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Twin and Family Studies of Epigenetics - 1st Edition - ISBN: 9780128209516

Twin and Family Studies of Epigenetics, Volume 29

1st Edition

Editors: Shuai Li John Hopper
Series Editor: Trygve Tollefsbol
Paperback ISBN: 9780128209516
Imprint: Academic Press
Published Date: 1st October 2021
Page Count: 408
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Table of Contents

  1. Twin and family study designs
    Prof John Hopper, Dr Shuai Li
    2. Epigenetics and measurement
    Dr Nicola Armstrong
    3. Discordant monozygotic twin pair studies of epigenetic mechanisms in cognitive and mental health
    Dr Jenny van Dongen
    4. Estimating the contribution of genome-wide SNPs, age, and sex to epigenetic variation
    Dr Jenny van Dongen
    5. The search for DNA methylation marks associated with breast cancer risk using twin pairs discordant for breast cancer
    Dr Ee Ming Wong
    6. DNA methylation and blood pressure in Chinese adult twins
    Dr Wenjing Gao
    7. Twin and family studies on epigenetics and paediatric dental health
    8. The role of epigenetics in the Developmental Origins of Health and Disease hypothesis
    9. Twin and family studies on epigenetics and ageing
    10. Twin and family studies on epigenetics and type 2 diabetes
    11. Twin and family studies on epigenetics and obesity
    12. Twin and family studies on epigenetics and cardiovascular diseases
    13. Imaging epigenetics: the radiogenomics
    Dr Adam Tarnoki, Dr David Tarnoki
    14. Identifying exposure-specific DNA Methylation changes: a forte of the twin study design
    Professor Joohon Sung
    15. Unravelling time trends in epigenetic effects by combining twin-based studies with secular trend data
    Professor Thorkild I.A. Sørensen

Description

Twin and Family Studies of Epigenetics, Volume 29, the latest release in the Translational Epigenetics series, gathers expert opinions on epigenetic twin and family study research methods, recent findings across various disease areas, and future directions. The book provides in-depth coverage of epigenetics fundamentals, twin and family epigenetic study design, and the broader role of epigenetics in answering questions on the developmental origins of health and disease. Throughout the volume, twin and family studies are employed to examine causes of epigenetic variation, the relationship between epigenetic modifications and mental illness, cancers, cardiovascular disease, diabetes, obesity, high blood pressure, and more.

Emerging research methods applied in twin and family studies discussed include imaging epigenetics, exposure-specific DNA methylation changes, and unravelling time trends in epigenetic effects.

Key Features

  • Offers a practical, interdisciplinary approach across epigenetics, epidemiology and various disease specialties
  • Applies epigenetic twin and family studies to determine the relationship between epigenetics and mental illness, cancers, cardiovascular disease, diabetes, obesity and high blood pressure, among other diseases and disorders
  • Features chapter contributions from a wide range of international researchers in the field

Readership

Human geneticists; human genomicists; translational researchers in genomic medicine, epigenetics, reproductive biology, epidemiology, public health, bioinformatics, and endocrinology; life science researchers; oncologists; obstetricians; pediatricians; immunologists; bioengineers; developmental biologists. Clinicians and graduate students in the biosciences


Details

No. of pages:
408
Language:
English
Copyright:
© Academic Press 2021
Published:
1st October 2021
Imprint:
Academic Press
Paperback ISBN:
9780128209516

Ratings and Reviews


About the Editors

Shuai Li

Dr Shuai Li has long-term experience in analyzing data from twin and family studies, including the novel epigenomic data. His PhD uses twin and family studies to research DNA methylation. He has published more than 10 papers on epigenetic epidemiological studies, specializing in twin and family designs.

Affiliations and Expertise

Centre for Epidemiology and Biostatistics, The University of Melbourne, Carlton, Australia

John Hopper

Professor John Hopper, AM, was one of the nine inaugural Australia Fellows awarded by NHMRC in 2007 and is currently a NHMRC Senior Principal Research Fellow. He is a Professorial Fellow with a PhD in Mathematical Statistics, and is currently Director (Research) of the Centre for Epidemiology and Biostatistics in the School of Population Global Health at The University of Melbourne. He has published more than 700 papers, specializing in the statistical methodology and its application for analyzing twin and family data, and addressing the genetic and environmental aetiology of diseases and health. He is principal or co-investigator on a number of case-control-family studies across a range of diseases and conditions, particularly breast cancer and colorectal cancer (both funded by the National Institutes of Health (USA)), prostate cancer, melanoma, childhood cancer and asthma. He is a co-investigator on several cohort studies, including Health 2020 and long term follow-up of the 1968 Tasmanian Asthma Study. Professor Hopper has been Director of the Australian Twin Registry (Now is Twins Research Australia) since 1990 and has been awarded a NHMRC CRE grant in Twin Research in 2014.

Affiliations and Expertise

Centre for Epidemiology and Biostatistics, The University of Melbourne, Carlton, Australia

About the Series Editor

Trygve Tollefsbol

Trygve Tollefsbol

Dr. Tollefsbol is a Professor of Biology and a Senior Scientist in the Center for Aging, Comprehensive Cancer Center, Nutrition Obesity Research Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the UAB Cell Senescence Culture Facility which he established in 1999 and a Steering Committee Member of the UAB Center for Aging. Dr. Tollefsbol trained as a Postdoctoral Fellow and Assistant Research Professor with members of the National Academy of Science at Duke University and the University of North Carolina. He earned doctorates in molecular biology and osteopathic medicine from the University of North Texas Health Sciences Center and his bachelor’s degree in Biology from the University of Houston. He has received prior funding from the NIA, NCI, NHLBI, NIMH and other federal institutes as well as the Glenn Foundation for Medical Research, Susan G. Komen for the Cure, the American Federation for Aging Research (AFAR), and the American Institute for Cancer Research (AICR) among many other sources.

Affiliations and Expertise

Professor of Biology and Senior Scientist, Center for Aging, Comprehensive Cancer Center, Nutrition Obesity Research Center, and the Comprehensive Diabetes Center, University of Alabama at Birmingham (UAB), USA