Translational Autoimmunity, Volume 1

Etiology of Autoimmune Diseases

1st Edition - October 22, 2021
Editor: Nima Rezaei
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 2 2 5 6 4 - 6
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 2 3 2 7 7 - 4

Translational Autoimmunity: Etiology of Autoimmune Diseases is the first volume of the Translational Immunology book series. To attain its purpose as a detailed translational st… Read more

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Translational Autoimmunity: Etiology of Autoimmune Diseases is the first volume of the Translational Immunology book series. To attain its purpose as a detailed translational step to tackle autoimmunity, this volume sufficiently addresses basic questions on how the immune system is designed to distinguish self from nonself. It discusses the known mechanisms that lead to the maintenance of self-tolerance, presents potential triggers and malfunctions that impede normal immune processes, and demonstrates how the immune system induces an autoreactive state that results in the recognition of self-antigens seen in autoimmune conditions.

Cover image
Title page
Table of Contents
Copyright
Dedication
Contributors
Preface
Series editor biography
Acknowledgment
Abbreviations
Chapter 1: Introduction on translational autoimmunity: From bench to bedside
Abstract
1: Introduction
2: Autoimmune disorders
3: Pathogenesis and mechanisms of autoimmune diseases
4: Predisposing factors
5: Role of genetics
6: Obstacles in treatment
7: Diagnostic tools
8: Role of innate immunity
9: Conclusion
References
Chapter 2: Autophagy in autoimmunity
Abstract
1: Introduction
2: An overview of autophagy
3: Autophagy in immunity
4: Autophagy in autoimmune diseases
5: Conclusion
References
Chapter 3: Immunometabolism and autoimmunity
Abstract
1: Introduction
2: Immunometabolism in homeostasis
3: Immunometabolism in autoimmunity
4: Conclusion
References
Chapter 4: T cell recognition of neoepitopes in autoimmunity
Abstract
1: Introduction
2: The mystery of lost tolerance in autoimmunity
3: Determinant spreading in autoimmune disease
4: Neoepitopes as a challenge to immune tolerance
5: T cell recognition of citrullinated neoepitopes in rheumatoid arthritis
6: T cell recognition of deamidated neoepitopes in CD
7: T cell recognition of neo-antigens in T1D
8: Prospects for diagnostic detection of neoepitope specific T cell responses
9: Conclusion
References
Chapter 5: Role of Th1 and Th2 in autoimmunity
Abstract
1: Introduction
2: Th1 and Th2 generation
3: Th1 and Th2 response in health
4: Breakdown of tolerance: Autoimmunity and allergy
5: Conclusion
References
Chapter 6: Role of Th17 cell in tissue inflammation and organ-specific autoimmunity
Abstract
Acknowledgments
1: Introduction
2: Differentiation of IL-17-producing Th17 cells
3: Amplification of Th17 cells
4: Stabilization of Th17 cells
5: Transcriptional regulation of Th17 cells
6: Regulators of Th17 cells
7: Small molecules inhibitor of Th17 cells
8: Role of Th17 cells in the pathogenesis of autoimmune diseases
9: Conclusion
References
Chapter 7: Peptide editing and its modulation in CD4+ T cell tolerance to self
Abstract
1: Introduction
2: Cellular adaptive immunity in health and disease
3: Tolerance mechanisms: training lymphocytes for a proper self and non-self recognition
4: Peptide editing in the targets of organ-specific autoimmune diseases
5: Conclusion
References
Chapter 8: Innate lymphoid cells in autoimmune diseases
Abstract
1: Introduction
2: ILCs as crucial components of the mammalian immune system
3: ILCs in ADs
4: Conclusion
References
Chapter 9: Autoimmune diseases and the role of Toll-like receptor-7 and -9 signaling cascades
Abstract
1: Introduction
2: Toll-like receptors
3: Autoimmune disorders with a role for TLR7 or TLR9
4: Manipulation of TLR7 and TLR9-induced signaling
5: Conclusion
References
Chapter 10: The role of type III interferons in systemic autoimmune diseases
Abstract
1: Introduction
2: The type III interferon family
3: Production of type III interferons
4: Response of target cells to type III interferons
5: Potential association between interferons and autoimmunity
6: Type III interferons in systemic lupus erythematosus
7: Type III interferons in Sjögren syndrome
8: Type III interferons in rheumatoid arthritis
9: Type III interferons in antiphospholipid syndrome
10: Type III interferons in systemic sclerosis
11: Conclusion
References
Chapter 11: Regulation of immunological tolerance and human autoimmunity by NF-κB
Abstract
1: Introduction
2: Immunological tolerance
3: Monogenic NF-κB defects and human autoimmunity
4: Conclusion
References
Chapter 12: Micro RNA, circular RNA, neutrophils, and myeloperoxydases in autoimmune diseases
Abstract
1: Introduction
2: Micro ribonucleic acids (MicroRNAs)
3: Circular RNAs
4: Neutrophils
5: Myeloperoxidase in autoimmune diseases
6: Conclusion
References
Chapter 13: Human leukocyte antigen and autoimmunity
Abstract
1: Introduction
2: HLA genetic organization and protein structure
3: Autoimmune HLA disease association
4: Mechanisms involved in HLA-mediated autoimmune pathology
5: Conclusion
References
Chapter 14: HLA-G-mediated immunological tolerance and autoimmunity
Abstract
Acknowledgments
1: Introduction
2: Genetic variation of HLA-G gene
3: Molecular structure of HLA-G
4: HLA-G expression regulation
5: HLA-G and receptor signaling pathways
6: HLA-G and autoimmunity
7: Implication of HLA-G-mediated immune tolerance in autoimmunity
8: Conclusion
References
Chapter 15: The immune system and the microbiota: The two sides of mucosal tolerance
Abstract
1: Introduction
2: Microbiota
3: Mucosal immune system
4: Mucosal tolerance
5: Mechanisms of mucosal tolerance toward commensal bacteria
6: Tolerance breaking at the mucous membranes and autoimmune diseases
7: Conclusion
References
Chapter 16: Role of free radicals in autoimmune diseases
Abstract
1: Introduction
2: Pathophysiology of free radicals
3: Inflammation and autoimmune diseases
4: Rheumatoid arthritis
5: Systemic lupus erythematosus
6: Conclusion
References
Chapter 17: Immunological tolerance and autoimmunity
Abstract
1: Introduction
2: Central tolerance of T cells and autoimmunity
3: Peripheral T cell tolerance and autoimmunity
4: Central B cell tolerance and autoimmunity
5: Peripheral B cell tolerance and autoimmunity
6: Conclusion
References
Chapter 18: Construction of bioscore for detection of self-tolerance failure: From analysis of silicosis cases
Abstract
1: Introduction
2: Effects of silica particles on human immune cells
3: Generating a bioscore/autoimmune score to detect early dysregulation of autoimmunity
4: Conclusion
References
Index

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Nima Rezaei