Translational Autoimmunity

Translational Autoimmunity

Autoimmune Disease Associated with Different Clinical Features

1st Edition - April 1, 2022

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  • Editor: Nima Rezaei
  • eBook ISBN: 9780323854160
  • Paperback ISBN: 9780323854153

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Description

Translational Autoimmunity: Autoimmune Diseases in Different Clinical Settings addresses autoimmunity and associated conditions, such as aging, infectious diseases, cancer, neurodegeneration, psychological disorders, fertility, inflammatory vascular diseases, and interstitial lung diseases.  The book addresses sufficiently basic questions on how the immune system is designed to distinguish self from no self and behave such that it's able to maintain self-tolerance, how does it work in infections, and how it elicits an auto-reactive state and develops self-antigens seen in autoimmune conditions. This is followed by an overview on the genetic and clinical aspects of the spectrum of autoimmune diseases which are broadly categorized into two types of organ specific autoimmune diseases and non-organ specific autoimmune diseases (also known as systemic autoimmune diseases).

Key Features

  • Covers clinical aspects of autoimmunity and translational immunology studies in autoimmunity in different clinical settings
  • Meets the needs of basic scientists, clinicians, translational scientists and industry partners
  • Supported by a systematic appraisal of the most recent evidence

Readership

Clinical immunologists; Endocrinologists; Microbiologists; Neurologists; Oncologists; Rheumatologists. Clinicians, research scientists, and industry partners

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Dedication
  • Contributors
  • Preface
  • Series editor biography
  • Acknowledgment
  • Abbreviations
  • Chapter 1: Introduction on autoimmunity and associated conditions
  • Abstract
  • 1: Introduction
  • 2: Autoimmunity and infection
  • 3: Autoimmunity and genetic syndromes
  • 4: Autoimmunity and inborn errors of immunity
  • 5: Autoimmunity and malignancies
  • 6: Autoimmunity and associated conditions affecting patients’ quality of life
  • 7: Conclusion
  • References
  • Chapter 2: Cross talks between autoimmunity and cancer
  • Abstract
  • 1: Introduction
  • 2: Autoimmunity and cancer mechanisms: Clinical features and similar mechanisms
  • 3: Rheumatoid arthritis
  • 4: Systemic lupus erythematosus
  • 5: Sjögren’s syndrome
  • 6: Systemic sclerosis
  • 7: Idiopathic inflammatory myopathy
  • 8: ANCA-associated vasculitis
  • 9: Conclusion
  • References
  • Chapter 3: Autoimmunity regulation within the tumor microenvironment
  • Abstract
  • 1: Introduction
  • 2: Targeting immune checkpoints in cancer immunotherapy
  • 3: Coinhibitory checkpoint pathways to cancer
  • 4: Costimulatory checkpoint pathways on cancer
  • 5: Conclusion
  • References
  • Chapter 4: Mechanisms of immune tolerance breakdown in inborn errors of immunity
  • Abstract
  • 1: Introduction
  • 2: Mechanisms implicated in the disruption of immune tolerance in IEI
  • 3: Central tolerance disruption
  • 4: Alterations of peripheral tolerance
  • 5: Conclusion
  • References
  • Chapter 5: Autoimmunity in combined immunodeficiency
  • Abstract
  • 1: Introduction
  • 2: Severe combined immunodeficiencies
  • 3: Combined immunodeficiencies
  • 4: Combined immunodeficiencies associated with significant autoimmunity
  • 5: Combined immunodeficiencies rarely associated with autoimmunity
  • 6: Combined immunodeficiencies not associated with autoimmunity
  • 7: Conclusion
  • References
  • Chapter 6: Autoimmunity and autoimmune diseases in primary selective IgM deficiency
  • Abstract
  • Acknowledgments
  • 1: Introduction
  • 2: Natural IgM antibodies
  • 3: Role of IgM in autoimmunity and autoimmune diseases
  • 4: Autoimmunity and autoimmune diseases in selective IgM deficiency
  • 5: Conclusion
  • References
  • Chapter 7: Autoimmunity and HIV infection
  • Abstract
  • 1: Introduction
  • 2: HIV structure
  • 3: HIV infection
  • 4: HIV and autoimmunity
  • 5: Autoimmune diseases in the HIV patient
  • 6: Conclusion
  • References
  • Chapter 8: Autoimmune diseases and metabolic disorders: Molecular connections and potential therapeutic targets
  • Abstract
  • 1: Introduction
  • 2: Molecular mechanisms of autoimmune responses and autoimmune diseases
  • 3: Molecular connections between autoimmune diseases and some important metabolic disorders
  • 4: Potential molecular targets to control autoimmune diseases and metabolic disorders
  • 5: Conclusion
  • References
  • Chapter 9: Autoimmunity and infertility
  • Abstract
  • 1: Introduction
  • 2: The association between autoimmunity and female infertility
  • 3: The association between autoimmunity and male infertility
  • 4: Clinical implications of serum autoantibodies in IVF/ICSI-ET
  • 5: Conclusion
  • References
  • Chapter 10: Autoimmune disease of the cardiovascular system
  • Abstract
  • 1: Introduction
  • 2: Rheumatic heart disease
  • 3: Myocarditis
  • 4: Vasculitis
  • 5: Conclusion
  • References
  • Chapter 11: Allergy and autoimmunity: Share of genetics and environment
  • Abstract
  • Acknowledgments
  • 1: Introduction
  • 2: Key elements regulating allergy and autoimmune disease
  • 3: Immunopathological reactions—Allergy and autoimmunity subtypes
  • 4: Conclusion
  • References
  • Chapter 12: Asthma and autoimmunity
  • Abstract
  • 1: Introduction
  • 2: Asthma endotypes—An overview
  • 3: Autoimmune responses following chronic inflammation
  • 4: Asthma and autoimmunity
  • 5: Conclusion
  • References
  • Chapter 13: Autoimmunity in interstitial lung disease
  • Abstract
  • 1: Introduction
  • 2: Interstitial lung disease in systemic sclerosis
  • 3: Rheumatoid arthritis
  • 4: Other rheumatic conditions associated with ILD
  • 5: Conclusion
  • References
  • Chapter 14: Role of autoimmunity in the pathogenesis of chronic obstructive pulmonary disease and pulmonary emphysema
  • Abstract
  • 1: Introduction
  • 2: Animal models of chronic obstructive pulmonary disease (COPD) and pulmonary emphysema
  • 3: Autoimmune responses in the pathogenesis of stable COPD and pulmonary emphysema
  • 4: Regulatory T (Treg) cells in the autoimmune pathogenesis of stable COPD and pulmonary emphysema
  • 5: B-cells and autoantibody-mediated lung damage in the pathogenesis of stable COPD and pulmonary emphysema
  • 6: Other autoantibodies in COPD and pulmonary emphysema
  • 7: Complement system and autoimmunity in COPD and pulmonary emphysema
  • 8: Role of the microbiota in COPD and pulmonary emphysema
  • 9: Cell-mediated autoimmune lung damage in the pathogenesis of stable COPD and pulmonary emphysema
  • 10: Therapeutic implications
  • 11: Conclusion
  • References
  • Chapter 15: Oxidative stress in oral autoimmune disorders
  • Abstract
  • 1: Introduction
  • 2: Oxidative stress and the immune system
  • 3: Biomarkers of oxidative stress in oral autoimmune disorders
  • 4: Antioxidants and related treatments for oral autoimmune disorders
  • 5: Conclusion
  • References
  • Chapter 16: Autoimmunity and psychosis
  • Abstract
  • 1: Introduction
  • 2: Infection, inflammation, and autoimmunity in psychosis
  • 3: Mechanisms of autoimmunity in the central nervous system
  • 4: Autoimmune encephalitis and psychosis
  • 5: Multiple sclerosis and psychosis
  • 6: Autoimmune epilepsy and psychosis
  • 7: Nonneurological autoimmune disorders and psychosis
  • 8: Possible causal treatment of psychosis in autoimmune diseases
  • 9: Conclusion
  • References
  • Index

Product details

  • No. of pages: 402
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: April 1, 2022
  • Imprint: Academic Press
  • eBook ISBN: 9780323854160
  • Paperback ISBN: 9780323854153

About the Editor

Nima Rezaei

Nima Rezaei is professor of clinical immunology at Tehran University of Medical Sciences (TUMS), vice dean of international affairs in the School of Medicine, and deputy president of Research Center for Immunodeficiencies. He received his PhD in clinical immunology and human genetics from the University of Sheffield in the UK after graduation in medicine (MD) from TUMS. He has written hundreds of papers and edited for leading book series and is the founding president of Universal Scientific Education and Research Network (USERN), where he is directing several interest groups such the Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA) and the Cancer Immunology Project (CIP). He is the Deputy President of the Research Center for Immunodeficiencies. He has presented more than 400 lectures/ posters in congresses and published more than 6700 articles and several books, and major reference works.

Affiliations and Expertise

Professor of Clinical Immunology, Research Center for Immunodeficiencies, Children's Medical Center and Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Iran; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran

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