Trends in Receptor Research, Volume 18

Preface (P. Angeli, U. Gulini, W. Quaglia). Bernard Belleau: Medicinal
Chemist. 1925-1989 (D.J. Triggle). Design, anti-HIV activity, cellular
pharmacology and conformation of BCH-189 [(±)3TC], a novel nucleoside
analogue (B. Belleau, et al.). Theoretical and practical advantages and
limitations of techniques used in functional pharmacological classification
of drug receptors (T.P. Kenakin, R.A Bond). Is pharmacological analysis of
agonist action useful in medical chemistry? (P. Leff, I.G. Dougall). The
hydrogen bonding of drugs: its experimental determination and role in
pharmacokinetics and pharmacodynamics (B. Testa, et al.). Presynaptic
receptors modulating transmitter release: physiological and pharmacological
aspects (M. Raiteri, et al.). Presynaptic auto- and hetero-receptors in the
cholinergic regulation of pain (C. Ghelardini, et al.). Heterogeneity of
&agr;2-adrenoceptors: clinical aspects (E.S. Vizi, et al.).
Histamine H3 receptors: novel ligands and responses (J.C. Schwartz,
et al.). Selective alpha adrenergic agents - Differentiation of receptor
subtypes (J.F. DeBernardis, D.J. Kerkman). Stereoisomeric, photoaffinity,
affinity and fluorescent probes for characterization of dopamine D1
and D2 receptors (J.L. Neumeyer, et al.). Serotonin receptors, 5-HT ligands and receptor modeling (R.A. Glennon, R.B Westkaemper). Excitatory
amino acid receptors: multiplicity and ligand specificity of the NMDA and AMPA
receptor subtypes (P. Krogsgaard-Larsen, et al.). Tricyclic compounds as
selective muscarinic antagonists: structure activity relationships and
therapeutic implications (W.G. Eberlein, et al.). Design of high efficacy
agonists at cortical muscarinic receptors (J. Saunders). Multidisciplinary
analysis of muscarinic receptors in guinea-pig isolated ileum, atria and
uterus in vitro (R.M. Eglen, et al.). Molecular biology of the
GABAA receptor (A.N. Bateson). Potassium channel openers:
pharmacology and therapeutic prospects (U. Quast, et al.). L-type calcium
channels and calcium channel ligands (J. Striessnig, H. Glossmann). Central
cholecystokinin receptors : opportunity for drug discovery (G. Gaviraghi, et
al.). Drug modeling at cell membrane receptors: the concept of pseudoreceptors
(J.P. Snyder, et al.). Concluding comments (D.J. Triggle). Messengers and
modulators - Receptors and enzymes (E.J. Ariëns). Author index. Subject
index.

The 8th Camerino-Noordwijkerhout Symposium has continued along its traditional path of interdisciplinary cooperation. Chemists, biochemists, pharmacologists, biophysicists and physiologists are all involved in the task of improving our knowledge of the mechanisms of drug-receptor interaction and of the heterogeneous nature of biological molecules. In this volume, leading researchers have contributed state of the art information on receptor chemistry. Newest developments are covered with particular reference to receptors of the nervous system; SAR studies; receptor isolation; receptor cloning; receptor topography; biomedical consequences of occupancy; receptor regulation and receptor theory. This will be of great interest to pharmacologists, biochemists and medicinal chemists, as well as a valuable source of reference for medical students and postgraduate students in related fields.