Treating Individuals - 1st Edition - ISBN: 9780080447391

Treating Individuals

1st Edition

From randomised trials to personalised medicine

Editors: Peter Rothwell
Paperback ISBN: 9780080447391
Imprint: Elsevier
Published Date: 2nd July 2007
Page Count: 340
Info/Buy

Description

Section 1: Reliable determination of the overall effects of treatments

1) Reliable assessment of the effects of treatment on mortality and major morbidity
2) The lethal consequences of failing to make full use of all relevant evidence about the effects of medical treatments: the importance of systematic reviews

Section 2: Is the trial relevant to this patient?

3) Assessment of the external validity of randomised trials
4) Applying results to treatment decisions in primary care
5) The older patient
6) Applying results to treatment decisions in complex clinical situations
7) External validity of pharmaceutical trials in neuropathic pain
8) External validity of pharmaceutical trials in asthma and chronic obstructive pulmonary disease

Section 3: Is the overall trial result sufficiently relevant this patient?

9) When should we expect clinically important differences in response to treatment?
10) Genes and the individual response to treatment
11) Reliable estimation and interpretation of the effects of treatment in subgroups
12) Can meta-analysis help target interventions at individuals most likely to benefit?
13) Use of risk models to predict the likely effects of treatment in individuals
14) Evaluating the performance of prognostic models
15) Are “n-of-1” trials of any practical value to clinicians or researchers?

Section 4: Targeting of treatment in routine practice

16) Primary prevention of cardiovascular disease: the absolute risk-based approach
17) Antithrombotic therapy to prevent stroke in patients with atrial fibrillation
18) Reperfusion therapies in acute cardiovascular and cerebrovascular syndromes
19) Choice of agent in treatment of epilepsy
20) Pharmacogenomic targeting of treatment for cancer

Table of Contents

Section 1: Reliable determination of the overall effects of treatments

1) Reliable assessment of the effects of treatment on mortality and major morbidity
2) The lethal consequences of failing to make full use of all relevant evidence about the effects of medical treatments: the importance of systematic reviews

Section 2: Is the trial relevant to this patient?

3) Assessment of the external validity of randomised trials
4) Applying results to treatment decisions in primary care
5) The older patient
6) Applying results to treatment decisions in complex clinical situations
7) External validity of pharmaceutical trials in neuropathic pain
8) External validity of pharmaceutical trials in asthma and chronic obstructive pulmonary disease

Section 3: Is the overall trial result sufficiently relevant this patient?

9) When should we expect clinically important differences in response to treatment?
10) Genes and the individual response to treatment
11) Reliable estimation and interpretation of the effects of treatment in subgroups
12) Can meta-analysis help target interventions at individuals most likely to benefit?
13) Use of risk models to predict the likely effects of treatment in individuals
14) Evaluating the performance of prognostic models
15) Are “n-of-1” trials of any practical value to clinicians or researchers?

Section 4: Targeting of treatment in routine practice

16) Primary prevention of cardiovascular disease: the absolute risk-based approach
17) Antithrombotic therapy to prevent stroke in patients with atrial fibrillation
18) Reperfusion therapies in acute cardiovascular and cerebrovascular syndromes
19) Choice of agent in treatment of epilepsy
20) Pharmacogenomic targeting of treatment for cancer

Details

No. of pages:
340
Language:
English
Copyright:
© Elsevier 2007
Published:
Imprint:
Elsevier
Paperback ISBN:
9780080447391

About the Editor

Peter Rothwell

Affiliations and Expertise

Professor, Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK