Understanding Cancer

Understanding Cancer

From Basics to Therapeutics

1st Edition - January 13, 2022

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  • Editors: Buddhi Jain, Shweta Pandey
  • Paperback ISBN: 9780323998833
  • eBook ISBN: 9780323983969

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Description

Understanding Cancer: From Basics to Therapeutics presents both basic concepts and research prospects in the field of cancer biology. This book summarizes the fundamental aspects of cancer and presents a detailed description of molecular aspects as well as treatment and therapeutics for patients.   The book is divided into three parts: the first part deals with the basics of cancer, including etiology and medical diagnosis; the second part explores the molecular mechanisms associated with cancer, focusing on cell cycle and apoptosis, cell metabolism, gene regulation, epigenetics, and stem cells; and the third part is dedicated to therapeutics, discussing chemo and radiotherapies, gene, hormone, herbal, and immunotherapies.   It is a valuable resource for cancer researchers, oncologists, graduate students, and biomedical researchers who need to understand the fundamental topics related to cancer to apply to their research work or clinical setting.

Key Features

  • Presents fundamental aspects of cancer in a didactic way to make the content easily applicable by readers
  • Illustrates the content through detailed images developed by the authors exclusively for the book to facilitate comprehension
  • Summarizes the content of each chapter with several tables and schematic diagrams for quick consult

Readership

Graduate students, cancer researchers; Medical doctors, clinicians, oncologists

Table of Contents

  • Cover Image
  • Title Page
  • Copyright
  • Table of Contents
  • Contributors
  • Editorial Desk
  • Preface
  • Chapter 1 A brief tour guide to cancer disease
  • Abstract
  • Keywords
  • 1.1 Overview of cancer
  • 1.2 Neoplasm
  • 1.3 Types of tumor
  • 1.4 Stages of tumor development leading to cancer
  • 1.5 Essential hallmarks of cancer
  • 1.6 Metastasis
  • 1.7 Angiogenesis
  • 1.8 Structure of tumor vasculature
  • 1.9 Summary
  • References
  • Chapter 2 Malignant tumors – as cancer
  • Abstract
  • Keywords
  • 2.1 Introduction
  • 2.2 Tumors arise from normal tissue
  • 2.3 Specialized cells of the body are involved in cancer development
  • 2.4 Cancer incidence
  • 2.5 Common cancers among male and female
  • 2.6 Tumor grading and staging
  • 2.7 Summary
  • References
  • Chapter 3 Etiology of cancer
  • Abstract
  • Keywords
  • 3.1 Introduction
  • 3.2 Conclusion
  • References
  • Chapter 4 Medical diagnosis of cancer
  • Abstract
  • Keywords
  • 4.1 Cancer screening
  • 4.2 Tumor markers in aiding cancer diagnosis
  • 4.3 Biopsy
  • 4.4 Imaging screening and diagnostics
  • 4.5 Immunohistochemistry
  • 4.6 Fluorescence in situ hybridization
  • 4.7 MicroRNA as cancer diagnostic tools
  • 4.8 Liver cancer
  • 4.9 Breast cancer
  • 4.10 Lung cancer
  • 4.11 Prostate and cervical cancer
  • 4.12 Other cancer
  • 4.13 Cancer management in older age
  • 4.14 Conclusion
  • References
  • Chapter 5 Molecular mechanisms in cancer development
  • Abstract
  • Keywords
  • 5.1 Introduction
  • 5.2 Cancer cells versus normal cells
  • 5.3 How cancer develops?
  • 5.4 Molecular changes that occur in cancer cells
  • 5.5 Important genes in cancer development
  • 5.6 Genetic stability loss in the tumor cells
  • 5.7 Chromosomal changes in cancer cells
  • 5.8 Few biomolecules involved in cancer development
  • 5.9 Summary
  • References
  • Chapter 6 Cancer and cell cycle
  • Abstract
  • Keywords
  • 6.1 Introduction
  • 6.2 Growth factors in cell cycle and cancer
  • 6.3 Cell cycle regulators
  • 6.4 The relevance of cell cycle regulator in carcinogenesis
  • 6.5 DNA damage response and cell cycle regulator in cancer
  • 6.6 DNA damage checkpoints
  • 6.7 The relevance of checkpoint alteration in carcinogenesis
  • 6.8 Targeting cell cycle in cancer therapeutics
  • 6.9 Combination of chemotherapy and cell cycle inhibitor in cancer
  • 6.10 Summary
  • References
  • Chapter 7 Cancer and apoptosis
  • Abstract
  • Keywords
  • 7.1 Introduction
  • 7.2 Role of caspases in apoptosis
  • 7.3 Apoptosis signaling pathway
  • 7.4 Deregulation of the apoptotic pathway in cancer
  • 7.5 Therapeutic targets of apoptosis in cancer
  • 7.6 Apoptosis assay in cancer
  • 7.7 Summary
  • References
  • Chapter 8 Fundamentals of cell metabolism and cancer
  • Abstract
  • Keywords
  • 8.1 Introduction
  • 8.2 Importance of understanding the metabolism of cancer cells
  • 8.3 Glucose metabolism
  • 8.4 Pentose phosphate pathway/phosphogluconate pathway/hexose monophosphate shunt
  • 8.5 Amino acid metabolism
  • 8.6 Hexosamine biosynthetic pathway
  • 8.7 Fatty acid metabolism
  • 8.8 Cancer metabolism in histone modifications
  • 8.9 Mitochondria and cancer
  • 8.10 Role of signaling pathways and transcription factors in cancer cell metabolism
  • 8.11 Conclusion
  • References
  • Chapter 9 Cancer epigenetics: DNA methylation and histone modifications
  • Abstract
  • Keywords
  • 9.1 An introduction to cancer epigenetics
  • 9.2 Chromatin and DNA packaging
  • 9.3 Covalent modifications of DNA
  • 9.4 Histone code hypothesis and histone modifications
  • 9.5 Summary
  • Acknowledgments
  • References
  • Chapter 10 Cancer epigenetics: Chromatin remodeling and other epigenetic mechanisms
  • Abstract
  • Keywords
  • 10.1 Chromatin remodelers and cancer
  • 10.2 Chromatin remodeling complexes
  • 10.3 Other epigenetic mechanisms leading to cancer: MicroRNA biogenesis
  • 10.4 Nonmalignant epigenetic disorders
  • 10.5 Diagnostic and therapeutic approaches
  • 10.6 Summary
  • Acknowledgments
  • References
  • Chapter 11 Alteration in major cell signaling pathways in cancer
  • Abstract
  • Keywords
  • 11.1 Introduction
  • 11.2 Cancer and tyrosine kinase signaling
  • 11.3 Cancer and mitogen-activated protein kinase pathway
  • 11.4 Cancer and phosphatidylinositol 3-kinase signaling
  • 11.5 Cancer and transforming growth factor-beta signaling pathway
  • 11.6 Cancer and G-protein coupled receptor kinase signaling pathway
  • 11.7 Cancer and WNT signaling
  • 11.8 Cancer and notch pathway
  • 11.9 Cancer and Hedgehog signaling
  • 11.10 Cancer and integrin pathway
  • 11.11 Summary
  • References
  • Chapter 12 Cancer stem cells
  • Abstract
  • Keywords
  • 12.1 Historical perspective
  • 12.2 Definition of cancer stem cells
  • 12.3 Cancer stem cells in hematopoietic cancers
  • 12.4 Cancer stem cells in solid tumors
  • 12.5 Contributions of cancer stem cells in tumor formation, resistance, and relapse
  • 12.6 Cancer stem cell and miRNA
  • 12.7 Controversies concerning the stem cell theory and the “CSC niche” concept
  • 12.8 Therapeutic approaches to cancer stem cells
  • 12.9 Summary
  • References
  • Chapter 13 Cancer and regulation of gene expression
  • Abstract
  • Keywords
  • 13.1 Introduction
  • 13.2 Central dogma of molecular biology
  • 13.3 Transcriptional and post-transcriptional events
  • 13.4 Summary
  • Acknowledgments
  • References
  • Chapter 14 Chemotherapy and radiation therapy for cancer
  • Abstract
  • Keywords
  • 14.1 Introduction
  • 14.2 History of cancer
  • 14.3 Cancer and its hallmarks
  • 14.4 Processes of carcinogenesis
  • 14.5 Biology of tumor
  • 14.6 Etiological factors
  • 14.7 Cancer management
  • 14.8 Targeting cancer stem cells in combination with chemotherapy and radiotherapy
  • 14.9 Summary
  • Acknowledgments
  • References
  • Chapter 15 Cancer gene therapies progress in pre and postgenomics era
  • Abstract
  • Keywords
  • 15.1 Introduction
  • 15.2 Cancer treatment
  • 15.3 Recent techniques used for gene editing
  • 15.4 Summary
  • References
  • Chapter 16 Hormone therapy for cancer treatment
  • Abstract
  • Keywords
  • 16.1 Hormone therapy
  • 16.2 Types of hormone-sensitive cancer
  • 16.3 Summary
  • References
  • Chapter 17 Natural herbal products for cancer therapy
  • Abstract
  • Keywords
  • 17.1 Introduction
  • 17.2 Natural products and cancer
  • 17.3 Summary
  • Acknowledgment
  • References
  • Chapter 18 Immunotherapy for cancer treatment
  • Abstract
  • Keywords
  • 18.1 Introduction
  • 18.2 Evolutionary background of cancer immunotherapy
  • 18.3 Types of immunotherapies
  • 18.4 Summary
  • References
  • Index

Product details

  • No. of pages: 308
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: January 13, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780323998833
  • eBook ISBN: 9780323983969

About the Editors

Buddhi Jain

Dr. Buddhi Prakash Jain is an Assistant Professor at the Department of Zoology, Mahatma Gandhi Central University, Motihari, Bihar, India. He completed his doctoral studies at the School of Life Sciences, Jawaharlal Nehru University (JNU), New Delhi, India. His research interests include gene expression regulation and endoplasmic reticulum stress in cancer. He was awarded a gold medal in Master Programme (M.Sc.), and has published several papers in reputed international journals and many books and book chapters. The native place of Dr. Jain is Sawar in Ajmer District of Rajasthan, India.

Affiliations and Expertise

Assistant Professor, Department of Zoology, School of Life Sciences, Mahatma Gandhi Central University Bihar, Motihari, India

Shweta Pandey

Shweta Pandey is an Assistant Professor at the Department of Biotechnology, Govt VYT PG Autonomous College, Durg Chhatisgarh, India. Dr. Pandey received a PhD from the School of Life Sciences, Jawaharlal Nehru University (JNU), New Delhi, India. She has vast teaching experience and has published several papers in reputed international journals, many book chapters in edited books, and co-edited Protocols in Biochemistry and Clinical Biochemistry (Elsevier, 2020). Her research interests include cell cycle regulation, molecular and cell mechanisms of tumor cells, and cancer biology.

Affiliations and Expertise

Govt VYT PG Autonomous College, Durg, Chhatishgarh, India

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