Ultrastructure of Rat Adenohypophysis

Ultrastructure of Rat Adenohypophysis

Correlation with Function

1st Edition - January 1, 1973

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  • Author: Allen Costoff
  • eBook ISBN: 9780323159579

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Ultrastructure of Rat Adenohypophysis: Correlation with Function discusses the ultrastructure of the anterior pituitary in the normal intact rat, as well as in animal after various treatments and changes in its physiology. Wherever possible, the book attempts to coordinate and associate changes in pituitary ultrastructure with physiological aspects. The book also presents a method for the isolation of various populations of pituitary secretory granules that can be used in experimental endocrinological research. It also discusses the various cell types, including the chromophobe; the pars tuberalis and pars intermedia of the adenohypophysis; and the chemical and physical properties of the secretory granules and their formation and release. This reference will serve as a guide for pituitary ultrastructural studies in other species. It is valuable to students and experienced investigators in the field of endocrinology, anatomy, pathology, physiology, biochemistry, and related disciplines.

Table of Contents

  • Preface

    Abbreviations and Terminology Used in Text

    Abbreviations used in Electron Micrograph Descriptions

    Chapter 1 Introduction



    Chapter 2 Experimental Procedures Animals

    Preparation of Tissues for Electron Microscopic Study

    Preparation of Pituitary Granules

    Biological Assays


    Chapter 3 Thyrotropes

    Light Microscopy

    Ultrastructure of Thyrotropes


    TSH Content of Pituitary Granule Fractions


    Chapter 4 Gonadotropes

    Light Microscopy of Gonadotropes

    Ultrastructure of Gonadotropes

    Discussion of Gonadotropes

    FSH and L H Activity of Isolated Secretory Granule Fractions


    Chapter 5 Adrenocorticotropes

    Light Microscopy

    Electron Microscopy




    Adrenal Cortical Steroids

    Exogenous ACTH


    Corticotropes after Adrenalectomy and Castration

    General Discussion of Corticotropes

    Biological Activities of Pituitary Granule Fractions


    Chapter 6 Somatotropes

    Light Microscopy

    Ultrastructure of Somatotropes

    Discussion of Ultrastructural Findings

    Somatotropic Activities of Granule Fractions


    Chapter 7 Mammotropes

    Light Microscopy

    Ultrastructure of the Mammotrope in Intact and Treated Rats

    Pituitary Autografts


    Chapter 8 Chromophobes

    Electron Microscopy of Chromophobes


    Chapter 9 Pars Tuberalis

    Histochemical Studies

    Recent Histochemistry, Immunochemistry, and Electron Microscopy of the Pars Tuberalis


    Chapter 10 Pars Intermedia

    Hypophyseal Cleft

    Cells of the Central Region of the Pars Intermedia

    Cells of the Pars Intermedia after Pituitary Is Autografted to the Kidney Capsule

    Other Hormones of the Pituitary Gland


    Chapter 11 Hormonal Activities and Biochemical Properties of Isolated Granule Fractions

    Biological Activities of Granule Fractions

    Biochemical and Physical Properties of Granules


    Chapter 12 Synthesis, Storage, and Release of Anterior Pituitary Hormones

    Formation of Secretory Granules

    Release of Pituitary Secretory Granules

    Summary of Synthesis and Release of Anterior Pituitary Hormones


    Author Index

    Subject Index

Product details

  • No. of pages: 234
  • Language: English
  • Copyright: © Academic Press 1973
  • Published: January 1, 1973
  • Imprint: Academic Press
  • eBook ISBN: 9780323159579

About the Author

Allen Costoff

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