Treating Individuals

1st Edition

From randomised trials to personalised medicine


  • Peter Rothwell
    • Print ISBN 9780080447391

    Table of Contents

    Section 1: Reliable determination of the overall effects of treatments

    1) Reliable assessment of the effects of treatment on mortality and major morbidity
    2) The lethal consequences of failing to make full use of all relevant evidence about the effects of medical treatments: the importance of systematic reviews

    Section 2: Is the trial relevant to this patient?

    3) Assessment of the external validity of randomised trials
    4) Applying results to treatment decisions in primary care
    5) The older patient
    6) Applying results to treatment decisions in complex clinical situations
    7) External validity of pharmaceutical trials in neuropathic pain
    8) External validity of pharmaceutical trials in asthma and chronic obstructive pulmonary disease

    Section 3: Is the overall trial result sufficiently relevant this patient?

    9) When should we expect clinically important differences in response to treatment?
    10) Genes and the individual response to treatment
    11) Reliable estimation and interpretation of the effects of treatment in subgroups
    12) Can meta-analysis help target interventions at individuals most likely to benefit?
    13) Use of risk models to predict the likely effects of treatment in individuals
    14) Evaluating the performance of prognostic models
    15) Are “n-of-1” trials of any practical value to clinicians or researchers?

    Section 4: Targeting of treatment in routine practice

    16) Primary prevention of cardiovascular disease: the absolute risk-based approach
    17) Antithrombotic therapy to prevent stroke in patients with atrial fibrillation
    18) Reperfusion therapies in acute cardiovascular and cerebrovascular syndromes
    19) Choice of agent in treatment of epilepsy
    20) Pharmacogenomic targeting of treatment for cancer


    No. of pages:
    © 2007
    Print ISBN:

    About the author

    Peter Rothwell

    Affiliations and Expertise

    Professor, Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK