Tumor Vascularization

Tumor Vascularization

1st Edition - January 7, 2020

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  • Editors: Domenico Ribatti, Francesco Pezzella
  • eBook ISBN: 9780128220276
  • Paperback ISBN: 9780128194942

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Tumor Vascularization discusses the different types of growth of tumor blood vessels and their implications on research and healthcare. The book is divided into three parts: the first one, General Mechanisms, discusses different vessel growth mechanisms, such as sprouting angiogenesis, non-angiogenesis dependent growth, intussusceptive microvascular growth, vascular co-option and vasculogenic mimicry. The second and third parts, entitled Clinical Implications and Therapeutic Implications are dedicated to translating recent findings in this field to patient treatment and healthcare. This book is a valuable source for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in tumor progression and blood vessels.

Key Features

  • Explains new, non-orthodox concepts recently developed and related to the modality of growth of tumor blood vessels
  • Provides information on the types of angiogenesis, non-angiogenesis dependent growth and vascular co-option, discussing both their similarities and differences
  • Encompasses a discussion on clinical implications of tumor vascularization to translate research findings into treatment


cancer researchers, medical scientists, clinicians, graduate students

Table of Contents

  • Preface
    Domenico Ribatti and Francesco Pezzella
    1. Sprouting and non-sprouting angiogenesis in tumors
    Domenico Ribatti and Francesco Pezzella
    2. Nonangiogenic tumor growth
    Peter Vermeulen and Francesco Pezzella
    3. Vascular co-option
    Pedro García-Gómez and Manuel Valiente
    4. Pericyte mimicry: an embryonic-like mechanism for tumor metastasis
    Claire Lugassy, Hynda Kleinman and Raymond Barnhill
    5. Vasculogenic mimicry
    Yun Cao and Chao-Nan Miles Qian
    6. Postnatal vasculogenesis
    Latetitia Andrique, Gaelle Recher, Pierre Nassoy and Andreas Bikfalvi
    7. The perivascular niche
    Alia Komsany and Francesco Pezzella
    8. Zebrafish as an experimental model to study tumor angiogenesis
    Jessica Guerra, Chiara Tobia, Marco Presta and Andrea Barbieri
    9. Clinical implications
    Adrian Harris

Product details

  • No. of pages: 198
  • Language: English
  • Copyright: © Academic Press 2020
  • Published: January 7, 2020
  • Imprint: Academic Press
  • eBook ISBN: 9780128220276
  • Paperback ISBN: 9780128194942

About the Editors

Domenico Ribatti

Domenico Ribatti was awarded his M.D. degree in October 1981, with full marks. In 1983, D.R. joined the Medical School as Assistant at the Institute of Human Anatomy, University of Bari. In 1984, he took the specialization in Allergology. In 1989, he spent one year in Geneva, working at the Department of Morphology (Prof. R. Montesano). In 2008, he received the honoris causa degree in Medicine and Pharmacy form the University of Timisoara (Romania). D.R. is author of 866 publications as reported in PUBmed and contributed to 50 chapters to books. Overall, his papers have been cited 51153 times. He has published many books with both Elsevier and Springe

Affiliations and Expertise

Full Professor of Human Anatomy, University of Bari Medical School, Bari, Italy

Francesco Pezzella

Francesco Pezzella is a histopathologist and is currently Professor of Tumour Pathology at Oxford. He worked in the past on the pathology of HIV (at the time HTLV III) infection and molecular alterations in lymphoma. Because of his friends pushing him into the field of cancer and blood vessels, eventually he discovered in the mid-nineties, by pure chance, the tumours growing without angiogenesis.

Affiliations and Expertise

Professor of Tumour Pathology, Nuffield Division of Clinical Laboratory Science-Radcliffe Department of Medicine, University of Oxford, UK

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