Transporters in Drug Discovery and Development - 1st Edition - ISBN: 9781907568213, 9781908818287

Transporters in Drug Discovery and Development

1st Edition

Detailed Concepts and Best Practice

Authors: Yurong Lai
Hardcover ISBN: 9781907568213
eBook ISBN: 9781908818287
Imprint: Woodhead Publishing
Published Date: 31st October 2013
Page Count: 780
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Table of Contents

Membrane transporters and the diseases corresponding to functional defects; P-glycoprotein (P-gp/MDR1)/ABCB1; Multidrug resistance- associated protein 2 (MRP2/ABCC2); Breast cancer resistance protein (BCRP)/ABCG2; The bile salt export pump (BSEP/ABCB11); Organic anion- transporting polypeptides (OATPs/SLCOs); Organic anion, organic cation and zwitterion transporters of the SLC22 and SLC47 superfamily (OATs, OCTs, OCTNs and MATEs); Drug transporters in drug discovery and development; Transporter study methodologies.


Description

Membrane transporters and the diseases corresponding to functional defects; P-glycoprotein (P-gp/MDR1)/ABCB1; Multidrug resistance- associated protein 2 (MRP2/ABCC2); Breast cancer resistance protein (BCRP)/ABCG2; The bile salt export pump (BSEP/ABCB11); Organic anion- transporting polypeptides (OATPs/SLCOs); Organic anion, organic cation and zwitterion transporters of the SLC22 and SLC47 superfamily (OATs, OCTs, OCTNs and MATEs); Drug transporters in drug discovery and development; Transporter study methodologies.

Key Features

  • A comprehensive overview of drug transporter families and their clinical relevance in drug discovery and development
  • Balanced coverage of molecular biology aspects and functional outcomes
  • State of art knowledge related to transporter-mediated DDI and the clinical relevance in pharmacokinetics, dynamics, and toxicity

Readership

Scientists working in biopharmaceutical science, drug discovery/development in understanding the principles and techniques for testing drug candidates


Details

No. of pages:
780
Language:
English
Copyright:
© Woodhead Publishing 2013
Published:
Imprint:
Woodhead Publishing
eBook ISBN:
9781908818287
Hardcover ISBN:
9781907568213

About the Authors

Yurong Lai Author

Yurong Lai is a senior principal scientist at a US-based pharmaceutical company. He received his M.D. from Fujian Medical University in China and a Ph.D. (Toxicology) from Sapporo Medical University in Japan. From 1998 to 2001, he was a research fellow of Japanese Society for Promotion (JSPS) in Department of Physiopathology, Graduate School of Medicine of Hokkaido University, followed by a position as Research Associate in Department of Pharmaceutics, University of Washington

Affiliations and Expertise

A major US pharmaceutical company, USA