Therapeutic cancer vaccines 1018

43 Cytomegalovirus vaccines 1032

44 Dengue vaccines 1042

45 Diarrhea caused by bacteria 1052

46 Ebola vaccine 1060

47 Epstein-Barr virus vaccines 1068

48 Hepatitis C vaccines 1074

49 Hepatitis E vaccines 1085

50 Herpes simplex virus vaccines 1090

51 Human immunodeficiency virus vaccines 1097

52 Lyme disease vaccines 1122

53 Malaria vaccines 1133

54 Noninfectious disease vaccines 1138

55 Respiratory syncytial virus and parainfluenza virus vaccines 1146

56 Parasitic disease vaccines 1154

57 Staphylococcus aureus vaccines 1161

58 Streptococcus group A vaccines 1169

59 Streptococcus group B vaccines 1176

60 Technologies for making new vaccines 1182

61 Alternative vaccine delivery methods 1200

62 The development of gene-based vectors for immunization 1232

SECTION 4: Vaccination of special groups

63 Vaccination of immunocompromised hosts 1243

64 Vaccination of human immunodeficiency virus-infected persons 1257

65 Vaccines for international travel 1270

66 Vaccines for health care personnel 1290

SECTION 5: Public health and regulatory issues

67 Immunization in the United States 1310

68 Immunization in Europe . 1334

69 Immunization in the Asia-Pacific region 1353

70 Immunization in developing countries 1369

71 Community immunity 1395

72 Economic analyses of vaccine policies 1413

73 Regulation and testing of vaccines 1427

74 Regulation of vaccines in Europe 1447

75 Regulation of vaccines in developing countries 1454

76 Vaccine safety 1464

77 Legal issues . 1481

78 Ethics 1508


No. of pages:
© Saunders 2012
22nd September 2012
Hardcover ISBN:
eBook ISBN:

About the Authors

Stanley Plotkin

Affiliations and Expertise

Emeritus Professor of Pediatrics, University of Pennsylvania, Emeritus Professor, Wistar Institute, Former Chief, Division of Infectious Diseases, The Children's Hospital of Philadelphia, Philadelphia, PA; Former Medical and Scientific Director, Pasteur Merieux Connaught (now Sanofi Pasteur), Marnes-la-Coquette, France

Walter Orenstein

Affiliations and Expertise

Professor of Medicine and Pediatrics, and Global Health, Emory University; Associate Director, Emory Vaccine Center, Atlanta GA; Bill & Melinda Gates Foundation, Seattle, WA; Former Director, National Immunization Program, Centers for Disease Control and Prevention, Atlanta GA

Paul Offit

Affiliations and Expertise

Chief, Division of Infectious Diseases, Director, Vaccine Education Center, The Childrne's Hospital of Philadelphia; Professor of Pediatrics, Maurice R. Hilleman Professor of Vaccinology, Perelman School of Medicine, The University of Pennsylvania School of Medicine, Philadelphia, PA.


"Widely regarded as The Bible for vaccinologists… the book remains the work of reference that every person working in the field of vaccines and those with an interest in infectious diseases should have."

The Lancet: Infectious Diseases, June 2008

"For anyone wishing to know everything important about existing vaccines, this book provides an indispensable source of authoritative information."

Immunology News, February 2009

"The new foreword by Bill Gates emphasizes the importance of vaccines and the value of this book.  This is the leading reference that covers all aspects of vaccinology.  There are no comparable books available.  In the rapidly evolving field of vaccinology, this new edition is essential."

- Archana NMI Chatterjee, MD PhD, Creighton University

5 Star - Doody's Rating, March 2013