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Translational Glycobiology in Human Health and Disease - 1st Edition - ISBN: 9780128196557

Translational Glycobiology in Human Health and Disease

1st Edition

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Editors: Michelle Kilcoyne Lokesh Joshi
Paperback ISBN: 9780128196557
Imprint: Academic Press
Published Date: 1st November 2020
Page Count: 480
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Description

Along with nucleic acids, proteins, and lipids, carbohydrates stand as one of four main components of cellular architecture. However, glycobiology (or carbohydrate bioscience) is little understood by non-experts, partly because carbohydrates are a complex, diverse class of molecules structurally and functionally. In recent years, advances in computational analytics (glycomics) have allowed us to better interpret and realize the importance of glycobiology in human health and disease, and glycans and their associated processes have been shown to play a significant role across a variety of disease types. As the biomedical sciences continue to adopt multi-omic and precision medicine approaches, a greater understanding of glycobiology is essential for maintaining healthy physiology and advancing disease treatment.

Translational Glycobiology in Human Health and Disease offers a deep examination of glycobiology for experts and non-experts alike in areas ranging from the role of glycobiology in chronic and infectious diseases to advances in technologies for higher throughput analysis and diagnosis. While keeping human health in the forefront, this book integrates a thorough discussion of glycobiology fundamentals with its growing areas of application and societal impact. With emphasis throughout on the interdisciplinary nature of glycosciences, this book also features perspectives from the health, computational (glycoanalytics), materials, biopharmaceutical, and diagnostic sciences.

Disease and speciality areas addressed include gycoimmunology, neuroglycobiology, commensal glycobiology, gut health, regenerative medicine and glycobiology, glycobiology and cancer, congenital disorders of glycosylation, infectious disease glycobiology, and parasite glycobiology. Computational approaches discussed, supporting the advance of new research, include advanced glycoanalytics, glycomics microarrays, glycoengineering, and glycol systems biology. Additionally, authors consider impact areas for society and public health, such as glycobiology and entrepreneurship, policy and regulatory requirements for glycosylation, future research, and translation to new diagnostics and drug discovery.

Key Features

  • Provides a deep, foundational overview of glycoscience and its translational potential, highlighting glycobiology’s growing role in human health and disease study
  • Examines a broad range of relevant disease areas and applications of glycobiology in policy and public health
  • Features chapter contributions from leading, international experts in the field, fully integrating perspectives from the health, computational, materials, biopharmaceutical, and diagnostic sciencess

Readership

Active researchers in biochemistry, molecular biology, nutrition, and cell biology; industrial scientists; biomedical engineers; nutritional scientists; pharmacologists; clinician scientists; medicinal chemists; analytical chemists

Table of Contents

1. Introduction

Section 1: Glycobiology
2. Carbohydrates and human glycosylation
3. Carbohydrate-binding proteins
4. Carbohydrate-active enzymes

Section 2: Glycobiology and health
5. Glycoimmunology
6. Neuroglycobiology
7. Commensal glycobiology and gut health
8. Microbiota accessible carbohydrates and the gut microbiome
9. Regenerative medicine and glycobiology
10. Exosome glycosylation for signalling and function

Section 3: Glycobiology and disease
11. Cancer 
12. Altered glycosylation in autoimmune diseases
13. Metabolic diseases: Disorders of carbohydrate metabolism and lysosomal storage
14. Congenital Disorders of Glycosylation
15. Microbial infectious disease glycobiology
16. Parasite glycobiology
17. Glycobiology of neurodegenerative diseases 
18. Glycobiology of neural injury and regeneration

Section 4: Glycotechnologies
19. Diagnostics and novel carbohydrate recognition molecules
20. Advanced glycoanalytics
21. Glycomics microarrays
22. Glycoengineering and systems biology
23. Computational Glycobiology
24. Carbohydrate-incorporated Biomaterials

Section 5: Glycobiology and Society
25. Translational glycobiology and entrepreneurship for health
26. Glycobiology: Public engagement and society
27. Policy and regulatory requirements for glycosylation 
28. Public health and translational glycobiology
29. Future perspectives/ summary

Details

No. of pages:
480
Language:
English
Copyright:
© Academic Press 2021
Published:
1st November 2020
Imprint:
Academic Press
Paperback ISBN:
9780128196557

About the Editors

Michelle Kilcoyne

Dr. Michelle Kilcoyne is Lecturer in Glycosciences at the National University of Ireland Galway. Dr. Michelle Kilcoyne completed her PhD in analytical carbohydrate chemistry in the School of Chemistry at NUI Galway in 2004, specialising in structural analysis of bacterial polysaccharides. She then took up a postdoctoral position in Arizona State University where she further specialised in mass spectrometry and HPLC, as well as expanding her interests to mammalian glycosylation. She returned as a postdoctoral researcher to NUI Galway in 2007 working on industry-supported and European projects, developing high throughput platforms for carbohydrate profiling. In 2014 Dr. Kilcoyne was appointed Lecturer in Glycosciences, is currently a member of Discipline of Microbiology at NUI Galway and leads the Carbohydrate Signalling Group. She is the recipient of a Royal Society of Chemistry Analytical Chemistry Trust Fund Fellowship for 2018. Her main interests are in glycoanalytics, novel glycomics platform development and carbohydrate-mediated host-microbe interactions.

Affiliations and Expertise

Lecturer in Glycosciences, National University of Ireland, Galway, Ireland

Lokesh Joshi

Prof. Lokesh Joshi is Director of the Advanced Glycoscience Research Cluster and leader of the Glycoscience Group at NUI Galway, a Co-Director of CÚRAM, a medical device centre, and the Vice-President for Research at NUI Galway. His principal focus of research is in understanding the roles of glycans and lectins in health and diseases and developing novel technologies for glycomics. Prof. Joshi has been involved in two spin out companies, Arizona Engineered Therapeutics (AzERx) and Aquila Biosciences. The NIH and VC sources funded AzERx to develop peptide-based therapeutics for vascular applications and AzERx was acquired by Orthologic (Now Capstone Therapeutics) in 2006. Aquila Bioscience is a healthcare company working on various projects funded by EI, EU, European Defence Agency and private industries. Prof. Joshi is an SFI-Stokes Professor of Glycosciences and the Irish representative on European Universities Association’s Research Programme Working group.

Affiliations and Expertise

Director, Advanced Glycoscience Research Cluster and Leader, Glycoscience Group, NUI Galway, Ireland

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