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Tumor Vascularization discusses the different types of growth of tumor blood vessels and their implications on research and healthcare. The book is divided into three parts: the first one, General Mechanisms, discusses different vessel growth mechanisms, such as sprouting angiogenesis, non-angiogenesis dependent growth, intussusceptive microvascular growth, vascular co-option and vasculogenic mimicry. The second and third parts, entitled Clinical Implications and Therapeutic Implications are dedicated to translating recent findings in this field to patient treatment and healthcare. This book is a valuable source for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in tumor progression and blood vessels.
- Explains new, non-orthodox concepts recently developed and related to the modality of growth of tumor blood vessels
- Provides information on the types of angiogenesis, non-angiogenesis dependent growth and vascular co-option, discussing both their similarities and differences
- Encompasses a discussion on clinical implications of tumor vascularization to translate research findings into treatment
cancer researchers, medical scientists, clinicians, graduate students
Domenico Ribatti and Francesco Pezzella
1. Sprouting and non-sprouting angiogenesis in tumors
Domenico Ribatti and Francesco Pezzella
2. Nonangiogenic tumor growth
Peter Vermeulen and Francesco Pezzella
3. Vascular co-option
Pedro García-Gómez and Manuel Valiente
4. Pericyte mimicry: an embryonic-like mechanism for tumor metastasis
Claire Lugassy, Hynda Kleinman and Raymond Barnhill
5. Vasculogenic mimicry
Yun Cao and Chao-Nan Miles Qian
6. Postnatal vasculogenesis
Latetitia Andrique, Gaelle Recher, Pierre Nassoy and Andreas Bikfalvi
7. The perivascular niche
Alia Komsany and Francesco Pezzella
8. Zebrafish as an experimental model to study tumor angiogenesis
Jessica Guerra, Chiara Tobia, Marco Presta and Andrea Barbieri
9. Clinical implications
- No. of pages:
- © Academic Press 2020
- 7th January 2020
- Academic Press
- Paperback ISBN:
- eBook ISBN:
Domenico Ribatti was awarded his M.D. degree on October 1981, with full marks. In 1983, Dr. Ribatti joined the Medical School as Assistant at the Institute of Human Anatomy, University of Bari. In 1984, he took the specialization in Allergology. In 1989, he spent one year in Geneva, working at the Department of Morphology (Prof. R. Montesano). In 2008, he received the honoris causa degree in Medicine and Pharmacy from the University of Timisoara (Romania). His present position is full professor of Human Anatomy at the University of Bari Medical School. Domenico Ribatti is author of 718 publications as reported in PubMed and contributed to 50 chapters to books. With Dr. Francesco Pezzella, Dr. Ribatti co-edited the book Tumor Vascularization, published on January 2020 by Elsevier/Academic Press.
Professor of Human Anatomy, Department of Basic Biomedical Sciences, Neurosciences and Sensory Organs, Section of Human Anatomy and Histology, University of Bari Medical School, Italy
Francesco Pezzella is a histopathologist and is currently Professor of Tumour Pathology at Oxford. He worked in the past on the pathology of HIV (at the time HTLV III) infection and molecular alterations in lymphoma. Because of his friends pushing him into the field of cancer and blood vessels, eventually he discovered in the mid-nineties, by pure chance, the tumours growing without angiogenesis.
Professor of Tumour Pathology at Nuffield Division of Clinical Laboratory Science-Radcliffe Department of Medicine, University of Oxford, United Kingdom
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