Ultrastructure of the Kidney

Ultrastructure of the Kidney

1st Edition - January 1, 1967

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  • Editors: Albert J. Dalton, Françoise Haguenau
  • eBook ISBN: 9781483266473

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Ultrastructure in Biological Systems, Volume 2: Ultrastructure of the Kidney provides an overview of the state of knowledge on the ultrastructure of the mammalian kidney. The application of the electron microscope to studies of the kidney resulted in the demonstration of the hitherto undetected early thickening of the basement membrane of glomerular capillaries in glomerulonephritis. Yet many problems remain, particularly in relation to the correlation between function and the ultrastructure of components of the kidney—mesangium, glomerulus, juxtaglomerular apparatus, and the renal tubules. It is only recently that the mesangium has come to be accepted as real, and many questions remain as to the function of its cells. The existence of true membranes between foot processes of the epithelial cells of glomeruli is a newly established fact; but what this has to do with glomerular filtration is not known at present. Granules apparently secretory in nature have been identified in cells of the juxtaglomerular apparatus, but so far their presence has not been correlated with specific functional change. Artifacts introduced at fixation are now known to have considerable relevance in interpreting the ultrastructure of the normal nephron. These are paraphrased views of the contributors to this monograph who, while acquainting the reader with the research being carried on in these areas, have also brought into focus the many problems still awaiting solution.

Table of Contents

  • Contributors


    The Fine Structure of Renal Tubules in Cortex and Medulla

    I. Introduction

    II. Anatomy

    III. Renal Physiology

    IV. Proximal Tubule

    V. Thin Segment of Loop of Henle

    VI. Distal Tubule

    VII. Collecting Tubule

    VIII. Other Structures in Cortex and Medulla

    IX. Embryology

    X. Renal Phylogenetic Differences

    XI. Other Tissues Transporting Salts and Fluids

    XII. Physiological and Pathological Reactions

    XIII. Conclusion


    The Structure and Function of the Glomerular Mesangium

    I. Introduction

    II. The Topological Localization of the Mesangial Cell

    III. The Fine Structure of the Mesangial Cell

    IV. The Nature of the Mesangial Cell

    V. The Function of the Mesangial Cell

    VI. Conclusion


    Some Morphological Considerations of Transport in the Glomerulus

    I. Introduction

    II. Structural Considerations

    III. Pathway of Transported Material

    IV. Summary


    The Juxtaglomerular Apparatus

    I. Introduction

    II. Historical Background

    III. The Juxtaglomerular Apparatus of the Rat as Seen in the Electron Microscope

    IV. Physiological Significance


    Ultrastructural Pathology of the Glomerulus

    I. Introduction

    II. Physiopathology and Ultrastructure of the Diseased Glomerulus

    III. Concluding Remarks


    Author Index

    Subject Index

Product details

  • No. of pages: 252
  • Language: English
  • Copyright: © Academic Press 1967
  • Published: January 1, 1967
  • Imprint: Academic Press
  • eBook ISBN: 9781483266473

About the Editors

Albert J. Dalton

Françoise Haguenau

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