Volume 18. Trends in Receptor Research

Preface (P. Angeli, U. Gulini, W. Quaglia). Bernard Belleau: Medicinal Chemist. 1925-1989 (D.J. Triggle). Design, anti-HIV activity, cellular pharmacology and conformation of BCH-189 [(±)3TC], a novel nucleoside analogue (B. Belleau, et al.). Theoretical and practical advantages and limitations of techniques used in functional pharmacological classification of drug receptors (T.P. Kenakin, R.A Bond). Is pharmacological analysis of agonist action useful in medical chemistry? (P. Leff, I.G. Dougall). The hydrogen bonding of drugs: its experimental determination and role in pharmacokinetics and pharmacodynamics (B. Testa, et al.). Presynaptic receptors modulating transmitter release: physiological and pharmacological aspects (M. Raiteri, et al.). Presynaptic auto- and hetero-receptors in the cholinergic regulation of pain (C. Ghelardini, et al.). Heterogeneity of &agr;2-adrenoceptors: clinical aspects (E.S. Vizi, et al.). Histamine H3 receptors: novel ligands and responses (J.C. Schwartz, et al.). Selective alpha adrenergic agents - Differentiation of receptor subtypes (J.F. DeBernardis, D.J. Kerkman). Stereoisomeric, photoaffinity, affinity and fluorescent probes for characterization of dopamine D1 and D2 receptors (J.L. Neumeyer, et al.). Serotonin receptors, 5-HT ligands and receptor modeling (R.A. Glennon, R.B Westkaemper). Excitatory amino acid receptors: multiplicity and ligand specificity of the NMDA and AMPA receptor subtypes (P. Krogsgaard-Larsen, et al.). Tricyclic compounds as selective muscarinic antagonists: structure activity relationships and therapeutic implications (W.G. Eberlein, et al.). Design of high efficacy agonists at cortical m