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Tumor Vascularization - 1st Edition - ISBN: 9780128194942, 9780128220276

Tumor Vascularization

1st Edition

Editors: Domenico Ribatti Francesco Pezzella
Paperback ISBN: 9780128194942
eBook ISBN: 9780128220276
Imprint: Academic Press
Published Date: 7th January 2020
Page Count: 198
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Tumor Vascularization discusses the different types of growth of tumor blood vessels and their implications on research and healthcare. The book is divided into three parts: the first one, General Mechanisms, discusses different vessel growth mechanisms, such as sprouting angiogenesis, non-angiogenesis dependent growth, intussusceptive microvascular growth, vascular co-option and vasculogenic mimicry. The second and third parts, entitled Clinical Implications and Therapeutic Implications are dedicated to translating recent findings in this field to patient treatment and healthcare. This book is a valuable source for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in tumor progression and blood vessels.

Key Features

  • Explains new, non-orthodox concepts recently developed and related to the modality of growth of tumor blood vessels
  • Provides information on the types of angiogenesis, non-angiogenesis dependent growth and vascular co-option, discussing both their similarities and differences
  • Encompasses a discussion on clinical implications of tumor vascularization to translate research findings into treatment


cancer researchers, medical scientists, clinicians, graduate students

Table of Contents

Domenico Ribatti and Francesco Pezzella
1. Sprouting and non-sprouting angiogenesis in tumors
Domenico Ribatti and Francesco Pezzella
2. Nonangiogenic tumor growth
Peter Vermeulen and Francesco Pezzella
3. Vascular co-option
Pedro García-Gómez and Manuel Valiente
4. Pericyte mimicry: an embryonic-like mechanism for tumor metastasis
Claire Lugassy, Hynda Kleinman and Raymond Barnhill
5. Vasculogenic mimicry
Yun Cao and Chao-Nan Miles Qian
6. Postnatal vasculogenesis
Latetitia Andrique, Gaelle Recher, Pierre Nassoy and Andreas Bikfalvi
7. The perivascular niche
Alia Komsany and Francesco Pezzella
8. Zebrafish as an experimental model to study tumor angiogenesis
Jessica Guerra, Chiara Tobia, Marco Presta and Andrea Barbieri
9. Clinical implications
Adrian Harris


No. of pages:
© Academic Press 2020
7th January 2020
Academic Press
Paperback ISBN:
eBook ISBN:

About the Editors

Domenico Ribatti

Domenico Ribatti

Domenico Ribatti is Professor of Human Anatomy, in the Department of Basic Biomedical Sciences, Neurosciences and Sensory Organs, Section of Human Anatomy and Histology, University of Bari Medical School, Italy. He was awarded his M.D. degree in 1981, with full marks. In 1983, he joined the Medical School as Assistant at the Institute of Human Anatomy, University of Bari. In 1984, he took the specialization in Allergology. In 1989, he spent one year in Geneva, working at the Department of Morphology. In 2008, he received the honoris causa degree in Medicine and Pharmacy form the University of Timisoara, Romania. He is the author of over 800 publications and 50 chapters, as well as a number of books for Elsevier/Academic Press including: Milestones in Immunology (2017) In Vivo Models to Study Angiogenesis (2017) Immunology in the Twentieth Century (2018) Tumor Vascularization (2020) Tumor Microenvironment Regulation of Tumor Expansion (2021) .

Affiliations and Expertise

Professor of Human Anatomy, Department of Basic Biomedical Sciences, Neurosciences and Sensory Organs, Section of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy

Francesco Pezzella

Francesco Pezzella

Francesco Pezzella is a histopathologist and is currently Professor of Tumour Pathology at Oxford. He worked in the past on the pathology of HIV (at the time HTLV III) infection and molecular alterations in lymphoma. Because of his friends pushing him into the field of cancer and blood vessels, eventually he discovered in the mid-nineties, by pure chance, the tumours growing without angiogenesis.

Affiliations and Expertise

Professor of Tumour Pathology, Nuffield Division of Clinical Laboratory Science-Radcliffe Department of Medicine, University of Oxford, UK


"This will be a useful book for scientists and clinicians interested in angiogenesis and related mechanisms. The information is current and the topics are well covered. I am not aware of another recent book focused solely on this subject." --Doody

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