Tumor Microenvironment Regulation of Tumor Expansion

Tumor Microenvironment Regulation of Tumor Expansion

1st Edition - April 4, 2021

Write a review

  • Author: Domenico Ribatti
  • Paperback ISBN: 9780128228036
  • eBook ISBN: 9780128228043

Purchase options

Purchase options
Available
DRM-free (Mobi, PDF, EPub)
Sales tax will be calculated at check-out

Institutional Subscription

Free Global Shipping
No minimum order

Description

Tumor Microenvironment Regulation of Tumor Expansion is a practical guide to understand and perform research on tumor microenvironments, and to support related clinical decisions. Tumor progression is linked to an imbalance between positive and negative regulators, and mainly depends on the release of specific growth factors by inflammatory or neoplastic cells. Inflammatory infiltrate contributes to tumor progression and the metastatic process, and there are many reports of associations between tumor inflammatory infiltrate, progression, and prognosis. Understanding different contexts of organs is a key factor in improving treatment outcome, especially in new therapeutic treatments targeting components of the tumor microenvironment. This book is a valuable resource for cancer researchers, clinicians, graduate students, and scientists in many biomedical fields who are interested in the complex relationship between the tumor microenvironment and its context in specific organs.

Key Features

  • Provides a holistic approach to understanding the crucial role of the tumor microenvironment in tumor progression
  • Encompasses the basic knowledge necessary to understand and undertake further studies related to tumor microenvironments
  • Discusses new therapeutic approaches developed to control tumor progression by targeting different components of the tumor microenvironment

Readership

Cancer researchers, medical scientists, clinicians, graduate students

Table of Contents

  • 1. Tumor microenvironment
    1.1. Metastatic cascade
    1.2. Epithelial-mesenchymal transition
    1.3. The extracellular matrix
    2. Tumor blood vessels and tumor endothelial cells
    3. Tumor angiogenesis
    4. Inflammatory cells in tumor microenvironment
    4.1. Neutrophils
    4.2. Eosinophils and dendritic cells
    4.3. Lymphocytes and platelets
    4.4. Mast cells
    4.5. Macrophages
    4.6. Tie-2 expressing monocytes (TEMs)
    4.7.  Fibroblasts
    4.8.  Osteoblasts and osteoclasts
    4.9. Cancer stem cells (CSCs)
    4.10. Circulating endothelial cells and endothelial precursor cells
    4.11. Multipotents adult progenitor cells (MAPCs) and myeloid-derived suppressor cells (MDSCs)
    5. Therapeutic strategies

Product details

  • No. of pages: 172
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: April 4, 2021
  • Imprint: Academic Press
  • Paperback ISBN: 9780128228036
  • eBook ISBN: 9780128228043

About the Author

Domenico Ribatti

Domenico Ribatti is Professor of Human Anatomy, in the Department of Basic Biomedical Sciences, Neurosciences and Sensory Organs, Section of Human Anatomy and Histology, University of Bari Medical School, Italy. He was awarded his M.D. degree in 1981, with full marks. In 1983, he joined the Medical School as Assistant at the Institute of Human Anatomy, University of Bari. In 1984, he took the specialization in Allergology. In 1989, he spent one year in Geneva, working at the Department of Morphology. In 2008, he received the honoris causa degree in Medicine and Pharmacy form the University of Timisoara, Romania. He is the author of over 800 publications and 50 chapters, as well as a number of books for Elsevier/Academic Press including: Milestones in Immunology (2017) In Vivo Models to Study Angiogenesis (2017) Immunology in the Twentieth Century (2018) Tumor Vascularization (2020) Tumor Microenvironment Regulation of Tumor Expansion (2021) .

Affiliations and Expertise

Professor of Human Anatomy, Department of Basic Biomedical Sciences, Neurosciences and Sensory Organs, Section of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy

Ratings and Reviews

Write a review

There are currently no reviews for "Tumor Microenvironment Regulation of Tumor Expansion"