Transporters in Drug Discovery and Development

Transporters in Drug Discovery and Development

Detailed Concepts and Best Practice

1st Edition - October 31, 2013

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  • Author: Yurong Lai
  • eBook ISBN: 9781908818287
  • Hardcover ISBN: 9781907568213

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Written by a leading researcher in the field, Transporters in Drug Discovery and Development provides a comprehensive and practical guide to drug transporter families that are the most important for drug discovery and development. It covers: an overview of transporter families and organ distribution; clinical relevant drug-drug interaction; clinical relevant polymorphism; drug transporter related pharmacokinetic, pharmacodynamics and toxicity; in vitro/in vivo probes of drug transport studies; the practical methodologies of industrial transporter screening and translational aspect in drug discovery and developments.

Key Features

  • A comprehensive overview of drug transporter families and their clinical relevance in drug discovery and development
  • Balanced coverage of molecular biology aspects and functional outcomes
  • State of art knowledge related to transporter-mediated DDI and the clinical relevance in pharmacokinetics, dynamics, and toxicity


Scientists working in biopharmaceutical science, drug discovery/development in understanding the principles and techniques for testing drug candidates

Table of Contents

  • Membrane transporters and the diseases corresponding to functional defects; P-glycoprotein (P-gp/MDR1)/ABCB1; Multidrug resistance- associated protein 2 (MRP2/ABCC2); Breast cancer resistance protein (BCRP)/ABCG2; The bile salt export pump (BSEP/ABCB11); Organic anion- transporting polypeptides (OATPs/SLCOs); Organic anion, organic cation and zwitterion transporters of the SLC22 and SLC47 superfamily (OATs, OCTs, OCTNs and MATEs); Drug transporters in drug discovery and development; Transporter study methodologies.

Product details

  • No. of pages: 780
  • Language: English
  • Copyright: © Woodhead Publishing 2013
  • Published: October 31, 2013
  • Imprint: Woodhead Publishing
  • eBook ISBN: 9781908818287
  • Hardcover ISBN: 9781907568213

About the Author

Yurong Lai

Yurong Lai is a senior principal scientist at a US-based pharmaceutical company. He received his M.D. from Fujian Medical University in China and a Ph.D. (Toxicology) from Sapporo Medical University in Japan. From 1998 to 2001, he was a research fellow of Japanese Society for Promotion (JSPS) in Department of Physiopathology, Graduate School of Medicine of Hokkaido University, followed by a position as Research Associate in Department of Pharmaceutics, University of Washington

Affiliations and Expertise

A major US pharmaceutical company, USA

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